Mónica García-Solache, M.D., PhD., Is Assistant Professor of Medicine in the Department of Medicine in the Alpert Medical School of Brown University and Research Scientist in Rhode Island Hospital. She obtained her medical degree from the School of Medicine from the National Autonomous University of Mexico followed by a PhD in Developmental genetics from the University of Cambridge. She received her microbiological training under the supervision of Dr. Arturo Casdevall and Dr. Louis B Rice. Her research interests are the role of extracellular membrane-derived vesicles in antibiotic resistance, secretion and communication in Enterococcus faecium and evolution of antibiotic resistance in gram-positive bacteria, mostly focused on the evolutionary trajectories of penicillin binding proteins in enterococci and streptococci.
|García-Solache M, Rice LB. "The Enterococcus: a Model of Adaptability to Its Environment." Clin Microbiol Rev, vol. 32, no. 2, 2019, pp. e00058-18.|
|Rice, Louis B., Desbonnet, Charlene, Tait-Kamradt, Amelia, Garcia-Solache, Monica, Lonks, John, Moon, Thomas M., D’Andréa, Éverton D., Page, Rebecca, Peti, Wolfgang. "Structural and Regulatory Changes in PBP4 Trigger Decreased β-Lactam Susceptibility in Enterococcus faecalis." mBio, vol. 9, no. 2, 2018, pp. e00361-18.|
|Moon TM, D'Andréa ÉD, Lee CW, Soares A, Jakoncic J, Desbonnet C, Solache MG, Rice LB, Page R, Peti W. "The structures of penicillin binding protein 4 (PBP4) and PBP5 from Enterococci provide structural insights into β-lactam resistance." Journal of Biological Chemistry, 2018.|
|García-Solache M, Rice LB. "Draft Genome Sequence of Vancomycin-Susceptible, Ampicillin-Intermediate Enterococcus faecium Strain D344RRF." Genome Announcements, vol. 4, no. 3, 2016, pp. e01720-15.|
|García-Solache M, Rice LB. "Genome Sequence of the Multiantibiotic-ResistantEnterococcus faeciumStrain C68 and Insights on the pLRM23 Colonization Plasmid." Genome Announcements, vol. 4, no. 3, 2016, pp. e01719-15.|
|García-Solache M, Lebreton F, McLaughlin RE, Whiteaker JD, Gilmore MS, Rice LB. "Homologous Recombination within Large Chromosomal Regions Facilitates Acquisition of β-Lactam and Vancomycin Resistance in Enterococcus faecium." Antimicrobial Agents and Chemotherapy, vol. 60, no. 10, 2016, pp. 5777-86.|
|Desbonnet C, Tait-Kamradt A, Garcia-Solache M, Dunman P, Coleman J, Arthur M, Rice LB. "Involvement of the Eukaryote-Like Kinase-Phosphatase System and a Protein That Interacts with Penicillin-Binding Protein 5 in Emergence of Cephalosporin Resistance in Cephalosporin-Sensitive Class A Penicillin-Binding Protein Mutants in Enterococcus faecium." mBio, vol. 7, no. 2, 2016, pp. e02188-15.|
|Crombach A, García-Solache MA, Jaeger J. "Evolution of early development in dipterans: reverse-engineering the gap gene network in the moth midge Clogmia albipunctata (Psychodidae)." Bio Systems, vol. 123, 2014, pp. 74-85.|
|Garcia-Solache MA, Izquierdo-Garcia D, Smith C, Bergman A, Casadevall A. "Fungal virulence in a lepidopteran model is an emergent property with deterministic features." mBio, vol. 4, no. 3, 2013, pp. e00100-13.|
|Monica Garcia-Solache, Arturo Casadevall. "Phylogenetics and Evolution of Virulence in the Kingdom Fungi." Evolution of Virulence in Eukaryotic Microbes, edited by David Sibley, Barbara J. Howlett and Joseph Heitman, USA, Wiley-Blackwell, 2012, pp. 70-90.|
|García-Solache M, Jaeger J, Akam M. "A systematic analysis of the gap gene system in the moth midge Clogmia albipunctata." Developmental Biology, vol. 344, no. 1, 2010, pp. 306-18.|
|Garcia-Solache MA, Casadevall A. "Global warming will bring new fungal diseases for mammals." mBio, vol. 1, no. 1, 2010.|
|Martínez-Barnetche J, García Solache M, Neri Lecona A, Tello López AT, del Carmen Rodríguez M, Gamba G, Vázquez N, Rodríguez MH, Lanz-Mendoza H. "Cloning and functional characterization of the Anopheles albimanus DMT1/NRAMP homolog: implications in iron metabolism in mosquitoes." Insect biochemistry and molecular biology, vol. 37, no. 6, 2007, pp. 532-9.|
It was curiosity and passion for knowledge what persuaded me to follow an academic career. In Mexico, as a medical student I discovered the incredible satisfaction of scientific discovery by participating in the Medical Student Research Program. This program was determinant in my decision to be a researcher. After completing a master’s in science, I decided it was time to gain international experience and I chose to go to the University of Cambridge for my PhD. Working in Cambridge as a teaching assistant in microbiology led me to re-discovered my great passion for microorganisms and infectious diseases. Therefore, during my postdoctoral phase I centred my research on new ideas that challenge our standard way of conceiving a pathogen. I have had the great opportunity to work in the laboratories of Dr. Arturo Casadevall and Dr. Louis Rice. Arturo and Lou are not only extremely bright; they are also incredibly generous with their students and postdocs and encourage them to pursue their own interests giving great freedom to develop their projects. It was this environment of support and liberty that allowed me to explore my interests and to engage in research not based on an organism but on a scientific question.
|2009||PhD||University of Cambridge|
|2005||MD||Universidad Nacional Autónoma de México|
|2004||MS||Universidad Nacional Autónoma de México|
|Research Associate||Brown Univeristy , Rhode Island Hospital, Medicine||2013-2017||Providence, RI, USA|
|Postdoctoral Research Fellow||Albert Einstein College of Medicine, Immunology and Microbiology||2010-2013||New York, NY, USA|
2016-2018 National Researchers System (SNI), National Researcher Level I, National Council for Science and Technology, Mexico.
2012-2014 National Researchers System (SNI) Candidate National Researcher, National Council for Science and Technology, Mexico.
2010- 2011 International Postdoctoral Fellowship, National Council for Science and Technology, Mexico.
2009 Short term EMBO fellowship: Quantifying Gap Gene Expression in the Basal Fly Clogmia albipunctata, Centre for Genomic Regulation, Barcelona, Spain. Group Leader: Dr. Johannes Jaeger.
2008 Lundgren Research Award, Board of Graduate Studies, University of Cambridge.
Cambridge Philosophical Society Research Studentship.
2005 -2008 PhD Fellowship, National Council for Science and Technology, Mexico.
2002 Poster presentation. First Place Award: “Cloning and Characterization of NRAMP homologous gene in the mosquito Anopheles albimanus”. XV National Congress of Immunology. Area Innate Immunity. Ixtapa Zihuatanejo, México, April 28 to May 1st, 2002.
2000 First Place Award: Plasmatic and Placental Levels of CETP in Preeclamptic Patients. XII Internship Medical Journeys, Dr. Manuel Gea González General Hospital, Health Ministry.
|Rice, Louis||Joukowsky Family Professor of Medicine, Professor of Molecular Microbiology and Immunology, Chair of Medicine|
American Society for Microbiology. 2010-Present
Society for Molecular Biology and Evolution. 2012-Present
National Researchers System, National Council for Science and Technology, Mexico. 2012-Present
|Research Scientist. Rhode Island Hospital, 2017-2020|