Nancy Thompson, Ph.D., was the inaugural Associate Dean for Graduate and Postdoctoral Studies, Division of Biology and Medicine, appointed in January 2006. She stepped down from this position July 30, 2010. Dr. Thompson is currently Professor Emerita (Research), Medicine and Pathology and Laboratory Medicine. Dr. Thompson was founding co-Prinicipal Investigator of Brown's Initiative to Maximize Student Development R25 grant from NIH's NIGMS (2008-12) with PI Professor Andrew G. Campbell. She received her Ph.D. from Brown. Past peer review funded research and publications focused on hepatic cancer and injury related gene expression /biomarkers with particular emphasis on LAT1/CD98 amino acid transporters. She no longer directs a research laboratory.
Leong, H.X., Simkevich, C., Lesieur-Brooks, A., Lau, B., Fugere, C., Sabo, E. and Thompson, N.L.
Short term arginine deprivation results in large scale modulation of hepatic gene expression in both normal and tumor cells: microarray bioinformatics analysis..
Nutr. Metab. 2006; 8 (3) : 37.
Erickson, B. Thompson, N.L. and Hixson, D.C. Tightly regulated induction of the adhesion molecule necl-5/CD155 during rat liver regeneration and acute liver injury. Hepatology 43:325-334, 2006
Storey, B.T., Fugere, C., Lesieur-Brooks, A., Vaslet, C. and Thompson, N.L. Adenoviral modulation of the tumor-associated system L amino acid transporter, LAT1, alters amino acid transport, cell growth and 4F2/CD98 expression in cultured hepatic cells. Int. J. Cancer, 117:387-397, 2005.
Padbury, J.F., Diah, S.K., McGonnigal, Miller, C., Fugere, C., Kuzniar, M. and Thompson, N.L. Transcriptional regulation of the LAT-1/CD98 light chain. Biochem. Biophys. Res. Comm. 318:529-534, 2004.
Campbell, W.A., and Thompson, N.L. Overexpression of LAT-1/CD98 light chain is sufficient to increase system L amino acid transport activity in mouse hepatocytes but not fibroblasts. J. Biol. Chem. 276:16877-16884, 2001.
Diah, S.K., Padbury, J.F., Campbell, W.A., Britt, D., and Thompson, N.L. Molecular cloning of the rat TA1/LAT-1/CD98 light chain gene promoter. Biochimica et Biophysica Acta 1518:267-270, 2001.
Campbell, W. A., Sah, D.E., Albina J.E., Coleman, W.B., and Thompson, N.L. TA1/LAT-1/CD98 light chain and system L activity, but not 4F2/CD98 heavy chain, respond to arginine availability in rat hepatic cells: loss of response in tumor cells. J. Biol. Chem., 275:5347-5354, 2000.
Shultz, V.D., Campbell, W., Karr, S., Hixson, D.C. and Thompson, N.L. TA1 oncofetal rat liver cDNA and putative amino acid permease: temporal correlation with c-myc during acute CCL4 liver injury and variation of RNA levels in response to amino acids in hepatocyte cultures. Toxicol. Appl. Pharm. 154:84-96, 1999.
Liu, J., Pan, J., Naik, S., Santiangini, H., Trenkler, D., Thompson, N., Rifai, A., Chowdhury, J. R. and Jauregui, H. Characterization and evaluation of detoxification functions of a nontumorigenic immortalized porcine hepatoctye cell line (HepLiu). Cell Transplantation 8:219-232, 1999.
Mannion, B.A., Kolesnikova, T.V., Lin, S.H., Wang, S., Thompson, N.L., and Hemler, M.E. The light chain of CD98 is identified as E16/TA1 Protein. J. Biol. Chem. 273, 33127-33129, 1998.
Shultz, V.D., Degli Esposti, S., Panzica, M.A., Abraham, A., Finch, P. and Thompson, N.L. Expression of TA1, a rat oncofetal cDNA with homology to transport-associated genes, in carbon tetrachloride-induced liver injury. Pathobiology, 65:14-25, 1997.
Lim, Y.P., Fowler, L.C., Hixson, D.C., Wehbe, T. and Thompson, N.L. TuAg.1 is the liver isoform of the rat colon tumor-associated antigen, pE4, and a member of the immunoglobulin-like supergene family. Cancer Res., 56:3934-3940, 1996.
Knuckey, N.W., Finch, P., Palm, D.E., Primiano, M.J., Johanson, C., Flanders, K.C. and Thompson, N.L. Differential neuronal expression of transforming growth factor ß isoforms following transient forebrain ischemia. Mol. Brain Res., 40:1-14, 1996.
Chapman, L., Sang, J., Lin, S.H., Hixson, D.C. and Thompson, N.L. Cloning of cDNAs from a mammalian expression library by a direct selection - amplification method. Mol. Biotech., 5:77-83, 1996.
Wolf, D.A., Panzica, M.A., Wang, S., Bassily, N.H. and Thompson, N.L. Expression of a highly conserved oncofetal gene, TA1/E16, in human colon carcinoma and other primary tumors: homology to S. mansoni amino acid permease and C. elegans gene products. Cancer Res. 56:5012-5022, 1996.
Sang, J., Lim, Y.-P., Panzica, M., Finch, P. and Thompson, N.L. TA1, a highly conserved oncofetal cDNA from rat hepatoma encodes an integral membrane protein associated with liver development, carcinogenesis and cell activation. Cancer Res., 55:1152-1159, 1995.
Pinar, M.H., Thompson, N.L., Flanders, K.C. and Rogers, B.B. Spatiotemporal distribution of TGF-ß1, TGF-ß2 and TGF-ß1 precursor in human embryonic development. Cell Vision, 1:200-207, 1994.
Thompson, N.L., Lin, S-H., Panzica, M.A. and Hixson, D.C. Cell CAM 105 isoform RNA expression is differentially regulated during rat liver regeneration and carcinogenesis. Pathobiology, 62:209-220, 1994.
Sang, J. and Thompson, N.L. An efficient procedure for obtaining long cDNA clones from phage library screening. BioTechniques, 17(3):446-451, 1994.
Niles, R.M., Thompson, N.L. and Fenton, F.: Expression of TGF-ß during in vitro differentiation of hamster tracheal epithelial cells. In Vitro Cell. Dev. Biol., 30A:256-262, 1994.
Lim, Y-P., Callanan, H., Lin, S-H., Thompson, N.L. & Hixson, D.C.: Preparative mini slab gel continuous elution electrophoresis: application for the isolation of proteins associated with the rat hepatocyte cell adhesion molecule, cell CAM 105. Anal. Biochem., 214:156-164, 1993.
Cheung, P.H., Culic, O., Qui, Y., Earley, K., Thompson, N., Hixson, D.C. and Lin, S-H.: The cytoplasmic domain of C-CAM is required for C-CAM mediated adhesion function: studies of a C-CAM transcript containing an unspliced intron. Biochem. J., 295:427-435, 1993.
Thompson, N.L., Panzica, M.A., Hull, G., Lin,S-H, Curran,T.R., Gruppuso, P.A.,Baum, O., Reutter, W. and Hixson, D.C.: Spatiotemporal expression of two cell-cell adhesion molecule 105 isoforms during liver development. Cell Growth and Different., 4:257-268, 1993.
Cheung, P.H., Thompson, N.L., Earley, K., Culic, O., Hixson, D, and Lin, S.-H.: Cell-CAM 105 isoforms with different adhesion functions are co-expressed in adult rat tissues and during liver development. J. Biol. Chem., 268:6139-6146, 1993.
Pinar, H., Thompson, N.L., Flanders, K.C., Sporn, M.B., Sung, J. and Rogers, B.B.: Distribution of transforming growth factor beta in a two week human embryo. Growth Factors, 6:203-208, 1992.
Thompson, N.L., Hixson, D.C., Callanan, H., Panzica, M., Flanagan, D., Faris, R.A., Hong, W., Hartel-Schenk, S. and Doyle, D.: A Fischer rat substrain deficient in dipeptidyl peptidase IV activity makes normal steady state RNA levels and an altered protein: use as a liver cell transplantation model. Biochem. J., 273:497-502, 1991.
Casscells, W., Bazoberry, F., Speir, E., Thompson, N., Flanders, K., Kondaiah, P., Ferrans, V.J., Epstein, S.E. and Sporn, M.B.: Transforming growth factor -ß1 in normal heart and in myocardial infarction. Annals of the New York Academy of Sciences, 593:148-160, 1990.
Sieweke, M.H., Thompson, N.L., Sporn, M.B. and Bissell, M.J.: TGF-beta is a mediator of wound related Rous sarcoma virus tumorigenesis. Science, 248:1656-1660, 1990.
Faris, R.A., McEntire, K.D., Thompson, N.L. and Hixson, D.C.: Identification and characterization of a novel hepatic oncofetal membrane glycoprotein. Cancer Res., 50:4755-4763, 1990.
Hixson, D.C., Faris, R.A. and Thompson, N.L.: An antigenic portrait of the liver during carcinogenesis. Pathobiology, 58:65-77, 1990.
Van Obberghen-Schilling, E., Thompson, N.L., Flanders, K.C., Sporn, M.B., Lambert, P.F. and Baker, C.C.: Transforming growth factor ß expression in fibropapillomas induced by bovine papillomavirus type 1, in normal bovine skin, and in BPV-1 transformed cells. Growth Factors, 2:111-121, 1990.
Thompson, N.L., Flanders, K.C., Smith, J.M., Ellingsworth, L.R., Roberts, A.B., and Sporn, M.B.: Expression of TGF ß1 in specific cells and tissues of adult and neonatal mice. J. Cell Biol., 108:661-669, 1989.
Flanders, K.C., Thompson, N.L., Cissel, D.S., Van Obberglen-Schilling, E., Baker, C.C., Kass, M.E., Ellingsworth, L.R., Roberts, A.B., and Sporn, M.B.: Transforming growth factor ß1: histochemical localization with antibodies to different epitopes. J. Cell Biol., 108:653-660, 1989.
Wakefield, L.M., Thompson, N.L., Flanders, K.C., O'Connor-McCourt, M.D., and Sporn, M.B.: Transforming growth factor-beta: multifunctional regulator of cell growth and phenotype. Annals of the New York Academy of Sciences, 551:290-298, 1989.
Lafyatis, R., Thompson, N.L., Remmers, E.F., Flanders, K.C., Roche, N.S., Kim, S-J., Case, J.P., Sporn, M.B., Roberts, A.B. and Wilder, R.L.: Transforming growth factor ß production by synovial tissues from rheumatoid patients and Streptococcal cell wall arthritic rats. J. Immunol., 143:1142-1148, 1989.
Thompson, N.L., Bazoberry, F., Speir, E.H., Casscells, W., Ferrans, V.J., Flanders, K.C., Kondaiah, P., Geiser, A.G., and Sporn, M.B.: Transforming growth factor beta-1 in acute myocardial infarction in rats. Growth Factors, 1:91-98, 1988.
Roberts, A.B., Thompson, N.L., Flanders, K.C., Wilder, R.L, and Sporn, M.B.: Transforming growth factor-beta: possible roles in carcinogenesis. Br. J. Cancer, 57: 594-600, 1988.
Jakowlew, S.B., Kondaiah, P., Flanders, K.C., Thompson, N.L., Dillard, P.J., Sporn, M.B., and Roberts, A.B.: Increased expression of growth factor mRNAs accompanies viral transformation of rodent cells. Oncogene Res., 2: 135-148, 1988.
Braun, L., Goyette, M., Yaswen, P., Thompson, N.L., and Fausto, N.: Liver epithelial cells from carcinogen treated rats: Growth in culture and tumorigenicity after transfection with the ras oncogene. Cancer Res., 47: 4116-4124, 1987.
Thompson, N.L., Mead, J.E., Braun, L., Goyette, M., Shank, P.R., and Fausto, N.: Sequential proto-oncogene expression during liver regeneration. Cancer Res., 46: 3111-3117, 1986.
Sigma Xi Scientific Honorary
American Society for Cell Biology (currently non-active)
American Association for Advancement of Science
American Society for Microbiology
American Association for Cancer Research
American Society for Investigative Pathology