Dr. Dubielecka is an AssociateProfessor of Medicine at the Alpert Medical School of Brown University, head of the Signal Transduction Lab and Director of Cellular Profiling within the Division of Hematology/Oncology in the Department of Medicine at the Rhode Island Hospital. Dr. Dubielecka received her undergraduate (summa cum laude) and PhD degrees (with honors) from the University of Wroclaw, Poland. She was a scholar of the Socrates/Erasmus Program established by the European Commission, and trained at the University of Helsinki, Finland and at Charles University in Hradec Kralove, Czech Republic. Dr. Dubielecka did her postdoctoral training at the Lindsley F. Kimball Research Institute in New York and was a visiting scientist in training at the University of Michigan, Ann Arbor and Helmholtz Centre for Infection Research in Braunschweig, Germany. Dr. Dubielecka established her independent scientific program in 2012. Her program is focused on the biology of blood cancer-initiating stem cells and their role in the development, progression and relapse of myeloproliferative neoplasms with the translational goal of therapeutically targeting neoplasm-initiating stem cells.
| Ollila TA, Kurt H, Waroich J, Vatkevich J, Sturtevant A, Patel NR, Dubielecka PM, Treaba DO, Olszewski AJ. "Genomic subtypes may predict the risk of central nervous system recurrence in diffuse large B-cell lymphoma." Blood, 2020. |
| Yano N, Zhang L, Wei D, Dubielecka PM, Wei L, Zhuang S, Zhu P, Qin G, Liu PY, Chin YE, Zhao TC. "Irisin counteracts high glucose and fatty acid-induced cytotoxicity by preserving the AMPK-insulin receptor signaling axis in C2C12 myoblasts." AJP: Endocrinology and Metabolism, vol. 318, no. 5, 2020, pp. E791-E805. |
| Wang J, Zhao YT, Zhang L, Dubielecka PM, Zhuang S, Qin G, Chin YE, Zhang S, Zhao TC. "Irisin Improves Myocardial Performance and Attenuates Insulin Resistance in Spontaneous Mutation (Leprdb ) Mice." Frontiers in pharmacology, vol. 11, 2020, pp. 769. |
| So EY, Sun C, Wu KQ, Driesman A, Leggett S, Isaac M, Spangler T, Dubielecka-Szczerba PM, Reginato AM, Liang OD. "Lipid phosphatase SHIP-1 regulates chondrocyte hypertrophy and skeletal development." Journal of cellular physiology, vol. 235, no. 2, 2020, pp. 1425-1437. |
| So EY, Jeong EM, Wu KQ, Dubielecka PM, Reginato AM, Quesenberry PJ, Liang OD. "Sexual dimorphism in aging hematopoiesis: an earlier decline of hematopoietic stem and progenitor cells in male than female mice." Aging, vol. 12, no. 24, 2020, pp. 25939-25955. |
| Olszewski AJ, Chorzalska AD, Kim AS, Quesenberry PJ, Lopresti ML, Fenton MA, Reagan JL, Butera JN, Sahin I, Hamel C, Robison J, Petersen M, Dubielecka PM. "Clonal haematopoiesis of indeterminate potential among cancer survivors exposed to myelotoxic chemotherapy." British Journal of Haematology, vol. 186, no. 3, 2019, pp. e31-e35. |
| So EY, Sun C, Reginato AM, Dubielecka PM, Ouchi T, Liang OD. "Loss of lipid phosphatase SHIP1 promotes macrophage differentiation through suppression of dendritic cell differentiation." Cancer biology & therapy, vol. 20, no. 2, 2019, pp. 201-211. |
| Zhao YT, Du J, Yano N, Wang H, Wang J, Dubielecka PM, Qin G, Zhang LX, Zhuang S, Liu PY, Chin YE, Zhao TC. "p38-Regulated/activated protein kinase plays a pivotal role in protecting heart against ischemia-reperfusion injury and preserving cardiac performance." AJP: Cell Physiology, vol. 317, no. 3, 2019, pp. C525-C533. |
| Chorzalska A, Morgan J, Ahsan N, Treaba DO, Olszewski AJ, Petersen M, Kingston N, Cheng Y, Lombardo K, Schorl C, Yu X, Zini R, Pacilli A, Tepper A, Coburn J, Hryniewicz-Jankowska A, Zhao TC, Oancea E, Reagan JL, Liang O, Kotula L, Quesenberry PJ, Gruppuso PA, Manfredini R, Vannucchi AM, Dubielecka PM. "Bone marrow-specific loss of <i>ABI1</i> induces myeloproliferative neoplasm with features resembling human myelofibrosis." Blood, vol. 132, no. 19, 2018, pp. 2053-2066. |
| Zhao YT, Wang J, Yano N, Zhang LX, Wang H, Zhang S, Qin G, Dubielecka PM, Zhuang S, Liu PY, Chin YE, Zhao TC. "Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heart." Journal of cellular physiology, vol. 234, no. 2, 2018, pp. 1671-1681. |
| Zhang L, Wang H, Zhao Y, Wang J, Dubielecka PM, Zhuang S, Qin G, Chin YE, Kao RL, Zhao TC. "Myocyte-specific overexpressing HDAC4 promotes myocardial ischemia/reperfusion injury." Molecular Medicine, vol. 24, no. 1, 2018, pp. 37. |
| Chorzalska A, Ahsan N, Rao RSP, Roder K, Yu X, Morgan J, Tepper A, Hines S, Zhang P, Treaba DO, Zhao TC, Olszewski AJ, Reagan J, Liang O, Gruppuso PA, Dubielecka PM. "Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK-ERK and NF-κB pathways in a model of chronic myeloid leukemia." Molecular oncology, vol. 12, no. 5, 2018, pp. 630-647. |
| Zhang LX, Du J, Zhao YT, Wang J, Zhang S, Dubielecka PM, Wei L, Zhuang S, Qin G, Chin YE, Zhao TC. "Transgenic overexpression of active HDAC4 in the heart attenuates cardiac function and exacerbates remodeling in infarcted myocardium." Journal of Applied Physiology, vol. 125, no. 6, 2018, pp. 1968-1978. |
| Liang OD, So EY, Egan PC, Goldberg LR, Aliotta JM, Wu KQ, Dubielecka PM, Ventetuolo CE, Reginato AM, Quesenberry PJ, Klinger JR. "Endothelial to haematopoietic transition contributes to pulmonary arterial hypertension." Cardiovascular research, vol. 113, no. 13, 2017, pp. 1560-1573. |
| Wang H, Zhao YT, Zhang S, Dubielecka PM, Du J, Yano N, Chin YE, Zhuang S, Qin G, Zhao TC. "Irisin plays a pivotal role to protect the heart against ischemia and reperfusion injury." Journal of cellular physiology, vol. 232, no. 12, 2017, pp. 3775-3785. |
| Chorzalska A, Kim JF, Roder K, Tepper A, Ahsan N, Rao RSP, Olszewski AJ, Yu X, Terentyev D, Morgan J, Treaba DO, Zhao TC, Liang O, Gruppuso PA, Dubielecka PM. "Long-term exposure to imatinib mesylate downregulates Hippo pathway and activates YAP in a model of chronic myelogenous leukemia." Stem Cells and Development, vol. 26, no. 9, 2017, pp. 656-677. |
| Wu KQ, Muratore CS, So EY, Sun C, Dubielecka PM, Reginato AM, Liang OD. "M1 Macrophage-Induced Endothelial-to-Mesenchymal Transition Promotes Infantile Hemangioma Regression." The American Journal of Pathology, vol. 187, no. 9, 2017, pp. 2102-2111. |
| Lim SH, Dubielecka PM, Raghunathan VM. "Molecular targeting in acute myeloid leukemia." Journal of translational medicine, vol. 15, no. 1, 2017, pp. 183. |
| Zhang L, Du J, Yano N, Wang H, Zhao YT, Dubielecka PM, Zhuang S, Chin YE, Qin G, Zhao TC. "Sodium Butyrate Protects -Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice." Journal of cellular biochemistry, vol. 118, no. 8, 2017, pp. 2395-2408. |
| Du J, Zhang L, Wang Z, Yano N, Zhao YT, Wei L, Dubielecka-Szczerba P, Liu PY, Zhuang S, Qin G, Zhao TC. "Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts." AJP: Cell Physiology, vol. 310, no. 4, 2016, pp. C270-83. |
| Michalczyk I, Toporkiewicz M, Dubielecka PM, Chorzalska A, Sikorski AF. "PKC-θ is a negative regulator of TRAIL-induced and FADD-mediated apoptotic spectrin aggregation." Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, vol. 54, no. 1, 2016, pp. 1-13. |
| Chorzalska A, Salloum I, Shafqat H, Khan S, Marjon P, Treaba D, Schorl C, Morgan J, Bryke CR, Falanga V, Zhao TC, Reagan J, Winer E, Olszewski AJ, Al-Homsi AS, Kouttab N, Dubielecka PM. "Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced leukemia." Leukemia, vol. 28, no. 11, 2014, pp. 2165-77. |
| Chorzalska A, Dubielecka PM. "New Abelson interactor-1 (Abi-1)-driven mechanism of acquired drug resistance." Leukemia Supp, vol. 3, no. Suppl 1, 2014, pp. S7-S8. |
| Bartos A, Dubielecka PM. "The emerging role of Bcr-Abl-induced cystoskeletal remodeling in systemic persistence of leukemic stem cells." Current Drug Delivery, vol. 11, no. 5, 2014, pp. 582-91. |
| Toporkiewicz, Monika, Grzybek, Michał, Meissner, Justyna, Michalczyk, Izabela, Dubielecka, Patrycja M., Korycka, Justyna, Seweryn, Ewa, Sikorski, Aleksander F. "Release of an ~55kDa fragment containing the actin-binding domain of β-spectrin by caspase-8 during FND-induced apoptosis depends on the presence of protein 4.1." Archives of Biochemistry and Biophysics, vol. 535, no. 2, 2013, pp. 205-13. |
| Michalczyk I, Sikorski AF, Kotula L, Junghans RP, Dubielecka PM. "The emerging role of protein kinase Cθ in cytoskeletal signaling." Journal of Leukocyte Biology, vol. 93, no. 3, 2013, pp. 319-27. |
| Hossain, S., Dubielecka, P. M., Sikorski, A. F., Birge, R. B., Kotula, L. "Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton." Genes & Cancer, vol. 3, no. 5-6, 2012, pp. 402-413. |
| Xiong, X, Chorzalska, A, Dubielecka, P M, White, J R, Vedvyas, Y, Hedvat, C V, Haimovitz-Friedman, A, Koutcher, J A, Reimand, J, Bader, G D, Sawicki, J A, Kotula, L. "Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice." Oncogenesis, vol. 1, no. 9, 2012, pp. e26. |
| Zhang L, Chen B, Zhao Y, Dubielecka PM, Wei L, Qin GJ, Chin YE, Wang Y, Zhao TC. "Inhibition of histone deacetylase-induced myocardial repair is mediated by c-kit in infarcted hearts." Journal of Biological Chemistry, vol. 287, no. 47, 2012, pp. 39338-48. |
| Dubielecka, P. M., Ladwein, K. I., Xiong, X., Migeotte, I., Chorzalska, A., Anderson, K. V., Sawicki, J. A., Rottner, K., Stradal, T. E., Kotula, L. "Essential role for Abi1 in embryonic survival and WAVE2 complex integrity." Proceedings of the National Academy of Sciences, vol. 108, no. 17, 2011, pp. 7022-7027. |
| Dubielecka PM, Hwynn N, Sengun C, Lee S, Lomas-Francis C, Singer C, Fernandez HH, Walker RH. "Two McLeod patients with novel mutations in XK." Journal of the Neurological Sciences, vol. 305, no. 1-2, 2011, pp. 160-164. |
| Dubielecka, Patrycja M., Machida, Kazuya, Xiong, Xiaoling, Hossain, Sajjad, Ogiue-Ikeda, Mari, Carrera, Ana C., Mayer, Bruce J., Kotula, Leszek. "Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells." FEBS Letters, vol. 584, no. 15, 2010, pp. 3279-86. |
| Dubielecka PM, Grzybek M, Kolondra A, Jaźwiec B, Draga A, Aleksandrowicz P, Kołodziejczyk M, Serwotka A, Dolińska-Krajewska B, Warchoł J, Kuliczkowski K, Sikorski AF. "Aggregation of spectrin and PKCtheta is an early hallmark of fludarabine/mitoxantrone/dexamethasone-induced apoptosis in Jurkat T and HL60 cells." Molecular and Cellular Biochemistry, vol. 339, no. 1-2, 2010, pp. 63-77. |
| Dubielecka PM, Cui P, Xiong X, Hossain S, Heck S, Angelov L, Kotula L. "Differential regulation of macropinocytosis by Abi1/Hssh3bp1 isoforms." PLoS ONE, vol. 5, no. 5, 2010, pp. e10430. |
| Bok E, Plazuk E, Hryniewicz-Jankowska A, Chorzalska A, Szmaj A, Dubielecka PM, Stebelska K, Diakowski W, Lisowski M, Langner M, Sikorski AF. "Lipid-binding role of βII-spectrin ankyrin-binding domain." Cell Biology International, vol. 31, no. 12, 2007, pp. 1482-94. |
| Dubielecka, Patrycja M., Trusz, Anna, Diakowski, Witold, Grzybek, Michał, Chorzalska, Anna, Jaźwiec, Bozena, Lisowski, Marek, Jezierski, Adam, Sikorski, Aleksander F. "Mitoxantrone changes spectrin-aminophospholipid interactions." Molecular Membrane Biology, vol. 23, no. 3, 2006, pp. 235-43. |
| Dubielecka PM, Jaźwiec B, Potoczek S, Wróbel T, Miłoszewska J, Haus O, Kuliczkowski K, Sikorski AF. "Changes in spectrin organisation in leukaemic and lymphoid cells upon chemotherapy." Biochemical pharmacology, vol. 69, no. 1, 2005, pp. 73-85. |
| Grzybek M, Kozubek A, Dubielecka P, Sikorski AF. "Rafts--the current picture." Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, vol. 43, no. 1, 2005, pp. 3-10. |
| Stebelska, K., Dubielecka, P.M., Sikorski, A.F. "The Effect of PS Content on the Ability of Natural Membranes to Fuse with Positively Charged Liposomes and Lipoplexes." J Membrane Biol, vol. 206, no. 3, 2005, pp. 203-214. |
| Hryniewicz-Jankowska A, Bok E, Dubielecka P, Chorzalska A, Diakowski W, Jezierski A, Lisowski M, Sikorski AF. "Mapping of an ankyrin-sensitive, phosphatidylethanolamine/phosphatidylcholine mono- and bi-layer binding site in erythroid beta-spectrin." Biochem. J., vol. 382, no. Pt 2, 2004, pp. 677-85. |
| Dubielecka PM, Stebelska K, Jaźwiec B, Sikorski AF. "Cystocyte and lymphocyte derived fusomes/spectrosomes: analogies and differences: a mini-review." Cellular & molecular biology letters, vol. 8, no. 1, 2003, pp. 221-9. |
| Zhao H, Dubielecka PM, Söderlund T, Kinnunen PK. "Interactions of adriamycin, cytochrome c, and serum albumin with lipid monolayers containing poly(ethylene glycol)-ceramide." Biophysical Journal, vol. 83, no. 2, 2002, pp. 954-67. |
| Dubielecka P, Potoczek S, Jazwiec B, Miloszewska J, Kuliczkowski K, Sikorski AF. "The Effect Of Chemotherapy With Fluodarabine/Mitoxantrone/Dexamethasone On The Distribution Of Spectrin In Lymphocytes Of Non-Hodgkin Lymphoma Patients." Cellular & molecular biology letters, vol. 6, no. 2, 2001, pp. 200. |
The JAK/STAT cascade is dysregulated in nearly all myeloproliferative neoplasms (MPNs), however, currently available inhibitors that target the JAK/STAT pathway are not able to eradicate disease-initiating malignant hematopoietic stem cells. The objective of our reserch is to determine the role of newly identified Abelson interactor 1 (Abi-1)-driven immunomodulatory mechanisms responsible for malignant transformation of hematopoietic stem cells and initiation of MPN. Our ultimate goal is to develop new therapeutic strategies to eradicate disease initiating MPN stem cells.
NIH/NCI 1R01CA218079-01 (Dubielecka)
‘The role of Abelson interactor 1 (Abi-1) in hematopoietic stem cell self-renewal and malignant transformation’
NIH/NIGMS 1P20GM119943 (Quesenberry, Dubielecka)
‘Stem Cells and Aging’. Project 1: ‘Interrogating the Role of Abelson Interactor 1 in Age-Related Myelofibrosis.’
| Year | Degree | Institution |
|---|---|---|
| 2005 | PhD | University of Wroclaw |
| 2001 | MSc | University of Wroclaw |
| 1999 | BS | University of Wroclaw |
Polish Ministry of Education Award 3P04C09725 PhD project "Spectrin in early apoptosis in lymphoid and lymphoblastic cells'.
Socrates/Erasmus Scholarship of EU, Helsinki Biophysics & Biomembrane Group, Department Of Medical Chemistry, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
Socrates/Erasmus Scholarship of EU, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Department of Medical Biology and Genetics, Hradec Kralove, Czech Republic
2016 DEANS Award Brown University
Associate Professor of Medicine at the Alpert Medical School of Brown University
Head, Signal Transduction lab at the Rhode Island Hospital
