Dubielecka-Szczerba, Patrycja

selected

Chorzalska, Anna, Salloum, Ibrahem, Marjon, Philip, Treaba, Diana, Schorl, Christoph, John, Morgan, Bryke, Christine R., Reagan, John, Winer, Eric, Olszewski, Adam J., Dubielecka, Patrycja M. Abstract B08: New Abelson interactor-1(Abi-1)-driven mechanism of acquired drug resistance Clin Cancer Res . 2015; 21 (4 Supplement) : B08-B08 . full text
Chorzalska, A, Salloum, I, Shafqat, H, Khan, S, Marjon, P, Treaba, D, Schorl, C, Morgan, J, Bryke, C R, Falanga, V, Zhao, T C, Reagan, J, Winer, E, Olszewski, A J, Al-Homsi, A S, Kouttab, N, Dubielecka, P M. Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced leukemia Leukemia. 2014; 28 (11) : 2165-2177 . full text
Chorzalska, A, Dubielecka, P M. New Abelson interactor-1 (Abi-1)-driven mechanism of acquired drug resistance Leukemia Supp. 2014; 3 : S7-S8 . full text
Chorzalska, Anna, Salloum, Ibrahem, Treaba, Diana, Schorl, Christoph, Morgan, John, Bryke, Christine, Reagan, John, Winer, Eric, Olszewski, Adam, Dubielecka, Patrycja. New abelson interactor-1(Abi-1)-driven mechanism of acquired drug resistance Experimental hematology. 2014; 42 (8) : S31 . full text
Bartos, Adrian, Dubielecka, Patrycja. The Emerging Role of Bcr-Abl-Induced Cystoskeletal Remodeling in Systemic Persistence of Leukemic Stem Cells Current Drug Delivery. 2014; 11 (5) : 582-591 . full text
Chorzalska, Anna D., Salloum, Ibrahem, Shafqat, Hammad, Khan, Saad, Marjon, Philip, Falanga, Vincent, Zhao, Ting, Reagan, John, Winer, Eric, Al-Homsi, Samer, Kouttab, Nicola, Dubielecka, Patrycja M. Abstract LB-350: Abelson interactor-1 (Abi1) expression levels as a prognostic and drug resistance marker in Bcr-Abl positive leukemias. Cancer Research. 2013; 73 (8 Supplement) : LB-350-LB-350 . full text
Toporkiewicz, Monika, Grzybek, Michał, Meissner, Justyna, Michalczyk, Izabela, Dubielecka, Patrycja M., Korycka, Justyna, Seweryn, Ewa, Sikorski, Aleksander F. Release of an ∼55kDa fragment containing the actin-binding domain of β-spectrin by caspase-8 during FND-induced apoptosis depends on the presence of protein 4.1 Archives of Biochemistry and Biophysics. 2013; 535 (2) : 205-213 . full text
Hossain, S., Dubielecka, P. M., Sikorski, A. F., Birge, R. B., Kotula, L. Crk and Abi1: Binary Molecular Switches That Regulate Abl Tyrosine Kinase and Signaling to the Cytoskeleton Genes & Cancer. 2012; 3 (5-6) : 402-413 . full text
Xiong, X, Chorzalska, A, Dubielecka, P M, White, J R, Vedvyas, Y, Hedvat, C V, Haimovitz-Friedman, A, Koutcher, J A, Reimand, J, Bader, G D, Sawicki, J A, Kotula, L. Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice Oncogenesis. 2012; 1 (9) : e26 . full text
Zhang, L., Chen, B., Zhao, Y., Dubielecka, P. M., Wei, L., Qin, G. J., Chin, Y. E., Wang, Y., Zhao, T. C. Inhibition of Histone Deacetylase-induced Myocardial Repair Is Mediated by c-kit in Infarcted Hearts Journal of Biological Chemistry. 2012; 287 (47) : 39338-39348 . full text
Michalczyk, I., Sikorski, A. F., Kotula, L., Junghans, R. P., Dubielecka, P. M. The emerging role of protein kinase C in cytoskeletal signaling Journal of Leukocyte Biology. 2012; 93 (3) : 319-327 . full text
Dubielecka, P. M., Ladwein, K. I., Xiong, X., Migeotte, I., Chorzalska, A., Anderson, K. V., Sawicki, J. A., Rottner, K., Stradal, T. E., Kotula, L. Essential role for Abi1 in embryonic survival and WAVE2 complex integrity Proceedings of the National Academy of Sciences. 2011; 108 (17) : 7022-7027 . full text
Dubielecka, Patrycja M., Hwynn, Nelson, Sengun, Cenk, Lee, Soohee, Lomas-Francis, Christine, Singer, Carlos, Fernandez, Hubert H., Walker, Ruth H. Two McLeod patients with novel mutations in XK Journal of the Neurological Sciences. 2011; 305 (1-2) : 160-164 . full text
Dubielecka, Patrycja M., Machida, Kazuya, Xiong, Xiaoling, Hossain, Sajjad, Ogiue-Ikeda, Mari, Carrera, Ana C., Mayer, Bruce J., Kotula, Leszek. Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells FEBS Letters. 2010; 584 (15) : 3279-3286 . full text
Dubielecka, Patrycja M., Grzybek, Michał, Kolondra, Adam, Jaźwiec, Bożena, Draga, Anna, Aleksandrowicz, Paulina, Kołodziejczyk, Monika, Serwotka, Anna, Dolińska-Krajewska, Barbara, Warchoł, Jerzy, Kuliczkowski, Kazimierz, Sikorski, Aleksander F. Aggregation of spectrin and PKCθ is an early hallmark of fludarabine/mitoxantrone/dexamethasone-induced apoptosis in Jurkat T and HL60 cells Molecular and Cellular Biochemistry. 2010; 339 (1-2) : 63-77 . full text
Dubielecka, Patrycja M., Cui, Ping, Xiong, Xiaoling, Hossain, Sajjad, Heck, Susanne, Angelov, Lyudmil, Kotula, Leszek. Differential Regulation of Macropinocytosis by Abi1/Hssh3bp1 Isoforms PLoS ONE. 2010; 5 (5) : e10430 . full text
BOK, E, PLAZUK, E, HRYNIEWICZJANKOWSKA, A, CHORZALSKA, A, SZMAJ, A, DUBIELECKA, P, STEBELSKA, K, DIAKOWSKI, W, LISOWSKI, M, LANGNER, M. Lipid-binding role of βII-spectrin ankyrin-binding domain Cell Biology International. 2007; 31 (12) : 1482-1494 . full text
Dubielecka, Patrycja M., Trusz, Anna, Diakowski, Witold, Grzybek, Michał, Chorzalska, Anna, Jaźwiec, Bozena, Lisowski, Marek, Jezierski, Adam, Sikorski, Aleksander F. Mitoxantrone changes spectrin-aminophospholipid interactions Molecular Membrane Biology. 2006; 23 (3) : 235-243 . full text
Dubielecka, Patrycja M., Jaźwiec, Bożena, Potoczek, Stanisław, Wróbel, Tomasz, Miłoszewska, Joanna, Haus, Olga, Kuliczkowski, Kazimierz, Sikorski, Aleksander F. Changes in spectrin organisation in leukaemic and lymphoid cells upon chemotherapy Biochemical pharmacology. 2005; 69 (1) : 73-85 . full text
Stebelska, K., Dubielecka, P.M., Sikorski, A.F. The Effect of PS Content on the Ability of Natural Membranes to Fuse with Positively Charged Liposomes and Lipoplexes J Membrane Biol. 2005; 206 (3) : 203-214 . full text
HRYNIEWICZ-JANKOWSKA, Anita, BOK, Ewa, DUBIELECKA, Patrycja, CHORZALSKA, Anna, DIAKOWSKI, Witold, JEZIERSKI, Adam, LISOWSKI, Marek, SIKORSKI, Aleksander F. Mapping of an ankyrin-sensitive, phosphatidylethanolamine/phosphatidylcholine mono- and bi-layer binding site in erythroid β-spectrin Biochem. J.. 2004; 382 (2) : 677-685 . full text

scholarly work

1. Michalczyk I, Dubielecka PM, Sikorski AF. PKC θ is a negative regulator of TRAIL-induced and FADD-mediated apoptotic spectrin aggregation. Folia Histochem Cytobiol. 2016;54(1):1-13.

2. Du J, Zhang L, Wang Z, Yano N, Zhao YT, Wei L, Dubielecka-Szczerba P, Liu P, Zhuang S, Qin G, Zhao T. Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts. Am J Physiol Cell Physiol. 2016 Feb 15;310(4):C270-83.

3. Chorzalska A, Salloum I, Shafqat H, Khan S, Marjon P, Falanga V, Zhao TC, Reagan J, Winer E, Olszewski A, Al-Homsi AS, Kouttab N, Dubielecka PM. Low expression of Abelson interactor-1 is linked with systemic persistence and acquired drug resistance in Bcr-Abl-induced leukemia. Leukemia. 2014; 28(11):2165-77. PMID: 24699303, PMCID: PMC4185277

4. Chorzalska A, Dubielecka PM. New Abelson interactor-1 (Abi-1)-driven mechanism of acquired drug resistance. Leukemia Supplements. 2014 December; 3:S7-S8.

5. Toporkiewicz M, Michalczyk I, Grzybek M, Dubielecka PM, Korycka J, Seweryn E, Sikorski AF. Release of a 55 kDa fragment containing the actin-binding domain of β-spectrin by caspase 8 during FND induced apoptosis depends on the presence of protein 4.1 Arch Biochem Biophys. 2013 Jul 15;535(2):205-13. doi: 10.1016/j.abb.2013.03.009. Epub 2013 Apr 8. PMID:23578573

6. Bartos A, Dubielecka PM. Cytoskeletal response to Bcr-Abl and its emerging role in systemic persistence of leukemic stem cells. Curr Drug Deliv. 2013 Mar 18. [Epub ahead of print] PMID: 23517626

7. Michalczyk I, Sikorski AF, Kotula L, Junghans RP, Dubielecka PM. The emerging role of PKCθ in cytoskeletal signal transduction. J Leukoc Biol. 2013 Mar;93(3):319-27. doi: 10.1189/jlb.0812371. Epub 2012 Nov 27. Review. PMID: 23192428

8. Zhang L, Qin X, Chen B, Zhao Y, Dubielecka PM, Lei Wei, Qin JG, Zhao TC. Inhibition of histone deacetylases-induced myocardial repair is mediated by c-kit in infarcted hearts. J Biol Chem. 2012 Nov 16;287(47):39338-48. doi: 10.1074/jbc.M112.379115. Epub 2012 Sep 28. PMID: 23024362

9. Hossain S, Dubielecka PM, Sikorski AF, Birge RB, Kotula L. Crk and Abi1: Binary molecular switches that regulate Abl tyrosine kinase and signaling to the cytoskeleton. Genes Cancer. 2012 May;3(5-6):402-13. doi: 10.1177/1947601912460051. PMID: 23226578

10. Xiong X, Chorzalska A, Dubielecka PM, White J, Vedvyas Y, Hedvat CV, Haimovitz-Friedman A, Koutcher JA, Reimand J, Bader G, Sawicki JA, Kotula L. Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice. Oncogenesis. 2012 Sep 3;1:e26. doi: 10.1038/oncsis.2012.28. PMID: 23552839

11. Dubielecka PM, Ladwein KI, Xiong X, Migeotte I, Chorzalska A, Anderson KV, Sawicki JA, Rottner K, Stradal TE, Kotula L. Essential role for Abi1 in embryonic survival and WAVE2 complex integrity. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7022-7. doi: 10.1073/pnas.1016811108. Epub 2011 Apr 11. PMID: 21482783

12. Dubielecka PM, Hwynn N, Sengun C, Lee S, Lomas-Francis C, Singer C, Fernandez HH, Walker RH. Two McLeod patients with novel mutations in XK. J Neurol Sci. 2011 Jun 15;305(1-2):160-4. doi: 10.1016/j.jns.2011.02.028. Epub 2011 Apr 3. PMID: 21463873

13. Dubielecka PM, Machida K, Xiong X, Hossain S, Ogiue-Ikeda M, Carrera AC, Mayer BJ, Kotula L. Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells. FEBS Lett. 2010 Aug 4;584(15):3279-86. doi: 10.1016/j.febslet.2010.06.029. Epub 2010 Jun 23. PMID: 20598684

14. Dubielecka PM, Cui P, Xiong X, Hossain S, Heck S, Angelov L, Kotula L. Differential regulation of macropinocytosis by Abi1/Hssh3bp1 isoforms. PLoS One. 2010 May 10;5(5):e10430. doi: 10.1371/journal.pone.0010430. PMID: 20479892

15. Dubielecka PM, Grzybek M, Kolondra A, Jazwiec B, Draga A, Aleksandrowicz P, Kolodziejczyk M, Dolinska-Krajewska B, Warchol J, Kuliczkowski K and Sikorski AF. Aggregation of spectrin and PKCθ is an early hallmark of fludarabine/mitoxantrpoe/dexamethasone-induced apoptosis in Jurkat T and HL60 cells. Mol Cell Biochem. 2010 Jun;339(1-2):63-77. doi: 10.1007/s11010-009-0370-4. Epub 2010 Jan 8. PMID: 20058056

16. Bok E, Plazuk E, Hryniewicz-Jankowska A, Chorzalska A, Szmaj A, Dubielecka PM, Stebelska K, Diakowski W, Lisowski M, Langner M, Sikorski AF. Lipid-binding role of betaII-spectrin ankyrin-binding domain. Cell Biol Int. 2007 Dec;31(12):1482-94. Epub 2007 Jul 15. PMID: 17716929

17. Dubielecka PM, Trusz A Diakowski W, Grzybek M, Chorzalska A, Jazwiec B, Lisowski M, Jezierski A, Sikorski AF. Mitoxantrone changes spectrin-aminophospholipid interactions. Mol Membr Biol. 2006 May-Jun;23(3):235-43. PMID: 16785207

18. Dubielecka PM, Jazwiec B, Potoczek S, Wrobel T, Miloszewska J, Haus O, Kuliczkowski K, Sikorski AF. Changes in spectrin organisation in leukaemic and lymphoid cells upon chemotherapy. Biochem Pharmacol. 2005 Jan 1;69(1):73-85. PMID: 15588716

19. Stebelska K, Dubielecka PM, Sikorski AF. The effect of PS content on the ability of natural membranes to fuse with positively charged liposomes and lipoplexes. J Membr Biol. 2005 Aug;206(3):203-14. PMID: 16456715.

20. Grzybek M, Kozubek A, Dubielecka P, Sikorski AF. Rafts--the current picture. Folia Histochem Cytobiol. 2005;43(1):3-10. Review.PMID: 15871556.

21. Hryniewicz-Jankowska A, Bok E, Dubielecka P, Chorzalska A, Diakowski W, Jezierski A, Lisowski M, Sikorski AF. Mapping of an ankyrin-sensitive, phosphatidylethanolamine/phosphatidylcholine mono- and bi-layer binding site in erythroid beta-spectrin. Biochem J. 2004 Sep 1;382(Pt 2):677-85. PMID: 15171729; PMCID: PMC1133825.

22. Dubielecka PM, Stebelska K, Jaźwiec B, Sikorski AF. Cystocyte and lymphocyte derived fusomes/spectrosomes: analogies and differences: a mini-review. Cell Mol Biol Lett. 2003;8(1):221-9. Review. PMID: 12655376.

23. Zhao H, Dubielecka PM, Söderlund T, Kinnunen PK. Interactions of adriamycin, cytochrome c, and serum albumin with lipid monolayers containing poly(ethylene glycol)-ceramide. Biophys J. 2002 Aug;83(2):954-67. PMID: 12124277; PMCID: PMC1302199.

24. Dubielecka P, Potoczek S, Jazwiec B, Miloszewska J, Kuliczkowski K, Sikorski AF. The Effect Of Chemotherapy With Fluodarabine/Mitoxantrone/Dexamethasone On The Distribution Of Spectrin In Lymphocytes Of Non-Hodgkin Lymphoma Patients. Cell Mol Biol Lett. 2001;6(2):200. PMID: 11544653.

research overview

Specific niches within the bone marrow microenvironment allow subpopulations of leukemic stem cells (LSCs) to evade chemotherapy, providing a reservoir of drug resistant LSCs. Eradication of these cells possesses a major challenge to the development of curative treatment for CML and other types of leukemia. Our approach to meeting this challenge is aimed at understanding the molecular characteristics of the interactions between leukemic stem cells and the bone marrow microenvironment. The goal of our research is to identify new targets for therapies aimed at eradicating drug resistant leukemic stem cells responsible for relapse.

education and training

awards and honors

Polish Ministry of Education Award 3P04C09725 PhD project "Spectrin in early apoptosis in lymphoid and lymphoblastic cells'.

Socrates/Erasmus Scholarship of EU, Helsinki Biophysics & Biomembrane Group, Department Of Medical Chemistry, Institute of Biomedicine, University of Helsinki, Helsinki, Finland

Socrates/Erasmus Scholarship of EU, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Department of Medical Biology and Genetics, Hradec Kralove, Czech Republic

NIH/NCRR Center of Biomedical Research Excellence Award 2 P20 RR018757-08 (PI: Prof. Vincent Falanga, Boston University/Roger Williams Medical Center) 06/05/08 04/30/13; Role: Project Leader

affiliations

Assistant Professor of Medicine (Research) at the Alpert Medical School of Brown University

Head, Signal Transduction lab at the Rhode Island Hospital

courses

BIOL 1290 - Cancer Biology. Fall 2016.

Researchers @ Brown

Patrycja Dubielecka-Szczerba Assistant Professor of Medicine (Research)

Brown Affiliations

Research Areas

Publications

selected

Research

scholarly work

research overview

Background

education and training

awards and honors

Affiliation

affiliations

Teaching

courses