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Doke T, Mukherjee S, Mukhi D, Dhillon P, Abedini A, Davis JG, Chellappa K, Chen B, Baur JA, Susztak K.
"NAD(+) precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury." Nature metabolism, vol. 5, no. 3, 2023, pp. 414-430.
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Dohnalová L, Lundgren P, Carty JRE, Goldstein N, Wenski SL, Nanudorn P, Thiengmag S, Huang KP, Litichevskiy L, Descamps HC, Chellappa K, Glassman A, Kessler S, Kim J, Cox TO, Dmitrieva-Posocco O, Wong AC, Allman EL, Ghosh S, Sharma N, Sengupta K, Cornes B, Dean N, Churchill GA, Khurana TS, Sellmyer MA, FitzGerald GA, Patterson AD, Baur JA, Alhadeff AL, Helfrich EJN, Levy M, Betley JN, Thaiss CA.
"A microbiome-dependent gut-brain pathway regulates motivation for exercise." J. Geophys. Res., vol. 612, no. 7941, 2022, pp. 739-747.
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Chellappa K, McReynolds MR, Lu W, Zeng X, Makarov M, Hayat F, Mukherjee S, Bhat YR, Lingala SR, Shima RT, Descamps HC, Cox T, Ji L, Jankowski C, Chu Q, Davidson SM, Thaiss CA, Migaud ME, Rabinowitz JD, Baur JA.
"NAD precursors cycle between host tissues and the gut microbiome." Cell Metabolism, vol. 34, no. 12, 2022, pp. 1947-1959.e5.
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McReynolds MR, Chellappa K, Chiles E, Jankowski C, Shen Y, Chen L, Descamps HC, Mukherjee S, Bhat YR, Lingala SR, Chu Q, Botolin P, Hayat F, Doke T, Susztak K, Thaiss CA, Lu W, Migaud ME, Su X, Rabinowitz JD, Baur JA.
"NAD(+) flux is maintained in aged mice despite lower tissue concentrations." Cell Systems, vol. 12, no. 12, 2021, pp. 1160-1172.e4.
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Chellappa K, Baur JA.
"Reducing NAD(H) to amplify rhythms." Nature metabolism, vol. 3, no. 12, 2021, pp. 1589-1590.
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Mukherjee S, Mo J, Paolella LM, Perry CE, Toth J, Hugo MM, Chu Q, Tong Q, Chellappa K, Baur JA.
"SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside." JCI insight, vol. 6, no. 7, 2021.
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McReynolds MR, Chellappa K, Baur JA.
"Age-related NAD(+) decline." Experimental Gerontology, vol. 134, 2020, pp. 110888.
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Chini CCS, Peclat TR, Warner GM, Kashyap S, Espindola-Netto JM, de Oliveira GC, Gomez LS, Hogan KA, Tarragó MG, Puranik AS, Agorrody G, Thompson KL, Dang K, Clarke S, Childs BG, Kanamori KS, Witte MA, Vidal P, Kirkland AL, De Cecco M, Chellappa K, McReynolds MR, Jankowski C, Tchkonia T, Kirkland JL, Sedivy JM, van Deursen JM, Baker DJ, van Schooten W, Rabinowitz JD, Baur JA, Chini EN.
"CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD(+) and NMN levels." Nature metabolism, vol. 2, no. 11, 2020, pp. 1284-1304.
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Paolella LM, Mukherjee S, Tran CM, Bellaver B, Hugo M, Luongo TS, Shewale SV, Lu W, Chellappa K, Baur JA.
"mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia." Molecular Metabolism, vol. 32, 2020, pp. 136-147.
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Zhang Z, Xu HN, Li S, Jr AD, Chellappa K, Davis JG, Guan Y, Frederick DW, Chu W, Zhao H, Li LZ, Baur JA.
"Rapamycin maintains NAD(+)/NADH redox homeostasis in muscle cells." Aging, vol. 12, no. 18, 2020, pp. 17786-17799.
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Chellappa K, Brinkman JA, Mukherjee S, Morrison M, Alotaibi MI, Carbajal KA, Alhadeff AL, Perron IJ, Yao R, Purdy CS, DeFelice DM, Wakai MH, Tomasiewicz J, Lin A, Meyer E, Peng Y, Arriola Apelo SI, Puglielli L, Betley JN, Paschos GK, Baur JA, Lamming DW.
"Hypothalamic mTORC2 is essential for metabolic health and longevity." Aging Cell, vol. 18, no. 5, 2019, pp. e13014.
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Xu HN, Zhao H, Chellappa K, Davis JG, Nioka S, Baur JA, Li LZ.
"Optical Redox Imaging of Fixed Unstained Muscle Slides Reveals Useful Biological Information." Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, vol. 21, no. 3, 2019, pp. 417-425.
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Chellappa K, Perron IJ, Naidoo N, Baur JA.
"The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms." Aging Cell, vol. 18, no. 3, 2019, pp. e12874.
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Perron IJ, Keenan BT, Chellappa K, Lahens NF, Yohn NL, Shockley KR, Pack AI, Veasey SC.
"Dietary challenges differentially affect activity and sleep/wake behavior in mus musculus: Isolating independent associations with diet/energy balance and body weight." PLoS ONE, vol. 13, no. 5, 2018, pp. e0196743.
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Davila A, Liu L, Chellappa K, Redpath P, Nakamaru-Ogiso E, Paolella LM, Zhang Z, Migaud ME, Rabinowitz JD, Baur JA.
"Nicotinamide adenine dinucleotide is transported into mammalian mitochondria." eLife, vol. 7, 2018.
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Liu L, Su X, Quinn WJ 3rd, Hui S, Krukenberg K, Frederick DW, Redpath P, Zhan L, Chellappa K, White E, Migaud M, Mitchison TJ, Baur JA, Rabinowitz JD.
"Quantitative Analysis of NAD Synthesis-Breakdown Fluxes." Cell Metabolism, vol. 27, no. 5, 2018, pp. 1067-1080.e5.
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Mukherjee S, Chellappa K, Moffitt A, Ndungu J, Dellinger RW, Davis JG, Agarwal B, Baur JA.
"Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration." Hepatology, vol. 65, no. 2, 2017, pp. 616-630.
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Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa K, Silverman IM, Quinn WJ 3rd, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA.
"Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle." Cell Metabolism, vol. 24, no. 2, 2016, pp. 269-82.
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Chellappa K, Deol P, Evans JR, Vuong LM, Chen G, Briançon N, Bolotin E, Lytle C, Nair MG, Sladek FM.
"Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer." eLife, vol. 5, 2016.
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Vuong LM, Chellappa K, Dhahbi JM, Deans JR, Fang B, Bolotin E, Titova NV, Hoverter NP, Spindler SR, Waterman ML, Sladek FM.
"Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells." Molecular and Cellular Biology, vol. 35, no. 20, 2015, pp. 3471-90.
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Deol P, Evans JR, Dhahbi J, Chellappa K, Han DS, Spindler S, Sladek FM.
"Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver." PLoS ONE, vol. 10, no. 7, 2015, pp. e0132672.
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Chellappa K, Robertson GR, Sladek FM.
"HNF4α: a new biomarker in colon cancer?." Biomarkers in medicine, vol. 6, no. 3, 2012, pp. 297-300.
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Chellappa K, Jankova L, Schnabl JM, Pan S, Brelivet Y, Fung CL, Chan C, Dent OF, Clarke SJ, Robertson GR, Sladek FM.
"Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer." Proceedings of the National Academy of Sciences, vol. 109, no. 7, 2012, pp. 2302-7.
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Bolotin E, Chellappa K, Hwang-Verslues W, Schnabl JM, Yang C, Sladek FM.
"Nuclear receptor HNF4α binding sequences are widespread in Alu repeats." BMC genomics, vol. 12, 2011, pp. 560.
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Sun K, Montana V, Chellappa K, Brelivet Y, Moras D, Maeda Y, Parpura V, Paschal BM, Sladek FM.
"Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localization." Molecular endocrinology (Baltimore, Md.), vol. 21, no. 6, 2007, pp. 1297-311.
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