- Sturla, L., Donahue, J., Machan, J., Delamonte, S., Jeyapalan, S. IB-11 * PSEUDO-PROGRESSION (PsdPg) IS A HARBINGER OF A MORE EFFECTIVE ANTI-TUMOR RESPONSE Neuro-Oncology. 2014; 16 (suppl 5) : v109-v109 . full text
Expertise/Certifications: Neuropathology, Neurology
Office number: 444-5152
(Lab Customer Service: 401-793-4242)
John E. Donahue received his M.D. from Tufts University in 1992. He trained in neurology at Tufts-New England Medical Center and in neuropathology at Rhode Island Hospital. After spending four years at the New Jersey Neuroscience Institute as Director of Neuropathology, he returned to RIH/Brown Medical School in 2003 to practice clinical neuropathology and pursue academic research in neurodegenerative diseases (e.g. Alzheimer's disease) and the blood-brain barrier. Being both a neurologist and neuropathologist enables him to bring a clinical perspective to neuropathology material and an underlying pathologic understanding to clinical areas. Translational research in neurodegenerative diseases is ideally-suited for a neurologist-neuropathologist like him. This is a very rare combination in the 21st century; most newly-trained neuropathologists are trained in general anatomic and surgical pathology, rather than neurology.
Prior academic appointments:
Assistant Professor of Neuroscience, Seton Hall University
Gaitanis JN, Donahue JE, "Focal cortical dysplasia," Pediatr Neurol [in press].
Jeyapalan S, Boxerman J, Donahue J, Goldman M, Kinsella T, DiPetrillo T, Evans D, Elinzano H, Constantinou M, Stopa E, Puthawala Y, Cielo D, Santaniello A, Oyelese A, Mantripragada K, Rosati K, Isdale D, Safran H, "Paclitaxel poliglumex, temozolomide, and radiation for newly-diagnosed high-grade glioma: a Brown University Oncology Group study," Am J Clin Oncol 2013 Feb 5 [Epub ahead of print].
Donahue JE, "'Normal' and pathological changes with age in the brain," Med Health R I 2012; 95: 75-76.
Miller MC, Lambert-Messerlian, GM, Eklund EE, Heath NL, Donahue JE, Stopa EG, "Expression of inhibin/activin proteins and receptors in the human hypothalamus and basal forebrain," J Neuroendocrinol 2012; 24: 962-972. Epub 2012 Feb 1.
Podvin S, Gonzalez AM, Miller MC, Dang X, Botfield H, Donahue JE, Kurabi A, Boissaud-Cooke M, Rossi R, Leadbeater WE, Johanson CE, Coimbra R, Stopa EG, Eliceiri BP, Baird A, "Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury," PLoS ONE 2011; 6: e24609. Epub 2011 Sep 14.
Harris T, Shur N, Donahue JE, Tung G, "Case 168: rhabdoid predisposition syndrome—familial cancer syndromes in children," Radiology 2011; 259: 298-302.
Gonzalez AM, Podvin S, Lin SY, Miller MC, Botfield H, Leadbeater W, Roberton A, Dang X, Knowling S, Cardenas-Galindo E, Donahue JE, Stopa EG, Johanson CE, Coimbra R, Eliceiri B, Baird A, "ECRG4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury," Fluids Barriers CNS 2011 Jan 18; 8(1): 6.
Silverberg GD, Messier AA, Miller MC, Machan JT, Majmudar S, Stopa EG, Donahue JE, Johanson CE, "Blood-brain barrier amyloid transporter expression decreases as amyloid increases in normal aging," J Neuropathol Exp Neurol 2010; 69: 1034-1043.
Boxerman JL, Rogg JM, Donahue JE, Machan JT, Goldman MA, Doberstein C, "Preoperative MRI evaluation of pituitary macroadenoma: imaging features predictive of successful transsphenoidal surgery," AJR 2010; 195: 720-728.
Brown WD, Bearer EL, Donahue JE, "Chronic active herpes simplex type 2 encephalitis in an asymptomatic immunocompetent child," J Child Neurol 2010; 25: 901-908. Epub 2010 Feb 22.
Silverberg GD, Miller MC, Messier AA, Majmudar S, Machan JT, Donahue JE, Stopa EG, Johanson CE, "Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging," J Neuropathol Exp Neurol 2010; 69: 98-108.
Ott BR, Cohen RA, Gongvatana A, Okonkwo OC, Johanson CE, Stopa EG, Donahue JE, Silverberg GD, and the Alzheimer's Disease Neuroimaging Initiative, "Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer's disease," J Alzheimers Dis 2010; 20: 647-657. Epub 2010 Feb 24.
Dewan S, Alvarez VE, Donahue JE, Cielo D, "Intracranial collision metastases of prostate and esophageal carcinoma," J Neurooncol 2009; 95: 147-150. Epub 2009 May 10.
Chang HJ, Donahue JE, Sciandra KT, Evangelista PT, "Best cases from the AFIP: juvenile ossifying fibroma of the calvaria," Radiographics 2009; 29: 1195-1199.
Miller MC, Tavares R, Johanson CE, Hovanesian V, Donahue JE, Gonzalez L, Silverberg GD, Stopa EG, "Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease," Brain Res 2008; 1230C: 273-280. Epub 2008 July 14.
Aboagye-Kumi M, Yango A Jr, Fischer S, Donahue J, Morrissey P, Taylor N, Gautam A, Mendonca C, Kumar S, Gohh R, "Acute disseminated encephalomyelitis in a renal transplant recipient: case report," Transplant Proc 2008; 40: 1751-1753.
Donahue JE, Johanson CE, "Apolipoprotein E, amyloid-β, and blood-brain barrier permeability in Alzheimer disease," J Neuropathol Exp Neurol 2008; 67: 261-270. (Published erratum appears on p. 634.) [Cover story of April, 2008 issue.]
Park MC, Goldman MA, Donahue JE, Tung GA, Goel R, Sampath P, "Endonasal ethmoidectomy and bifrontal craniotomy with craniofacial approach for resection of frontal ethmoidal osteoma causing tension pneumocephalus," Skull Base 2008; 18: 67-72.
Mayrin JV, Donahue JE, Laufgraben MJ, "Visual vignette. Prolactinoma," Endocr Pract 2008; 14: 256.
Davis JD, Podolanczuk A, Donahue JE, Stopa E, Hennessey JV, Luo LG, Lim Y-P, Stern RA, "Thyroid hormone levels in the prefrontal cortex of post-mortem brains of Alzheimer's disease patients," Curr Aging Sci 2008; 1: 175-181.
Bagdasaryan R, Donahue JE, "Granulomatous myositis in association with chronic graft vs. host disease," Med Health R I 2007; 90: 287.
Blum A, Tremont G, Donahue J, Tung G, Duncan JA, Buchbinder B, Gascon G, "Landau-Kleffner syndrome with lateral temporal focal cortical dysplasia and mesial temporal sclerosis: a 30-year follow-up," Epilepsy Behav 2007; 10: 495-503. Epub 2007 Mar 7.
Donahue JE, Flaherty SL, Johanson CE, Duncan JA III, Silverberg GD, Miller MC, Tavares R, Yang W, Wu Q, Sabo E, Hovanesian V, Stopa EG, "RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease," Acta Neuropathol (Berl) 2006; 112: 405-415. Epub 2006 Jul 25.
Johanson CE, Donahue JE, Spangenberger A, Stopa EG, Duncan JA, Sharma HS, "Atrial natriuretic peptide: its putative role in modulating the choroid plexus-CSF system for intracranial pressure regulation," Acta Neurochir Suppl 2006; 96: 451-456.
Park MC, Weaver CE Jr, Donahue JE, Sampath P, "Intracavitary chemotherapy (Gliadel®) for recurrent esthesioneuroblastoma: case report and review of the literature," J Neurooncol 2006; 77: 47-51. Epub 2005 Sep 2.
Hariharan S, Donahue JE, Garre C, Origone P, Grewal R, "Clinicopathologic and genetic analysis of siblings with NF1 and adult-onset gliomas," J Neurol Sci 2006; 247:105-108. Epub 2006 May 23.
Abubakr A, Wambacq I, Donahue JE, Zappulla R, "The presence of polyglucosan bodies in temporal lobe epilepsy: its role and significance," J Clin Neurosci 2005; 12: 911-914. Epub 2005 Oct 24.
Fischer SA, Donahue J, "Pachymeningitis in a Mexican immigrant," Med Health R I 2005; 88: 236.
Hariharan S, Zhu J, Nadkarni MA, Donahue JE, "Metastatic lung cancer in the cerebellopontine angles mimicking bilateral acoustic neuroma," J Clin Neurosci 2005; 12: 184-186.
Donahue JE, Hanna PA, Hariharan S, "Autopsy-proven Creutzfeldt-Jakob disease in a patient with a negative 14-3-3 assay and nonspecific EEG and MRI," Neurol Sci 2004; 24: 411-413.
Donahue JE, Stopa EG, Chorsky RL, King JC, Schipper HM, Tobet SA, Blaustein JD, Reichlin S, "Cells containing immunoreactive estrogen receptor-alpha in the human basal forebrain," Brain Res 2000; 856: 142-151.
Donahue JE, Stopa EG, "Benign meningioma," Arch Pathol Lab Med 1999; 123: 855.
Donahue JE, Stopa EG, "Multiple neurofibromas in severe neurofibromatosis type 1," Arch Pathol Lab Med 1999; 123: 644-645.
Tabamo REJ, Donahue JE, "Eastern equine encephalitis: case report and literature review," Med Health R I 1999; 82: 23-26.
Donahue JE, Berzin TM, Rafii MS, Glass DJ, Yancopoulos GD, Fallon JR, Stopa EG, "Agrin in Alzheimer's disease: altered solubility and abnormal distribution within microvasculature and brain parenchyma," Proc Natl Acad Sci U S A 1999; 96: 6468-6472.
Donahue JE, Khurana JS, Adelman LS, "Intracerebral hemorrhage in two patients with Down's syndrome and cerebral amyloid angiopathy," Acta Neuropathol (Berl) 1998; 95: 213-216.
Donahue JE, Raynor EM, Rutkove SB, "Forearm velocity in carpal tunnel syndrome: when is slow too slow?" Arch Phys Med Rehabil 1998; 79: 181-183. (Published erratum appears on p. 723.)