| Marion, Chad R., Wang, Jianmiao, Sharma, Lokesh, Losier, Ashley, Lui, Wei, Andrews, Nathaniel, Elias, Jack A., Kazmierczak, Barbara I., Roy, Craig R., Dela Cruz, Charles S. "Chitinase 3-Like 1 (Chil1) Regulates Survival and Macrophage-Mediated Interleukin-1β and Tumor Necrosis Factor Alpha during Pseudomonas aeruginosa Pneumonia." Infection and Immunity, vol. 84, no. 7, 2016, pp. 2094-2104. |
| Kim, Lark Kyun, Morita, Rimpei, Kobayashi, Yasushi, Eisenbarth, Stephanie C., Lee, Chun Geun, Elias, Jack, Eynon, Elizabeth E., Flavell, Richard A. "AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites." Proceedings of the National Academy of Sciences, vol. 112, no. 22, 2015, pp. E2891-E2899. |
| Wiesner, Darin L., Specht, Charles A., Lee, Chrono K., Smith, Kyle D., Mukaremera, Liliane, Lee, S. Thera, Lee, Chun G., Elias, Jack A., Nielsen, Judith N., Boulware, David R., Bohjanen, Paul R., Jenkins, Marc K., Levitz, Stuart M., Nielsen, Kirsten. "Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection." PLoS Pathog, vol. 11, no. 3, 2015, pp. e1004701. |
| He, Chuan Hua, Lee, Chun Geun, Dela Cruz, Charles S., Lee, Chang-Min, Zhou, Yang, Ahangari, Farida, Ma, Bing, Herzog, Erica L., Rosenberg, Stephen A., Li, Yue, Nour, Adel M., Parikh, Chirag R., Schmidt, Insa, Modis, Yorgo, Cantley, Lloyd, Elias, Jack A. "Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2." Cell Reports, vol. 10, no. 8, 2015, pp. 1433. |
| Ahangari, Farida, Sood, Akshay, Ma, Bing, Takyar, Seyedtaghi, Schuyler, Mark, Qualls, Clifford, Dela Cruz, Charles S., Chupp, Geoffrey L., Lee, Chun G., Elias, Jack A. "Chitinase 3–like-1 Regulates Both Visceral Fat Accumulation and Asthma-like Th2 Inflammation." Am J Respir Crit Care Med, vol. 191, no. 7, 2015, pp. 746-757. |
| Zhou, Yang, He, Chuan Hua, Herzog, Erica L., Peng, Xueyan, Lee, Chang-Min, Nguyen, Tung H., Gulati, Mridu, Gochuico, Bernadette R., Gahl, William A., Slade, Martin L., Lee, Chun Geun, Elias, Jack A. "Chitinase 3–like–1 and its receptors in Hermansky-Pudlak syndrome–associated lung disease." Journal of Clinical Investigation, vol. 125, no. 8, 2015, pp. 3178-3192. |
| Vock, C., Yildirim, A. Ö., Wagner, C., Schlick, S., Lunding, L. P., Lee, C. G., Elias, J. A., Fehrenbach, H., Wegmann, M. "Distal airways are protected from goblet cell metaplasia by diminished expression of IL-13 signalling components." Clinical & Experimental Allergy, vol. 45, no. 9, 2015, pp. 1447-1458. |
| Patel, Avignat S., Song, Jin Woo, Chu, Sarah G., Mizumura, Kenji, Osorio, Juan C., Shi, Ying, El-Chemaly, Souheil, Lee, Chun Geun, Rosas, Ivan O., Elias, Jack A., Choi, Augustine M. K., Morse, Danielle. "Epithelial Cell Mitochondrial Dysfunction and PINK1 Are Induced by Transforming Growth Factor- Beta1 in Pulmonary Fibrosis." PLoS ONE, vol. 10, no. 3, 2015, pp. e0121246. |
| Wang, Jianmiao, Liu, Wei, Marion, Chad, Singh, Rajvir, Andrews, Nathaniel, Lee, Chun Geun, Elias, Jack A., Dela Cruz, Charles S. "Regulation of Retinoic Acid Receptor Beta by Interleukin-15 in the Lung during Cigarette Smoking and Influenza Virus Infection." American Journal of Respiratory Cell and Molecular Biology, vol. 53, no. 6, 2015, pp. 822-833. |
| Ma, B., Herzog, E. L., Lee, C. G., Peng, X., Lee, C.-M., Chen, X., Rockwell, S., Koo, J. S., Kluger, H., Herbst, R. S., Sznol, M., Elias, J. A. "Role of chitinase 3-like-1 and semaphorin 7a in pulmonary melanoma metastasis." Cancer Research, vol. 75, no. 3, 2015, pp. 487-496. |
| Kang, Min-Jong, Yoon, Chang Min, Nam, Milang, Kim, Do-Hyun, Choi, Je-Min, Lee, Chun Geun, Elias, Jack A. "Role of Chitinase 3–Like-1 in Interleukin-18–Induced Pulmonary Type 1, Type 2, and Type 17 Inflammation; Alveolar Destruction; and Airway Fibrosis in the Murine Lung." American Journal of Respiratory Cell and Molecular Biology, vol. 53, no. 6, 2015, pp. 863-871. |
| Erdman, Laura K, Petes, Carlene, Lu, Ziyue, Dhabangi, Aggrey, Musoke, Charles, Cserti-Gazdewich, Christine M, Lee, Chun, Liles, Wayne, Elias, Jack A, Kain, Kevin C. "Chitinase 3-like 1 is induced by Plasmodium falciparum malaria and predicts outcome of cerebral malaria and severe malarial anaemia in a case–control study of African children." Malar J, vol. 13, no. 1, 2014, pp. 279. |
| Zhou, Y., Peng, H., Sun, H., Peng, X., Tang, C., Gan, Y., Chen, X., Mathur, A., Hu, B., Slade, M. D., Montgomery, R. R., Shaw, A. C., Homer, R. J., White, E. S., Lee, C.-M., Moore, M. W., Gulati, M., Geun Lee, C., Elias, J. A., Herzog, E. L. "Chitinase 3-Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis." Science Translational Medicine, vol. 6, no. 240, 2014, pp. 240ra76-240ra76. |
| Tran, Hoa T., Lee, In-Ah, Low, Daren, Kamba, Alan, Mizoguchi, Atsushi, Shi, Hai N., Lee, Chun G., Elias, Jack A., Mizoguchi, Emiko. "Chitinase 3-like 1 Synergistically Activates IL6-mediated STAT3 Phosphorylation in Intestinal Epithelial Cells in Murine Models of Infectious Colitis." Inflammatory Bowel Diseases, vol. 20, no. 5, 2014, pp. 835-846. |
| Jafari, Behrouz, Elias, Jack A., Mohsenin, Vahid. "Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea." PLoS ONE, vol. 9, no. 5, 2014, pp. e98629. |
| Mannam, P., Shinn, A. S., Srivastava, A., Neamu, R. F., Walker, W. E., Bohanon, M., Merkel, J., Kang, M.-J., Cruz, C. S. D., Ahasic, A. M., Pisani, M. A., Trentalange, M., West, A. P., Shadel, G. S., Elias, J. A., Lee, P. J. "MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury." American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 306, no. 7, 2014, pp. L604-L619. |
| Lee, Chang-Min, Park, Jin Wook, Cho, Won-Kyung, Zhou, Yang, Han, Boram, Yoon, Pyoung Oh, Chae, Jeiwook, Elias, Jack A, Lee, Chun Geun. "Modifiers of TGF-β1 effector function as novel therapeutic targets of pulmonary fibrosis." Korean J Intern Med, vol. 29, no. 3, 2014, pp. 281. |
| Ridker, P. M., Chasman, D. I., Rose, L., Loscalzo, J., Elias, J. A. "Plasma Levels of the Proinflammatory Chitin-Binding Glycoprotein YKL-40, Variation in the Chitinase 3-Like 1 Gene (CHI3L1), and Incident Cardiovascular Events." Journal of the American Heart Association, vol. 3, no. 3, 2014, pp. e000897-e000897. |
| Low, Daren, Tran, Hoa, Lee, In-Ah, Kamba, Alan, Mizoguchi, Atsushi, Shi, Hai Ning, Lee, Chun Geun, Elias, Jack A., Mizoguchi, Emiko. "Tu1733 Chitinase 3-Like 1 Synergistically Activates IL6-Mediated STAT3 Phosphorylation in Intestinal Epithelial Cells in Murine Models of Infectious Colitis." Gastroenterology, vol. 146, no. 5, 2014, pp. S-829. |
| Hall, Isaac E, Stern, Edward P, Cantley, Lloyd G, Elias, Jack A, Parikh, Chirag R. "Urine YKL-40 is associated with progressive acute kidney injury or death in hospitalized patients." BMC Nephrology, vol. 15, no. 1, 2014, pp. 133. |
| Lee, Chun Geun, Ma, Bing, Koo, Ja Seok, Herbst, Roy S., Elias, Jack A. "Abstract 3938: Role of Chi3l1/YKL-40 in the tumor progression and metastasis in the lung." Cancer Research, vol. 73, no. 8 Supplement, 2013, pp. 3938-3938. |
| He, Chuan Hua, Lee, Chun Geun, Dela Cruz, Charles S., Lee, Chang-Min, Zhou, Yang, Ahangari, Farida, Ma, Bing, Herzog, Erica L., Rosenberg, Stephen A., Li, Yue, Nour, Adel M., Parikh, Chirag R., Schmidt, Insa, Modis, Yorgo, Cantley, Lloyd, Elias, Jack A. "Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2." Cell Reports, vol. 4, no. 4, 2013, pp. 830-841. |
| He, Chuan Hua, Lee, Chun Geun, Dela Cruz, Charles S., Lee, Chang-Min, Zhou, Yang, Ahangari, Farida, Ma, Bing, Herzog, Erica L., Rosenberg, Stephen A., Li, Yue, Nour, Adel M., Parikh, Chirag R., Schmidt, Insa, Modis, Yorgo, Cantley, Lloyd, Elias, Jack A. "Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2." Cell Reports, vol. 5, no. 4, 2013, pp. 1156. |
| Schmidt, I. M., Hall, I. E., Kale, S., Lee, S., He, C.-H., Lee, Y., Chupp, G. L., Moeckel, G. W., Lee, C. G., Elias, J. A., Parikh, C. R., Cantley, L. G. "Chitinase-Like Protein Brp-39/YKL-40 Modulates the Renal Response to Ischemic Injury and Predicts Delayed Allograft Function." Journal of the American Society of Nephrology, vol. 24, no. 2, 2013, pp. 309-319. |
| Ghelfi, Elisa, Yu, Chen-Wei, Elmasri, Harun, Terwelp, Matthew, Lee, Chun G., Bhandari, Vineet, Comhair, Suzy A., Erzurum, Serpil C., Hotamisligil, Gökhan S., Elias, Jack A., Cataltepe, Sule. "Fatty Acid Binding Protein 4 Regulates VEGF-Induced Airway Angiogenesis and Inflammation in a Transgenic Mouse Model." The American Journal of Pathology, vol. 182, no. 4, 2013, pp. 1425-1433. |
| Reilkoff, Ronald A., Peng, Hong, Murray, Lynne A., Peng, Xueyan, Russell, Thomas, Montgomery, Ruth, Feghali-Bostwick, Carol, Shaw, Albert, Homer, Robert J., Gulati, Mridu, Mathur, Aditi, Elias, Jack A., Herzog, Erica L. "Semaphorin 7a + Regulatory T Cells Are Associated with Progressive Idiopathic Pulmonary Fibrosis and Are Implicated in Transforming Growth Factor-β1–induced Pulmonary Fibrosis." Am J Respir Crit Care Med, vol. 187, no. 2, 2013, pp. 180-188. |
| Takyar, S., Vasavada, H., Zhang, J.-g., Ahangari, F., Niu, N., Liu, Q., Lee, C. G., Cohn, L., Elias, J. A. "VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis." The Journal of cell biology, vol. 202, no. 7, 2013, pp. 2027OIA101-2027OIA101. |
| Takyar, S., Vasavada, H., Zhang, J.-g., Ahangari, F., Niu, N., Liu, Q., Lee, C. G., Cohn, L., Elias, J. A. "VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis." Journal of Experimental Medicine, vol. 210, no. 10, 2013, pp. 1993-2010. |
| Zhou, Y., Lee, J.-Y., Lee, C.-M., Cho, W.-K., Kang, M.-J., Koff, J. L., Yoon, P.-O., Chae, J., Park, H.-O., Elias, J. A., Lee, C. G. "Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of Transforming Growth Factor- -induced Pulmonary Fibrosis." Journal of Biological Chemistry, vol. 287, no. 50, 2012, pp. 41991-42000. |
| Lee, Chang-Min, Herzog, Erica, He, Chuan-Hua, Lee, Chun Geun, Elias, Jack A. "Chitinase 1 Enhances TGF-²1 Signaling And TGF-²1 Receptor Expression In Lung Fibroblasts." C68. OLD AND NEW PATHWAYS TO PULMONARY FIBROSIS, 2012. |
| Lee, C. G., Herzog, E. L., Ahangari, F., Zhou, Y., Gulati, M., Lee, C.-M., Peng, X., Feghali-Bostwick, C., Jimenez, S. A., Varga, J., Elias, J. A. "Chitinase 1 Is a Biomarker for and Therapeutic Target in Scleroderma-Associated Interstitial Lung Disease That Augments TGF- 1 Signaling." The Journal of Immunology, vol. 189, no. 5, 2012, pp. 2635-2644. |
| Ahangari, Farida, Takyar, Seyedtaghi (Shervin), Herzog, Erica, Dela Cruz, Charles S., He, Chuan, Lee, Chun Geun, Elias, Jack A. "Chitinase 3 Like 1 (CHI3L1) Is A Critical Regulator Of Visceral Adiposity And The PPAR Pathway." C29. FAT SIGNALS: CROSSTALK BETWEEN THE ADIPOSE TISSUE AND THE LUNG, 2012. |
| Zhou, Yang, Herzog, Erica, Gochuico, Bernadette R., Gahl, William, Lee, Chun G., Elias, Jack A. "Chitinase 3-Like 1 (CHI3L1) As A Biomarker And Therapeutic Target In The Pulmonary Fibrosis Of Hermansky-Pudlak Syndrome." A45. NON-IDIOPATHIC PULMONARY FIBROSIS INTERSTITIAL LUNG DISEASES, 2012. |
| Dela Cruz, Charles S., Liu, Wei, He, Chuan Hua, Jacoby, Adam, Gornitzky, Alex, Flavell, Richard, Elias, Jack A. "Chitinase 3-Like-1 (Chi3l1) Is A Critical Regulator Of Bacterial Killing, Pyroptosis And Inflammasome And Purinergic Activation In Streptococcus Pneumoniae Lung Infection." B55. HOST DEFENSE IN PULMONARY INFECTION AND TUBERCULOSIS, 2012. |
| He, Chuan-Hua, Lee, Chun Geun, Dela Cruz, Charles, Liu, Wei, Ahangari, Farida, Elias, Jack A. "Chitinase 3-Like-1 (Chi3l1) Stimulates The Wnt/²-Catenin Pathway Via An IL-13 Receptor Alpha 2 Dependent Mechanism." D28. DEVELOPMENTAL SIGNALING REBORN IN ADULT LUNG DISEASE, 2012. |
| Dela Cruz, Charles S., Liu, Wei, He, Chuan Hua, Jacoby, Adam, Gornitzky, Alex, Ma, Bing, Flavell, Richard, Lee, Chun Geun, Elias, Jack A. "Chitinase 3-like-1 Promotes Streptococcus pneumoniae Killing and Augments Host Tolerance to Lung Antibacterial Responses." Cell Host & Microbe, vol. 12, no. 1, 2012, pp. 34-46. |
| Ma, Bing, Herzog, Erica, Dela Cruz, Charles S., Tang, Chu Y., Homer, Robert J., Lee, Chun G., Elias, Jack A. "Chitinase 3-Like-1 Regulates Melanoma Cell Metastasis In The Murine Lung." C31. REGULATION OF LUNG INFLAMMATION, 2012. |
| Lee, Chun Geun, Dela Cruz, Charles S., Ma, Bing, Ahangari, Farida, Zhou, Yang, Halaban, Ruth, Sznol, Mario, Elias, Jack A. "Chitinase-like Proteins in Lung Injury, Repair, and Metastasis." Proc Am Thorac Soc, vol. 9, no. 2, 2012, pp. 57-61. |
| Cho, W.-K., Lee, C.-M., Kang, M.-J., Huang, Y., Giordano, F. J., Lee, P. J., Trow, T. K., Homer, R. J., Sessa, W. C., Elias, J. A., Lee, C. G. "IL-13 receptor 2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension." American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 304, no. 2, 2012, pp. L112-L124. |
| Kang, Min-Jong, Choi, Je-Min, Kim, Bo Hye, Lee, Chang-Min, Cho, Won-Kyung, Choe, Gina, Kim, Do-Hyun, Lee, Chun Geun, Elias, Jack A. "IL-18 Induces Emphysema and Airway and Vascular Remodeling via IFN-γ, IL-17A, and IL-13." Am J Respir Crit Care Med, vol. 185, no. 11, 2012, pp. 1205-1217. |
| Kang, Min-Jong, Choi, Je-Min, Kim, Bo Hye, Lee, Chang-Min, Cho, Won-Kyung, Choe, Gina, Kim, Do-Hyun, Lee, Chun Geun, Elias, Jack A. "IL-18 Induces Emphysema and Airway and Vascular Remodeling via IFN-γ, IL-17A, and IL-13." Am J Respir Crit Care Med, vol. 185, no. 11, 2012, pp. 1205-1217. |
| Bhandari, Vineet, Choo-Wing, Rayman, Harijith, Anantha, Sun, Huanxing, Syed, Mansoor Ali, Homer, Robert J., Elias, Jack A. "Increased Hyperoxia-Induced Lung Injury in Nitric Oxide Synthase 2 Null Mice Is Mediated via Angiopoietin 2." American Journal of Respiratory Cell and Molecular Biology, vol. 46, no. 5, 2012, pp. 668-676. |
| Dela Cruz, Charles S., Kang, Ming-Jong, Liu, Wei, Lee, Chun G., Elias, Jack A. "Interleukin-15 and Influenza Virus Infection in a Mouse Model of Chronic Obstructive Pulmonary Disease." Proc Am Thorac Soc, vol. 9, no. 2, 2012, pp. 85-85. |
| Takyar, Seyedtaghi (Shervin), Ahangari, Farida, Vasavada, Hema, Lee, Chun Geun, Elias, Jack A. "Mpl Is Targeted By MiR-1 In The Lung Endothelial Cells And Regulates Th2 Inflammation By Controlling Adhesion Molecule Expression." B14. CONTROL OF INNATE AND ADAPTIVE IMMUNITY IN THE LUNG, 2012. |
| Cho, Won-Kyung, Lee, Chang-Min, Zhou, Yang, Elias, Jack A., Lee, Chun Geun. "Role Of Arginase2 In TGF-Beta1-Induced Pulmonary Fibrosis." C68. OLD AND NEW PATHWAYS TO PULMONARY FIBROSIS, 2012. |
| Kang, Min-Jong, Kim, Bo Hye, Lee, Chang-Min, Lee, Chun Geun, Homer, Robert, Elias, Jack A. "Role Of Mitochondrial Antiviral Signaling Molecule (MAVS) In IL-18-Induced Pulmonary Inflammation And Tissue Remodeling In The Murine Lung." A21. FIRST RESPONDERS: MUCOSAL INNATE IMMUNITY, 2012. |
| Kearns, M. T., Dalal, S., Horstmann, S. A., Richens, T. R., Tanaka, T., Doe, J. M., Boe, D. M., Voelkel, N. F., Taraseviciene-Stewart, L., Janssen, W. J., Lee, C. G., Elias, J. A., Bratton, D., Tuder, R. M., Henson, P. M., Vandivier, R. W. "Vascular endothelial growth factor enhances macrophage clearance of apoptotic cells." American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 302, no. 7, 2012, pp. L711-L718. |
| Lee, Chun Geun, Dela Cruz, Charles S., Herzog, Erica, Rosenberg, Stephen M., Ahangari, Farida, Elias, Jack A. "YKL-40, a Chitinase-like Protein at the Intersection of Inflammation and Remodeling." Am J Respir Crit Care Med, vol. 185, no. 7, 2012, pp. 692-694. |
| Ahangari, Farida, Takyar, Seyedtaghi (Shervin), Lee, Chun G., Vasavada, Hema H., Elias, Jack A. "Chitotriosidase (Chitinase 1) Plays An Essential Role In IL-13-Induced Inflammation, Fibrosis And Alternative (M2) Macrophage Activation." B36. AIRWAY IMMUNE MECHANISMS AND INFLAMMATION: ANIMAL MODELS, 2011. |
| Zhou, Yang, Lee, Chun G., Ahangari, Farida, Herzog, Erica, Elias, Jack A. "Chitotriosidase Contributes To The Pathogenesis Of Bleomycin-Induced Pulmonary Fibrosis." C32. STUDIES OF LUNG FIBROSIS, COPD AND AIRWAY REMODELING, 2011. |
| Elias, Jack A., Lee, Chun Geun. "IL-13 in Asthma." Am J Respir Crit Care Med, vol. 183, no. 8, 2011, pp. 957-958. |
| Peng, Xueyan, Mathai, Susan K, Murray, Lynne A, Russell, Thomas, Reilkoff, Ronald, Chen, Qingsheng, Gulati, Mridu, Elias, Jack A, Bucala, Richard, Gan, Ye, Herzog, Erica L. "Local apoptosis promotes collagen production by monocyte-derived cells in transforming growth factor β1-induced lung fibrosis." Fibrogenesis & Tissue Repair, vol. 4, no. 1, 2011, pp. 12. |
| Takyar, Seyedtaghi (Shervin), Vasavada, Hema H., Ma, Bing, Lee, Chun G., Elias, Jack A. "MicroRNA (miR)-1 Inhibits Adaptive Th2 Inflammation In The Lung Via A VEGF/Myeloproliferative Leukemia Virus Oncogene (MPL)-Dependent Mechanism." A13. MI-RNA AND EPIGENETIC REGULATION OF LUNG DISORDERS, 2011. |
| Ma, Bing, Cruz, Charles D., Kang, Min-Jong, Takyar, Seyedtaghi (Shervin), Homer, Robert, Lee, Chun G., Elias, Jack A. "Poly(I:C) And RIG-Like Helicase Regulation Of Pulmonary Melanoma Metastasis." A32. HUMAN AND ANIMAL STUDIES OF CHRONIC DISEASES THAT AFFECT THE LUNG, 2011. |
| Lee, Byung-Jae, Moon, Hyung-Geun, Shin, Tae-Seop, Jeon, Seong Gyu, Lee, Eun-Young, Gho, Yong Song, Lee, Chun Geun, Zhu, Zhou, Elias, Jack A., Kim, Yoon-Keun. "Protective effects of basic fibroblast growth factor in the development of emphysema induced by interferon-γ." Experimental and Molecular Medicine, vol. 43, no. 4, 2011, pp. 169. |
| Ma, Bing, Dela Cruz, Charles S., Hartl, Dominik, Kang, Min-Jong, Takyar, Shervin, Homer, Robert J., Lee, Chun Geun, Elias, Jack A. "RIG-like Helicase Innate Immunity Inhibits Vascular Endothelial Growth Factor Tissue Responses via a Type I IFN–dependent Mechanism." Am J Respir Crit Care Med, vol. 183, no. 10, 2011, pp. 1322-1335. |
| Zhou, Yang, Cho, Won-Kyung, Lee, Jae-Young, Elias, Jack A., Lee, Chun G. "Role Of Amphiregulin In TGF-B1-Induced Pulmonary Fibrosis." C32. STUDIES OF LUNG FIBROSIS, COPD AND AIRWAY REMODELING, 2011. |
| Matsuura, Hiroshi, Hartl, Dominik, Kang, Min-Jong, Cruz, Charles S. Dela, Koller, Barbara, Chupp, Geoffrey L., Homer, Robert J., Zhou, Yang, Cho, Won-Kyung, Elias, Jack A., Lee, Chun Geun. "Role of Breast Regression Protein–39 in the Pathogenesis of Cigarette Smoke–Induced Inflammation and Emphysema." American Journal of Respiratory Cell and Molecular Biology, vol. 44, no. 6, 2011, pp. 777-786. |
| Kang, Min-Jong, Choe, Gina, Kim, Bo Hye, Lee, Chun G., Elias, Jack A. "Role Of BRP-39/YKL-40 In IL-18 Induced Pulmonary Inflammation, Alveolar Destruction And Airway Fibrosis In Murine Lung." C21. NEW TARGETS FOR ASTHMA THERAPY, 2011. |
| Lee, Chun Geun, Da Silva, Carla A., Dela Cruz, Charles S., Ahangari, Farida, Ma, Bing, Kang, Min-Jong, He, Chuan-Hua, Takyar, Seyedtaghi, Elias, Jack A. "Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury." Annual review of physiology, vol. 73, no. 1, 2011, pp. 479-501. |
| Zhou, Yang, Kang, Min-Jong, Silverman, Robert H., Lee, Chun G., Elias, Jack A. "Role Of Rnasel In Virus/Viral PAMP And Cigarette Smoke-Induced Inflammation And Remodeling." A101. MECHANISMS AND MODELS OF COPD, 2011. |
| Gan, Ye, Reilkoff, Ronald, Peng, Xueyan, Russell, Thomas, Chen, Qingsheng, Mathai, Susan K., Homer, Robert, Gulati, Mridu, Siner, Jonathan, Elias, Jack, Bucala, Richard, Herzog, Erica. "Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease." Arthritis and rheumatism, vol. 63, no. 8, 2011, pp. 2484-2494. |
| Dela Cruz, Charles S., Kang, Min-Jong, Liu, Wei, Lee, Chun G., Elias, Jack A. "Roles Of Interleukin-15 And Influenza Virus Infection In The Pathogenesis Of Chronic Obstructive Pulmonary Disease." B31. COMPLICATING INFECTIONS: INFLUENZA AND RHINOVIRUS, 2011. |
| Reilkoff, Ronald, Russell, Thomas, Peng, Xueyan, Gulati, Mridu, Homer, Robert, Elias, Jack A., Herzog, Erica. "Semaphorin 7A Expression On Lymphocytes Promotes Alternative Macrophage Activation In Murine Models Of Lung Fibrosis And Human IPF." D14. INSIGHTS INTO PATHOGENESIS OF LUNG FIBROSIS AND GRANULOMAS, 2011. |
| Lee, C. G., Ma, B., Takyar, S., Ahangari, F., DelaCruz, C., He, C. H., Elias, J. A. "Studies of Vascular Endothelial Growth Factor in Asthma and Chronic Obstructive Pulmonary Disease." Proc Am Thorac Soc, vol. 8, no. 6, 2011, pp. 512-515. |
| Murray, Lynne A., Chen, Qingsheng, Kramer, Michael S., Hesson, David P., Argentieri, Rochelle L., Peng, Xueyang, Gulati, Mridu, Homer, Robert J., Russell, Thomas, van Rooijen, Nico, Elias, Jack A., Hogaboam, Cory M., Herzog, Erica L. "TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P." The International Journal of Biochemistry & Cell Biology, vol. 43, no. 1, 2011, pp. 154-162. |
| He, Chuan H., Lee, Chun G., Ma, Bing, Cruz, Charles D., Liu, Wei, Zhou, Yang, Ahangari, Farida, Homer, Robert, Elias, Jack A. "YKL-40 Binds To And Signals Via IL-13 Receptor Alpha2 Using A Glycosylation-Dependent Mechanism." A65. MECHANISMS OF AIRWAY RESPONSE TO INJURY (RESPIRATORY VIRUSES, CIGARETTE SMOKE, AND ASTHMA), 2011. |
| Cho, Won-Kyung, Chen, Ning-Yuan, Tang, Chu-Yan, Elias, Jack A., Lee, Chun Geun. "Arginase 2 Plays An Essential Role In TGF-²-induced Pulmonary Fibrosis." B28. OXIDATIVE STRESS, SIGNAL TRANSDUCTION AND MECHANISMS OF LUNG INJURY, 2010. |
| He, Chuan H., Lee, Chun Geun, Chen, Ning-Yuan, Zhang, Li, Liu, Wei, Homer, Robert J., Elias, Jack A. "Breast Regression Protein 39 (BRP-39) Binds To, Co-localizes With And Signals Via IL-13 Receptor Alpha 2 (IL-13Ra2)." C61. GENE REGULATION DURING DEVELOPMENT AND IN INJURY, 2010. |
| Da Silva, Carla A., Pochard, Pierre, Lee, Chun Geun, Elias, Jack A. "Chitin Particles Are Multifaceted Immune Adjuvants." Am J Respir Crit Care Med, vol. 182, no. 12, 2010, pp. 1482-1491. |
| Lu, Qing, Newton, Julie, Ortiz, Melanie, Kang, Min-Jong, Lee, Chun Geun, Elias, Jack A., Harrington, Elizabeth O., Rounds, Sharon I.S. "Cigarette Smoke Causes Lung Vascular Endothelial Cell Apoptosis And Activation Of Unfolded Protein Response And Autophagy." B60. REGULATION OF THE ENDOTHELIUM: BARRIER FUNCTION AND ENDOTHELIAL CELL INTEGRITY, 2010. |
| Lu, Qing, Newton, Julie, Kang, Min-Jong, Lee, Chun Geun, Elias, Jack A., Harrington, Elizabeth O., Rounds, Sharon I.S. "Cigarette Smoke Causes Lung Vascular Endothelial Cell Apoptosis And Alterations Of TGF-²1 Signaling." B60. REGULATION OF THE ENDOTHELIUM: BARRIER FUNCTION AND ENDOTHELIAL CELL INTEGRITY, 2010. |
| Gan, Ye, Kang, Min jong, Homer, Robert J., Chen, Qingsheng, Peng, Xueyan, Elias, Jack A., Herzog, Erica. "Epithelial Progenitor Responses And Anti-viral Innate Immunity In COPD." A18. MECHANISMS OF VIRAL INFECTION AND H1N1 INFLUENZA, 2010. |
| Wright, P. L., Yu, J., Di, Y. P. P., Homer, R. J., Chupp, G., Elias, J. A., Cohn, L., Sessa, W. C. "Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation." Journal of Experimental Medicine, vol. 207, no. 12, 2010, pp. 2595-2607. |
| Ober, Carole, Butte, Atul J., Elias, Jack A., Lusis, A. Jake, Gan, Weiniu, Banks-Schlegel, Susan, Schwartz, David. "Getting from Genes to Function in Lung Disease." Am J Respir Crit Care Med, vol. 182, no. 6, 2010, pp. 732-737. |
| Kim, You-Sun, Choi, Seng-Jin, Choi, Jun-Pyo, Jeon, Seong Gyu, Oh, Sun-Young, Lee, Byung-Jae, Gho, Yong Song, Lee, Chun Geun, Zhu, Zhou, Elias, Jack A., Kim, Yoon-Keun. "IL-12-STAT4-IFN-γ axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model." Experimental and Molecular Medicine, vol. 42, no. 8, 2010, pp. 533-46. |
| Cho, Won-Kyung, Chen, Ning-Yuan, Tang, Chu-Yan, Elias, Jack A., Lee, Chun Geun. "IL-13-induces Vascular Remodeling And Pulmonary Arterial Hyptertension Via Arginase 2-dependent Pathway." D61. ANIMAL MODELS OF PULMONARY ARTERIAL HYPERTENSION: NEW IDEAS AND INSIGHTS, 2010. |
| Ma, Bing, Lee, Chun Geun, Dela Cruz, Charles S., Kang, Min-Jong, Takyar, Sherwin, Homer, Robert J., Elias, Jack A. "Innate Immune RIG-like Helicase (RLH) Pathway Activation Inhibits VEGF-Induced Vascular And Angiogenic Responses." A21. AIRWAY REMODELING: FROM BENCH TO CLINIC, 2010. |
| Kang, Min-Jong, Choi, Je-Min, Lee, Chun Geun, Elias, Jack A. "Interleukin-18 Induces Pulmonary Inflammation And Remodeling Via An IL-17-Dependent Pathway." C92. IL-17 IN LUNG IMMUNITY, FRIEND OR FOE?, 2010. |
| Segawa, Mayuko, Zhang, Jiang, Eurich, Katrin, Kanneganti, Manasa, Kozhich, Alexander, Elias, Jack A., Coyle, Anthony J., Mizoguchi, Emiko. "M1936 Chitinase 3-Like-1 Enhances Inflammation-Associated Tumorigenesis by Activating the β-Catenin/Wnt Signaling Pathway of CECs." Gastroenterology, vol. 138, no. 5, 2010, pp. S-443. |
| Dela Cruz, Charles S., Liu, Wei, Jacoby, Adam, Lee, Chun Geun, Elias, Jack A. "Role Of Breast Regression Protein 39 (BRP-39)/chitinase 3-like 1 In Streptococcus Pneumoniae Lung Infection." C97. ACUTE PNEUMONIA: NOVEL HOST DEFENSE MECHANISMS WITH THERAPEUTIC IMPLICATIONS, 2010. |
| Lee, Chun Geun, Elias, Jack A. "Role of breast regression protein-39/YKL-40 in asthma and allergic responses." Allergy, Asthma & Immunology Research, vol. 2, no. 1, 2010, pp. 20. |
| Herzog, Erica, Chen, Qingsheng, Peng, Xueyan, Lee, Chun Geun, Homer, Robert J., Elias, Jack A. "Semaphorin 7a Promotes M2 Differentiation And Fibrocyte Accumulation In TGF-ß1 Induced Pulmonary Fibrosis." A58. ANIMAL MODELS OF PULMONARY FIBROSIS, 2010. |
| Sohn, Myung Hyun, Kang, Min-Jong, Matsuura, Hiroshi, Bhandari, Vineet, Chen, Ning-Yuan, Lee, Chun Geun, Elias, Jack A. "The Chitinase-like Proteins Breast Regression Protein-39 and YKL-40 Regulate Hyperoxia-induced Acute Lung Injury." Am J Respir Crit Care Med, vol. 182, no. 7, 2010, pp. 918-928. |
| Sohn, M, Kang, M, Hartl, D, Matsuura, H, Lee, C, Elias, J. "A Chitinase-Like Protein Breast Regression Protein-39 (BRP-39) Protects Hyperoxygen-Induced Acute Lung Injury." B108. ACUTE LUNG INJURY: FROM GENES, PATHWAYS AND MODELS TO PATIENTS, 2009. |
| Hartl, D., He, C. H., Koller, B., Da Silva, C. A., Kobayashi, Y., Lee, C. G., Flavell, R. A., Elias, J. A. "Acidic Mammalian Chitinase Regulates Epithelial Cell Apoptosis via a Chitinolytic-Independent Mechanism." The Journal of Immunology, vol. 182, no. 8, 2009, pp. 5098-5106. |
| Matsuura, H, Hartl, D, Kang, MJ, Homer, RJ, Chupp, GL, Lee, CG, Elias, JA. "BRP-39/YKL-40 Contribute to Cigarette Smoke-Induced Inflammation and Emphysema in Mice and Humans." B37. COPD PATHOGENESIS, 2009. |
| Da Silva, C. A., Chalouni, C., Williams, A., Hartl, D., Lee, C. G., Elias, J. A. "Chitin Is a Size-Dependent Regulator of Macrophage TNF and IL-10 Production." The Journal of Immunology, vol. 182, no. 6, 2009, pp. 3573-3582. |
| Kang, M, Lee, C, Lee, J, Dela Cruz, CS, Chen, ZJ, Enelow, R, Elias, JA. "Cigarette Smoke Enhances poly(I:C)-Induced Innate Immune and Remodeling Responses Via a RIG-1 like Helicase, Mitochondrial Antiviral Signaling Protein (MAVS)-Dependent Mechanism." C31. MECHANISMS OF INFLAMMATION IN THE AIRWAY, 2009. |
| Dela Cruz, CS, Kang, MJ, Weibel, C, Kahn, JS, Elias, J. "Cigarette Smoke Enhances Respiratory Syncytial Virus (RSV)-Induced Inflammatory, Cytokine and Alveolar Remodeling Responses." A13. INSIGHTS IN COPD PATHOGENESIS, 2009. |
| Dela Cruz, CS, Yamamoto, N, Askenase, PW, Elias, JA. "Cigarette Smoke Exposure Enhances Streptococcus pneumoniae Induced Inflammatory and Cytokine Responses Despite Comparable Bacterial Clearance." B50. LUNG HOST DEFENSES TO INFECTION AND HOST CELL PATHOGEN INTERACTION, 2009. |
| Siner, Jonathan M., Bhandari, Vineet, Engle, Kathryn M., Elias, Jack A., Siegel, Mark D. "ELEVATED SERUM ANGIOPOIETIN 2 LEVELS ARE ASSOCIATED WITH INCREASED MORTALITY IN SEPSIS." Shock, vol. 31, no. 4, 2009, pp. 348-353. |
| He, CH, Hartl, D, Da Silva, CA, Homer, RJ, Lee, CG, Elias, JA. "Galectin-3 Binds to AMCase and Reciprocally Regulates Their Bioactivities." C66. TRANSPORT AND SECRETION, 2009. |
| Lee, CG, Takyar, S, Tang, C, Boyden, L, Lifton, RP, Elias, JA. "Genes Controlling TGF-β-Induced Pulmonary Phenotypes Defined by Genetic Mapping and mRNA Expression Array Analysis." D21. GENETICS OF AIRWAY DISEASES II, 2009. |
| Sohn, Myung Hyun, Lee, Ji Hyun, Kim, Kyung Won, Kim, So Won, Lee, Sung Hee, Kim, Kyu-Earn, Kim, Kyung Hwan, Lee, Chun Geun, Elias, Jack A., Lee, Min Goo. "Genetic Variation in the Promoter Region of Chitinase 3-Like 1 Is Associated with Atopy." Am J Respir Crit Care Med, vol. 179, no. 6, 2009, pp. 449-456. |
| Cho, W, Homer, RJ, Sessa, WC, Elias, JA, Lee, CG. "IL-13 Induces Pulmonary Vascular Remodeling and Pulmonary Hypertension." A106. ROLE OF INFLAMMATION IN PULMONARY VASCULAR REMODELING AND INJURY, 2009. |
| Lee, J, Hartl, D, Da Silva, CA, Homer, RJ, Elias, JA, Lee, CG. "In Vivo Chitin Induces Neutrophil and Eosinophil Inflammation in the Lung Via Dectin-1 Dependent Pathway." D92. MECHANISMS OF IMMUNE ACTIVATION AND REGULATION, 2009. |
| Hong, E.-G., Ko, H. J., Cho, Y.-R., Kim, H.-J., Ma, Z., Yu, T. Y., Friedline, R. H., Kurt-Jones, E., Finberg, R., Fischer, M. A., Granger, E. L., Norbury, C. C., Hauschka, S. D., Philbrick, W. M., Lee, C.-G., Elias, J. A., Kim, J. K. "Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle." Diabetes, vol. 58, no. 11, 2009, pp. 2525-2535. |
| Chapoval, Svetlana P., Lee, Chun Geun, Tang, Chuyan, Keegan, Achsah D., Cohn, Lauren, Bottomly, Kim, Elias, Jack A. "Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation." Clinical Immunology, vol. 132, no. 3, 2009, pp. 371-384. |
| Takyar, S, Lee, CG, Hartl, D, Liu, W, Ahangari, F, Elias, JA. "MiR-1 Is a Critical Regulator of VEGF-Induced Angiogenesis." B18. microRNAs IN THE LUNG: BIT PLAYER OR LEADING ROLE?, 2009. |
| Hartl, Dominik, Lee, Chun G, Da Silva, Carla A, Chupp, Geoffrey L, Elias, Jack A. "Novel biomarkers in asthma: chemokines and chitinase-like proteins." Current Opinion in Allergy and Clinical Immunology, vol. 9, no. 1, 2009, pp. 60-66. |
| Ma, B, Homer, RJ, Hartl, D, Liu, W, Tang, CY, Chen, SP, Lee, CG, Elias, JA. "Poly (I:C) Inhibits VEGF-Induced Tissue Responses Via Type I Interferon Receptor (IFNαβR) Dependent Pathway in the Murine Lung." A54. ALVEOLAR GENE EXPRESSION REGULATION: TRANSCRIPTION AND GROWTH FACTORS, 2009. |
| Lee, C. G., Hartl, D., Lee, G. R., Koller, B., Matsuura, H., Da Silva, C. A., Sohn, M. H., Cohn, L., Homer, R. J., Kozhich, A. A., Humbles, A., Kearley, J., Coyle, A., Chupp, G., Reed, J., Flavell, R. A., Elias, J. A. "Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis." Journal of Experimental Medicine, vol. 206, no. 5, 2009, pp. 1149-1166. |
| Dalal, SA, Tuder, RM, Voelkel, NF, Lee, CG, Elias, JA, Henson, PM, Vandivier, RW. "Role of Vascular Endothelial Growth Factor (VEGF) in the Phagocytosis of Apoptotic Cells by Macrophages: Implications in Obstructive Airways Disease." A32. GRANULOCYTE AND MACROPHAGE BIOLOGY, 2009. |
| Smith, Elizabeth, Lipsky, Michael M., DeTolla, Louis J., Elias, Jack A., Keegan, Achsah D., Chapoval, Svetlana P. "156 Lung immune semaphorins and their receptors." Cytokine, vol. 43, no. 3, 2008, pp. 272-273. |
| Hartl, D., He, C. H., Koller, B., Da Silva, C. A., Homer, R., Lee, C. G., Elias, J. A. "Acidic Mammalian Chitinase Is Secreted via an ADAM17/Epidermal Growth Factor Receptor-dependent Pathway and Stimulates Chemokine Production by Pulmonary Epithelial Cells." Journal of Biological Chemistry, vol. 283, no. 48, 2008, pp. 33472-33482. |
| Lee, Chun Geun, Da Silva, Carla A, Lee, Jae-Young, Hartl, Dominik, Elias, Jack A. "Chitin regulation of immune responses: an old molecule with new roles." Current Opinion in Immunology, vol. 20, no. 6, 2008, pp. 684-689. |
| Kang, Min-Jong, Lee, Chun Geun, Lee, Jae-Young, Dela Cruz, Charles S., Chen, Zhijian J., Enelow, Richard, Elias, Jack A. "Cigarette smoke selectively enhances viral PAMP– and virus-induced pulmonary innate immune and remodeling responses in mice." Journal of Clinical Investigation, 2008. |
| Bhandari, Vineet, Choo-Wing, Rayman, Lee, Chun G., Yusuf, Kamran, Nedrelow, Jonathan H., Ambalavanan, Namasivayam, Malkus, Herbert, Homer, Robert J., Elias, Jack A. "Developmental Regulation of NO-Mediated VEGF-Induced Effects in the Lung." American Journal of Respiratory Cell and Molecular Biology, vol. 39, no. 4, 2008, pp. 420-430. |
| Ober, Carole, Tan, Zheng, Sun, Ying, Possick, Jennifer D., Pan, Lin, Nicolae, Raluca, Radford, Sadie, Parry, Rodney R., Heinzmann, Andrea, Deichmann, Klaus A., Lester, Lucille A., Gern, James E., Lemanske, Robert F., Nicolae, Dan L., Elias, Jack A., Chupp, Geoffrey L. "Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function." New England Journal of Medicine, vol. 358, no. 16, 2008, pp. 1682-1691. |
| Lee, Chun Geun, Hartl, Dominik, Matsuura, Hiroshi, Dunlop, Felicity M., Scotney, Pierre D., Fabri, Louis J., Nash, Andrew D., Chen, Ning-Yuan, Tang, Chu-Yan, Chen, Qingsheng, Homer, Robert J., Baca, Manuel, Elias, Jack A. "Endogenous IL-11 Signaling Is Essential in Th2- and IL-13–Induced Inflammation and Mucus Production." American Journal of Respiratory Cell and Molecular Biology, vol. 39, no. 6, 2008, pp. 739-746. |
| Pulichino, Anne-Marie, Wang, I-Ming, Caron, Alexandre, Mortimer, James, Auger, Anick, Boie, Yves, Elias, Jack A., Kartono, Aileen, Xu, Lijing, Menetski, Joseph, Sayegh, Camil E. "Identification of Transforming Growth Factor β1–Driven Genetic Programs of Acute Lung Fibrosis." American Journal of Respiratory Cell and Molecular Biology, vol. 39, no. 3, 2008, pp. 324-336. |
| Yamasaki, Masashi, Kang, Hye–Ryun, Homer, Robert J., Chapoval, Svetlana P., Cho, Soo Jung, Lee, Byung Jae, Elias, Jack A., Lee, Chun Geun. "P21 Regulates TGF-β 1 –Induced Pulmonary Responses via a TNF-α–Signaling Pathway." American Journal of Respiratory Cell and Molecular Biology, vol. 38, no. 3, 2008, pp. 346-353. |
| Chupp, Geoffrey L., Lee, Chun Geun, Jarjour, Nizar, Shim, Yun Michael, Holm, Carole T., He, Susan, Dziura, James D., Reed, Jennifer, Coyle, Anthony J., Kiener, Peter, Cullen, Mark, Grandsaigne, Martine, Dombret, Marie-Christine, Aubier, Michel, Pretolani, Marina, Elias, Jack A. "A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma." New England Journal of Medicine, vol. 357, no. 20, 2007, pp. 2016-2027. |
| Choo-Wing, R., Nedrelow, J. H., Homer, R. J., Elias, J. A., Bhandari, V. "Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia." American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 293, no. 1, 2007, pp. L142-L150. |
| Jeon, Seong Gyu, Lee, Chun Geun, Oh, Min-Hee, Chun, Eun-Young, Gho, Yong Song, Cho, Sang-Heon, Kim, Jong-Hoon, Min, Kyung-Up, Kim, You-Young, Kim, Yoon-Keun, Elias, Jack A. "Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge." Journal of Allergy and Clinical Immunology, vol. 119, no. 4, 2007, pp. 831-837. |
| Kang, H.-R., Lee, C. G., Homer, R. J., Elias, J. A. "Semaphorin 7A plays a critical role in TGF- 1-induced pulmonary fibrosis." Journal of Experimental Medicine, vol. 204, no. 5, 2007, pp. 1083-1093. |
| Bhandari, Vineet, Elias, Jack A. "The Role of Angiopoietin 2 in Hyperoxia-Inuduced Acute Lung Injury." Cell Cycle, vol. 6, no. 9, 2007, pp. 1049-1052. |
| Siner, J. M., Jiang, G., Cohen, Z. I., Shan, P., Zhang, X., Lee, C. G., Elias, J. A., Lee, P. J. "VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo." The FASEB Journal, vol. 21, no. 7, 2007, pp. 1422-1432. |
| Ma, B. "Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis." Journal of Clinical Investigation, vol. 116, no. 5, 2006, pp. 1274-1283. |
| Peebles, R., Hashimoto, K., Sheller, J.R., Moore, M.L., Morrow, J.D., Ji, S., Elias, J.A., Goleniewska, K., O'Neal, J.F., Mitchell, D.B., Graham, B.S., Zhou, W. "Allergen-Induced Airway Hyperresponsiveness Mediated by Cyclooxygenase Inhibition is not Dependent on 5-Lipoxygenase or IL-5, but is IL-13 Dependent." Journal of Allergy and Clinical Immunology, vol. 117, no. 2, 2006, pp. S145. |
| Homer, R. J. "Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation." American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 291, no. 3, 2006, pp. L502-11. |
| Bhandari, V., Choo-Wing, R., Chapoval, S. P., Lee, C. G., Tang, C., Kim, Y. K., Ma, B., Baluk, P., Lin, M. I., McDonald, D. M., Homer, R. J., Sessa, W. C., Elias, J. A. "Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung." Proceedings of the National Academy of Sciences, vol. 103, no. 29, 2006, pp. 11021-11026. |
| Lee, C. G. "Genetic Control of Transforming Growth Factor- 1-induced Emphysema and Fibrosis in the Murine Lung." Proc Am Thorac Soc, vol. 3, no. 6, 2006, pp. 476a-477. |
| Bhandari, Vineet, Choo-Wing, Rayman, Lee, Chun G, Zhu, Zhou, Nedrelow, Jonathan H, Chupp, Geoffrey L, Zhang, Xucher, Matthay, Michael A, Ware, Lorraine B, Homer, Robert J, Lee, Patty J, Geick, Anke, de Fougerolles, Antonin R, Elias, Jack A. "Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death." Nature Medicine, vol. 12, no. 11, 2006, pp. 1286-1293. |
| Kang, M. J. "IFN- -dependent DNA Injury and/or Apoptosis Are Critical in Cigarette Smoke-induced Murine Emphysema." Proc Am Thorac Soc, vol. 3, no. 6, 2006, pp. 517a-518. |
| Zhou W, Hashimoto K, Moore ML, Elias JA, Zhu Z, Durbin J, Colasurdo G, Rutigliano JA, Chiappetta CL, Goleniewska K, O'Neal JF, Graham BS, Peebles RS Jr. "IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse." Microbes and infection / Institut Pasteur, vol. 8, no. 14-15, 2006, pp. 2880-9. |
| Cho, S. J., Kang, M. J., Homer, R. J., Kang, H. R., Zhang, X., Lee, P. J., Elias, J. A., Lee, C. G. "Role of Early Growth Response-1 (Egr-1) in Interleukin-13-induced Inflammation and Remodeling." Journal of Biological Chemistry, vol. 281, no. 12, 2006, pp. 8161-8168. |
| Cho, S. J., Kang, M. J., Homer, R. J., Kang, H. R., Zhang, X., Lee, P. J., Elias, J. A., Lee, C. G. "Role of Early Growth Response-1 (Egr-1) in Interleukin-13-induced Inflammation and Remodeling." Journal of Biological Chemistry, vol. 281, no. 12, 2006, pp. 8161-8168. |
| Elias, J. A. "State of the Art. Mechanistic Heterogeneity in Chronic Obstructive Pulmonary Disease: Insights from Transgenic Mice." Proc Am Thorac Soc, vol. 3, no. 6, 2006, pp. 494-498. |
| Kang, H.-R., Cho, S. J., Lee, C. G., Homer, R. J., Elias, J. A. "Transforming Growth Factor (TGF)-beta1 Stimulates Pulmonary Fibrosis and Inflammation via a Bax-dependent, Bid-activated Pathway That Involves Matrix Metalloproteinase-12." Journal of Biological Chemistry, vol. 282, no. 10, 2006, pp. 7723-7732. |
| Lee, C. G. "Transgenic Modeling of Transforming Growth Factor- 1: Role of Apoptosis in Fibrosis and Alveolar Remodeling." Proc Am Thorac Soc, vol. 3, no. 5, 2006, pp. 418-423. |
| Homer, R. J. "Airway Remodeling in Asthma: Therapeutic Implications of Mechanisms." Physiology, vol. 20, no. 1, 2005, pp. 28-35. |
| He, Chuan Hua, Waxman, Aaron B., Lee, Chun Geun, Link, Holger, Rabach, Morgan E., Ma, Bing, Chen, Qingsheng, Zhu, Zhou, Zhong, Mei, Nakayama, Keiko, Nakayama, Keiichi I., Homer, Robert, Elias, Jack A. "Bcl-2–related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury." Journal of Clinical Investigation, vol. 115, no. 4, 2005, pp. 1039-1048. |
| He, Chuan Hua, Waxman, Aaron B., Lee, Chun Geun, Link, Holger, Rabach, Morgan E., Ma, Bing, Chen, Qingsheng, Zhu, Zhou, Zhong, Mei, Nakayama, Keiko, Nakayama, Keiichi I., Homer, Robert, Elias, Jack A. "Bcl-2–related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury." Journal of Clinical Investigation, vol. 115, no. 4, 2005, pp. 1039-1048. |
| Elias, Jack A., Homer, Robert J., Hamid, Qutayba, Lee, Chun Geun. "Chitinases and chitinase-like proteins in TH2 inflammation and asthma." Journal of Allergy and Clinical Immunology, vol. 116, no. 3, 2005, pp. 497-500. |
| Lee, P. J. "ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo." Journal of Clinical Investigation, vol. 116, no. 1, 2005, pp. 163-173. |
| Elias, Jack A, Lee, Chun Geun. "Lipid let loose in pulmonary emphysema." Nature Medicine, vol. 11, no. 5, 2005, pp. 471-472. |
| Zheng T, Rabach M, Chen NY, Rabach L, Hu X, Elias JA, Zhu Z. "Molecular cloning and functional characterization of mouse chitotriosidase." Gene, vol. 357, no. 1, 2005, pp. 37-46. |
| Becker, P. M. "Neuropilin-1 Regulates Vascular Endothelial Growth Factor-Mediated Endothelial Permeability." Circulation research, vol. 96, no. 12, 2005, pp. 1257-1265. |
| Chunn, J. L. "Partially adenosine deaminase-deficient mice develop pulmonary fibrosis in association with adenosine elevations." American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 290, no. 3, 2005, pp. L579-L587. |
|
Kalomenidis, Ioannis.
"Pneumothorax-Associated Pleural Eosinophilia in Mice Is Interleukin-5 but Not Interleukin-13 Dependent |
| Peng, Tao, Hao, Liming, Madri, Joseph A., Su, Xiao, Elias, Jack A., Stahl, Gregory L., Squinto, Stephen, Wang, Yi. "Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response." Journal of Clinical Investigation, vol. 115, no. 6, 2005, pp. 1590-1600. |
| Ma, B. "Role of CCR5 in IFN- -induced and cigarette smoke-induced emphysema." Journal of Clinical Investigation, vol. 115, no. 12, 2005, pp. 3460-3472. |
| Cohn, Lauren, Elias, Jack A., Chupp, Geoffrey L. "A sthma : Mechanisms of Disease Persistence and Progression." Annual Review of Immunology, vol. 22, no. 1, 2004, pp. 789-815. |
| Zhu, Z. "Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation." Science, vol. 304, no. 5677, 2004, pp. 1678-82. |
| Vicencio, Alfin G., Lee, Chun Geun, Cho, Soo Jung, Eickelberg, Oliver, Chuu, Ying, Haddad, Gabriel G., Elias, Jack A. "Conditional Overexpression of Bioactive Transforming Growth Factor–β1 in Neonatal Mouse Lung." American Journal of Respiratory Cell and Molecular Biology, vol. 31, no. 6, 2004, pp. 650-656. |
| Lee, C. G. "Early Growth Response Gene 1-mediated Apoptosis Is Essential for Transforming Growth Factor 1-induced Pulmonary Fibrosis." Journal of Experimental Medicine, vol. 200, no. 3, 2004, pp. 377-389. |
| Hjoberg, J. "Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness." Journal of Applied Physiology, vol. 97, no. 1, 2004, pp. 249-259. |
| Baluk, Peter, Lee, Chun Geun, Link, Holger, Ator, Erin, Haskell, Amy, Elias, Jack A., McDonald, Donald M. "Regulated Angiogenesis and Vascular Regression in Mice Overexpressing Vascular Endothelial Growth Factor in Airways." The American Journal of Pathology, vol. 165, no. 4, 2004, pp. 1071-1085. |
| Elias, Jack. "The Relationship Between Asthma and COPD *." Chest, vol. 126, no. 2_suppl_1, 2004, pp. 111S. |
| Lee, Chun Geun, Link, Holger, Baluk, Peter, Homer, Robert J, Chapoval, Svetlana, Bhandari, Vineet, Kang, Min Jong, Cohn, Lauren, Kim, Yoon Keun, McDonald, Donald M, Elias, Jack A. "Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung." Nature Medicine, vol. 10, no. 10, 2004, pp. 1095-1103. |
| EINARSSON, O., GEBA, G. P., ZHOU, Z., LANDRY, M. L., PANETTIERI, R. A., TRISTRAM, D., WELLIVER, R., METINKO, A., ELIAS, J. A. "Interleukin-11 in Respiratory Inflammation." Annals of the New York Academy of Sciences, vol. 762, no. 1, 1995, pp. 89-101. |
| ELIAS, J. A., TRINCHIERI, G., SIMON, P., KERN, J. "Interleukin-6 as a Fibroblast-derived Stimulator." Annals of the New York Academy of Sciences, vol. 557, no. 1, 1989, pp. 555-557. |
My laboratory has a longstanding history of cellular and molecular investigations into the pathogenesis of lung injury and repair. We use murine modeling systems that were pioneered in our lab, genetically modified mice that were generated using these systems and human samples. We attempt to work in an iterative fashion, going from mouse to man and back again, to define basic paradigms of biology and their relevance to important human lung diseases. Major foci of the lab include (a) mechanism of Th2 inflammation and remodeling in the lung with a focus on asthma, (b) mechanisms of cigarette smoke-induced lung injury with a focus on COPD, (c) mechanisms and biomarkers of injury and repair in pulmonary fibrosis with a focus on IPF, Hermansky Pudlak Syndrome (HPS) and scleroderma, (d) chitinases and chitinase-like proteins (C/CLP) such as chitinase 3-like-1 (Chi3l1), chitinase 1 and acidic mammalian chitinase (AMCase) in lung injury and repair (e) the receptor systems for chitinase-like proteins, (f) the roles and regulation of chitinase 3-like-1 in primary and metastatic lung cancer, and (g) genetic modifiers of TGF-B1 and other mediators of injury and fibrosis.
| Year | Degree | Institution |
|---|---|---|
| 1976 | MD | University of Pennsylvania |
| 1973 | BA | University of Pennsylvania |
1973 Phi Beta Kappa
1976 Alpha Omega Alpha
1982 Edward Livingston Trudeau Scholar, American Lung Association
1983 Leonard Dalsemer Scholar, American Lung Association
1984 Edward Livingston Trudeau Scholar, American Lung Association
1986 RJR Nabisco Scholar
1987 Selected Speaker: National Heart, Lung, and Blood Institute Symposium Honoring Clinical Investigator/Physician Scientist Awardees, American Thoracic Society Meeting, New Orleans, LA
1988 Career Investigator, American Lung Association
1991 Fellow, American College of Chest Physicians
1992 American Society for Clinical Investigation
1997 Interurban Clinical Club
1998 Association of American Physicians
1998 Pfizer Visiting Professor in Allergic Diseases and Asthma, University of Iowa
2003 Recognition Award For Scientific Accomplishment, American Thoracic Society
2005 Trudeau Speaker, New York Thoracic Society Meeting, New York City, NY
2005 The Harold and Marilyn Menkes Memorial Lecture, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, MD
2006 Sheldon C. Siegel Lectureship, State-of-the Art Session, American Academy of Allergy, Asthma and Immunology Meeting, Miami Beach, FL
2007 Twentieth Annual Lee E. Far, M.D. Lectureship, Yale University School of Medicine Student Research Day
2003 - 2011 Association of American Physicians, Councilor
2009 - 2010 Association of American Physicians, Vice President
2010 - 2011 Association of American Physicians, President
2009 - 2012 Council of the National Heart, Lung, and Blood Institute, National Institutes of Health
2010 - 2013 Council of Councils of the NIH
2010 - present Institute of Medicine of the National Academies/ National Academy of Medicine
2010 The Herbert Y. and Anne L. Reynolds Grand Rounds Lecturer, Penn State Milton S. Hershey Medical Center, Hershey, PA
2011 Annual Physician-in-Chief Pro Tempore, Department of Medicine Brigham and Women’s Hospital, Boston, MA
2012 Selected Keynote Address, the John B. Amberson Lectureship, Annual Meeting of the American Thoracic Society, San Francisco, CA, “Transgenic Modeling and Chitinase-like Proteins in Lung Injury and Repair.”
2012 The British Thoracic Society Lecturer, British Thoracic Society Winter Meeting, London, “Chitinase-like Proteins in Asthma, Lung Injury and Repair.”
2013 The E. Ross Kyger, Jr. Visiting Professor, University of Pennsylvania, Medical Grand Rounds, “New Concepts in Asthma: From Mouse to Man and Back Again.”
2013 The 13th Joseph Henry Bates Lecturer and Visiting Professor, University of Arkansas for Medical Sciences, Little Rock, AR, “New Concepts in the Pathogenesis of Asthma – From Mouse to Man and Back Again.”
2013 Pulmonary and Critical Care Visiting Professor of 2013, Harvard University, Boston, MA.
2014 Sue Kim Hanson Visiting Professor Grand Rounds, Boston University Medical School, Boston, MA
2015 - Present National Academy of Medicine
2016- Trudeau Lecturer at the meeting of the New York State Thoracic Society, at Memorial Sloan KeHering Hospoitl in New York city.
| Medical Doctor- Rhode Island | State of ri | 2013-Present | #MD14490 |
| Critical Care Medicine | ABIM | 1991-Present | #73286 |
| Medical Doctor | State of CT | 1990-Present | #030931 |
| Pulmonary Medicine | ABIM, Pulmonary medicine | 1982-Present | #73286 |
| Allergy and Immunology | Allergy and Immunology | 1981-Present | #2120 |
| Boards in Internal Medicine | American Board of Internal Medicine, Internal medicine | 1979-Present | #73286 |
| Dean of Medicine and Biology. Alpert Medical School, Brown University, 2013-Present |
| Physician In Chief. Yale-New Haven Hospital, 2006-Present |
| Chairman of Medicine. Yale School of Medicine, 2006-2013 |
| Waldemar Von Zedtwitz Professor. Yale School of Medicine, 2000-2013 |
| Professor of Medicine and Chief of Pulmonary and Critical Care Medicine. Yale University School of Medicine, 1990-2006 |
