Katherine (Katie) Siddle is an assistant professor in the Molecular Microbiology and Immunology department at Brown University. Katie is interested in how pathogens (in particular viruses) emerge, spread and evolve, and the selective pressures this places on infected hosts. To address these questions, Katie's research integrates the analysis of large biological data sets, experimentation and fieldwork to investigate the genetic diversity of emerging viruses and the role of host and pathogen genetic variation in disease severity.
Katie joined Brown University in January 2023. Prior to this, Katie was a postdoctoral fellow at the Broad Institute of MIT and Harvard in the lab of Pardis Sabeti. Katie obtained her BA and MPhil in Biological Anthropology at the University of Cambridge, UK, and her Ph.D. in human immunogenomics from the Institut Pasteur and the Université Pierre et Marie Curie in Paris, France.
Siddle, Katherine J., Krasilnikova, Lydia A., Moreno, Gage K., Schaffner, Stephen F., Vostok, Johanna, Fitzgerald, Nicholas A., Lemieux, Jacob E., Barkas, Nikolaos, Loreth, Christine, Specht, Ivan, Tomkins-Tinch, Christopher H., Paull, Jillian S., Schaeffer, Beau, Taylor, Bradford P., Loftness, Bryn, Johnson, Hillary, Schubert, Petra L., Shephard, Hanna M., Doucette, Matthew, Fink, Timelia, Lang, Andrew S., Baez, Stephanie, Beauchamp, John, Hennigan, Scott, Buzby, Erika, Ash, Stephanie, Brown, Jessica, Clancy, Selina, Cofsky, Seana, Gagne, Luc, Hall, Joshua, Harrington, Rachel, Gionet, Gabrielle L., DeRuff, Katherine C., Vodzak, Megan E., Adams, Gordon C., Dobbins, Sabrina T., Slack, Sarah D., Reilly, Steven K., Anderson, Lisa M., Cipicchio, Michelle C., DeFelice, Matthew T., Grimsby, Jonna L., Anderson, Scott E., Blumenstiel, Brendan S., Meldrim, James C., Rooke, Heather M., Vicente, Gina, Smith, Natasha L., Messer, Katelyn S., Reagan, Faye L., Mandese, Zoe M., Lee, Matthew D., Ray, Marianne C., Fisher, Marissa E., Ulcena, Maesha A., Nolet, Corey M., English, Sean E., Larkin, Katie L., Vernest, Kyle, Chaluvadi, Sushma, Arvidson, Deirdre, Melchiono, Maurice, Covell, Theresa, Harik, Vaira, Brock-Fisher, Taylor, Dunn, Molly, Kearns, Amanda, Hanage, William P., Bernard, Clare, Philippakis, Anthony, Lennon, Niall J., Gabriel, Stacey B., Gallagher, Glen R., Smole, Sandra, Madoff, Lawrence C., Brown, Catherine M., Park, Daniel J., MacInnis, Bronwyn L., Sabeti, Pardis C. "Transmission from vaccinated individuals in a large SARS-CoV-2 Delta variant outbreak." Cell, vol. 185, no. 3, 2022, pp. 485-492.e10. |
Gaye, Amy, Ndiaye, Tolla, Sy, Mouhamad, Deme, Awa B., Thiaw, Alphonse B., Sene, Aita, Ndiaye, Cheikh, Diedhiou, Younouss, Mbaye, Amadou M., Ndiaye, Ibrahima, Tomkins-Tinch, Christopher, Gomis, Jules F., Badiane, Aida S., MacInnis, Bronwyn, Park, Daniel J., Ndiaye, Mouhamadou, Sy, Ngayo, Sabeti, Pardis C., Siddle, Katherine J., Ndiaye, Daouda. "Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018." Scientific Reports, vol. 11, no. 1, 2021. |
Lemieux, Jacob E., Siddle, Katherine J., Shaw, Bennett M., Loreth, Christine, Schaffner, Stephen F., Gladden-Young, Adrianne, Adams, Gordon, Fink, Timelia, Tomkins-Tinch, Christopher H., Krasilnikova, Lydia A., DeRuff, Katherine C., Rudy, Melissa, Bauer, Matthew R., Lagerborg, Kim A., Normandin, Erica, Chapman, Sinéad B., Reilly, Steven K., Anahtar, Melis N., Lin, Aaron E., Carter, Amber, Myhrvold, Cameron, Kemball, Molly E., Chaluvadi, Sushma, Cusick, Caroline, Flowers, Katelyn, Neumann, Anna, Cerrato, Felecia, Farhat, Maha, Slater, Damien, Harris, Jason B., Branda, John A., Hooper, David, Gaeta, Jessie M., Baggett, Travis P., O’Connell, James, Gnirke, Andreas, Lieberman, Tami D., Philippakis, Anthony, Burns, Meagan, Brown, Catherine M., Luban, Jeremy, Ryan, Edward T., Turbett, Sarah E., LaRocque, Regina C., Hanage, William P., Gallagher, Glen R., Madoff, Lawrence C., Smole, Sandra, Pierce, Virginia M., Rosenberg, Eric, Sabeti, Pardis C., Park, Daniel J., MacInnis, Bronwyn L. "Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events." Science, vol. 371, no. 6529, 2021. |
Lagerborg, Kim A., Normandin, Erica, Bauer, Matthew R., Adams, Gordon, Figueroa, Katherine, Loreth, Christine, Gladden-Young, Adrianne, Shaw, Bennett M., Pearlman, Leah R., Berenzy, Daniel, Dewey, Hannah B., Kales, Susan, Dobbins, Sabrina T., Shenoy, Erica S., Hooper, David, Pierce, Virginia M., Zachary, Kimon C., Park, Daniel J., MacInnis, Bronwyn L., Tewhey, Ryan, Lemieux, Jacob E., Sabeti, Pardis C., Reilly, Steven K., Siddle, Katherine J. "Synthetic DNA spike-ins (SDSIs) enable sample tracking and detection of inter-sample contamination in SARS-CoV-2 sequencing workflows." Nature Microbiology, vol. 7, no. 1, 2021, pp. 108-119. |
Metsky, Hayden C., None, None, Siddle, Katherine J., Gladden-Young, Adrianne, Qu, James, Yang, David K., Brehio, Patrick, Goldfarb, Andrew, Piantadosi, Anne, Wohl, Shirlee, Carter, Amber, Lin, Aaron E., Barnes, Kayla G., Tully, Damien C., Corleis, Bjӧrn, Hennigan, Scott, Barbosa-Lima, Giselle, Vieira, Yasmine R., Paul, Lauren M., Tan, Amanda L., Garcia, Kimberly F., Parham, Leda A., Odia, Ikponmwosa, Eromon, Philomena, Folarin, Onikepe A., Goba, Augustine, Simon-Lorière, Etienne, Hensley, Lisa, Balmaseda, Angel, Harris, Eva, Kwon, Douglas S., Allen, Todd M., Runstadler, Jonathan A., Smole, Sandra, Bozza, Fernando A., Souza, Thiago M. L., Isern, Sharon, Michael, Scott F., Lorenzana, Ivette, Gehrke, Lee, Bosch, Irene, Ebel, Gregory, Grant, Donald S., Happi, Christian T., Park, Daniel J., Gnirke, Andreas, Sabeti, Pardis C., Matranga, Christian B. "Capturing sequence diversity in metagenomes with comprehensive and scalable probe design." Nature Biotechnology, vol. 37, no. 2, 2019, pp. 160-168. |
Siddle, Katherine J., Eromon, Philomena, Barnes, Kayla G., Mehta, Samar, Oguzie, Judith U., Odia, Ikponmwosa, Schaffner, Stephen F., Winnicki, Sarah M., Shah, Rickey R., Qu, James, Wohl, Shirlee, Brehio, Patrick, Iruolagbe, Christopher, Aiyepada, John, Uyigue, Eghosa, Akhilomen, Patience, Okonofua, Grace, Ye, Simon, Kayode, Tolulope, Ajogbasile, Fehintola, Uwanibe, Jessica, Gaye, Amy, Momoh, Mambu, Chak, Bridget, Kotliar, Dylan, Carter, Amber, Gladden-Young, Adrianne, Freije, Catherine A., Omoregie, Omigie, Osiemi, Blessing, Muoebonam, Ekene B., Airende, Michael, Enigbe, Rachael, Ebo, Benevolence, Nosamiefan, Iguosadolo, Oluniyi, Paul, Nekoui, Mahan, Ogbaini-Emovon, Ephraim, Garry, Robert F., Andersen, Kristian G., Park, Daniel J., Yozwiak, Nathan L., Akpede, George, Ihekweazu, Chikwe, Tomori, Oyewale, Okogbenin, Sylvanus, Folarin, Onikepe A., Okokhere, Peter O., MacInnis, Bronwyn L., Sabeti, Pardis C., Happi, Christian T. "Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018." New England Journal of Medicine, vol. 379, no. 18, 2018, pp. 1745-1753. |
Siddle, Katherine J., Tailleux, Ludovic, Deschamps, Matthieu, Loh, Yong-Hwee Eddie, Deluen, Cécile, Gicquel, Brigitte, Antoniewski, Christophe, Barreiro, Luis B., Farinelli, Laurent, Quintana-Murci, Lluís. "Bacterial Infection Drives the Expression Dynamics of microRNAs and Their isomiRs." PLOS Genetics, vol. 11, no. 3, 2015, pp. e1005064. |
Siddle, Katherine J., Deschamps, Matthieu, Tailleux, Ludovic, Nédélec, Yohann, Pothlichet, Julien, Lugo-Villarino, Geanncarlo, Libri, Valentina, Gicquel, Brigitte, Neyrolles, Olivier, Laval, Guillaume, Patin, Etienne, Barreiro, Luis B., Quintana-Murci, Lluís. "A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection." Genome Research, vol. 24, no. 5, 2014, pp. 850-859. |
Siddle, K. J., Goodship, J. A., Keavney, B., Santibanez-Koref, M. F. "Bases adjacent to mononucleotide repeats show an increased single nucleotide polymorphism frequency in the human genome." Bioinformatics, vol. 27, no. 7, 2011, pp. 895-898. |
Active funding:
COBRE Computational Biology of Human Disease pilot award (2023)
Year | Degree | Institution |
---|---|---|
2014 | PhD | Universite Pierre et Marie Curie & Institut Pasteru |
2009 | MPhil | University of Cambridge |
2008 | BA | University of Cambridge |
Department of Molecular Microbiology and Immunology (primary appointment)
Center for Computational Biology (affiliated faculty)
Pandemic Center (affiliated faculty)
BIOL 1525 - Pathogenomics: Analysis, interpretation and applications of microbial genomes |