Sweeney, Joseph

Joseph D Sweeney

Professor of Medicine, Professor of Pathology and Laboratory Medicine

Overview

Expertise/Certifications: Transfusion Medicine, Coagulation Medicine, Blood Bank, Clinical Pathology
Office number: 793-4810
(Lab Customer Service: 401-793-4242)

Dr. Sweeney received his Medical Degree from the National University of Ireland in 1976 and trained in Internal Medicine and Hematology in Dublin, Ireland. He subsequently trained in New York in Clinical Hematology, Blood Banking and Medical Oncology. From 1986 -1991, he was Medical Director of the Hemophilia Center and Medical Director of the Blood Bank at Roswell Park Cancer Center in Buffalo. He subsequently served as Chief Medical Officer and Head of Research at the American Red Cross in Norfolk Virgina and since 1994 has been in Providence RI where he is Professor of Pathology and Laboratory Medicine and Director of Transfusion Medicine and Coagulation at Brown University. Dr Sweeney is Board Certified in Internal Medicine, Hematology and Blood Banking. He is a Fellow of the American College of Physicians; a Fellow of the Royal College of Pathologists (UK) and a Fellow of the Royal College of Physicians of Ireland in the Faculty of Pathology. Dr. Sweeney has extensive experience and expertise in Transfusion Medicine: He has edited two books, written several book chapters and over 230 scientific papers and abstracts. He has served as a member of the Technical Committee of the American Association of Blood Banks, and currently serves on the editorial board of Transfusion, and is a reviewer for several Journals including the American Journal of Clinical Pathology and Vox Sanguinis.

Brown Affiliations

Research Areas

blood transfusion | hemostasis | platelets

Research

Research Overview

Research is centered on methods to test patients with bleeding or clotting disorders and the types of blood products and role of blood transfusion in treating these conditions.

Research Statement

Research interests have centered on disorders of hemostasis, especially platelets, - their detection, quantitation and management. Related to this, methods to characterize and improve platelets and plasma blood components. More recently, research on best transfusion practices and patient blood management with an emphasis on transfusion avoidance.

Funded Research

August 2001 P.I. -Sigma-tau Corporation Red cell microvesiculation during storage. Effects of L-carnitine. $52,940.

March 2003- P.I.- PALL Corporation- Comparison of prestorage versus post storage pooling of whole blood derived platelet concentrates- $102,960.

March- 2003- P.I. Haemonetics Corporation- A Study of the SDPD versus the SDPE protocol for plateletpheresis - $29,700.

October 2004- PI- PALL Corporation- Study of Pooled platelet storage in a new container (ELX)- $120,000.

April, 2005- PI - PALL Corporation- Additive Solutions with prestorage pooled whole blood derived platelets. $25,000.

March 2006: P.I. PALL Corporation: Evaluation of the CLX-HP Storage Bag and the Use of Mixed A and O Platelets. $78,213.

February: 2007: P.I. PALL Corporation Post market evaluation of prestorage pooled whole blood derived platelets. $22,500.

November 2008 .P.I. PALL Corporation: In Vitro evaluation of platelets suspended in either plasma or PAS-G additive solution. $226,000.

March 2009 PI. PALL Corporation: Evaluation of plasma processed and stored in Covina made Euro set (top&top, cpd/sag-m) system as compared to Ascoli made set. $34,000.

March 2011: PI . Smiths Medical: Effect of a new gas vent filter on red cells Hemolysis and plasma clotting factors: $58,300.

August 2012: PI. Studies on the effect of PER977 on coagulation and hemostasis. Persophere Inc $15,000.

October 2012: PI . Evaluation of the IH-1000 for automated compatibility testing. Bio_Rad Corp. $186,341.

Scholarly Work

Alhumaidan H, Cheves T, Holme S, Sweeney JD. Stability of Clotting Factors After 24-Hour Room Temperature Hold. Transfusion. 50: 1934-1942, 2010.

Sweeney JD. Venous Thromboembolic Disease. Medicine & Health, Rhode Island. 94: 98-104, 2011.

Tavares M, DiQuattro P, Nolette N, Conti G, Sweeney JD. Reduction in Plasma Transfusion After Enforcement of Transfusion Guidelines. Transfusion. 51: 754-761, 2011.

Heddle NM, Wu C , Vassallo R, Carey P, Arnold D, Lozano M, Pavenski K, Sweeney J, Stanworth S, Liu Y, Traore A, Barty R, Tinmouth A. Challenges Adjudicating Bleeding Events in a Platelet Dose Study. Transfusion. 51: 2304-10, 2011.

Alhumaidan H, Cheves T, Holme S, Sweeney JD. Manufacture of Pooled Platelets in Additive Solution and a New Container After an Overnight Room Temperature Hold of Platelet Rich Plasma. Am J Clin Pathol. 136: 638-645, 2011.

Carino GP, Tsapenko AY, Sweeney JD. Central Line Placement in Patients With Coagulopathy With or Without Prophylactic Plasma. J Crit Care. 27: 529e9-529e, 2012.

Alhumaidan H, Sweeney JD. Current Status of Additive Solutions for Platelets. J Clin Apher. 7: 93-98, 2012.

Chu LM, Lassaletta AD, Robich MP, Liu Y, Burgess T, Laham RJ, Sweeney JD, Shen T, Sellke FW. Effects of Red Wine and Vodka on Collateral-Dependent Perfusion and Cardiovascular Function in Hypercholesterolemic Swine. Circulation. 126(suppl 1): S65-S72, 2012.

Meehan R, Tavares M, Sweeney JD. Clinical Experience With Oral Versus Intravenous Vitamin K for Warfarin Reversal. Transfusion (in press 2013).

Alhumaidan H, Esteva C, Young C, Berardi V, Westerly B, Sweeney JD. Transfusion Transmitted Anaplasmosis From a Leukoreduced Red Cell. Transfusion (in press 2013).

Alhumaidan H, Cheves T, Holme S, Sweeney JD. The Effect of Leukofiltration on Plasma Clotting Factors. Am J Clin Path. 139: 110-116, 2013.

Layton J, Rubin L, Sweeney JD. Avoidance of Transfusion in Orthopedic Surgery. Medicine & Health, Rhode Island (in press 2013).

Background

Education and Training

Year	Degree	Institution
1976	MD	University College Dublin National University of Ireland
1973	BSc	University College Dublin National University of Ireland

Honors and Awards

Milton Hamolskyk Lifetime Achievement Award

Alpha Omega Alpha, elected Faculty Member

Teaching

Teaching Overview

UNIVERSITY TEACHING EXPERIENCE:

Teaching Awards:
Brown University Pathology Residents: Outstanding Teaching in Transfusion Medicine Award 2002-2003
Brown University: Dean's Teaching Excellence Award. 2003
Brown University Hematology-Oncology Fellows: Teacher of the year Award 2003-2004
Brown University Pathology Residents: Best Teacher in Pathology Award 2007-2008
Medical Staff, Miriam Hospital: Marcia C Reisman Award for Excellence in Teaching 2010

State University of New York at Buffalo (SUNYAB): 1986-1991
Sole Lecturer & Course Coordinator: Coagulation and Hemostasis: M.S. Degree course, Medical Technologists 1986, 1988, 1989 and 1991 (21 Contact Hours per year).

Lecturer: Coagulation and Bleeding Disorders: Lectures for 2nd year Medical Students 1989, 1990, and 1991 (2 Contact Hours per year).

Eastern Virginia Medical School (EVMS): 1992-1994
Course Coordinator: Hematology (28 Contact Hours per year), 2nd year medical students. 1992 and 1993.
Lecturer: Transfusion Medicine; Hemostasis; Anemia's

Brown University School of Medicine: 1995 Present
Medical Students:
Lecturer: Hematology - Pathophysiology course and small group facilitator, 1995. (17 Contact Hours)

Lecturer: Hematology - Pathophysiology course, 1996 2005. (2 Contact Hours per year)
Lecturer; Principles of Transfusion Medicine: Pathophysiology course, 2005 2013 (1 Contact Hour per year)

Residents and Fellows:
Lecturer: Coagulation Course. A series of 13 lectures. A comprehensive series of lectures on basic and applied aspects of coagulation for Clinical Pathology Residents, and Hematology-Oncology Fellows. 2001-2002; 2004; 2006, 2007, 2009

Lecturer: Transfusion Medicine: A series of 11 lectures. A series of lectures intended for Clinical Pathology residents and Hematology- Oncology Fellows. 2003, 2005, 2008

Lecturer: Laboratory Coagulation: A series of 5 lectures. Lectures describing basic aspects of Coagulation and hemostasis with emphasis on the principles of laboratory testing : intended for Clinical Pathology residents and Hematology- Oncology Fellows : 2011

Lecturer: Applied Transfusion Medicine: A series of 5 lectures. Lectures presenting clinical problems in Transfusion Medicine as a basis for teaching basic Transfusion Medicine. intended for Clinical Pathology residents and Hematology- Oncology Fellows: 2012

University of Rhode Island:
Lecturer: Basic Coagulation. Masters Degree candidates. 3 6 contact hours. 1996, 1999, 2002, 2004, and 2010

Researchers@Brown