Pinar, M

M Halit Pinar

Professor Emeritus of Pathology and Laboratory Medicine

Overview

A member of the Brown faculty since 1990, Halit Pinar, MD is a graduate of Ankara University and completed his postgraduate training in various Academic Medical Centers in the US. After completing a residency in Anatomic Pathology in NYU Medical Center, he continued his training and completed a residency in General Pediatrics and a fellowship in Neonatal and Perinatal Medicine at Dartmouth-Hitchcock Medical Center. Board certified in these specialties he came to Women and Infants Hospital and finalized his training by completing a fellowship in Perinatal and Pediatric Pathology under the mentorship of Dr. D. B. Singer. Currently, he is the Director of Division of Perinatal and Pediatric Pathology. In addition to his administrative duties, he is the Co-PI and Lead Perinatal Pathologist in the network grant funded by NICHD to determine the causes of stillbirth (Stillbirth Collaborative Research Network - SCRN). He is the past President of Rhode Island Society of Pathologists and worked in various capacities in the Society for Pediatric Pathology. He is an invited advisor in various Federal Projects that include The National Children's Study, various projects by CDC and contributed to the latest report by the Surgeon General about the effects of tobacco. The focus of his publications is Perinatal and Placental Pathology. He is recently invited to be a member of the American Board of Pathology's Pediatric Pathology Division.

Brown Affiliations

Pathology and Laboratory Medicine

Research Areas

perinatal pathology | placental pathology | SCRN | stillbirth

Research

Research Overview

The National Institute of Child Health and Human Development (NICHD), a branch of the National Institutes of Health (NIH), established the Stillbirth Collaborative Research Network (SCRN) in 2003 to understand the epidemiology and etiology of stillbirth. Brown University is one of the five academic centers that form this network. Dr. Pinar is the Principal Investigator and Lead Perinatal Pathologist responsible for implementing standardized postmortem and placental examinations.

Research Statement

The NICHD established the Stillbirth Collaborative Research Network (SCRN) in 2003 to understand the epidemiology and etiology of stillbirth. This network includes five clinical centers: Brown University, Emory University, University of Utah, University of Texas Medical Branch, the University of Texas at San Antonio; and a data coordinating center at Research Triangle International. The specific aims of this five-year study are: (1) to obtain a geographic population-based determination of the incidence of stillbirth defined as fetal death at 20 weeks gestation or greater; (2) to determine the causes of stillbirth using a standard stillbirth postmortem protocol that includes a review of clinical history, protocols for autopsies and pathologic examinations of the fetus and placenta, and other postmortem tests to illuminate genetic, maternal, and other environmental influences; and (3) elucidate risk factors for stillbirth.

Dr. Pinar is the Principal Investigator and Lead Perinatal Pathologist responsible for all the sections related to pathology.

Funded Research

Stillbirth Research Collaborative NetworkSCRN
Principal Investigator: M. W. Carpenter, MD
Co-Principal Investigator and Lead Pathologist: H. Pinar, MD
Agency: NICHD
Type: RFA/PA HD02-025
Period: November 2003November 2011
Amount: $800,000/year.
The objective of this grant is to determine the scope and causes of stillbirth in the U.S. by implementing standardized postmortem and placental examination techniques and detailed investigation of the surroundings. The study will involve an area that includes the entire state of Rhode Island and Bristol County, MA where annually 21,000 deliveries occur.

Collaborator- The National Standard for Normal Fetal Growth - NIH-NICHD-DESPR-10-24. HHSN27520100009C Funding Period 9/30/2010-9/29/2012. Direct $2,567,966/Total $3,736,391. 2.1 Calendar Months. (4% Effort)

Scholarly Work

Pinar H, Pinar E. Septic shock: A review of the literature. Lepra Mec. 1973;4:210-20.
Pinar H, Flotte T. Papillary elastofibroma of the left ventricular septum. Am J Surg Pathol 1980;4:585-8.
Pinar H, Rogers BB. Renal dysplasia, situs inversus totalis, and multisystem fibrosis: A new syndrome. Pediatr Pathol 1991;12:215-21.
Pinar H, Thompson NL, Flanders KC, Sporn MB, Sung J, Rogers BB. Distribution of transforming factor β in a two-week-old embryo. Growth Factors 1992;6:203-8.
Deftos LJ, Burton DW, Brandt DW, Pinar H, Rubin LP. Neoplastic hormone-producing cells of the placenta produce and secrete parathyroid hormone-related protein. Studies by immunohistochemistry, immunoassay, and polymerase chain reaction. Lab Invest 1994;71:847-52.
Pinar H, Makarova N, Rubin LP, Singer DB. Pathology of the lung in surfactant-treated neonates. Pediatr Pathol 1994;14:627-36.
Pinar H, Abuelo D, Carpenter M, Singer DB. Fryns syndrome: A new definition. Pediatr Pathol 1994;467-78.
Pinar H, Thompson NL, Flanders KC, Rogers BB. Distribution of TGF-β1 precursor, TGF-β1 and TGF-β2 in human embryogenesis. CellVision 1994;1:200-7.
Koduri PR, Patel AR, Pinar H. Acute hepatic sequestration caused by parvovirus B19 infection in a patient with sickle cell anemia. Am J Hematol 1994;47:250-1.
Sung CJ, Singer DB, Oyer CE, Pinar H. Fetal weights and measurements. Arch Pathol Lab Med 1995;993-4.
Pinar H, Sung CJ, Oyer CE, Singer DB. Reference values for singleton and twin placental weights. Pediatr Pathol Lab Med 1996;16:901-7.
Paparella A, DeLuca FG, Oyer CE, Pinar H, Stonestreet BS. Ischemia-reperfusion injury in the intestines of newborn pigs. Pediatr Res 1997;42:180-8.
Pinar H, Tatevosyants N, Singer DB. Central nervous system malformations in a perinatal/neonatal autopsy series. Pediatr Dev Pathol 1998;142-8.
Pinar H, Sotomayor E, Singer DB. Turquoise discoloration of the umbilical cord and membranes after intra-amniotic injection of indigo-carmine dye. Arch Pediatr Adolesc Med 1998;152:199-200.
Yashima K, Maitra A, Timmons CF, Rogers BB, Pinar H, Gazdar AF. Expression of the RNA component of telomerase in Wilms tumor and nephrogenic rest recapitulates renal embryogenesis. Hum Pathol. 1998;29:536-42.
Yashima K, Maitra A, Timmons CF, Rogers BB, Pinar H, Milchgrub S, Shay JW, Gazdar AF. Expression of the RNA component of human telomerase during development and differentiation. Cell Growth Differ 1998;9:805-13.
Singer DB, Neave C, Oyer CE, Pinar H. Hepatic subcapsular hematomas in fetuses and neonatal infants. Pediatr Dev Pathol 1999;2:215-20.
Dexter SC, Malee MP, Pinar H, et al. Influence of chorioamnionitis on developmental outcome in very low birth weight infants. Obstet Gynecol. 1999;94:267-73.
Pinar H, Pinar T, Singer DB. Beta-cell hyperplasia in macrosomic infants and fetuses of nondiabetic mothers. Pediatr Dev Pathol 2000;3:42-8.
Dexter SC, Pinar H, Malee MP, et al. Outcome of very low birth weight infants with histopathologic chorioamnionitis. Obstet Gynecol 2000;96:172-7.
Phornphutkul C, Okubo T, Harel Z, Tracy FT, Pinar H, et al. Aromatase p450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty. J Clin Endocrinol Metab. 2001;86(2):649-52.
Plevyak M, Hanna N, Mayer S, Murphy S, Pinar H, Fast L, et al. Deficiency of decidual IL-10 in the first trimester missed abortion: a lack of correlation with the decidual immune cell profile. Am J Reprod Immunol 2002;47:242-50.
DePaepe ME, Burke S, Luks FI, Pinar H, Singer DB. Demonstration of placental vascular anatomy in monochorionic twin gestations. Pediatr Dev Pathol 2002;5:37-44.
Petersson KH, Pinar H, Stopa EG, Faris RA. Sadowska GB, Hanumara RC, Stonestreet BS. White matter injury after cerebral ischemia in ovine fetuses. Pediatr Res 2002;51:768-76.
Pinar H, Burke SH, Huang CW, Singer DB, Sung CJ. Reference values for transverse cerebellar diameter throughout gestation. Pediatr Dev Pathol 2002;5:489-94.
Pinar H, Stephens M, Singer DB, Boyd TK, Pflüger SM, Gang DL, Roberts DJ, Sung CJ. Triplet placentas: reference values for weights. Pediatr Dev Pathol 2002;5:495-98.
McCormack WM Jr, Shen JJ, Curry SM, Berend SA, Kashork C, Pinar H, Potocki L, Bejjani BA. Partial deletions of the long arm of chromosome 13 associated with holoprosencephaly and Dandy-Walker malformation. Am J Med Genet 2002;112:384-9.
Hansen K, Sung CJ, Huang C, Pinar H, Singer DB, Oyer CE. Reference values for second trimester fetal and neonatal organ weights and measurement. Pediatr Dev Pathol. 2003;6:160-7.
Baek YW, Brokat S, Padbury JF, Pinar H, et al. Inter-alpha inhibitor proteins in infants and decreased levels in neonatal sepsis. J Pediatr 2003;143:1-15.
Elitt CM, Sadowska GB, Stopa EG, Pinar H, Petersson KH, Stonestreet BS. Effects of antenatal steroids on ischemic brain injury in near term ovine fetuses. Early Hum Dev 2003;73:1-15.
De Paepe ME, Friedman RM, Gündoğan F, Pinar H, Oyer CE. The histologic fetoplacental inflammatory response in fatal perinatal group B-streptococcus infection. J Perinatol. 2004;24(7):441-5.
Wharton KN, Pinar H, Stonestreet BS, Tucker R, McLean KR, Wallach M, Vohr BR. Severe umbilical cord inflammation-a predictor of periventricular leukomalacia in very low birth weight infants. Early Hum Dev. 2004 Apr;77(1-2):77-87.
Pinar H. Bone Dysplasias: An Atlas of Genetic Disorders of Skeletal Development, Second Edition. Pediatr Dev Pathol 2003;6:601.
Pinar H. Postmortem findings in term neonates. Semin Neonatol. 2004;4:289-302.
Petersson KH, Pinar H, Stopa EG, Sadowska GB, Hanumara RC, Stonestreet BS. Effects of exogenous glucose on brain ischemia in ovine fetuses. Pediatr Res. 2004;56(4):621-9.
Lambert-Messerlian GM, Pinar H, Laprade E, Tantravahi U, Schneyer A, Canick JA. Inhibins and activins in human fetal abnormalities. Mol Cell Endocrinol. 2004;225(1-2):101-8.
Oyer CE Sung CJ, Friedman R, Hansen K, De Paepe ME, Pinar H and Singer DB. Reference values for valve circumferences and ventricular wall thicknesses of fetal and neonatal hearts. Pediatr and Dev Pathol. 2004;7:499–505.
De Paepe ME, Friedman RM, Gündoğan F, Pinar H. Postmortem Lung Weight/Body Weight Standards for Term and Preterm Infants. Pediatr Pulmonol. 2005;40(5):445-8.
Lambert-Messerlian G, Pinar H, Rubin LP, DePaepe ME, Tantravahi U, Steinhoff MM, Russell M, Canick JA. Second-trimester maternal serum markers in twin pregnancy with complete mole: report of 2 cases. Pediatr Dev Pathol. 2005;8(2):230-4.
Kostadinov S, Pinar H. Amniotic fluid infection syndrome and neonatal mortality caused by Eikenella corrodens. Pediatr Dev Pathol. 2005;8(4):489-92.
Chan C, Moore BE, Cotman CW, Okano H, Tavares R, Hovanesian V, Pinar H, Johansson CE, Svendsen CN, Stopa EG. Musashi 1 antigen expression in human fetal germinal matrix development. Exp Neurol. 2006;201(2):515-8.
Gündoğan F, Elwood G, Greco D, Rubin LP, Pinar H, Carlson RI, Wands JR, de la Monte SM. Role of aspartyl- (asparaginyl) beta-hydroxylase in placental implantation: relevance to early pregnancy loss. Hum Pathol. 2007;38(1):50-9.
Lambert-Messerlian G, Eklund E, Pinar H, Tantravahi U, Schneyer A. Activin subunit and receptor expression in normal and cleft human fetal palate tissues. Pediatr Dev Pathol. 2007;10(6):436-45.
Silver RM, Varner MW, Reddy U, Goldenberg R, Pinar H, Conway D, Bukowski R, Carpenter M, Hogue C, Willinger M, Dudley D, Saade G, Stoll B. Work-up of stillbirth: a review of the evidence. Am J Obstet Gynecol. 2007;196(5):433-44.
Frøen JF, Pinar H, Norwitz ER. Genetic epidemiologic studies of preterm birth: studies of disease or of "rescue by birth"? Am J Obstet Gynecol. 2007;197(4):438-9.
Torabi R, Charnova S, Abellar RG, Pinar H, DePaepe ME. Intrauterine infection with Klebsiella pneumoniae: report of a case and literature review. Pediatr Dev Pathol. 2008;11(2):152-5.
Pinar H, Basu S, Hotmire K, Laffineuse L, Presley L, Carpenter M, Catalano PM. Hauguel-de Mouzon S. High molecular mass multimer complexes and vascular expression contribute to high adiponectin in the fetus. J Clin Endocrinol Metab. 2008;93(7):2885-90.
Frøen JF, Pinar H, Flenady V, Bahrin S, Charles A, Chauke L, Day K, Duke Facchinetti F, Fretts RC, Gardener G, Gilshenan K, Gordijn SJ, Gordon A Guyon G, Harrison C, Koshy R, Pattinson RC, Petersson K, Russell L, Saastad E, Smith GC, Torabi R. Causes of death and associated conditions (CODAC): a utilitarian approach to the classification of perinatal deaths. BMC Pregnancy Childbirth. 2009 Jun 10;9:22.
Flenady V, Frøen JF, Pinar H, Torabi R, Saastad E, Guyon G, Russell L, Charles A, Harrison C, Chauke L, Pattinson R, Koshy R, Bahrin S, Gardener G, Day K, Petersson K, Gordon A, Gilshenan K. An evaluation of classification systems for stillbirth. BMC Pregnancy Childbirth. 2009 Jun 19;9:24.
Reddy U, Silver R, Smith GC, Pauli RM, Wapner RJ, Gardosi J. Pinar H, Grafe M, Kupferminc M, Hulthen Varli I, Erwich JJ, Fretts RC, Willinger M. Stillbirth classification-developing an international consensus for research: executive summary of a National Institute of Child Health and Human Development workshop. Obstet Gynecol. 2009 Oct;114(4):901-14. Erratum in: Obstet Gynecol. 2010 Jan;115(1):191.
Pinar H, Iyigün M. A comparison of stillborn birth weights and postmortem weights. Pediatr Dev Pathol. 2010 Nov-Dec;13(6):442-6.
Dudley DJ, Goldenberg R, Conway D, Silver RM, Saade GR, Varner MW, Pinar H, Coustan D, Bukowski R, Stoll B, Koch MA, Parker CB, Reddy UM; Stillbirth Research Collaborative Network. A new system for determining the causes of stillbirth. Obstet Gynecol. 2010 Aug;116(2 Pt 1):254-60.
Pinar H, Carpenter M. Placenta and umbilical cord abnormalities seen with stillbirth. Clin Obstet Gynecol. 2010 Sep;53(3):656-72. Review.
He M, Hong T, Lauro P, Pinar H. Identification of Bacteria in Paraffin-Embedded Tissues Using 16S rDNA Sequencing: a Case Report and Review of the Literature. Pediatr Dev Pathol. Pediatr Dev Pathol. 2011 Mar-Apr;14(2):149-52.
Pinar H, Koch MA, Hawkins H, Heim-Hall J, Shehata B, Thorsten VR, Carpenter M, Lowichik A, Reddy UM. The Stillbirth Collaborative Research Network (SCRN) Placental and Umbilical Cord Examination Protocol. Am J Perinatol. 2011 Dec;28(10):781-92.
Pinar H, Koch MA, Hawkins H, Heim-Hall J, Shehata B, Thorsten VR, Chin S, Willinger M, De la Monte S. The Stillbirth Collaborative Research Network Neuropathologic Examination Protocol. Am J Perinatol. 2011 Dec;28(10):793-802.
Parker CB, Hogue CJR, Koch MA, Willinger M, Reddy U, Thorsten V, Dudley D, Silver RM, Coustan D, Saade GR, Conway D, Varner MW, Stoll B, Pinar H, Bukowski R, Carpenter M, Goldenberg R for the Stillbirth Collaborative Research Network: Design, Methods and Recruitment Experience. Paediatric and Perinatal Epidemiology 2011; 25: 425–435.
Pinar, H. Listeriosis. [Review] Pathology Case Reviews. 16(5):189-194, September/October 2011.
Pinar H. Hydranencephaly. [Review] Pathology Case Reviews 16(5):195-201, September/October 2011
Stillbirth Collaborative Research Network Writing Group. Association between stillbirth and risk factors known at pregnancy confirmation. JAMA. 2011 Dec 14;306(22):2469-79.
Stillbirth Collaborative Research Network Writing Group. Causes of death among stillbirths. JAMA. 2011 Dec 14;306(22):2459-68
Pinar H, Koch MA, Hawkins H, Heim-Hall J, Abramowsky CR, Thorsten VR, Carpenter MW, Zhou HH, Reddy UM. The stillbirth collaborative research network postmortem examination protocol. Am J Perinatol. 2012 Mar;29(3):187-202.
Reddy UM, Page GP, Saade GR, Silver RM, Thorsten VR, Parker CB, Pinar H, Willinger M, Stoll BJ, Heim-Hall J, Varner MW, Goldenberg RL, Bukowski R, Wapner RJ, Drews-Botsch CD, O'Brien BM, Dudley DJ, Levy B; NICHD Stillbirth Collaborative Research Network. Karyotype versus microarray testing for genetic abnormalities after stillbirth. N Engl J Med. 2012 Dec 6;367(23):2185-93.
Crespo F, Pinar H, Kostadinov S. Case Report: Cases of limb-body wall complex: early amnion rupture, vascular disruption, or abnormal splitting of the embryo? J Pediatr Genet 2013;1(4).
Hogue CJR, Parker CB, Koch MA, Willinger M, Reddy U, Thorsten V, Dudley D, Silver RM, Coustan D, Saade GR, Conway D, Varner MW, Stoll B, Pinar H, Bukowski R, Carpenter M, Goldenberg R for the Stillbirth Collaborative Research Network: A Population-based Case-Control Study of Stillbirth: The Relationship of Significant Life Events to the Racial Disparity for African Americans. Am J Epidemiol. 2013;177 (8): 755-76
Silver RM, Parker CB, Pinar H, Koch MA, Willinger M, Reddy U, Thorsten V, Dudley D, Coustan D, Saade GR, Conway D, Varner MW, Stoll B, Bukowski R, Carpenter M, Goldenberg R for the Stillbirth Collaborative Research Network: Bile Acid Metabolism and Stillbirth. Am J Obstet Gynecol. 2013 Nov 8. pii: S0002-9378(13)02016-4.
He M, Kostadinov S, Gündoğan F, Struminsky J, Pinar H, Sung CJ. Pregnancy and Perinatal Outcomes Associated with Acinetobacter baumannii Infection. AJP Rep. 2013 May;3(1):51-6.
Silver RM, Parker CB, Reddy UM, Goldenberg R, Coustan D, Dudley DJ, Saade GR, Stoll B, Koch MA, Conway D, Bukowski R, Hogue CJ, Pinar H, Moore J, Willinger M, Branch DW. Antiphospholipid antibodies in stillbirth. Obstet Gynecol. 2013 Sep;122(3):641-57.
Pinar H, Palomaki GE, Haddow HR, Rowles A, Torabi R. Comparison of Radiographic Femur Measurements in Stillbirths and Neonatal Deaths to Ultrasound Measurements in Ongoing Pregnancies. Pediatr Dev Pathol. 2014 Feb 27. [Epub ahead of print] PubMed PMID: 24575801.
Varner MW, Silver RM, Rowland Hogue CJ, Willinger M, Parker CB, Thorsten VR, Goldenberg RL, Saade GR, Dudley DJ, Coustan D, Stoll B, Bukowski R, Koch MA, Conway D, Pinar H, Reddy UM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Stillbirth Collaborative Research Network. Association between stillbirth and illicit drug use and smoking during pregnancy. Obstet Gynecol. 2014 Jan;123(1):113-25.
Pinar H, Goldenberg RL, Koch MA, Heim-Hall J, Hawkins HK, Shehata B, Abramowsky C, Parker CB, Dudley DJ, Silver RM, Stoll B, Carpenter M, Saade G, Moore J, Conway D, Varner MW, Hogue CJ, Coustan DR, Sbrana E, Thorsten V, Willinger M, Reddy UM. Placental findings in singleton stillbirths. Obstet Gynecol. 2014 Feb;123(2 Pt 1):325-36.
Bukowski R, Hansen NI, Willinger M, Reddy UM, Parker CB, Pinar H, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Rowland Hogue CJ, Varner MW, Conway DL, Coustan D, Goldenberg RL; Eunice Kennedy Shriver National Institute of Child Health and Human Development Stillbirth Collaborative Research Network. Fetal growth and risk of stillbirth: a population-based case-control study. PLoS Med.2014 Apr 22;11(4):e1001633.
He M, Pepperell JR, Gundogan F, De Paepe ME, Maggio L, Lu S, Kostadinov S, O'Brien B, Delamonte S, Pinar H, Tantravahi U. Monochorionic twins discordant for mosaic trisomy 14. Am J Med Genet A. 2014 May;164A(5):1227-33.
Silver RM, Parker CB, Goldenberg R, Reddy UM, Dudley DJ, Saade GR, Hogue CJ, Coustan D, Varner MW, Koch MA, Conway D, Bukowski R, Pinar H, Stoll B, Moore J, Willinger M. Bile acids in a multicenter, population-based case-control study of stillbirth. Am J Obstet Gynecol. 2014 May;210(5):460.e1-9.
Starikov R, Inman K, Chen K, Lopes V, Coviello E, Pinar H, He M. Comparison of placental findings in type 1 and type 2 diabetic pregnancies. Placenta. 2014 Dec;35(12):1001-6.
Pinar H, Goldenberg RL. Ebolavirus Hemorrhagic Fever (EHF) and the Obstetric Patient. Pediatr Dev Pathol. 2014 Dec 1. [Epub ahead of print]
Barbaux S, Erwich JJ, Favaron PO, Gil S, Gallot D, Golos TG, Gonzalez-Bulnes A, Guibourdenche J, Heazell AE, Jansson T, Laprévote O, Lewis RM, Miller RK, Monk D, Novakovic B, Oudejans C, Parast M, Peugnet P, Pfarrer C, Pinar H, Roberts CT, Robinson W, Saffery R, Salomon C, Sexton A, Staff AC, Suter M, Tarrade A, Wallace J, Vaillancourt C, Vaiman D, Worton SA, Lash GE. IFPA meeting 2014 workshop report: Animal models to study pregnancy pathologies; new approaches to study human placental exposure to xenobiotics; biomarkers of pregnancy pathologies; placental genetics and epigenetics; the placenta and stillbirth and fetal growth restriction. Placenta. 2015 Apr;36 Suppl 1:S5-10.
Pinar H, et al. Early pregnancy losses: a review of nomenclature, histopathology, and possible etiologies. Pediatr Dev Pathol. Accepted for publication. September 2015.
Pinar H. A practical method to diagnose accreta from the placental examination. BJOG. 2016 Dec;123(13):2146.
Silver RM, Saade GR, Thorsten V, Parker CB, Reddy UM, Drews- Botsch C, Conway D, Coustan D, Dudley DJ, Bukowski R, Rowland Hogue CJ, Pinar H, Varner MW, Goldenberg R, Willinger M. Factor V Leiden, prothrombin G20210A, and methylene tetrahydrofolate reductase mutations and stillbirth: The Stillbirth Collaborative Research Network. Am J Obstet Gynecol. 2016 Oct;215(4): 468.e1-468.e17.
Gibbins KJ, Silver RM, Pinar H, Reddy UM, Parker CB, Thorsten V, Willinger M, Dudley DJ, Bukowski R, Saade GR, Koch MA, Conway D, Hogue CJ, Stoll BJ, Goldenberg RL. Stillbirth, hypertensive disorders of pregnancy, and placental pathology. Placenta. 2016 Jul;43:61-8.
He M, Migliori AR, Lauro P, Sung CJ, Pinar H. Perinatal Mortality Associated with Positive Postmortem Cultures for Common Oral Flora. Infect Dis Obstet Gynecol. 2017; 2017:9027918.
Page JM, Christiansen-Lindquist L, Thorsten V, Parker CB, Reddy UM, Dudley DJ, Saade GR, Coustan D, Rowland Hogue CJ, Conway D, Bukowski R, Pinar H, Heuser CC, Gibbins KJ, Goldenberg RL, Silver RM. Diagnostic Tests for Evaluation of Stillbirth: Results from the Stillbirth Collaborative Research Network. Obstet Gynecol. 2017 Apr;129(4):699-706.
Freedman AA, Cammack AL, Temple JR, Silver RM, Dudley DJ, Stoll BJ, Varner MW, Saade GR, Conway D, Goldenberg RL, Pinar H, Hogue CJ. Maternal exposure to childhood maltreatment and risk of stillbirth. Ann Epidemiol. 2017 Aug;27(8):459-465.e2. doi:10.1016/j.annepidem.2017.07.005. Epub 2017 Jul 13. PubMed PMID: 28755869.
Bukowski R, Hansen NI, Pinar H, Willinger M, Reddy UM, Parker CB, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Hogue C, Varner MW, Conway DL, Coustan D, Goldenberg RL; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Stillbirth Collaborative Research Network (SCRN). Altered fetal growth, placental abnormalities, and stillbirth. PLoS One. 2017 Aug 18;12(8):e0182874. doi: 10.1371/journal.pone.0182874. eCollection 2017. PubMed PMID: 28820889; PubMed Central PMCID: PMC5562325.
Page JM, Christiansen-Lindquist L, Thorsten V, Parker CB, Reddy UM, Dudley DJ, Saade GR, Coustan D, Rowland Hogue CJ, Conway D, Bukowski R, Pinar H, Heuser CC, Gibbins KJ, Goldenberg RL, Silver RM. Diagnostic Tests for Evaluation of Stillbirth: Stillbirth Collaborative Research Network. Obstet Gynecol. 2017 Mar 6. doi: 10.1097/AOG.0000000000001937. [Epub ahead of print]
Freedman AA, Hogue CJ, Dudley DJ, Silver RM, Stoll BJ, Pinar H, Goldenberg RL, Drews-Botsch C. Associations between Maternal and Fetal Inherited Thrombophilias, Placental Characteristics Associated with Vascular Malperfusion, and Fetal Growth. TH Open. 2017 Jun; 1(1): e43–e55. Published online 2017 Jun 28. doi: 10.1055/s-0037-1603925.
Metz TD, Allshouse AA, Hogue CJ, Goldenberg RL, Dudley DJ, Varner MW, Conway DL, Saade GR, Pinar H, Silver RM. Maternal marijuana use, adverse pregnancy outcomes, and neonatal morbidity. Am J Obstet Gynecol. 2017 Oct;217(4):478.e1-478.e8. doi: 10.1016/j.ajog.2017.05.050. Epub 2017 May 31. PubMed PMID: 28578174; PubMed Central PMCID: PMC5614818.
Angley M, Thorsten VR, Drews-Botsch C, Dudley DJ, Goldenberg RL, Silver RM, Stoll BJ, Pinar H, Hogue CJR. Association of participation in a supplemental nutrition program with stillbirth by race, ethnicity, and maternal characteristics. BMC Pregnancy Childbirth. 2018 Jul 24;18(1):306. doi:10.1186/s12884-018-1920-0. PubMed PMID: 30041624; PubMed Central PMCID: PMC6056947.
Page JM, Thorsten V, Reddy UM, Dudley DJ, Hogue CJR, Saade GR, Pinar H, Parker CB, Conway D, Stoll BJ, Coustan D, Bukowski R, Varner MW, Goldenberg RL, Gibbins K, Silver RM. Potentially Preventable Stillbirth in a Diverse U.S. Cohort. Obstet Gynecol. 2018 Feb;131(2):336-343. doi: 10.1097/ AOG.0000000000002421. PubMed PMID: 29324601; PubMed Central PMCID: PMC5785410.
Gibbins KJ, Reddy UM, Saade GR, Goldenberg RL, Dudley DJ, Parker CB, Thorsten V, Pinar H, Bukowski R, Hogue CJ, Silver RM. Smith-Lemli-Opitz Mutations in Unexplained Stillbirths. Am J Perinatol. 2018 Aug;35(10):936- 939. doi:10.1055/s-0038-1626705. Epub 2018 Feb 12. PubMed PMID: 29433144; PubMed Central PMCID: PMC6060008.
Freedman AA, Kipling LM, Labgold K, Marsit CJ, Hogue CJ, Rajakumar A, Smith AK, Pinar H, Conway DL, Bukowski R, Varner MW, Goldenberg RL, Dudley DJ, Drews-Botsch C. Comparison of diameter-based and image-based measures of surface area from gross placental pathology for use in epidemiologic studies. Placenta. 2018 Sep;69:82-85. doi: 10.1016/j.placenta.2018.07.013. Epub 2018 Jul 27. PubMed PMID: 30213489; PubMed Central PMCID: PMC6176918.
Pinar H, Gibbins K, He M, Kostadinov S, Silver R. Early Pregnancy Losses: Review of Nomenclature, Histopathology, and Possible Etiologies. Fetal Pediatr Pathol. 2018 Jun;37(3):191-209. doi: 10.1080/15513815.2018.1455775. Epub 2018 May
Margo S, Harrison MS, Thorsten VR, Dudley DJ, Parker CB, Koch MA, Hogue CJR, Stoll BJ, Silver RM, Varner MW, Pinar H, Coustan DR, Saade GR, Bukowski RK, Conway DL, Willinger M, Reddy UM, Goldenberg RL. Stillbirth, Inflammatory Markers, and Obesity: Results from the Stillbirth Collaborative Research Network. Am J Perinatol. 2018 Sep;35(11):1071-1078.
Gibbins KJ, Pinar H, Reddy UM, Saade GR, Goldenberg RL, Dudley DJ, Drews- Botsch C, Freedman AA, Daniels LM, Parker CB, Thorsten V, Bukowski R, Silver RM. Findings in Stillbirths Associated with Placental Disease. Am J Perinatol. 2019 May 14. doi: 10.1055/s-0039-1688472. [Epub ahead of print] PubMed. PMID: 31087311.
Freedman AA, Silver RM, Gibbins KJ, Hogue CJ, Goldenberg RL, Dudley DJ, Pinar H, Drews-Botsch C. The association of stillbirth with placental abnormalities in growth-restricted and normally grown fetuses. Paediatr Perinat Epidemiol. 2019 Jul;33(4):274-383. doi: 10.1111/ppe.12563. PubMed PMID:31347723; PubMed Central PMCID: PMC6662619.
Cassandra M, Pickens CM, Hogue CJ, Howards PP, Kramer MR, Badell ML, Dudley DJ, Silver RM, Goldenberg RL, Pinar H, Saade GR, Varner MW, Stoll BJ. The association between gestational weight gain z-score and stillbirth: a case-control study. BMC Pregnancy Childbirth. 2019 Nov 29;19(1):451. doi: 10.1186/s12884- 019-2595-x. PubMed PMID: 31783735; PubMed Central PMCID: PMC6883690.
Hamad IA, Blue NR, Allshouse AA, Silver RM, Gibbins KJ, Page JM, Goldenberg RL, Reddy UM, Saade GR, Dudley DJ, Thorsten VR, Conway D, Pinar H. Umbilical Cord Abnormalities and Stillbirth. Obstet Gynecol. 2020 Mar135(3):644-652.
Kim B, De La Monte S, Hovanesian V, Petra A, C, Ray Chen X, Chen RH, Miller MC, Pinar H, Lim YP, Stopa EG, Stonestreet BS. Ontogeny of Inter-Alpha Inhibitor Protein (IAIP) Expression in Human Brain. J Neurosci Res. 2020 May;98(5):869-887. doi: 10.1002/jnr. 24565.
Page JM, Allshouse MS, Cassimatis I, Arslan E, Thorsten V, Parker C, Varner MW, Dudley DJ, Saade GR, Goldenberg RL, Stoll B, Hogue CJ, Bukowski R, Conway D, Pinar H, Reddy UM, Silver RM. Characteristics of Stillbirths Associated with Diabetes in a Diverse United States Cohort. Obstet Gynecol 2020 Dec;136(6):1095-1102. PMID: 33156199.
Stanley KE, Giordano J, Buchovecky C, Thomas A, Ganapathi M, Liao J, Avinash Dharmadhikari A, Revah-Politi A, Ernst M, Lippa N, Holmes H, Povysil G, Hostyk J, Parker C, Goldenberg R, Saade G, Dudley D, Pinar H, Hogue C, Thorsten V, Reddy U, Silver R, Aggarwal V, Wapner R, Goldstein DB. Causal Genetic Variants in Stillbirth. N Engl J Med 2020 Sep 17;383(12):1107-1116. PMID: 32786180.
Son SL, Allshouse MS, Cassimatis I, Arslan E, Thorsten V, Parker C, Varner MW, Dudley DJ, Saade GR, Goldenberg RL, Stoll B, Hogue CJ, Bukowski R, Conway D, Pinar H, Reddy UM, Silver RM. Stillbirth and fetal anomalies: secondary analysis of a case–control study Stillbirth and Fetal Anomalies. BJOG 2020; https://doi.org/10.1111/1471-0528.16517
Heerema-McKenney A, Rabinowitz A, Weir A, Oltean I, Barkey J, Pinar H. Heterotopic nodules in the placenta, an immunohistochemical re-evaluation of the diagnosis of adrenocortical heterotopia. Pediatr Dev Pathol. 2021;24(1):27-33.
E Arslan AA, Allshouse MS, Page JM, Varner MW, Thorsten V, Parker C, Dudley DJ, Saade GR, Goldenberg RL, Stoll BJ, Hogue CJ, Bukowski R, Conway D, Pinar H, Reddy UM, Silver RM. Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network. BJOG. First published: 16 September 2021 https://doi.org/10.1111/1471-0528.16922
Pinar H, Gordijn SJ, Grynspan D, Kingdom J, Roberts DJ, Kerzner L, Bates SV, Carreon CK, Leeman KT, Salafia C, Cohen M, Castro E, Ravishankar S, Kliman HJ, Dahlstrom J, Silver B, Heazell A. Pathologic Assessment of the Placenta: Evidence Compared With Tradition. Obstet Gynecol. 2022 Aug 1;140(2):341-342. doi: 10.1097/AOG.0000000000004883. PMID: 35852288.
Cersonsky TEK, Lord M, Pinar H. Intrauterine Fetal Demise Associated with Vascular Malperfusion and Multiple Uterine Leiomyomata: A Report of Two Cases. Fetal Pediatr Pathol. 2022 Mar 4:1-10. doi: 10.1080/15513815.2022.2047847. Epub ahead of print. PMID: 35243966.
Seifer DB, Lambert-Messerlian G, Palomaki GE, Silver RM, Parker C, Rowland, Hogue CJ, Stoll BJ, Saade GR, Goldenberg RL, Dudley DJ, Bukowski R, Pinar H, Reddy UM. Preeclampsia at delivery is associated with lower serum vitamin D and higher antiangiogenic factors: a case-control study. Reprod Biol Endocrinol. 2022 Jan 6;20(1):8. doi: 10.1186/s12958-021-00885-z. PMID: 34991614; PMCID: PMC8734360.
Workalemahu T, Dalton S, Allshouse A, Carey AZ, Page JM, Blue NR, Thorsten V, Goldenberg RL, Pinar H, Reddy UM, Silver RM. Copy number variants and placental abnormalities in stillborn fetuses: A secondary analysis of the Stillbirth Collaborative Research Network study. BJOG. 2022 Jul 25. doi: 10.1111/1471-0528.17269. Epub ahead of print. PMID: 35876766.
Cersonsky TEK, Pinar H, Silver RM, Goldenberg RL, Dudley DJ, Saade GR, Reddy UM. Holding a baby after stillbirth: the impact of fetal congenital and structural abnormalities. J Perinatol. 2022 Aug 5:1–6. doi: 10.1038/s41372-022-01480-9. Epub ahead of print. PMID: 35931797; PMCID: PMC9362406.

Medical License	State of Vermont	2020-2025	#042.0015257
Doctor of Medicine	State of Rhode Island	1990-2025	#MD08222

Researchers@Brown

Researchers@Brown

M Halit Pinar

Professor Emeritus of Pathology and Laboratory Medicine

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