Dr. Joseph is Chief of Cardiology and Chair of the Inclusion, Diversity, Equity and Access Committee at VA Providence Healthcare System. His Translational Data Science research program focuses on Big Data approaches to precision prevention and treatment of cardiovascular disease.
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| Kroshian G, Joseph J, Kinlay S, Peralta AO, Hoffmeister PS, Singh JP, Yuyun MF. "Atrial fibrillation and risk of adverse outcomes in heart failure with reduced, mildly reduced, and preserved ejection fraction: A systematic review and meta-analysis." Journal of cardiovascular electrophysiology, 2024. |
| Verma, Anurag, Huffman, Jennifer E., Rodriguez, Alex, Conery, Mitchell, Liu, Molei, Ho, Yuk-Lam, Kim, Youngdae, Heise, David A., Guare, Lindsay, Panickan, Vidul Ayakulangara, Garcon, Helene, Linares, Franciel, Costa, Lauren, Goethert, Ian, Tipton, Ryan, Honerlaw, Jacqueline, Davies, Laura, Whitbourne, Stacey, Cohen, Jeremy, Posner, Daniel C., Sangar, Rahul, Murray, Michael, Wang, Xuan, Dochtermann, Daniel R., Devineni, Poornima, Shi, Yunling, Nandi, Tarak Nath, Assimes, Themistocles L., Brunette, Charles A., Carroll, Robert J., Clifford, Royce, Duvall, Scott, Gelernter, Joel, Hung, Adriana, Iyengar, Sudha K., Joseph, Jacob, Kember, Rachel, Kranzler, Henry, Kripke, Colleen M., Levey, Daniel, Luoh, Shiuh-Wen, Merritt, Victoria C., Overstreet, Cassie, Deak, Joseph D., Grant, Struan F. A., Polimanti, Renato, Roussos, Panos, Shakt, Gabrielle, Sun, Yan V., Tsao, Noah, Venkatesh, Sanan, Voloudakis, Georgios, Justice, Amy, Begoli, Edmon, Ramoni, Rachel, Tourassi, Georgia, Pyarajan, Saiju, Tsao, Philip, O'Donnell, Christopher J., Muralidhar, Sumitra, Moser, Jennifer, Casas, Juan P., Bick, Alexander G., Zhou, Wei, Cai, Tianxi, Voight, Benjamin F., Cho, Kelly, Gaziano, J. Michael, Madduri, Ravi K., Damrauer, Scott, Liao, Katherine P. "Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program." Science, vol. 385, no. 6706, 2024. |
| Ruizhi Liao PhD, Claire Beskin MBA, Arash Harzand MD, MBA, Grace Lin MD, MBA, Jacob Joseph MBBS, MD and Biykem Bozkurt MD, PhD. "Early Recognition of Clinical Trajectories Using Machine Learning in Hospitalized Heart Failure Patients." JACC. Advances, vol. 3, no. 2, 2024. |
| Yuyun, Matthew F, Joseph, Jacob, Erqou, Sebhat A, Kinlay, Scott, Echouffo-Tcheugui, Justin B, Peralta, Adelqui O, Hoffmeister, Peter S, Boden, William E, Yarmohammadi, Hirad, Martin, David T, Singh, Jagmeet P. "Evolution and prognosis of tricuspid and mitral regurgitation following cardiac implantable electronic devices: a systematic review and meta-analysis." Europace, vol. 26, no. 7, 2024. |
| Dehghani, Payam, Srivatsav, Varun, Vardeny, Orly, Grewal, Jasmine, Opotowsky, Alexander R., Muhll, Isabelle Vonder, Keir, Michelle, Ducas, Robin, Singh, Jyotpal, Kim, KyungMann, Joseph, Jacob, Aboulhosn, Jamil, Havighurst, Tom, Hegde, Sheila M., Bhatt, Deepak L., Solomon, Scott, Farkouh, Michael, Goodman, Shaun G., Moe, Tabitha G., Udell, Jacob A. "Feasibility and Findings of Including Self-Identified Adult Congenital Heart Disease Patients in the INVESTED Trial." JACC: Advances, vol. 3, no. 4, 2024, pp. 100897. |
| Liu, Chang, Chiang, Yiyun, Hui, Qin, Zhou, Jin J., Wilson, Peter W. F., Joseph, Jacob, Sun, Yan V. "High Variability of Body Mass Index Is Independently Associated With Incident Heart Failure." Journal of the American Heart Association, vol. 13, no. 9, 2024. |
| Sun, Yan V., Liu, Chang, Hui, Qin, Zhou, Jin J., Gaziano, J. Michael, Wilson, Peter W.F., Joseph, Jacob, Phillips, Lawrence S. "Identification and correction for collider bias in a genome-wide association study of diabetes-related heart failure." The American Journal of Human Genetics, vol. 111, no. 7, 2024, pp. 1481-1493. |
| Peikert A, Claggett BL, Udell JA, Joseph J, Hegde SM, Kim K, Mao L, Wang T, Havighurst TC, Farkouh ME, Bhatt DL, Tattersall MC, Cooper LS, Solomon SD, Vardeny O. "Influenza Vaccine Immune Response in Patients With High-Risk Cardiovascular Disease: A Secondary Analysis of the INVESTED Randomized Clinical Trial." JAMA Cardiology, 2024. |
| Orkaby, Ariela R., Goyal, Parag, Charest, Brian, Qazi, Saadia, Sheikh, Shamlan, Shah, Sanjiv, Gaziano, J. Michael, Djousse, Luc, Gagnon, David, Joseph, Jacob. "Initiation of Statins for Primary Prevention in Heart Failure With Preserved Ejection Fraction." JACC: Advances, vol. 3, no. 4, 2024, pp. 100869. |
| Qianqian Yang, Qian Yang, Xueyan Wu, Ruizhi Zheng, Hong Lin, Shuangyuan Wang, Jacob Joseph, Yan V. Sun, Mian Li, Tiange Wang, Zhiyun Zhao, Min Xu, Jieli Lu, Yuhong Chen, Guang Ning, Weiqing Wang, Yufang Bi, Jie Zheng Yu Xu. "Sex-stratified genome-wide association and transcriptome-wide Mendelian randomization studies reveal drug targets of heart failure." Cell Reports Medicine, 2024. |
| Kurgansky, Katherine E., Parker, Rachel, Djousse, Luc, Gagnon, David R., Joseph, Jacob. "Spironolactone Reduces the Risk of Death in Veterans With Heart Failure With Preserved Ejection Fraction." Journal of the American Heart Association, vol. 13, no. 14, 2024. |
| Haji M, Soares C, Agyeman H, Ehsan A, Longenecker CT, Bloomfield GS, Joseph J, Rudolph JL, Wu WC, Erqou S. "Systematic Review of Advanced Heart Failure Therapy Outcomes in People With Human Immunodeficiency Virus." JACC. Advances, vol. 3, no. 3, 2024, pp. 100842. |
| Yuyun MF, Kinlay S, Singh JP, Joseph J. "Are arrhythmias the drivers of sudden cardiac death in heart failure with preserved ejection fraction? A review." ESC Heart Failure, vol. 10, no. 3, 2023, pp. 1555-1569. |
| Huang S, Cai T, Weber BN, He Z, Dahal KP, Hong C, Hou J, Seyok T, Cagan A, DiCarli MF, Joseph J, Kim SC, Solomon DH, Cai T, Liao KP. "Association Between Inflammation, Incident Heart Failure, and Heart Failure Subtypes in Patients With Rheumatoid Arthritis." Arthritis Care & Research, vol. 75, no. 5, 2023, pp. 1036-1045. |
| Peikert A, Claggett BL, Kim K, Udell JA, Joseph J, Desai AS, Farkouh ME, Hegde SM, Hernandez AF, Bhatt DL, Gaziano JM, Talbot HK, Yancy C, Anand I, Mao L, Cooper LS, Solomon SD, Vardeny O. "Association of post-vaccination adverse reactions after influenza vaccine with mortality and cardiopulmonary outcomes in patients with high-risk cardiovascular disease: the INVESTED trial." European journal of heart failure, vol. 25, no. 2, 2023, pp. 299-310. |
| Rasooly, Danielle, Peloso, Gina M., Pereira, Alexandre C., Dashti, Hesam, Giambartolomei, Claudia, Wheeler, Eleanor, Aung, Nay, Ferolito, Brian R., Pietzner, Maik, Farber-Eger, Eric H., Wells, Quinn Stanton, Kosik, Nicole M., Gaziano, Liam, Posner, Daniel C., Bento, A. Patrícia, Hui, Qin, Liu, Chang, Aragam, Krishna, Wang, Zeyuan, Charest, Brian, Huffman, Jennifer E., Wilson, Peter W. F., Phillips, Lawrence S., Whittaker, John, Munroe, Patricia B., Petersen, Steffen E., Cho, Kelly, Leach, Andrew R., Magariños, María Paula, Gaziano, John Michael, Langenberg, Claudia, Sun, Yan V., Joseph, Jacob, Casas, Juan P., None, None. "Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure." Nature Communications, vol. 14, no. 1, 2023. |
| Mai HJ, Jutkowitz E, Kanaan G, Erqou S, Salvador V, Joseph J, Wu WC, Rudolph J, Caputo EL, Rickard T, Rieke K, Balk E. "In-Hospital Sodium Intake for Acute Decompensated Heart Failure: A Systematic Review." 2023. |
| Yuyun MF, Joseph J, Erqou SA, Kinlay S, Echouffo-Tcheugui JB, Peralta AO, Hoffmeister PS, Boden WE, Yarmohammadi H, Martin DT, Singh JP. "Persistence of significant secondary mitral regurgitation post-cardiac resynchronization therapy and survival: a systematic review and meta-analysis : Mitral regurgitation and mortality post-CRT." Heart Failure Reviews, vol. 29, no. 1, 2023, pp. 165-178. |
| Joseph J, Pajewski NM, Dolor RJ, Sellers MA, Perdue LH, Peeples SR, Henrie AM, Woolard N, Jones WS, Benziger CP, Orkaby AR, Mixon AS, VanWormer JJ, Shapiro MD, Kistler CE, Polonsky TS, Chatterjee R, Chamberlain AM, Forman DE, Knowlton KU, Gill TM, Newby LK, Hammill BG, Cicek MS, Williams NA, Decker JE, Ou J, Rubinstein J, Choudhary G, Gazmuri RJ, Schmader KE, Roumie CL, Vaughan CP, Effron MB, Cooper-DeHoff RM, Supiano MA, Shah RC, Whittle JC, Hernandez AF, Ambrosius WT, Williamson JD, Alexander KP, PREVENTABLE Trial Research Group. "Pragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale." Journal of the American Geriatrics Society, vol. 71, no. 6, 2023, pp. 1701-1713. |
| Hegde SM, Claggett BL, Udell JA, Kim K, Joseph J, Farkouh ME, Peikert A, Bhatt AS, Tattersall MC, Bhatt DL, Cooper LS, Solomon SD, Vardeny O. "Temporal Association Among Influenza-Like Illness, Cardiovascular Events, and Vaccine Dose in Patients With High-Risk Cardiovascular Disease: Secondary Analysis of a Randomized Clinical Trial." JAMA Network Open, vol. 6, no. 9, 2023, pp. e2331284. |
| Verma A, Minnier J, Wan ES, Huffman JE, Gao L, Joseph J, Ho YL, Wu WC, Cho K, Gorman BR, Rajeevan N, Pyarajan S, Garcon H, Meigs JB, Sun YV, Reaven PD, McGeary JE, Suzuki A, Gelernter J, Lynch JA, Petersen JM, Zekavat SM, Natarajan P, Dalal S, Jhala DN, Arjomandi M, Gatsby E, Lynch KE, Bonomo RA, Freiberg M, Pathak GA, Zhou JJ, Donskey CJ, Madduri RK, Wells QS, Huang RDL, Polimanti R, Chang KM, Liao KP, Tsao PS, Wilson PWF, Hung AM, O'Donnell CJ, Gaziano JM, Hauger RL, Iyengar SK, Luoh SW, Million Veteran Program COVID-19 Science Initiative. "A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality." Am J Respir Crit Care Med, vol. 206, no. 10, 2022, pp. 1220-1229. |
| Verma A, Huffman JE, Gao L, Minnier J, Wu WC, Cho K, Ho YL, Gorman BR, Pyarajan S, Rajeevan N, Garcon H, Joseph J, McGeary JE, Suzuki A, Reaven PD, Wan ES, Lynch JA, Petersen JM, Meigs JB, Freiberg MS, Gatsby E, Lynch KE, Zekavat SM, Natarajan P, Dalal S, Jhala DN, Arjomandi M, Bonomo RA, Thompson TK, Pathak GA, Zhou JJ, Donskey CJ, Madduri RK, Wells QS, Gelernter J, Huang RDL, Polimanti R, Chang KM, Liao KP, Tsao PS, Sun YV, Wilson PWF, O'Donnell CJ, Hung AM, Gaziano JM, Hauger RL, Iyengar SK, Luoh SW, VA Million Veteran Program COVID-19 Science Initiative. "Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait." JAMA Internal Medicine, vol. 182, no. 8, 2022, pp. 796-804. |
| Orlovic M, Mossialos E, Orkaby AR, Joseph J, Gaziano JM, Skarf LM, Nohria A, Warraich HJ. "Challenges for Patients Dying of Heart Failure and Cancer." Circulation: Heart Failure, vol. 15, no. 12, 2022, pp. e009922. |
| Velagaleti RS, Vetter J, Parker R, Kurgansky KE, Sun YV, Djousse L, Gaziano JM, Gagnon D, Joseph J. "Change in Left Ventricular Ejection Fraction With Coronary Artery Revascularization and Subsequent Risk for Adverse Cardiovascular Outcomes." Circulation: Cardiovascular Interventions, vol. 15, no. 4, 2022, pp. e011284. |
| Rucker D, Joseph J. "Defining the Phenotypes for Heart Failure With Preserved Ejection Fraction." Current heart failure reports, vol. 19, no. 6, 2022, pp. 445-457. |
| Joseph J, Liu C, Hui Q, Aragam K, Wang Z, Charest B, Huffman JE, Keaton JM, Edwards TL, Demissie S, Djousse L, Casas JP, Gaziano JM, Cho K, Wilson PWF, Phillips LS, VA Million Veteran Program, O'Donnell CJ, Sun YV. "Genetic architecture of heart failure with preserved versus reduced ejection fraction." Nature Communications, vol. 13, no. 1, 2022, pp. 7753. |
| Peloso GM, Tcheandjieu C, McGeary JE, Posner DC, Ho YL, Zhou JJ, Hilliard AT, Joseph J, O'Donnell CJ, Efird JT, Crawford DC, Wu WC, Arjomandi M, VA Million Veteran Program COVID-19 Science Initiative, Sun YV, Assimes TL, Huffman JE. "Genetic Loci Associated With COVID-19 Positivity and Hospitalization in White, Black, and Hispanic Veterans of the VA Million Veteran Program." Frontiers in Genetics, vol. 12, 2022, pp. 777076. |
| Levin MG, Tsao NL, Singhal P, Liu C, Vy HMT, Paranjpe I, Backman JD, Bellomo TR, Bone WP, Biddinger KJ, Hui Q, Dikilitas O, Satterfield BA, Yang Y, Morley MP, Bradford Y, Burke M, Reza N, Charest B, Regeneron Genetics Center, Judy RL, Puckelwartz MJ, Hakonarson H, Khan A, Kottyan LC, Kullo I, Luo Y, McNally EM, Rasmussen-Torvik LJ, Day SM, Do R, Phillips LS, Ellinor PT, Nadkarni GN, Ritchie MD, Arany Z, Cappola TP, Margulies KB, Aragam KG, Haggerty CM, Joseph J, Sun YV, Voight BF, Damrauer SM. "Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure." Nature Communications, vol. 13, no. 1, 2022, pp. 6914. |
| Gaziano L, Sun L, Arnold M, Bell S, Cho K, Kaptoge SK, Song RJ, Burgess S, Posner DC, Mosconi K, Robinson-Cohen C, Mason AM, Bolton TR, Tao R, Allara E, Schubert P, Chen L, Staley JR, Staplin N, Altay S, Amiano P, Arndt V, Ärnlöv J, Barr ELM, Björkelund C, Boer JMA, Brenner H, Casiglia E, Chiodini P, Cooper JA, Coresh J, Cushman M, Dankner R, Davidson KW, de Jongh RT, Donfrancesco C, Engström G, Freisling H, de la Cámara AG, Gudnason V, Hankey GJ, Hansson PO, Heath AK, Hoorn EJ, Imano H, Jassal SK, Kaaks R, Katzke V, Kauhanen J, Kiechl S, Koenig W, Kronmal RA, Kyrø C, Lawlor DA, Ljungberg B, MacDonald C, Masala G, Meisinger C, Melander O, Moreno Iribas C, Ninomiya T, Nitsch D, Nordestgaard BG, Onland-Moret C, Palmieri L, Petrova D, Garcia JRQ, Rosengren A, Sacerdote C, Sakurai M, Santiuste C, Schulze MB, Sieri S, Sundström J, Tikhonoff V, Tjønneland A, Tong T, Tumino R, Tzoulaki I, van der Schouw YT, Monique Verschuren WM, Völzke H, Wallace RB, Wannamethee SG, Weiderpass E, Willeit P, Woodward M, Yamagishi K, Zamora-Ros R, Akwo EA, Pyarajan S, Gagnon DR, Tsao PS, Muralidhar S, Edwards TL, Damrauer SM, Joseph J, Pennells L, Wilson PWF, Harrison S, Gaziano TA, Inouye M, Baigent C, Casas JP, Langenberg C, Wareham N, Riboli E, Gaziano JM, Danesh J, Hung AM, Butterworth AS, Wood AM, Di Angelantonio E, Emerging Risk Factors Collaboration/EPIC-CVD/Million Veteran Program. "Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses." Circulation, vol. 146, no. 20, 2022, pp. 1507-1517. |
| Tuteja S, Yu Z, Wilson O, Chen HC, Wendt F, Chung CP, Shah SC, Hunt CM, Suzuki A, Chanfreau C, Gorman BR, Joseph J, Luoh SW, Napolioni V, Robinson-Cohen C, Tao R, Zhou J, Chang KM, Hung AM, VA Million Veteran Program COVID-19 Science Initiative. "Pharmacogenetic variants and risk of remdesivir-associated liver enzyme elevations in Million Veteran Program participants hospitalized with COVID-19." Clinical and Translational Science, vol. 15, no. 8, 2022, pp. 1880-1886. |
| Rubinstein J, Robbins N, Evans K, Foster G, Mcconeghy K, Onadeko T, Bunke J, Parent M, Luo X, Joseph J, Wu WC. "Repurposing Probenecid for the Treatment of Heart Failure (Re-Prosper-HF): a study protocol for a randomized placebo-controlled clinical trial." Trials, vol. 23, no. 1, 2022, pp. 266. |
| Andersson C, Schou M, Boden WE, Schwartz B, Joseph J, Fosbøl E, Køber L, Gislason GH, Torp-Pedersen C. "Trends in Ischemic Evaluation in New-Onset Heart Failure Without Known Coronary Artery Disease." JACC. Heart failure, vol. 10, no. 11, 2022, pp. 807-815. |
| Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM, PROMINENT Investigators. "Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk." New England Journal of Medicine, vol. 387, no. 21, 2022, pp. 1923-1934. |
| Gaziano L, Giambartolomei C, Pereira AC, Gaulton A, Posner DC, Swanson SA, Ho YL, Iyengar SK, Kosik NM, Vujkovic M, Gagnon DR, Bento AP, Barrio-Hernandez I, Rönnblom L, Hagberg N, Lundtoft C, Langenberg C, Pietzner M, Valentine D, Gustincich S, Tartaglia GG, Allara E, Surendran P, Burgess S, Zhao JH, Peters JE, Prins BP, Angelantonio ED, Devineni P, Shi Y, Lynch KE, DuVall SL, Garcon H, Thomann LO, Zhou JJ, Gorman BR, Huffman JE, O'Donnell CJ, Tsao PS, Beckham JC, Pyarajan S, Muralidhar S, Huang GD, Ramoni R, Beltrao P, Danesh J, Hung AM, Chang KM, Sun YV, Joseph J, Leach AR, Edwards TL, Cho K, Gaziano JM, Butterworth AS, Casas JP, VA Million Veteran Program COVID-19 Science Initiative. "Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19." Nature Medicine, vol. 27, no. 4, 2021, pp. 668-676. |
| Parker MM, Damrauer SM, Tcheandjieu C, Erbe D, Aldinc E, Hawkins PN, Gillmore JD, Hull LE, Lynch JA, Joseph J, Ticau S, Flynn-Carroll AO, Deaton AM, Ward LD, Assimes TL, Tsao PS, Chang KM, Rader DJ, Fitzgerald K, Vaishnaw AK, Hinkle G, Nioi P. "Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry." Scientific reports, vol. 11, no. 1, 2021, pp. 11645. |
| Joseph J, Giczewska A, Alhanti B, Cheema AK, Handy DE, Mann DL, Loscalzo J, Givertz MM. "Associations of methyl donor and methylation inhibitor levels during anti-oxidant therapy in heart failure." Journal of physiology and biochemistry, vol. 77, no. 2, 2021, pp. 295-304. |
| Vardeny O, Kim K, Udell JA, Joseph J, Desai AS, Farkouh ME, Hegde SM, Hernandez AF, McGeer A, Talbot HK, Anand I, Bhatt DL, Cannon CP, DeMets D, Gaziano JM, Goodman SG, Nichol K, Tattersall MC, Temte JL, Wittes J, Yancy C, Claggett B, Chen Y, Mao L, Havighurst TC, Cooper LS, Solomon SD, INVESTED Committees and Investigators. "Effect of High-Dose Trivalent vs Standard-Dose Quadrivalent Influenza Vaccine on Mortality or Cardiopulmonary Hospitalization in Patients With High-risk Cardiovascular Disease: A Randomized Clinical Trial." JAMA, vol. 325, no. 1, 2021, pp. 39-49. |
| Bhatt AS, Vardeny O, Udell JA, Joseph J, Kim K, Solomon SD. "Influenza vaccination: a 'shot' at INVESTing in cardiovascular health." European heart journal, vol. 42, no. 20, 2021, pp. 2015-2018. |
| Joseph J. "Is there a purpose to medicine?." J Eval Clin Pract, vol. 27, no. 3, 2021, pp. 665-666. |
| Joseph J. "Life's irreducible structure: Where are we, five decades later?." BioEssays : news and reviews in molecular, cellular and developmental biology, vol. 43, no. 1, 2021, pp. e2000250. |
| Yuyun MF, Erqou SA, Peralta AO, Hoffmeister PS, Yarmohammadi H, Echouffo-Tcheugui JB, Martin DT, Joseph J, Singh JP. "Ongoing Risk of Ventricular Arrhythmias and All-Cause Mortality at Implantable Cardioverter Defibrillator Generator Change: A Systematic Review and Meta-Analysis." Circulation: Arrhythmia and Electrophysiology, vol. 14, no. 3, 2021, pp. e009139. |
| Gaziano L, Cho K, Djousse L, Schubert P, Galloway A, Ho YL, Kurgansky K, Gagnon DR, Russo JP, Di Angelantonio E, Wood AM, Danesh J, Gaziano JM, Butterworth AS, Wilson PWF, Joseph J. "Risk factors and prediction models for incident heart failure with reduced and preserved ejection fraction." ESC Heart Failure, vol. 8, no. 6, 2021, pp. 4893-4903. |
| Yuyun MF, Erqou SA, Peralta AO, Hoffmeister PS, Yarmohammadi H, Echouffo Tcheugui JB, Martin DT, Joseph J, Singh JP. "Risk of ventricular arrhythmia in cardiac resynchronization therapy responders and super-responders: a systematic review and meta-analysis." Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol. 23, no. 8, 2021, pp. 1262-1274. |
| Handy DE, Joseph J, Loscalzo J. "Selenium, a Micronutrient That Modulates Cardiovascular Health via Redox Enzymology." Nutrients, vol. 13, no. 9, 2021. |
| Almufleh A, Joseph J. "The time is now: role of pragmatic clinical trials in guiding response to global pandemics." Trials, vol. 22, no. 1, 2021, pp. 229. |
| Rasalingam R, Parker R, Kurgansky KE, Djousse L, Gagnon D, Joseph J. "Worsening Renal Function during Index Hospitalization Does Not Predict Prognosis in Heart Failure with Preserved Ejection Fraction Patients." Cardiology, vol. 146, no. 2, 2021, pp. 179-186. |
| Kurgansky KE, Schubert P, Parker R, Djousse L, Riebman JB, Gagnon DR, Joseph J. "Association of pulse rate with outcomes in heart failure with reduced ejection fraction: a retrospective cohort study." BMC cardiovascular disorders, vol. 20, no. 1, 2020, pp. 92. |
| Foster M, Albanese C, Chen Q, Sethares KA, Evans S, Lehmann LS, Spencer J, Joseph J. "Heart Failure Dashboard Design and Validation to Improve Care of Veterans." Applied Clinical Informatics, vol. 11, no. 1, 2020, pp. 153-159. |
| Vaduganathan M, van Meijgaard J, Mehra MR, Joseph J, O'Donnell CJ, Warraich HJ. "Prescription Fill Patterns for Commonly Used Drugs During the COVID-19 Pandemic in the United States." JAMA, vol. 323, no. 24, 2020, pp. 2524-2526. |
| Patel Y, Joseph J. "Sodium Intake and Heart Failure." International Journal of Molecular Sciences, vol. 21, no. 24, 2020. |
| Djoussé L, Cook NR, Kim E, Bodar V, Walter J, Bubes V, Luttmann-Gibson H, Mora S, Joseph J, Lee IM, Albert CM, Buring JE, Gaziano JM, Manson JE, VITAL Research Group. "Supplementation With Vitamin D and Omega-3 Fatty Acids and Incidence of Heart Failure Hospitalization: VITAL-Heart Failure." Circulation, vol. 141, no. 9, 2020, pp. 784-786. |
| Huynh T, Harty BJ, Claggett B, Fleg JL, McKinlay SM, Anand IS, Lewis EF, Joseph J, Desai AS, Sweitzer NK, EileenO'Meara, Pitt B, Pfeffer MA, Rouleau JL. "Comparison of Outcomes in Patients With Diabetes Mellitus Treated With Versus Without Insulin + Heart Failure With Preserved Left Ventricular Ejection Fraction (from the TOPCAT Study)." The American Journal of Cardiology, vol. 123, no. 4, 2019, pp. 611-617. |
| Metra, Marco, Teerlink, John R., Cotter, Gad, Davison, Beth A., Felker, G. Michael, Filippatos, Gerasimos, Greenberg, Barry H., Pang, Peter S., Ponikowski, Piotr, Voors, Adriaan A., Adams, Kirkwood F., Anker, Stefan D., Arias-Mendoza, Alexandra, Avendaño, Patricio, Bacal, Fernando, Böhm, Michael, Bortman, Guillermo, Cleland, John G.F., Cohen-Solal, Alain, Crespo-Leiro, Maria G., Dorobantu, Maria, Echeverría, Luis E., Ferrari, Roberto, Goland, Sorel, Goncalvesová, Eva, Goudev, Assen, Køber, Lars, Lema-Osores, Juan, Levy, Phillip D., McDonald, Kenneth, Manga, Pravin, Merkely, Béla, Mueller, Christian, Pieske, Burkert, Silva-Cardoso, Jose, Špinar, Jindřich, Squire, Iain, Stępińska, Janina, Van Mieghem, Walter, von Lewinski, Dirk, Wikström, Gerhard, Yilmaz, Mehmet B., Hagner, Nicole, Holbro, Thomas, Hua, Tsushung A., Sabarwal, Shalini V., Severin, Thomas, Szecsödy, Peter, Gimpelewicz, Claudio. "Effects of Serelaxin in Patients with Acute Heart Failure." New England Journal of Medicine, vol. 381, no. 8, 2019, pp. 716-726. |
| Metra M, Teerlink JR, Cotter G, Davison BA, Felker GM, Filippatos G, Greenberg BH, Pang PS, Ponikowski P, Voors AA, Adams KF, Anker SD, Arias-Mendoza A, Avendaño P, Bacal F, Böhm M, Bortman G, Cleland JGF, Cohen-Solal A, Crespo-Leiro MG, Dorobantu M, Echeverría LE, Ferrari R, Goland S, Goncalvesová E, Goudev A, Køber L, Lema-Osores J, Levy PD, McDonald K, Manga P, Merkely B, Mueller C, Pieske B, Silva-Cardoso J, Špinar J, Squire I, Stępińska J, Van Mieghem W, von Lewinski D, Wikström G, Yilmaz MB, Hagner N, Holbro T, Hua TA, Sabarwal SV, Severin T, Szecsödy P, Gimpelewicz C, RELAX-AHF-2 Committees Investigators. "Effects of Serelaxin in Patients with Acute Heart Failure." New England Journal of Medicine, vol. 381, no. 8, 2019, pp. 716-726. |
| Srivastava A, Do JM, Sales VL, Ly S, Joseph J. "Impact of patient-centred home telehealth programme on outcomes in heart failure." Journal of Telemedicine and Telecare, vol. 25, no. 7, 2019, pp. 425-430. |
| Zhang L, Joseph L, Joseph J. "In Vivo and In Vitro Effects of Vasopressin V2 Receptor Antagonism on Myocardial Fibrosis in Rats." The American Journal of the Medical Sciences, vol. 357, no. 2, 2019, pp. 151-159. |
| Joseph J. "Orchestrating Metabolic Flexibility: PGC-1α and Clinical Heart Failure." The American Journal of the Medical Sciences, vol. 357, no. 4, 2019, pp. 273-274. |
| Imran TF, Kurgansky KE, Patel YR, Orkaby AR, McLean RR, Ho YL, Cho K, Gaziano JM, Djousse L, Gagnon DR, Joseph J. "Serial sodium values and adverse outcomes in heart failure with preserved ejection fraction." International Journal of Cardiology, vol. 290, 2019, pp. 119-124. |
| Patel YR, Robbins JM, Kurgansky KE, Imran T, Orkaby AR, McLean RR, Ho YL, Cho K, Michael Gaziano J, Djousse L, Gagnon DR, Joseph J. "Development and validation of a heart failure with preserved ejection fraction cohort using electronic medical records." BMC cardiovascular disorders, vol. 18, no. 1, 2018, pp. 128. |
| Vardeny O, Udell JA, Joseph J, Farkouh ME, Hernandez AF, McGeer AJ, Talbot HK, Bhatt DL, Cannon CP, Goodman SG, Anand I, DeMets DL, Temte J, Wittes J, Nichol K, Yancy CW, Gaziano JM, Cooper LS, Kim K, Solomon SD. "High-dose influenza vaccine to reduce clinical outcomes in high-risk cardiovascular patients: Rationale and design of the INVESTED trial." American Heart Journal, vol. 202, 2018, pp. 97-103. |
| McMurray JJ, Krum H, Abraham WT, Dickstein K, Køber LV, Desai AS, Solomon SD, Greenlaw N, Ali MA, Chiang Y, Shao Q, Tarnesby G, Massie BM, ATMOSPHERE Committees Investigators. "Aliskiren, Enalapril, or Aliskiren and Enalapril in Heart Failure." New England Journal of Medicine, vol. 374, no. 16, 2016, pp. 1521-32. |
| Sridharan V, Thomas CJ, Cao M, Melnyk SB, Pavliv O, Joseph J, Singh SP, Sharma S, Moros EG, Boerma M. "Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart." Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 119, no. 2, 2016, pp. 259-64. |
| Imran TF, Shah R, Ha AS, Thomas R, Joseph J. "Heart failure associated with small molecule tyrosine kinase inhibitors." International Journal of Cardiology, vol. 206, 2016, pp. 110-1. |
| Church KM, Henalt R, Baker E, Smith GL Jr, Brennan MT, Joseph J. "Comparison of metoprolol succinate versus carvedilol in time to cardiovascular admission in a Veterans Affairs healthcare system: An observational study." American Journal of Health-system Pharmacy, vol. 72, no. 23 Suppl 3, 2015, pp. S183-90. |
| Joseph J. "Needling the heart to rejuvenate: the promise of intramyocardial injection of bone marrow stem cells." The Journal of Heart and Lung Transplantation, vol. 33, no. 6, 2014, pp. 565-6. |
| Pitt B, Pfeffer MA, Assmann SF, Boineau R, Anand IS, Claggett B, Clausell N, Desai AS, Diaz R, Fleg JL, Gordeev I, Harty B, Heitner JF, Kenwood CT, Lewis EF, O'Meara E, Probstfield JL, Shaburishvili T, Shah SJ, Solomon SD, Sweitzer NK, Yang S, McKinlay SM, TOPCAT Investigators. "Spironolactone for heart failure with preserved ejection fraction." New England Journal of Medicine, vol. 370, no. 15, 2014, pp. 1383-92. |
| Zavin A, Daniels K, Arena R, Allsup K, Lazzari A, Joseph J, Schulze PC, Lecker SH, Forman DE. "Adiposity facilitates increased strength capacity in heart failure patients with reduced ejection fraction." International Journal of Cardiology, vol. 167, no. 6, 2013, pp. 2468-71. |
| Zavin A, Arena R, Joseph J, Allsup K, Daniels K, Schulze PC, Lecker S, Forman DE. "Dynamic assessment of ventilatory efficiency during recovery from peak exercise to enhance cardiopulmonary exercise testing." European journal of preventive cardiology, vol. 20, no. 5, 2013, pp. 779-85. |
| Zhi H, Luptak I, Alreja G, Shi J, Guan J, Metes-Kosik N, Joseph J. "Effects of direct Renin inhibition on myocardial fibrosis and cardiac fibroblast function." PLoS ONE, vol. 8, no. 12, 2013, pp. e81612. |
| Joseph J, Loscalzo J. "Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology." Nutrients, vol. 5, no. 8, 2013, pp. 3235-56. |
| Joseph J, Loscalzo J. "Selenistasis: epistatic effects of selenium on cardiovascular phenotype." Nutrients, vol. 5, no. 2, 2013, pp. 340-58. |
| Joseph J. "Selenium and cardiometabolic health: inconclusive yet intriguing evidence." The American Journal of the Medical Sciences, vol. 346, no. 3, 2013, pp. 216-20. |
| Metes-Kosik N, Luptak I, Dibello PM, Handy DE, Tang SS, Zhi H, Qin F, Jacobsen DW, Loscalzo J, Joseph J. "Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance." Molecular Nutrition & Food Research, vol. 56, no. 12, 2012, pp. 1812-24. |
| Joseph J. "Fattening by deprivation: methyl balance and perinatal cardiomyopathy." The Journal of Pathology, vol. 225, no. 3, 2011, pp. 315-7. |
| Sharma GV, Woods PA, Lindsey N, O'Connell C, Connolly L, Joseph J, McIntyre KM. "Noninvasive monitoring of left ventricular end-diastolic pressure reduces rehospitalization rates in patients hospitalized for heart failure: a randomized controlled trial." Journal of cardiac failure, vol. 17, no. 9, 2011, pp. 718-25. |
| Joseph J, Pencina MJ, Wang TJ, Hayes L, Tofler GH, Jacques P, Selhub J, Levy D, D'Agostino RB Sr, Benjamin EJ, Vasan RS. "Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community." Journal of hypertension, vol. 27, no. 6, 2009, pp. 1317-24. |
| Joseph J, Handy DE, Loscalzo J. "Quo vadis: whither homocysteine research?." Cardiovascular toxicology, vol. 9, no. 2, 2009, pp. 53-63. |
| Joseph J, Joseph L, Devi S, Kennedy RH. "Effect of anti-oxidant treatment on hyperhomocysteinemia-induced myocardial fibrosis and diastolic dysfunction." The Journal of Heart and Lung Transplantation, vol. 27, no. 11, 2008, pp. 1237-41. |
| Boerma M, Fiser WP, Hoyt G, Berry GJ, Joseph L, Joseph J, Wang J, Crew MD, Robbins RC, Hauer-Jensen M. "Influence of mast cells on outcome after heterotopic cardiac transplantation in rats." Transplant international : official journal of the European Society for Organ Transplantation, vol. 20, no. 3, 2007, pp. 256-65. |
| Rajaram V, Joseph J. "Role of adenosine antagonism in the cardio-renal syndrome: pathophysiology and therapeutic potential." Current heart failure reports, vol. 4, no. 3, 2007, pp. 153-7. |
| Joseph J, Rimawi A, Mehta P, Cottler-Fox M, Sinha A, Singh BK, Pacheco R, Smith ES 3rd, Mehta JL. "Safety and effectiveness of granulocyte-colony stimulating factor in mobilizing stem cells and improving cytokine profile in advanced chronic heart failure." The American Journal of Cardiology, vol. 97, no. 5, 2006, pp. 681-4. |
| Boerma M, Wang J, Wondergem J, Joseph J, Qiu X, Kennedy RH, Hauer-Jensen M. "Influence of mast cells on structural and functional manifestations of radiation-induced heart disease." Cancer Research, vol. 65, no. 8, 2005, pp. 3100-7. |
| Joseph J, Kennedy RH, Devi S, Wang J, Joseph L, Hauer-Jensen M. "Protective role of mast cells in homocysteine-induced cardiac remodeling." AJP: Heart and Circulatory Physiology, vol. 288, no. 5, 2005, pp. H2541-5. |
| Kennedy RH, Owings R, Shekhawat N, Joseph J. "Acute negative inotropic effects of homocysteine are mediated via the endothelium." AJP: Heart and Circulatory Physiology, vol. 287, no. 2, 2004, pp. H812-7. |
| Pitt, Bertram, Remme, Willem, Zannad, Faiez, Neaton, James, Martinez, Felipe, Roniker, Barbara, Bittman, Richard, Hurley, Steve, Kleiman, Jay, Gatlin, Marjorie. "Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction." New England Journal of Medicine, vol. 348, no. 14, 2003, pp. 1309-1321. |
| Joseph J, Joseph L, Shekhawat NS, Devi S, Wang J, Melchert RB, Hauer-Jensen M, Kennedy RH. "Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats." AJP: Heart and Circulatory Physiology, vol. 285, no. 2, 2003, pp. H679-86. |
| Joseph J, Ranganathan S, Mehta JL. "Low density lipoproteins modulate collagen metabolism in fibroblasts." Journal of cardiovascular pharmacology and therapeutics, vol. 8, no. 2, 2003, pp. 161-6. |
| Pfeffer, Marc A., McMurray, John J.V., Velazquez, Eric J., Rouleau, Jean-Lucien, Køber, Lars, Maggioni, Aldo P., Solomon, Scott D., Swedberg, Karl, Van de Werf, Frans, White, Harvey, Leimberger, Jeffrey D., Henis, Marc, Edwards, Susan, Zelenkofske, Steven, Sellers, Mary Ann, Califf, Robert M. "Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both." New England Journal of Medicine, vol. 349, no. 20, 2003, pp. 1893-1906. |
| Abraham, William T., Fisher, Westby G., Smith, Andrew L., Delurgio, David B., Leon, Angel R., Loh, Evan, Kocovic, Dusan Z., Packer, Milton, Clavell, Alfredo L., Hayes, David L., Ellestad, Myrvin, Trupp, Robin J., Underwood, Jackie, Pickering, Faith, Truex, Cindy, McAtee, Peggy, Messenger, John. "Cardiac Resynchronization in Chronic Heart Failure." New England Journal of Medicine, vol. 346, no. 24, 2002, pp. 1845-1853. |
| Joseph J, Washington A, Joseph L, Koehler L, Fink LM, Hauer-Jensen M, Kennedy RH. "Hyperhomocysteinemia leads to adverse cardiac remodeling in hypertensive rats." AJP: Heart and Circulatory Physiology, vol. 283, no. 6, 2002, pp. H2567-74. |
| Melchert RB, Joseph J, Kennedy RH. "Interaction of xenobiotics with myocardial signal transduction pathways." Cardiovascular toxicology, vol. 2, no. 1, 2002, pp. 1-23. |
| Joseph, J. "Antiparallel polypurine phosphorothioate oligonucleotides form stable triplexes with the rat alpha1(I) collagen gene promoter and inhibit transcription in cultured rat fibroblasts." Nucleic Acids Research, vol. 25, no. 11, 1997, pp. 2182-2188. |
| Year | Degree | Institution |
|---|---|---|
| 1991 | MD | University of Kerala |
| 1988 | MBBS | University of Kerala |
| Member, National Physician Advocacy Council. US Veterans Health Administration, - |
| Chief, Inclusion, Diversity, Equity, and Access (IDEA) Committee. VA Providence Healthcare System, - |
| Chief of Cardiology. VA Providence Healthcare System, - |
