The Center for Cancer Signaling Networks (CCSN) in the Division of Biology and Medicine is supported by a type III Transitional COBRE grant. The major goal of this grant mechanism is to provide support for two core facilities in the division with the ultimate goal of making these cores self-sustaining. The grant supports an administrative core, a genomics core, and a mouse transgenic and gene targeting core. The grant also supports a limited number of pilot projects that focus on stimulating use of one or both of the cores. The pilot projects are administered through the administrative core.