Jay Trivedi
Jay Trivedi
Assistant Professor of Orthopaedics (Research)
Overview
Dr. Jay Trivedi is an assistant professor in the Department of Orthopaedics at The Warren Alpert Medical School of Brown University/Rhode Island Hospital, working in Dr. Jayasuriya’s laboratory. He obtained his B.Sc. in Zoology, and M.Sc. in Toxicology (University Gold Medalist) from M.S. University, India. Dr. Trivedi received his Ph.D. in Biotechnology from the National Centre for Cell Science, India. Dr. Trivedi is a molecular cell biologist with expertise in biotechnology, drug discovery, and tissue regeneration. His research interests focus on developing stem cell-based therapeutic strategies for soft tissue injury repair, including meniscus, cartilage, and tendon. Dr. Trivedi currently serves as the Section Education Chair of the Orthopaedics Research Society Meniscus section.
Brown Affiliations
On the Web
Publications
| "Intra-articular Injections of CXCR4-Overexpressing Human Cartilage-Derived Progenitor Cells Improve Meniscus Healing and Protect Against Posttraumatic Osteoarthritis in Immunocompetent Rabbits." The American Journal of Sports Medicine, 2025. |
| Yang, Daniel S., Trivedi, Jay, Betensky, Daniel, Desai, Salomi, Owens, Brett D., Jayasuriya, Chathuraka T. "Kartogenin Induces Chondrogenesis in Cartilage Progenitor Cells and Attenuates Cell Hypertrophy in Marrow-Derived Stromal Cells." Current Stem Cell Research & Therapy, vol. 19, 2024. |
| Shigley, Christian, Trivedi, Jay, Meghani, Ozair, Owens, Brett D., Jayasuriya, Chathuraka T. "Suppressing Chondrocyte Hypertrophy to Build Better Cartilage." Bioengineering, vol. 10, no. 6, 2023, pp. 741. |
| Trivedi, Jay, Jayasuriya, Chathuraka T. "Meniscus tissue engineering and repair." Musculoskeletal Tissue Engineering, 2022, pp. 107-132. |
| Desai, Salomi, Dooner, Mark, Newberry, Jake, Twomey-Kozak, John, Molino, Janine, Trivedi, Jay, Patel, Jay M., Owens, Brett D., Jayasuriya, Chathuraka T. "Stable human cartilage progenitor cell line stimulates healing of meniscal tears and attenuates post-traumatic osteoarthritis." Frontiers in Bioengineering and Biotechnology, vol. 10, 2022. |
| Acharya, Arpan, Pandey, Kabita, Thurman, Michellie, Klug, Elizabeth, Trivedi, Jay, Sharma, Kalicharan, Lorson, Christian L., Singh, Kamal, Byrareddy, Siddappa N. "Discovery and Evaluation of Entry Inhibitors for SARS-CoV-2 and Its Emerging Variants." Journal of Virology, vol. 95, no. 24, 2021. |
| Iyer, Kruthika, Chand, Kailash, Mitra, Alapani, Trivedi, Jay, Mitra, Debashis. "Diversity in heat shock protein families: functional implications in virus infection with a comprehensive insight of their role in the HIV-1 life cycle." Cell Stress and Chaperones, vol. 26, no. 5, 2021, pp. 743-768. |
| Trivedi, Jay, Betensky, Daniel, Desai, Salomi, Jayasuriya, Chathuraka T. "Post-Traumatic Osteoarthritis Assessment in Emerging and Advanced Pre-Clinical Meniscus Repair Strategies: A Review." Frontiers in Bioengineering and Biotechnology, vol. 9, 2021. |
| Trivedi, Jay, Alam, Aftab, Joshi, Shruti, Kumar, Togapur Pavan, Chippala, Venkatraju, Mainkar, Prathama S., Chandrasekhar, Srivari, Chattopadhyay, Samit, Mitra, Debashis. "A novel isothiocyanate derivative inhibits HIV-1 gene expression and replication by modulating the nuclear matrix associated protein SMAR1." Antiviral Research, vol. 173, 2020, pp. 104648. |
| Trivedi, Jay, Mohan, Mahesh, Byrareddy, Siddappa N. "Drug Repurposing Approaches to Combating Viral Infections." Journal of Clinical Medicine, vol. 9, no. 11, 2020, pp. 3777. |
| Agarwal, Rachna, Trivedi, Jay, Mitra, Debashis. "High yield production of recombinant cyanovirin-N (antiviral lectin) exhibiting significant anti-HIV activity, from a rationally selected Escherichia coli strain." Process Biochemistry, vol. 93, 2020, pp. 1-11. |
| Trivedi, Jay, Ghosh, Payel, Mitra, Debashis. "N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK) inhibits HIV-1 by suppressing the activity of viral protease." Biochemical and Biophysical Research Communications, vol. 527, no. 1, 2020, pp. 167-172. |
| Trivedi, Jay, Mahajan, Dinesh, Jaffe, Russell J., Acharya, Arpan, Mitra, Debashis, Byrareddy, Siddappa N. "Recent Advances in the Development of Integrase Inhibitors for HIV Treatment." Current HIV/AIDS Reports, vol. 17, no. 1, 2020, pp. 63-75. |
| Jayaprakash, Nisha Grandhi, Singh, Amrita, Vivek, Rahul, Yadav, Shivender, Pathak, Sanmoy, Trivedi, Jay, Jayaraman, Narayanaswamy, Nandi, Dipankar, Mitra, Debashis, Surolia, Avadhesha. "The barley lectin, horcolin, binds high-mannose glycans in a multivalent fashion, enabling high-affinity, specific inhibition of cellular HIV infection." Journal of Biological Chemistry, vol. 295, no. 34, 2020, pp. 12111-12129. |
| Trivedi, Jay, Parveen, Afsana, Rozy, Farhana, Mitra, Alapani, Bal, Chandralata, Mitra, Debashis, Sharon, Ashoke. "Discovery of 2-isoxazol-3-yl-acetamide analogues as heat shock protein 90 (HSP90) inhibitors with significant anti-HIV activity." European Journal of Medicinal Chemistry, vol. 183, 2019, pp. 111699. |
| Trivedi, Jay, Tripathi, Anjali, Chattopadhyay, Debprasad, Mitra, Debashis. "Plant-Derived Molecules in Managing HIV Infection." New Look to Phytomedicine, 2019, pp. 273-298. |
| Gawali, Rakhi, Trivedi, Jay, Bhansali, Sujit, Bhosale, Raghunath, Sarkar, Dhiman, Mitra, Debashis. "Design, synthesis, docking studies and biological screening of 2-thiazolyl substituted -2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazines as potent HIV-1 reverse transcriptase inhibitors." European Journal of Medicinal Chemistry, vol. 157, 2018, pp. 310-319. |
| Shrivastava, Surya, Trivedi, Jay, Mitra, Debashis. "Gene expression profiling reveals Nef induced deregulation of lipid metabolism in HIV-1 infected T cells." Biochemical and Biophysical Research Communications, vol. 472, no. 1, 2016, pp. 169-174. |
Research
Funded Research
ON/ORS Kick-starter Grant: Evaluation of role of DLX5 in cellular hypertrophy to prevent osteoarthritis.
Role – Principal Investigator
Funding agency – ON Foundation, Switzerland
Background
Education and Training
| Year | Degree | Institution |
|---|---|---|
| 2019 | PhD | Pune University |
| 2012 | MSc | Maharaja Sayajirao University of Baroda |
| 2010 | BSc | Maharaja Sayajirao University of Baroda |
Postdoctoral/Other Training
| Postdoctoral Research Associate | Rhode Island Hospital, , Orthopaedics | 2020-2023 | Providence, RI, USA |
Honors and Awards
- New Investigator Recognition Award (NIRA) finalist. Orthopaedic Research Society annual meeting (2025), Phoenix, AZ, USA
- New Investigator Recognition Award (NIRA) finalist. Orthopaedic Research Society annual meeting (2024), Long Beach, CA, USA
- Recipient of the ON/ORS Kick-starter Grant from ON Foundation (2024), Switzerland
- Recipient of the ON/ORS Education Grant from ON Foundation (2023), Switzerland
- Recipient of the best poster award in the meniscus section. Orthopaedic Research Society annual meeting (2022), Tampa, FL, USA
- Recipient of a travel merit award from the International Society for Antiviral Research. 30th International Conference for Antiviral Research (2017), Atlanta, GA, USA
- Recipient of a travel grant from the Council of Scientific and Industrial Research, India, for 30th International Conference for Antiviral Research (2017), India
- Awarded with DST-INSPIRE senior research fellowship by the Department of Science and Technology (2015), India
- Awarded with DST-INSPIRE junior research fellowship by the Department of Science and Technology (2013), India
- Qualified Graduate Aptitude Test for Engineering (GATE) conducted by the Indian Institute of Technology and Indian Institute of Science (2013), India
- Honoured with Prof. J. C. George Gold Medal for excellence in post-graduation by The Maharaja Sayajirao University of Baroda (2012), Vadodara, Gujarat, India
- Recipient of Minaxi Lalit Science Award (2010), Gujarat, India