I am a physician investigator with clinical interests in adult internal medicine, preventive cardiology, and venous thrombosis, and research interests in coronary artery disease, thrombosis, and neurodegenerative disease. I am a Diplomate of the American Board of Internal Medicine, and a Fellow of American College of Cardiology. My research focuses on large biobanks, such as the AllofUS research program, to understand the clinical risks and genetic architecture of complex phenotypes, such as coronary artery disease and age associated mild cognitive impairement and dementia.
Currently, I am an attending physician at the Rhode Island Hospital. I also manage two non-profit clinical practices in Massachusetts (MAASHA Trust) and India (BHAASHA Foundation). In this capacity, I practice adult internal medicine and preventive cardiology in Massachusetts, while remotely managing an outreach primary care/urgent care clinic in India.
| Hariharan, Praveen, Bagheri, Minoo, Asamoah, Emelia, Voiculescu, Ioana, Singh, Purnima, Machipisa, Tafadzwa, Pottinger, Tess, Opekun, Antone. "Association of coronary artery bypass with cognitive impairment in coronary artery disease across APO (ε) genotypes in AllofUS." [], 2026. |
| Hariharan, Praveen, Machipisa, Tafadzwa, Bagheri, Minoo, Asamoah, Emelia, Singh, Purnima, Pottinger, Tess. "Evaluation of Genetic Architecture of Impaired Cognitive Disease With Coronary Artery Disease in AllofUS." [], 2026. |
| Hariharan, Praveen, Bagheri, Minoo, Asamoah, Emelia, Voiculescu, Ioana, Singh, Purnima, Machipisa, Tafadzwa, Pottinger, Tess, Opekun, Antone. "Comorbidities & coronary vascular disease (CVD) conditions in impaired cognitive disease with coronary artery disease (ICAD) inAllofUS." [], 2025. |
| Hariharan, Praveen, Nemchenok, Lina, Hadi, Mohanad, Williams, Vaugh, Caliendo, Angela. "Young Female With Hypereosinophilia, Rash, and Gait Disturbance: A Case Report." Cureus, 2024. |
| Hariharan P, Giordano N, Muzikansky A, Kabrhel C. "Clinical factors associated with massive pulmonary embolism and PE-related adverse clinical events." International Journal of Cardiology, vol. 330, 2021, pp. 194-199. |
| Hariharan P, Dupuis J. "Mapping gene and gene pathways associated with coronary artery disease: a CARDIoGRAM exome and multi-ancestry UK biobank analysis." Scientific reports, vol. 11, no. 1, 2021, pp. 16461. |
| Hariharan, Praveen, Dupuis, Josée. "MAPPING GENE PATHWAYS ASSOCIATED WITH CORONARY ARTERY DISEASE THROUGH VERSATILE GENE-BASED ASSOCIATION STUDY: A CARDIOGRAM EXOME ANALYSIS." Journal of the American College of Cardiology, vol. 77, no. 18, 2021, pp. 42. |
| Rosovsky R, Chang Y, Rosenfield K, Channick R, Jaff MR, Weinberg I, Sundt T, Witkin A, Rodriguez-Lopez J, Parry BA, Harshbarger S, Hariharan P, Kabrhel C. "Changes in treatment and outcomes after creation of a pulmonary embolism response team (PERT), a 10-year analysis." J Thromb Thrombolysis, vol. 47, no. 1, 2019, pp. 31-40. |
| Rosovsky R, Chang Y, Rosenfield K, Channick R, Jaff MR, Weinberg I, Sundt T, Witkin A, Rodriguez-Lopez J, Parry BA, Harshbarger S, Hariharan P, Kabrhel C. "Correction to: Changes in treatment and outcomes after creation of a pulmonary embolism response team (PERT), a 10-year analysis." J Thromb Thrombolysis, vol. 47, no. 1, 2019, pp. 41. |
| Dudzinski DM, Hariharan P, Parry BA, Chang Y, Kabrhel C. "Assessment of Right Ventricular Strain by Computed Tomography Versus Echocardiography in Acute Pulmonary Embolism." Academic Emergency Medicine, vol. 24, no. 3, 2017, pp. 337-343. |
| Hariharan P. "Erratum for Hariharan et al. "Relation Among Clot Burden, Right-Sided Heart Strain, and Adverse Events After Acute Pulmonary Embolism" Am J Cardiol 2016;118:1568-1573." The American Journal of Cardiology, vol. 120, no. 3, 2017, pp. 515. |
| Hariharan, Praveen, Dudzinski, David, Rosovsky, Rachel, MacMahon, Peter, Haddad, Faris, Okechukwu, Ikenna, Parry, Blair, Chang, Yuchiao, Kabrhel, Christopher. "ASSOCIATION OF HIGH CLOT BURDEN IN PULMONARY EMBOLISM WITH RIGHT HEART STRAIN AND IMMEDIATE ADVERSE CLINICAL EVENTS." Journal of the American College of Cardiology, vol. 67, no. 13, 2016, pp. 2248. |
| Barnes GD, Kabrhel C, Courtney DM, Naydenov S, Wood T, Rosovsky R, Rosenfield K, Giri J, National PERT Consortium Research Committee. "Diversity in the Pulmonary Embolism Response Team Model: An Organizational Survey of the National PERT Consortium Members." Chest, vol. 150, no. 6, 2016, pp. 1414-1417. |
| Hariharan P, Dudzinski DM, Rosovsky R, Haddad F, MacMahon P, Parry B, Chang Y, Kabrhel C. "Relation Among Clot Burden, Right-Sided Heart Strain, and Adverse Events After Acute Pulmonary Embolism." The American Journal of Cardiology, vol. 118, no. 10, 2016, pp. 1568-1573. |
| Cefalo P, Weinberg I, Hawkins BM, Hariharan P, Okechukwu I, Parry BA, Chang Y, Rosovsky R, Liu SW, Jaff MR, Kabrhel C. "A comparison of patients diagnosed with pulmonary embolism who are ≥65 years with patients <65 years." The American Journal of Cardiology, vol. 115, no. 5, 2015, pp. 681-6. |
| Hariharan P, Dudzinski DM, Okechukwu I, Takayesu JK, Chang Y, Kabrhel C. "Association between electrocardiographic findings, right heart strain, and short-term adverse clinical events in patients with acute pulmonary embolism." Clinical Cardiology, vol. 38, no. 4, 2015, pp. 236-42. |
| Hariharan, Praveen, Dudzinski, David, Okechukwu, Ikenna, Takayesu, James, Chang, Yuchiao, Kabrhel, Christopher. "ASSOCIATION BETWEEN ELECTROCARDIOGRAPHIC FINDINGS, RIGHT HEART STRAIN AND SHORT-TERM ADVERSE CLINICAL EVENTS IN PATIENTS WITH ACUTE PULMONARY EMBOLISM." Journal of the American College of Cardiology, vol. 63, no. 12, 2014, pp. A1492. |
| Kabrhel C, Okechukwu I, Hariharan P, Takayesu JK, MacMahon P, Haddad F, Chang Y. "Factors associated with clinical deterioration shortly after PE." Thorax, vol. 69, no. 9, 2014, pp. 835-42. |
| Hariharan P, Takayesu JK, Kabrhel C. "Association between the Pulmonary Embolism Severity Index (PESI) and short-term clinical deterioration." Thrombosis and haemostasis, vol. 105, no. 4, 2011, pp. 706-11. |
| Hariharan P, Kabrhel C. "Sensitivity of erythrocyte sedimentation rate and C-reactive protein for the exclusion of septic arthritis in emergency department patients." The Journal of Emergency Medicine, vol. 40, no. 4, 2011, pp. 428-31. |
| Kabrhel C, Sacco W, Liu S, Hariharan P. "Outcomes considered most important by emergency physicians when determining disposition of patients with pulmonary embolism." International Journal of Emergency Medicine, vol. 3, no. 4, 2010, pp. 239-64. |
Age associated Impaired Cognitive Disease (IC), i.e, all-cause dementia (ACD) or mild cognitive impairment (MCI), and Coronary Artery Disease (CAD) are a significant cause of morbidity in the aging societies, with associated increased financial burden to health care systems and patients. My research projects focus of exploring large biobanks like the AllofUS research program, to understand the clinical risks and genetic architecture of complex phenotypes like coronary artery disease and age associated cognitive impairment. These are the list of ongoing projects
1) Evaluation of association of coronary artery bypass graft procedure with impaired cognitive disease:
What is already known on this topic – Coronary artery disease (CAD) and Impaired Cognitive (IC) disease, i.e., mild cognitive impairment and all-cause dementia, share genetic, sociodemographic, and clinical factors, including cardiovascular conditions like coronary artery bypass grafting (CABG) procedure.
What this study adds – We observed an association between CABG (n=8,135) and IC (n=908) in CAD (n=22,349) participants after adjusting for sociodemographic, clinical factors, and APO (ε) effects. Further, when CAD participants were stratified across APO (ε) groups, CABG was significantly associated with IC in the APO ε2/ε3 group.
How this study might affect research, practice or policy – Our observations highlight the role of APO (ε) genotype evaluation in CAD patients for IC risk assessment.
2) Evaluation of statin use with impaired cognitive disease:
What is already known on this topic – Statins are widely used for primary and secondary prevention of CAD, however, the associatio of statin use and IC has been debated for many years.
What this study adds – We observed an association between IC and statin use in CAD participants (n=22,089, including 1343 with IC) after adjusting for sociodemographics, clinical factors, and APO (ε) genotypes. The association persisted after propensity score matching for sociodemographics, clinical factors, and APO (ε) genotypes. Further, when CAD participants were stratified across APO (ε) groups and by sex, statin was significantly associated with IC in the APO ε3ε3 group, and in females. Among CAD participants with documented baseline and latest lipids (total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL)), IC was associated with statin use regardless of baseline lipid levels or latest lipid levels. While we did not observe any change in association between IC and statin use, based on the magnitude of decrease in TC and LDL levels, we observed a higher magnitude of association between IC and statin use, with a greater increase in HDL levels.
How this study might affect research, practice or policy – Our observations highlight the association of IC and statin use in CAD and the role of APO (ε) genotype evaluation, and serial lipid level assessments for evaluating for statin associated IC in CAD.
3) Evaluation of shared genetic architecture between IC and CAD:
What is already known on this topic –
Genetic studies have focused on coronary artery disease (CAD) and age-associated impaired cognition (IC) separately and understanding the genetic architecture of IC with CAD (ICAD) can provide insight into shared gene-based clinical pathophysiology.
What this study adds –
We performed exome-wide association (ExWAS) for common variants in AllofUS participants (Age ≥60) with ICAD, defined using ICD/SNOMED codes. We further curated a list of IC (n=230) and CAD (n=420) associated SNVs based on ExWAS and previous genetic studies to compare traits between IC and CAD SNVs using phenome-wide association analysis. We identified rs429358 (APOE, OR:1.35 (1.27-1.45), p=7.1 x 10-21), rs11556505 (TOMM40, OR:1.24 (1.16-1.33), p=3.34 X 10-10), rs6857 (NECTIN2, OR:1.27 (1.19-1.35), p=1.3 x 10-12) and rs112502960 (ZNF652, OR:1.16 (1.10-1.22), p=9.5 X10-8) to be significantly associated with ICAD. Among shared traits between IC and CAD SNVs, we identified coronary atherosclerosis and hyperlipidemia associated with loci in APOE/APOC1/NECTIN2/ABCA1; hypertension with loci in LAMB2/TSPAN14/ZNF652; and conduction deficits with loci in TREML2/TMEM106B.
How this study might affect research, practice or policy –
Our study underscores importance of common cardiometabolic traits shared between IC and CAD SNVs, thereby providing insight into gene-based clinical pathophysiology of these complex phenotypes. Hence, future genetic or biomarker studies evaluating the association with specific cardiovascular phenotypes, such as conduction deficits in IC or CAD participants, can provide genetic or biomarker based risk prediction models for these high-risk groups
1) AllofUS Biomedical Research Scholars Program Project (NIH OT2OD031932): 2024
Hariharan (PI); Role: Principal Investigator
Title: Evaluate clinical, socio-behavioral, and genetic risk factors associated with patients having impaired cognition and coronary artery disease
2) Healthy Americas Foundation (NIH 3OT2OD025277): 2025
Hariharan (PI); Role: Principal Investigator
Title: Evaluation of shared clinical and genetic risk factors in impaired cognition and coronary artery disease across diverse ancestries
| Year | Degree | Institution |
|---|---|---|
| 2014 | MPH | Boston University |
| 2008 | MD | B. J. Medical College |
| Fellow | Massachusetts General Hospital/Harvard Medical School, Massachusetts General Hospital, cardiovascular research | 2012-2014 | Boston, MA, USA |
| Resident | Boston University School of Medicine, internal medicine | 2009-2012 |
Rhode Island Hospital, Providence, RI
MAASHA Trust clinic, Framingham, MA
BHAASHA Foundation, Gujarat, India
| Allopathic physician | State of Rhode Island | 2023-2024 | #19463 |
| Allopathic physician | Commonwealth of Massachusetts | 2012-2024 | #250635 |
| Attending Physician. Rhode Island Hospital, 2023- |
| Physician and trustee. MAASHA Trust, 2020- |
| Attending Physician. VA Boston Healthcare System, 2013-2020 |
2024- current
Community Doctoring Program Mentor
2025- current
Ultrasound course preceptor
