Dr. Keszler obtained his medical degree from McGill University and his Pediatric, and Neonatal training at Children's Hospital Medical Center of Akron, Ohio. In 2010, Dr. Keszler was recruited to Brown University from Georgetown University in Washington DC where he was Professor of Pediatrics, chair of the IRB, Medical Director of NICU and Director of ECMO. He served on the Advisory Board of the Maternal-Fetal Medicine Units Network of the NICHD and was Vice Chair of the Data Safety and Monitoring Board of the NICHD Neonatal Research Network (NRN), prior to becoming an NRN investigator upon joining Brown. He has published numerous original papers, review articles, book chapters and editorials, presented over 300 lectures at National and International conferences, moderated or conducted over 50 workshops or round-table discussions and was a Visiting Professor in over 20 medical institutions in the USA and abroad.
| Arnautovic TI, Longo JL, Trail-Burns EJ, Tucker R, Keszler M, Laptook AR. "Antenatal Risk Factors Associated with Spontaneous Intestinal Perforation in Preterm Infants Receiving Postnatal Indomethacin." The Journal of Pediatrics, 2021. |
| Agarwal P, Shankaran S, Laptook AR, Chowdhury D, Lakshminrusimha S, Bonifacio SL, Natarajan G, Chawla S, Keszler M, Heyne RJ, Ambalavanan N, Walsh MC, Das A, Van Meurs KP, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. "Outcomes of infants with hypoxic ischemic encephalopathy and persistent pulmonary hypertension of the newborn: results from three NICHD studies." Journal of perinatology : official journal of the California Perinatal Association, 2021. |
| McKinney RL, Schmidhoefer JJ, Balasco AL, Machan JT, Hirway P, Keszler M. "Severe bronchopulmonary dysplasia: outcomes before and after the implementation of an inpatient multidisciplinary team." Journal of perinatology : official journal of the California Perinatal Association, vol. 41, no. 3, 2021, pp. 544-550. |
| Shalish W, Kanbar L, Kovacs L, Chawla S, Keszler M, Rao S, Latremouille S, Precup D, Brown K, Kearney RE, Sant'Anna GM. "Assessment of Extubation Readiness Using Spontaneous Breathing Trials in Extremely Preterm Neonates." JAMA Pediatrics, vol. 174, no. 2, 2020, pp. 178-185. |
| Shalish, Wissam, Lakshminrusimha, Satyanarayana, Manzoni, Paolo, Keszler, Martin, Sant'Anna, Guilherme M. "COVID-19 and Neonatal Respiratory Care: Current Evidence and Practical Approach." American Journal of Perinatology, vol. 37, no. 08, 2020, pp. 780-791. |
| Chandrasekharan, Praveen, Lakshminrusimha, Satyan, Chowdhury, Dhuly, Van Meurs, Krisa, Keszler, Martin, Kirpalani, Haresh, Das, Abhik, Walsh, Michele C., McGowan, Elisabeth C., Higgins, Rosemary D., None, None. "Early Hypoxic Respiratory Failure in Extreme Prematurity: Mortality and Neurodevelopmental Outcomes." Pediatrics, 2020, pp. e20193318. |
| McKinney RL, Keszler M, Truog WE, Norberg M, Sindelar R, Wallström L, Schulman B, Gien J, Abman SH, Bronchopulmonary Dysplasia Collaborative. "Multicenter Experience with Neurally Adjusted Ventilatory Assist in Infants with Severe Bronchopulmonary Dysplasia." American journal of perinatology, vol. 38, no. S 01, 2020, pp. e162-e166. |
| Keszler M. "Time to Abandon Your Comfort Zone?." Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, vol. 21, no. 5, 2020, pp. 495-496. |
| Keszler, Martin. "Time to Abandon Your Comfort Zone?*." Pediatric Critical Care Medicine, vol. 21, no. 5, 2020, pp. 495-496. |
| Keszler M. "Sustained Inflation of Infant Lungs: From Bench to Bedside and Back Again." Am J Respir Crit Care Med, vol. 200, no. 5, 2019, pp. 531-532. |
| McKinney RL, Shukla K, Daigle K, Zeigler J, Muller M, Keszler M. "The BIT:S (Bronchopulmonary Dysplasia Interdisciplinary Team: Severe) Initiative at Women and Infants Hospital of Rhode Island." Rhode Island medical journal (2013), vol. 102, no. 3, 2019, pp. 22-25. |
| Shalish W, Kanbar L, Kovacs L, Chawla S, Keszler M, Rao S, Panaitescu B, Laliberte A, Precup D, Brown K, Kearney RE, Sant'Anna GM. "The Impact of Time Interval between Extubation and Reintubation on Death or Bronchopulmonary Dysplasia in Extremely Preterm Infants." The Journal of Pediatrics, vol. 205, 2019, pp. 70-76.e2. |
| Goldstein, Justin, Laliberte, Alyse, Keszler, Martin. "Ambient Noise Production by High-Frequency Neonatal Ventilators." The Journal of Pediatrics, 2018. |
| Shalish, Wissam, Kanbar, Lara, Keszler, Martin, Chawla, Sanjay, Kovacs, Lajos, Rao, Smita, Panaitescu, Bogdan A, Laliberte, Alyse, Precup, Doina, Brown, Karen, Kearney, Robert E, Sant'Anna, Guilherme M. "Patterns of reintubation in extremely preterm infants: a longitudinal cohort study." Pediatric Research, vol. 83, no. 5, 2018, pp. 969-975. |
| Berg, Jennifer, Keszler, Martin, Abubakar, Kabir, Scala, Melissa. "Premature Infants Conceived with Assisted Reproductive Technology: An Analysis of Infant Morbidity, Compared with Infants Conceived Naturally." American Journal of Perinatology, 2018. |
| Lakshminrusimha, Satyan, Shankaran, Seetha, Laptook, Abbot, McDonald, Scott, Keszler, Martin, Van Meurs, Krisa, Guillet, Ronnie, Chawla, Sanjay, Sood, Beena G., Bonifacio, Sonia, Das, Abhik, Higgins, Rosemary D. "Pulmonary Hypertension Associated with Hypoxic-Ischemic Encephalopathy—Antecedent Characteristics and Comorbidities." The Journal of Pediatrics, vol. 196, 2018, pp. 45-51.e3. |
| Gupta, Ashish, Keszler, Martin. "Survey of Ventilation Practices in the Neonatal Intensive Care Units of the United States and Canada: Use of Volume-Targeted Ventilation and Barriers to Its Use." American Journal of Perinatology, 2018. |
| Keszler, Martin. "Volume-targeted ventilation: one size does not fit all. Evidence-based recommendations for successful use." Archives of Disease in Childhood - Fetal and Neonatal Edition, vol. 104, no. 1, 2018, pp. F108-F112. |
| Jensen, Erik A., Dysart, Kevin C., Gantz, Marie G., Carper, Benjamin, Higgins, Rosemary D., Keszler, Martin, Laughon, Matthew M., Poindexter, Brenda B., Stoll, Barbara J., Walsh, Michele C., Schmidt, Barbara, Caplan, Michael S., Polin, Richard A., Laptook, Abbot R., Keszler, Martin, Hensman, Angelita M., Basso, Kristin M., Vieira, Elisa, Little, Emily, Fanaroff, Avroy A., Hibbs, Anna Marie, Newman, Nancy S., Truog, William E., Kilbride, Howard W., Pallotto, Eugenia K., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Donovan, Edward F., Alexander, Barbara, Grisby, Cathy, Hessling, Jody, Fischer, Estelle E., Jackson, Lenora D., Kirker, Kristin, Muthig, Greg, Goldberg, Ronald N., Cotten, C. Michael, Fisher, Kimberley A., Auten, Kathy J., Foy, Katherine A., Grimes, Sandra, Finkle, Joanne, Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Carlton, David P., Hale, Ellen C., Archer, Stephanie Wilson, Poindexter, Brenda B., Sokol, Gregory M., Wilson, Leslie Dawn, Herron, Dianne E., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Besner, Gail E., Parikh, Nehal A., Das, Abhik, Wallace, Dennis, Auman, Jeanette O'Donnell, Crawford, Margaret M., Petrie Huitema, Carolyn M., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Adams, Marian M., Stevenson, David K., Ball, M. Bethany, Palmquist, Andrew W., Proud, Melinda S., Frantz, Ivan D., Fiascone, John M., MacKinnon, Brenda L., Nylen, Ellen, Carlo, Waldemar A., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Bell, Edward F., Ellsbury, Dan L., Widness, John A., Johnson, Karen J., Campbell, Donia B., Watterberg, Kristi L., Ohls, Robin K., Lacy, Conra Backstrom, Montman, Rebecca A., Brown, Sandra, Wussow, Theresa, Hartenberger, Carol, Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., D'Angio, Carl T., Guillet, Ronnie, Lakshminrusimha, Satyan, Reynolds, Ann Marie, Reubens, Linda J., Jensen, Rosemary, Maffett, Deana, Wadkins, Holly I.M., Sacilowski, Michael G., Williams, Ashley, Guilford, Stephanie, Horihan, Cassandra A., Kennedy, Kathleen A., Tyson, Jon E., Burson, Katrina, Harris, Beverly Foley, McDavid, Georgia E., Pierce Tate, Patti L., Wright, Sharon L., Sánchez, Pablo J., Brion, Luc P., Chen, Lijun, Guzman, Alicia, Leps, Melissa H., Miller, Nancy A., Morgan, Janet S., Vasil, Diana M., Torres, Lizette E., Faix, Roger G., Yoder, Bradley A., Osborne, Karen A., Bird, Karie, Burnett, Jill, Jensen, Jennifer J., Spencer, Cynthia, Weaver-Lewis, Kimberlee, Zanetti, Karen, Shankaran, Seetha, Barks, John, Bara, Rebecca, Johnson, Mary, Christensen, Mary, Wiggins, Stephanie, Ehrenkranz, Richard A., Jacobs, Harris, Cervone, Patricia, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet. "Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants." The Journal of Pediatrics, vol. 186, 2017, pp. 34-40.e2. |
| Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE, Truog WE, McGrath-Morrow SA, Moore PE, Rhein LM, Kirpalani H, Zhang H, Gratny LL, Lynch SK, Curtiss J, Stonestreet BS, McKinney RL, Dysart KC, Gien J, Baker CD, Donohue PK, Austin E, Fike C, Nelin LD, Bronchopulmonary Dysplasia Collaborative. "Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia." The Journal of Pediatrics, vol. 181, 2017, pp. 12-28.e1. |
| Keszler, Martin. "Mechanical ventilation strategies." Seminars in Fetal and Neonatal Medicine, vol. 22, no. 4, 2017, pp. 267-274. |
| Shalish, Wissam, Kanbar, Lara J., Rao, Smita, Robles-Rubio, Carlos A., Kovacs, Lajos, Chawla, Sanjay, Keszler, Martin, Precup, Doina, Brown, Karen, Kearney, Robert E., Sant’Anna, Guilherme M. "Prediction of Extubation readiness in extremely preterm infants by the automated analysis of cardiorespiratory behavior: study protocol." BMC Pediatrics, vol. 17, no. 1, 2017. |
| Hurley, Edward H, Keszler, Martin. "Effect of inspiratory flow rate on the efficiency of carbon dioxide removal at tidal volumes below instrumental dead space." Archives of Disease in Childhood - Fetal and Neonatal Edition, vol. 102, no. 2, 2016, pp. F126-F130. |
| Keszler, Martin, Sakuma, Mio, Kikuchi, Shin, Katayama, Yoshinori, Takei, Atsuko, Ikegami, Hitoshi, Minami, Hirotaka, Enomoto, Masahiro. "Effect of Volume Guarantee in Preterm Infants on High-Frequency Oscillatory Ventilation: A Pilot Study." American Journal of Perinatology, vol. 34, no. 01, 2016, pp. 26-30. |
| Foglia, Elizabeth E, Owen, Louise S, Keszler, Martin, Davis, Peter G, Kirpalani, Haresh. "Obtaining informed consent for delivery room research: the investigators' perspective." Archives of Disease in Childhood - Fetal and Neonatal Edition, vol. 102, no. 1, 2016, pp. F90-F91. |
| Al-Mandari, H, Shalish, W, Dempsey, E, Keszler, M, Davis, P G, Sant'Anna, G. "International survey on periextubation practices in extremely preterm infants." Arch Dis Child Fetal Neonatal Ed, vol. 100, no. 5, 2015, pp. F428-F431. |
| Keszler, Martin, Sant’Anna, Guilherme. "Mechanical Ventilation and Bronchopulmonary Dysplasia." Clinics in Perinatology, vol. 42, no. 4, 2015, pp. 781-796. |
| Lakshminrusimha S, Keszler M. "Persistent Pulmonary Hypertension of the Newborn." NeoReviews, vol. 16, no. 12, 2015, pp. e680-e692. |
| Foglia, Elizabeth E, Owen, Louise S, Thio, Marta, Ratcliffe, Sarah J, Lista, Gianluca, te Pas, Arjan, Hummler, Helmut, Nadkarni, Vinay, Ades, Anne, Posencheg, Michael, Keszler, Martin, Davis, Peter, Kirpalani, Haresh. "Sustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial." Trials, vol. 16, no. 1, 2015. |
| Keszler, Martin. "Sustained inflation during neonatal resuscitation." Current Opinion in Pediatrics, vol. 27, no. 2, 2015, pp. 145-151. |
| Sharma, Saumya, Abubakar, Kabir, Keszler, Martin. "Tidal Volume in Infants with Congenital Diaphragmatic Hernia Supported with Conventional Mechanical Ventilation." American Journal of Perinatology, vol. 32, no. 06, 2015, pp. 577-582. |
| Sharma, Saumya, Clark, Shane, Keszler, Martin, Abubakar, Kabir. "Tidal Volume Requirement in Mechanically Ventilated Infants with Meconium Aspiration Syndrome." Amer J Perinatol, vol. 32, no. 10, 2015, pp. 916-919. |
| Mazela J, Chmura K, Kulza M, Henderson C, Gregory TJ, Moskal A, Sosnowski TR, Florek E, Kramer L, Keszler M. "Aerosolized albuterol sulfate delivery under neonatal ventilatory conditions: in vitro evaluation of a novel ventilator circuit patient interface connector." Journal of aerosol medicine and pulmonary drug delivery, vol. 27, no. 1, 2014, pp. 58-65. |
| Corbett, Kelly L., Keszler, Martin. "Pulsatile Airway Obstruction Found on Ventilator Pulmonary Graphics." The Journal of Pediatrics, vol. 165, no. 5, 2014, pp. 1064. |
| Abubakar, Kabir, Keszler, Martin. "Volume Guarantee Ventilation during Surgical Closure of Patent Ductus Arteriosus." American Journal of Perinatology, vol. 32, no. 01, 2014, pp. 023-026. |
| Keszler M. "Congenital diaphragmatic hernia: not quite there yet." The Journal of Pediatrics, vol. 163, no. 1, 2013, pp. 15-6. |
| Keszler M. "The long road to acceptance. Commentary on O. Chowdhury et al.: Randomised trial of volume-targeted ventilation versus pressure-limited ventilation in acute respiratory failure in prematurely born infants (Neonatology 2013;104:290-294)." Neonatology, vol. 104, no. 4, 2013, pp. 295-7. |
| Keszler M. "What if you could see lung inflation in real time?." The Journal of Pediatrics, vol. 162, no. 4, 2013, pp. 670-2. |
| Sant'Anna GM, Keszler M. "Developing a neonatal unit ventilation protocol for the preterm baby." Early human development, vol. 88, no. 12, 2012, pp. 925-9. |
| Keszler M, Montaner MB, Abubakar K. "Effective ventilation at conventional rates with tidal volume below instrumental dead space: a bench study." Archives of Disease in Childhood - Fetal and Neonatal Edition, vol. 97, no. 3, 2012, pp. F188-92. |
| Keszler M. "Guidelines for Rational and Cost-Effective Use of iNO Therapy in Term and Preterm Infants." Journal of clinical neonatology, vol. 1, no. 2, 2012, pp. 59-63. |
| Morley CJ, Keszler M. "Ventilators do not breathe." Archives of Disease in Childhood - Fetal and Neonatal Edition, vol. 97, no. 6, 2012, pp. F392-4. |
| Sant'Anna GM, Keszler M. "Weaning infants from mechanical ventilation." Clinics in Perinatology, vol. 39, no. 3, 2012, pp. 543-62. |
| Keszler M. "Leaks cause problems not only in Washington politics! Has the time come for cuffed endotracheal tubes for newborn ventilation?." Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, vol. 12, no. 2, 2011, pp. 231-2. |
| Barton AM, Abubakar MK, Berg J, Keszler M. "The Effect of Arterial pH on Oxygenation Persists Even in Infants Treated with Inhaled Nitric Oxide." Pulmonary Medicine, vol. 2011, 2011, pp. 189205. |
| Keszler M, Nassabeh-Montazami S, Abubakar K. "Evolution of tidal volume requirement during the first 3 weeks of life in infants <800 g ventilated with Volume Guarantee." Archives of Disease in Childhood - Fetal and Neonatal Edition, vol. 94, no. 4, 2009, pp. F279-82. |
| Keszler M. "Functional capillary density measurement: a useful new tool to assess the peripheral circulation in infants?." Critical care medicine, vol. 37, no. 3, 2009, pp. 1173-4. |
| Keszler M. "INSURE, Infant Flow, Positive Pressure and Volume Guarantee--tell us what is best: selection of respiratory support modalities in the NICU." Early human development, vol. 85, no. 10 Suppl, 2009, pp. S53-6. |
| Keszler M. "State of the art in conventional mechanical ventilation." Journal of perinatology : official journal of the California Perinatal Association, vol. 29, no. 4, 2009, pp. 262-75. |
| Nassabeh-Montazami S, Abubakar KM, Keszler M. "The impact of instrumental dead-space in volume-targeted ventilation of the extremely low birth weight (ELBW) infant." Pediatric pulmonology, vol. 44, no. 2, 2009, pp. 128-33. |
| Keszler M. "Strategy matters." American journal of perinatology, vol. 24, no. 3, 2007, pp. 147-8. |
| Keszler M, Abubakar KM. "Volume guarantee ventilation." Clinics in Perinatology, vol. 34, no. 1, 2007, pp. 107-16, vii. |
| Plavka R, Dokoupilová M, Pazderová L, Kopecký P, Sebron V, Zapadlo M, Keszler M. "High-frequency jet ventilation improves gas exchange in extremely immature infants with evolving chronic lung disease." American journal of perinatology, vol. 23, no. 8, 2006, pp. 467-72. |
| Keszler M. "Volume guarantee and ventilator-induced lung injury: Goldilock's rules apply." Pediatric pulmonology, vol. 41, no. 4, 2006, pp. 364-6. |
| Keszler M. "Volume-targeted ventilation." Early human development, vol. 82, no. 12, 2006, pp. 811-8. |
| Abubakar K, Keszler M. "Effect of volume guarantee combined with assist/control vs synchronized intermittent mandatory ventilation." Journal of perinatology : official journal of the California Perinatal Association, vol. 25, no. 10, 2005, pp. 638-42. |
| Keszler M. "Volume-targeted ventilation." Journal of perinatology : official journal of the California Perinatal Association, vol. 25 Suppl 2, 2005, pp. S19-22. |
| Hines RN, Adams J, Buck GM, Faber W, Holson JF, Jacobson SW, Keszler M, McMartin K, Segraves RT, Singer LT, Sipes IG, Williams PL. "NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of fluoxetine." Birth Defects Res B, vol. 71, no. 4, 2004, pp. 193-280. |
| Keszler M, Abubakar K. "Volume guarantee: stability of tidal volume and incidence of hypocarbia." Pediatric pulmonology, vol. 38, no. 3, 2004, pp. 240-5. |
| Plavka R, Keszler M. "Interaction between surfactant and ventilatory support in newborns with primary surfactant deficiency." Biology of the neonate, vol. 84, no. 1, 2003, pp. 89-95. |
| Clark RH, Huckaby JL, Kueser TJ, Walker MW, Southgate WM, Perez JA, Roy BJ, Keszler M, Clinical Inhaled Nitric Oxide Research Group. "Low-dose nitric oxide therapy for persistent pulmonary hypertension: 1-year follow-up." Journal of perinatology : official journal of the California Perinatal Association, vol. 23, no. 4, 2003, pp. 300-3. |
| Keszler M, Abubakar KM, Mammel MC. "Response to Olsen, et al. study comparing SIMV & PSV." Journal of perinatology : official journal of the California Perinatal Association, vol. 23, no. 5, 2003, pp. 434-5. |
| Poggi, Sarah H, Barr, Sybil, Cannum, Rebecca, Collea, Joseph V, Landy, Helain J, Kezsler, Martin, Ghidini, Alessandro. "Risk Factors for Pulmonary Edema in Triplet Pregnancies." Journal of Perinatology, vol. 23, no. 6, 2003, pp. 462-465. |
| Barr S, Poggi S, Keszler M. "Triplet morbidity and mortality in a large case series." Journal of perinatology : official journal of the California Perinatal Association, vol. 23, no. 5, 2003, pp. 368-71. |
| Wiswell TE, Knight GR, Finer NN, Donn SM, Desai H, Walsh WF, Sekar KC, Bernstein G, Keszler M, Visser VE, Merritt TA, Mannino FL, Mastrioianni L, Marcy B, Revak SD, Tsai H, Cochrane CG. "A multicenter, randomized, controlled trial comparing Surfaxin (Lucinactant) lavage with standard care for treatment of meconium aspiration syndrome." Pediatrics, vol. 109, no. 6, 2002, pp. 1081-7. |
| Plavka R, Kopecký P, Sebron V, Leiská A, Svihovec P, Ruffer J, Dokoupilová M, Zlatohlávková B, Janus V, Keszler M. "Early versus delayed surfactant administration in extremely premature neonates with respiratory distress syndrome ventilated by high-frequency oscillatory ventilation." Intensive care medicine, vol. 28, no. 10, 2002, pp. 1483-90. |
| Keszler M, Durand DJ. "Neonatal high-frequency ventilation. Past, present, and future." Clinics in Perinatology, vol. 28, no. 3, 2001, pp. 579-607. |
| Abubakar KM, Keszler M. "Patient-ventilator interactions in new modes of patient-triggered ventilation." Pediatric pulmonology, vol. 32, no. 1, 2001, pp. 71-5. |
| Higgins RD, Keszler M. "Perinatal vascular development." Cardiovascular research, vol. 51, no. 1, 2001, pp. 7-8. |
| Clark RH, Kueser TJ, Walker MW, Southgate WM, Huckaby JL, Perez JA, Roy BJ, Keszler M, Kinsella JP. "Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group." New England Journal of Medicine, vol. 342, no. 7, 2000, pp. 469-74. |
| Holliday MA, Pinckert TL, Kiernan SC, Kunos I, Angelus P, Keszler M. "Dorsal penile nerve block vs topical placebo for circumcision in low-birth-weight neonates." Archives of Pediatrics & Adolescent Medicine, vol. 153, no. 5, 1999, pp. 476-80. |
| Keszler M. "The abuse of the English language." Journal of perinatology : official journal of the California Perinatal Association, vol. 19, no. 1, 1999, pp. 82. |
| Prabhu VG, Keszler M, Dhanireddy R. "Dose-dependent evaluation of the effects of nebulized furosemide on pulmonary function in ventilated preterm infants." Journal of perinatology : official journal of the California Perinatal Association, vol. 18, no. 5, 1998, pp. 357-60. |
| Ringer SA, Richardson DK, Sacher RA, Keszler M, Churchill WH. "Variations in transfusion practice in neonatal intensive care." Pediatrics, vol. 101, no. 2, 1998, pp. 194-200. |
| Keszler M, Modanlou HD, Brudno DS, Clark FI, Cohen RS, Ryan RM, Kaneta MK, Davis JM. "Multicenter controlled clinical trial of high-frequency jet ventilation in preterm infants with uncomplicated respiratory distress syndrome." Pediatrics, vol. 100, no. 4, 1997, pp. 593-9. |
| Prabhu VG, Keszler M, Dhanireddy R. "Pulmonary function changes after nebulised and intravenous frusemide in ventilated premature infants." Archives of Disease in Childhood - Fetal and Neonatal Edition, vol. 77, no. 1, 1997, pp. F32-5. |
| Keszler M, Moront MG, Cox C, Milewski M, Visner MS. "Oxygen delivery with a single cannula tidal flow venovenous system for extracorporeal membrane oxygenation." ASAIO Journal, vol. 41, no. 4, 1995, pp. 850-4. |
| Walsh-Sukys MC, Cornell DJ, Houston LN, Keszler M, Kanto WP Jr. "Treatment of persistent pulmonary hypertension of the newborn without hyperventilation: an assessment of diffusion of innovation." Pediatrics, vol. 94, no. 3, 1994, pp. 303-6. |
| Gibbons MD, Horan JJ, Dejter SW Jr, Keszler M. "Extracorporeal membrane oxygenation: an adjunct in the management of the neonate with severe respiratory distress and congenital urinary tract anomalies." The Journal of Urology, vol. 150, no. 2 Pt 1, 1993, pp. 434-7. |
| Kiernan SC, Pinckert TL, Keszler M. "Ultrasound guidance of suprapubic bladder aspiration in neonates." The Journal of Pediatrics, vol. 123, no. 5, 1993, pp. 789-91. |
| Keszler M, Ryckman FC, McDonald JV Jr, Sweet LD, Moront MG, Boegli MJ, Cox C, Leftridge CA. "A prospective, multicenter, randomized study of high versus low positive end-expiratory pressure during extracorporeal membrane oxygenation." The Journal of Pediatrics, vol. 120, no. 1, 1992, pp. 107-13. |
| Goldberg LA, Marmon LM, Keszler M. "High-frequency jet ventilation decreases air flow through a tracheoesophageal fistula." Critical care medicine, vol. 20, no. 4, 1992, pp. 547-9. |
| Keszler M, Carbone MT, Cox C, Schumacher RE. "Severe respiratory failure after elective repeat cesarean delivery: a potentially preventable condition leading to extracorporeal membrane oxygenation." Pediatrics, vol. 89, no. 4 Pt 1, 1992, pp. 670-2. |
| McVeen RV, Lorch V, Carroll RC, Goldberg L, Keszler M, Podlasek S, Stewart DL. "Changes in fibrinolytic factors in newborns during extracorporeal membrane oxygenation (ECMO)." American Journal of Hematology, vol. 38, no. 3, 1991, pp. 254-5. |
| Keszler M, Donn SM, Spitzer AR. "High-frequency jet ventilation in respiratory distress syndrome." The Journal of Pediatrics, vol. 119, no. 2, 1991, pp. 340-1. |
| Keszler M, Donn SM, Bucciarelli RL, Alverson DC, Hart M, Lunyong V, Modanlou HD, Noguchi A, Pearlman SA, Puri A. "Multicenter controlled trial comparing high-frequency jet ventilation and conventional mechanical ventilation in newborn infants with pulmonary interstitial emphysema." The Journal of Pediatrics, vol. 119, no. 1 Pt 1, 1991, pp. 85-93. |
| Moront MG, Katz NM, Keszler M, Visner MS, Hoy GR, O'Connell JJ, Cox C, Wallace RB. "Extracorporeal membrane oxygenation for neonatal respiratory failure. A report of 50 cases." The Journal of Thoracic and Cardiovascular Surgery, vol. 97, no. 5, 1989, pp. 706-14. |
| Zito L, Keszler M. "Massive edema and bilateral pleural effusions in a newborn infant." Annals of allergy, vol. 63, no. 4, 1989, pp. 277-80. |
| Keszler M, Subramanian KN, Smith YA, Dhanireddy R, Mehta N, Molina B, Cox CB, Moront MG. "Pulmonary management during extracorporeal membrane oxygenation." Critical care medicine, vol. 17, no. 6, 1989, pp. 495-500. |
| Keszler M, Klappenbach RS, Reardon E. "Lung pathology after high frequency jet ventilation combined with low rate intermittent mandatory ventilation in a canine model of meconium aspiration." Pediatric pulmonology, vol. 4, no. 3, 1988, pp. 144-9. |
| Keszler M, Molina B, Butterfield AB, Subramanian KN. "Combined high-frequency jet ventilation in a meconium aspiration model." Critical care medicine, vol. 14, no. 1, 1986, pp. 34-8. |
| Keszler M, Sivasubramanian KN. "Pseudohypoaldosteronism." American journal of diseases of children (1960), vol. 137, no. 8, 1983, pp. 738-40. |
| Keszler M, Klein R, McClellan L, Nelson D, Platt M. "Effects of conventional and high frequency jet ventilation on lung parenchyma." Critical care medicine, vol. 10, no. 8, 1982, pp. 514-6. |
Martin Keszler, MD. "Optimizing respiratory outcome in preterm infants through the use of novel respiratory support modalities" Advances in neonatal intensive care have improved survival of extremely low birth weight infants, but the immature lung is extremely vulnerable to injury due to a combination of mechanical injury (volutrauma), inflammatory response to biophysical forces and/or infection (biotrauma), and oxygen toxicity. As a consequence, chronic lung disease remains unacceptably high. The development of bronchopulmonary dysplasia (BPD) is influenced by a wide variety of factors, but there is mounting evidence that minimizing tidal volume, optimizing lung inflation (avoiding atelectasis) and reducing oxygen exposure are key factors in reducing the risk of chronic lung disease. Chronic lung disease adversely affects the infant's nutritional status, growth and neurodevelopment, in addition to predisposing to lower respiratory tract infections and reactive airway disease during infancy. Thus, reduction of this important complication of prematurity remains a high priority.
In recent years, my clinical research has focused on investigation of volume-targeted ventilation as a means of reducing adverse consequences of mechanical ventilation and on the complex interactions between spontaneously breathing infants and the ventilator. Continuing work will examine the effectiveness of volume targeted ventilation in maintaining more stable gas exchange in a variety of clinical situations that perturb the stability of the system, for example, during suctioning and other manipulations. We have been working to define optimal tidal volume targets in a variety of clinical situations with different types of lung pathology that may influence physiologic dead space. My clinical and bench research has recently challenged the accepted dogma that anatomical dead space gas does not mix with fresh gas during the respiratory cycle; we showed both in the clinical setting and on the bench that it is possible to ventilate effectively with tidal volume below anatomical and instrumental dead space even at conventional ventilator rates.
Early extubation is believed to reduce the probability of developing BPD, but our ability to predict extubation readiness is poor. We are presently exploring the ability of the combination of the Spontaneous Breathing Test combined with heart rate and respiratory rate variability to predict extubation readiness in ELBW infants (the APEX study).
I am the WIHRI representative in the BPD Collaborative group, a 17 center multidisciplinary consortium that has begun to collect longitudinal data on infants with severe BPD and plan a variety of prospective collaborative studies.
A non-inferiority clinical comparison of nasal CPAP and nasal intermittent mandatory ventilation (NIPPV) at equal mean airway pressure is currently underway to test the hypothesis that the apparent benefits of NIPPV are due to the higher mean airway pressure, rather than actually generating significant ventilation.
Currently, I am evaluating the capabilities of the newest state-ofthe-art neonatal ventilator in relation to other available devices in a series of bench studies with a focus on how the devices react to a variety of simulated perturbations. A clinical trial of a new high-frequency oscillator (HFO) which is unique in its ability to deliver volume-targeted HFO, has just been completed and the data are being analyzed. (updated 12.31.18)
GRANTS
1. Principal Investigator, Trustees of Akron Children's Hospital Research Foundation. "Clinical trial of high frequency jet ventilation in newborn infants", 02/28/1982 02/28/1983
2. Principal Investigator, IVAC Corporation equipment grant. "HFJV in an animal model of meconium aspiration". 09/1983
3. Principal Investigator, Basic Research Support Grant, Georgetown University. "High frequency jet ventilation in an animal model of meconium aspiration". 04/01/1983-04/30/1984
4. Principal Investigator, John Preston Marshall Foundation. "Extracorporeal Membrane Oxygenation". 01/01/1985-01/31/1987
5. Co - Sponsor of Awardee of Fellowship Grant. American Heart Association, Nation's Capital Affiliate. "Tidal flow veno-venous system for ECMO". 07/31/1986-06/30/1987
6. Principal Investigator, John Preston Marshall Foundation. "Extracorporeal Membrane Oxygenation". 06/01/198706/30/1989
7. Principal Investigator, American Heart Association, Nation's Capital Affiliate. "A tidal flow veno-venous system for ECMO: Long-term safety" 07/01/1988-06/30/1989 (extended till Sept 1990)
8. Site Principal Investigator, Pediatrix Medical Group. "Lung lavage with perfluorocarbons in an animal model of the meconium aspiration syndrome". 04/01/1993-06/30/1994
9. Site Principal Investigator, Abbot Laboratories/Ross Laboratories. "Evaluation of Survanta in term infants". 03/01/1994-12/31/1995
10. Site Principal Investigator I, Ohmeda Inc. "A double blind, placebo controlled dose response study of inhaled nitric oxide in the treatment of persistent pulmonary hypertension in the neonate". 07/01/1994-06/30/1996
11. Principal Investigator, Draeger Inc. "Validation and testing of new Babylog ventilator software". 05/01/1996-09/30/1996
12. Site Principal Investigator, Ohmeda Inc. "Multi-center trial of Nitric Oxide in near-term infants with hypoxemic respiratory failure". 04/01/1996-12/31/1998
13. Principal Investigator, Draeger Inc. "Clinical validation and testing of new Babylog ventilator software". 07/01/1997-03/31/1998
14. Site Principal Investigator, Acute Therapeutics Inc. (now Discovery Laboratories). "Multi-center randomized controlled trial of KL4 surfactant for treatment of MAS". 07/01/1997-07/31/1999
15. Site Principal Investigator, Discovery Laboratories. "Multi-center randomized controlled trial of Surfaxin for treatment of meconium aspiration syndrome". 05/01/2000-07/31/2001
16. Principal Investigator, Draeger Inc. "Randomized trial of the Volume Guarantee mode of ventilation in infants with periodic breathing. 12/01/2001-12/31/2003
17. Site Principal Investigator, Johnson and Johnson, Inc. "A Pharmacokinetic, Pharmacodynamic and Short-term Safety Study of Single and Multiple Day Doses of Rabeprazole Sodium in Neonates and Pre-term Infants with a Corrected Age of Less than 44 Weeks with a Presumptive Diagnosis of GERD". 12/01/2009-12/31/2010
18. Site Co- Principal Investigator Georgetown University, Canadian Institutes of Health Research MCT-80246 (Site CO-PI, Haresh Kirpalani, PI). "Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV) Trial". 12/01/2009-12/31/2010
19. Alternate (Co)-Principal Investigator, Brown University/WIHRI site. NIH-NICHD U10 HD27904. "NICHD Cooperative Multicenter Neonatal Research Network, 04/01/2011-03/31/2016
20. Subcontract Principal Investigator, NIH Subcontract: R43 HL106366-01, J Vassoughi (PI) "Engineering and Scientific Research Associates". Responsive to RFA-HD-09-017 Safe and Effective Instruments and Devices for Use in the Neonatal Intensive Care Units (SBIR [R43]) "Neonatal APD, a Simple Noninvasive Diagnostic/Monitoring Device for Neonatal ICU". 07/01/2010-06/01/2014
21. Senior/Key Collaborator, Site Principal Investigator, Small Business Innovation Research Grant 1R44HL107000-01; PI, Segal, Robert, Discovery Laboratories. "Development and Utilization of a Novel Aerosol Generating Technology to Deliver Lucinactant, a KL4 Peptide-containing, Synthetic Surfactant for the Prevention of Neonatal Respiratory Distress Syndrome". 01/01/2011-06/01/2014
22.Site PI, Draeger Medical, Inc. Retrospective Data Collection to establish a reference cohort for the prospective evaluation of the Draeger VN 500 in HFOV mode. 07/01/2014 – 09/2014.
23. Site PI. HIP Trial: Timing of Hernia Repair in in Premature Infants. NIH Subcontract, Martin Blakely PI, Vanderbilt University. Grant No. U01 HD076733-01A1. Project period 09/22/2014 – 05/03/2019
24. Overall Principal Investigator, Site PI at WIHRI, Draeger Medical, Inc. "Multicenter Clinical Trial of High-frequency Ventilation Using the Draeger VN500 Infant Ventilator in the Treatment of Respiratory Distress Syndrome in Premature Infants". 01/01/2014- 12/31/2018
25. Over all study Co PI, Site PI at WIHRI. "Sustained Aeration of infants Lungs (SAIL) Trial." NIH grant 1U01HD072906-01A1. 09/01/13 to 09/01/18
26. Site PI. Windtree Therapeutics. Protocol 03-CL-1401, A Multicenter, Randomized, Open-Label, Controlled Trial to Assess the Safety and Tolerability of Lucinactant for Inhalation in Preterm Neonates 26 to 28 Weeks PMA. 06/01/2016 – 12/31/2016.
27. Site PI. Windtree Therapeutics, 03-CL-1202 A Multinational, Multicenter, Masked, Randomized, Controlled Study to Assess the Safety and Efficacy of Lucinactant for Inhalation in Preterm Neonates 26 to 32 Weeks Gestational Age with Respiratory Distress Syndrome. 06/15/2016-12/31/2017
28. Alternate (Co)-Principal Investigator, Brown University/WIHRI site. NIH-NICHD U10 HD27904. "NICHD Cooperative Multicenter Neonatal Research Network, 04/01/2016-03/31/2021
29. Site PI. Mallinckrodt Inc. Multicenter, Prospectively Defined Observational Registry With Retrospective Data Collection, Evaluating Premature and Term-Near-Term Neonates With Pulmonary Hypertension Receiving Inhaled Nitric Oxide via Invasive or Noninvasive Ventilator Support at US Centers. MNK19050056 (The PaTTerN Registry Study). 09/15/17 - 12/31/19
30. COBRE for Perinatal Biology Pilot Project Award Program. PI Pilot study of Nasal Intermittent Positive Pressure Ventilation (NIPPV) vs. nasal Continuous Positive Airway Pressure (nCPAP) at equivalent mean airway pressure in preterm infants: Effect on oxygenation, CO2 elimination, work of breathing and frequency of cardiorespiratory events. 9/01/2017 – 08/31/2019
| Year | Degree | Institution |
|---|---|---|
| 1977 | MD | McGill University |
| Fellow | Children's Hospital Medical Center of Akron, neonatal-perinatal medicine | 1980-1982 | Akron, OH |
| Resident | Children's Hospital of Akron, Pedatrics | 1978-1980 | |
| Intern | St. Mary's Hospital | 1977-1978 | Montreal, Canada |
| Medical License | Rhode Island | 2010-Present | #13425 |
| Certification | American Academy of Pediatrics, Neonatal resuscitation program hospital trainer | 1994-2014 | |
| Certification | American Board of Pediatrics, Neonatal-perinatal medicine | 1985- | #146 |
| Certification | American Board of Pediatrics, General pediatrics | 1983- | #29602 |
| Medical License | Virginia | 1982- | #101034221 |
| Medical License | District of Columbia | 1982- | #13375 |
| Medical License | Ohio | 1980- | |
| Medical License | Canada | 1978- |
| Associate Director of NICU. Women & Infants Hospital of Rhode Island, 2010-2020 |
| Director of Respiratory Care Services. Women & Infants Hospital of Rhode Island, 2010-Present |
| Medical Director. Georgetown University, 1999-2010 |
| Director of Nurseries/Inborn Neonatal Services. Georgetown University, 1999-2010 |
| Director of the Neonatal-Perinatal Medicine Fellowship Program. Georgetown University, 1993-1999 |
| Co-Director. Georgetown University, 1992-1993 |
| Co-Director. Georgetown University, 1991-1998 |
| Director of the Neonatal Information System. Georgetown University, 1991-2010 |
| Director of Extracorporeal Membrane Oxygenation Program. Georgetown University, 1984-2010 |
