Dr. Howe is a Psychiatrist with a long-term goal of improving care for older patients with neurodegenerative disorders. To this end, Dr. Howe provides psychiatric consultation services to the Home-Based Primary Care program at VA Providence, and conducts clinical research focused on Alzheimer disease and related disorders.
Howe MD, Britton KJ, Joyce HE, Menard W, Emrani S, Kunicki ZJ, Faust MA, Dawson BC, Riddle MC, Huey ED, Janelidze S, Hansson O, Salloway SP. "Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer's disease." Alzheimer's research & therapy, vol. 16, no. 1, 2024, pp. 154. |
Howe MD, Riddle MC, Salloway SP. "Reply to the Letter to the Editor: Response to Concerns Raised on MRI Surveillance and Clinical Implications of ARIA in Disease Modifying Treatment." The journal of prevention of Alzheimer's disease, vol. 11, no. 1, 2024, pp. 261-262. |
Howe MD, Caruso MR, Manoochehri M, Kunicki ZJ, Emrani S, Rudolph JL, Huey ED, Salloway SP, Oh H, Alzheimer's Disease Neuroimaging Initiative. "Utility of cerebrovascular imaging biomarkers to detect cerebral amyloidosis." Alzheimer's & Dementia, vol. 20, no. 10, 2024, pp. 7220-7231. |
Georgakas, Joanna E., Howe, Matthew D., Thompson, Louisa I., Riera, Natalie M., Riddle, Meghan C. "Biomarkers of Alzheimer’s disease: Past, present and future clinical use." Biomarkers in Neuropsychiatry, vol. 8, 2023, pp. 100063. |
Howe MD, Britton KJ, Joyce HE, Pappas GJ, Faust MA, Dawson BC, Riddle MC, Salloway SP. "Initial Experiences with Amyloid-Related Imaging Abnormalities in Patients Receiving Aducanumab Following Accelerated Approval." The journal of prevention of Alzheimer's disease, vol. 10, no. 4, 2023, pp. 765-770. |
Howe MD, Rabinovici GD, Salloway SP. "Real-World Application of Anti-β-Amyloid Monoclonal Antibodies: Untangling Eligibility." Neurology, vol. 101, no. 19, 2023, pp. 811-812. |
Howe MD, McCullough LD, Urayama A. "The Role of Basement Membranes in Cerebral Amyloid Angiopathy." Frontiers in Physiology, vol. 11, 2020, pp. 601320. |
Gireud-Goss M, Reyes S, Tewari R, Patrizz A, Howe MD, Kofler J, Waxham MN, McCullough LD, Bean AJ. "The ubiquitin ligase UBE4B regulates amyloid precursor protein ubiquitination, endosomal trafficking, and amyloid β42 generation and secretion." Molecular and cellular neurosciences, vol. 108, 2020, pp. 103542. |
Sun P, Bu F, Min JW, Munshi Y, Howe MD, Liu L, Koellhoffer EC, Qi L, McCullough LD, Li J. "Inhibition of calcium/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood-brain barrier after stroke." European Journal of Neuroscience, vol. 49, no. 1, 2019, pp. 27-39. |
Howe MD, Furr JW, Zhu L, Edwards NJ, McCullough LD, Gonzales NR. "Sex-specific Association of Matrix Metalloproteinases with Secondary Injury and Outcomes after Intracerebral Hemorrhage." Journal of Stroke and Cerebrovascular Diseases, vol. 28, no. 6, 2019, pp. 1718-1725. |
Howe MD, Furr JW, Munshi Y, Roy-O'Reilly MA, Maniskas ME, Koellhoffer EC, d'Aigle J, Sansing LH, McCullough LD, Urayama A. "Transforming growth factor-β promotes basement membrane fibrosis, alters perivascular cerebrospinal fluid distribution, and worsens neurological recovery in the aged brain after stroke." GeroScience, vol. 41, no. 5, 2019, pp. 543-559. |
Howe MD, Atadja LA, Furr JW, Maniskas ME, Zhu L, McCullough LD, Urayama A. "Fibronectin induces the perivascular deposition of cerebrospinal fluid-derived amyloid-β in aging and after stroke." Neurobiology of aging, vol. 72, 2018, pp. 1-13. |
Howe MD, Zhu L, Sansing LH, Gonzales NR, McCullough LD, Edwards NJ. "Serum Markers of Blood-Brain Barrier Remodeling and Fibrosis as Predictors of Etiology and Clinicoradiologic Outcome in Intracerebral Hemorrhage." Frontiers in Neurology, vol. 9, 2018, pp. 746. |
Howe, Matthew, McCullough, Louise. "Immunologic Modulations to Enhance Post-Stroke Recovery." Current Immunology Reviews, vol. 11, no. 2, 2015, pp. 107-124. |
Howe MD, McCullough LD. "Prevention and management of stroke in women." Expert Review of Cardiovascular Therapy, vol. 13, no. 4, 2015, pp. 403-15. |
Jacobson TK, Howe MD, Schmidt B, Hinman JR, Escabí MA, Markus EJ. "Hippocampal theta, gamma, and theta-gamma coupling: effects of aging, environmental change, and cholinergic activation." Journal of Neurophysiology, vol. 109, no. 7, 2013, pp. 1852-65. |
Year | Degree | Institution |
---|---|---|
2020 | MD | University of Texas |
Resident | Brown University , Psychiatry | 2020-2024 |
Graduate
2016 - The Dee S. & Patricia Osborne Endowed Scholarship, GSBS, UT Houston.
2016 - First Prize, Research Retreat Poster Competition, McGovern Medical School, UT Houston.
2017 - Dean’s Research Scholarship Award, McGovern Medical School, UT Houston.
2018 - Ralph B. Arlinghaus, Ph.D. Scholarship, GSBS, UT Houston.
2019 - Physician/Scientist Fellowship, The Cullen Trust for Higher Education.
Postgraduate
2021 - First Prize (Psychiatry Trainee), Mind-Brain Research Day Academic Presentations, Brown University.
2022 - Recipient, Outstanding Resident Award, National Institute of Mental Health.
2023 - BH Starfish Award for Clinical Care, Butler Hospital.
2024 - Chair’s Choice Travel Award, Society of Biological Psychiatry Conference.
Name | Title |
---|---|
Huey, Edward | Martin M. Zucker Professor of Psychiatry and Human Behavior |
Rudolph, James | Professor of Medicine, Professor of Health Services, Policy and Practice |
Salloway, Stephen | Professor of Psychiatry and Human Behavior, Professor of Neurology |
Rhode Island Medical License (Allopathic Physician) | RIDOH | - |
Staff Psychiatrist. VA Providence Healthcare System, - |
Assistant Professor of Psychiatry and Human Behavior. Brown University School of Medicine, - |