Matthew Howe
Matthew Howe
Assistant Professor of Psychiatry and Human Behavior
Overview
Dr. Howe is a Psychiatrist with a long-term goal of improving care for older patients with neurodegenerative disorders. Dr. Howe conducts clinical research focused on Alzheimer disease and related disorders, and provides psychiatric consultation services to the Home-Based Primary Care program at VA Providence.
Brown Affiliations
Research Areas
AD/ADRD | Biomarkers | Cerebrovascular disease | Health services | Implementation science | Neuropsychiatric disorders | Veterans
On the Web
Publications Visualize it
| Howe, Matthew D., Jiang, Lan, Browne, Julia W., Bayer, Thomas A., Kunicki, Zachary J., De Vito, Alyssa N., McGeary, John E., Wu, Wen-Chih, Lind, Jason D., Kelso, Catherine M., Rudolph, James L. "Discharge Disposition in Veterans with Heart Failure: Impact of Dementia and Severe Mental Illness." Journal of the American Medical Directors Association, vol. 26, no. 5, 2025, pp. 105533. |
| Howe MD, Britton KJ, Joyce HE, Menard W, Emrani S, Kunicki ZJ, Faust MA, Dawson BC, Riddle MC, Huey ED, Janelidze S, Hansson O, Salloway SP. "Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer’s disease." Alzheimer's Research & Therapy, vol. 16, no. 1, 2024, pp. 154. |
| Howe MD, Riddle MC, Salloway SP. "Reply to the Letter to the Editor: Response to Concerns Raised on MRI Surveillance and Clinical Implications of ARIA in Disease Modifying Treatment." The journal of prevention of Alzheimer's disease, vol. 11, no. 1, 2024, pp. 261-262. |
| Howe, Matthew D., Caruso, Megan R., Manoochehri, Masood, Kunicki, Zachary J., Emrani, Sheina, Rudolph, James L., Huey, Edward D., Salloway, Stephen P., Oh, Hwamee, None, None. "Utility of cerebrovascular imaging biomarkers to detect cerebral amyloidosis." Alzheimer's & Dementia, vol. 20, no. 10, 2024, pp. 7220-7231. |
| Georgakas, Joanna E., Howe, Matthew D., Thompson, Louisa I., Riera, Natalie M., Riddle, Meghan C. "Biomarkers of Alzheimer’s disease: Past, present and future clinical use." Biomarkers in Neuropsychiatry, vol. 8, 2023, pp. 100063. |
| Howe MD, Britton KJ, Joyce HE, Pappas GJ, Faust MA, Dawson BC, Riddle MC, Salloway SP. "Initial Experiences with Amyloid-Related Imaging Abnormalities in Patients Receiving Aducanumab Following Accelerated Approval." The journal of prevention of Alzheimer's disease, vol. 10, no. 4, 2023, pp. 765-770. |
| Howe MD, Rabinovici GD, Salloway SP. "Real-World Application of Anti-β-Amyloid Monoclonal Antibodies: Untangling Eligibility." Neurology, vol. 101, no. 19, 2023, pp. 811-812. |
| Howe MD, McCullough LD, Urayama A. "The Role of Basement Membranes in Cerebral Amyloid Angiopathy." Frontiers in Physiology, vol. 11, 2020, pp. 601320. |
| Gireud-Goss M, Reyes S, Tewari R, Patrizz A, Howe MD, Kofler J, Waxham MN, McCullough LD, Bean AJ. "The ubiquitin ligase UBE4B regulates amyloid precursor protein ubiquitination, endosomal trafficking, and amyloid β42 generation and secretion." Molecular and cellular neurosciences, vol. 108, 2020, pp. 103542. |
| Sun P, Bu F, Min JW, Munshi Y, Howe MD, Liu L, Koellhoffer EC, Qi L, McCullough LD, Li J. "Inhibition of calcium/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood-brain barrier after stroke." European Journal of Neuroscience, vol. 49, no. 1, 2019, pp. 27-39. |
| Howe MD, Furr JW, Zhu L, Edwards NJ, McCullough LD, Gonzales NR. "Sex-specific Association of Matrix Metalloproteinases with Secondary Injury and Outcomes after Intracerebral Hemorrhage." Journal of Stroke and Cerebrovascular Diseases, vol. 28, no. 6, 2019, pp. 1718-1725. |
| Howe MD, Furr JW, Munshi Y, Roy-O'Reilly MA, Maniskas ME, Koellhoffer EC, d'Aigle J, Sansing LH, McCullough LD, Urayama A. "Transforming growth factor-β promotes basement membrane fibrosis, alters perivascular cerebrospinal fluid distribution, and worsens neurological recovery in the aged brain after stroke." GeroScience, vol. 41, no. 5, 2019, pp. 543-559. |
| Howe MD, Atadja LA, Furr JW, Maniskas ME, Zhu L, McCullough LD, Urayama A. "Fibronectin induces the perivascular deposition of cerebrospinal fluid-derived amyloid-β in aging and after stroke." Neurobiology of aging, vol. 72, 2018, pp. 1-13. |
| Howe MD, Zhu L, Sansing LH, Gonzales NR, McCullough LD, Edwards NJ. "Serum Markers of Blood-Brain Barrier Remodeling and Fibrosis as Predictors of Etiology and Clinicoradiologic Outcome in Intracerebral Hemorrhage." Frontiers in Neurology, vol. 9, 2018, pp. 746. |
| Howe, Matthew, McCullough, Louise. "Immunologic Modulations to Enhance Post-Stroke Recovery." Current Immunology Reviews, vol. 11, no. 2, 2015, pp. 107-124. |
| Howe MD, McCullough LD. "Prevention and management of stroke in women." Expert Review of Cardiovascular Therapy, vol. 13, no. 4, 2015, pp. 403-15. |
| Jacobson TK, Howe MD, Schmidt B, Hinman JR, Escabí MA, Markus EJ. "Hippocampal theta, gamma, and theta-gamma coupling: effects of aging, environmental change, and cholinergic activation." Journal of Neurophysiology, vol. 109, no. 7, 2013, pp. 1852-65. |
Research
Research Overview
Dr. Howe's research aims to develop novel approaches to diagnosing Alzheimer disease through the use of innovative clinical phenotyping and blood biomarker-based strategies.
Funded Research
Current:
- Department of Veterans Affairs, VISN 1 Career Development Award (V1CDA2025-82), Towards an Accessible Diagnostic Algorithm for Alzheimer's Disease: A Mixed Methods Study of Aging Veterans. PI: Howe. Total award: $521,685. 10/01/2025–09/30/2027.
Completed:
- University of Connecticut, Psychology Undergraduate Research Grant, Effects of Physostigmine on Hippocampal Theta Rhythms in Young and Aged Rats. PI: Howe. Total award: $1,400. 01/31/2010–05/15/2010.
- University of Connecticut, Life Sciences Honors Thesis Research Grant, Hippocampal Theta and Gamma: Effects of Learning. PI: Howe. Total award: $1,000. 01/31/2011 05/15/2011.
- Center for Clinical and Translational Sciences at UTHealth, TL1 Pre-Doctoral Fellowship (4TL1TR369-10), The Role of Perivascular Fibrosis in Post-Stroke Glymphatic Impairment. PI: Howe. Total award: $46,000. 09/01/2016–12/31/2016.
- American Heart Association, Pre-Doctoral Fellowship (17PRE33410369), The Role of Perivascular Fibrosis in Post-Stroke Glymphatic Impairment. PI: Howe. Total award: $52,000. 01/01/2017–09/01/2018.
- Department of Psychiatry and Human Behavior, Brown University, Research Training Program (2R25MH101076-06A1), Promoting Research Training During Psychiatry Residency. PI: Tyrka. Role: Trainee (Howe). 07/01/2020–06/30/2024.
Background
Education and Training
| Year | Degree | Institution |
|---|---|---|
| 2020 | MD | University of Texas |
Postdoctoral/Other Training
| Resident | Brown University , Psychiatry | 2020-2024 |
Honors and Awards
Graduate
2016 - The Dee S. & Patricia Osborne Endowed Scholarship, GSBS, UT Houston.
2016 - First Prize, Research Retreat Poster Competition, McGovern Medical School, UT Houston.
2017 - Dean’s Research Scholarship Award, McGovern Medical School, UT Houston.
2018 - Ralph B. Arlinghaus, Ph.D. Scholarship, GSBS, UT Houston.
2019 - Physician/Scientist Fellowship, The Cullen Trust for Higher Education.
Postgraduate
2021 - First Prize (Psychiatry Trainee), Mind-Brain Research Day Academic Presentations, Brown University.
2022 - Recipient, Outstanding Resident Award, National Institute of Mental Health.
2023 - BH Starfish Award for Clinical Care, Butler Hospital.
2024 - Chair’s Choice Travel Award, Society of Biological Psychiatry Conference.
AffiliationsVisualize it
Collaborators
| Name | Title |
|---|---|
| Huey, Edward | Martin M. Zucker Professor of Psychiatry and Human Behavior, Professor of Neurology |
| Rudolph, James | Professor of Medicine, Professor of Health Services, Policy and Practice |
| Salloway, Stephen | Professor, Professor of Neurology |
Affiliations
Credentials/Licenses
| Board Certified | American Board of Psychiatry and Neurology, Adult psychiatry | 2025- | #86964 |
| Rhode Island Medical License (Allopathic Physician) | RIDOH | 2023- |
Appointments
| Staff Psychiatrist. VA Providence Healthcare System, - |
| Assistant Professor of Psychiatry and Human Behavior. Brown University School of Medicine, - |
Teaching
Teaching Overview
Brown University Geriatric Psychiatry Fellowship Training Program
- Role: Site Director & Supervising Faculty
- Director(s): Laura A. Stanton, MD
- Institution(s): Brown University, Butler Hospital, VA Providence
Consultation-Liaison Psychiatry Fellowship Training Program
- Role: Site Director & Supervising Faculty
- Director(s): Paul Baker, MD & Colin J. Harrington, MD
- Institution(s): Brown University, Butler Hospital, VA Providence