Rishi R. Lulla, MD, MS, is the division director of pediatric hematology/oncology at Hasbro Children’s Hospital and an international expert in the care of children and young adults with brain and spinal cord tumors. After completing medical school at Boston University, he went on to residency and fellowship at Northwestern University in Chicago. Dr. Lulla spent several years as an attending physician on the pediatric neuro-oncology team at Ann and Robert H. Lurie Children's Hospital of Chicago before moving to The Warren Alpert Medical School of Brown University in 2018.
His current research activities are focused on translating laboratory findings into novel treatment for children with brain and spinal cord tumors. He has presented his findings on pediatric central nervous system tumors at the local, national, and international levels, and he has served as principal investigator to multiple grant-sponsored research investigations including novel clinical trials. He served as the executive chair of the Children’s Brain Tumor Tissue Consortium and is an active member of the American Society of Pediatric Hematology Oncology, the Children’s Oncology Group, and the Society of Neuro-Oncology.
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"Pediatric high-grade glioma resources from the Children's Brain Tumor Tissue Consortium." 2020.
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| Huang T, Garcia R, Qi J, Lulla R, Horbinski C, Behdad A, Wadhwani N, Shilatifard A, James C, Saratsis AM. "Correction: Detection of histone H3 K27M mutation and post-translational modifications in pediatric diffuse midline glioma via tissue immunohistochemistry informs diagnosis and clinical outcomes." Oncotarget, vol. 10, no. 28, 2019, pp. 2788. |
| Gross JP, Powell S, Zelko F, Hartsell W, Goldman S, Fangusaro J, Lulla RR, Smiley NP, Chang JH, Gondi V. "Improved neuropsychological outcomes following proton therapy relative to X-ray therapy for pediatric brain tumor patients." Neuro-Oncology, vol. 21, no. 7, 2019, pp. 934-943. |
| Ijaz, Heba, Koptyra, Mateusz, Gaonkar, Krutika S, Rokita, Jo Lynne, Baubet, Valerie P, Tauhid, Lamiya, Zhu, Yuankun, Brown, Miguel, Lopez, Gonzalo, Zhang, Bo, Diskin, Sharon J, Vaksman, Zalman, Mason, Jennifer L, Appert, Elizabeth, Lilly, Jena, Lulla, Rishi, De Raedt, Thomas, Heath, Allison P, Felmeister, Alex, Raman, Pichai, Nazarian, Javad, Santi, Maria Rita, Storm, Phillip B, Resnick, Adam, Waanders, Angela J, Cole, Kristina A, None, None. "Pediatric high-grade glioma resources from the Children’s Brain Tumor Tissue Consortium." Neuro-Oncology, vol. 22, no. 1, 2019, pp. 163-165. |
| Kieran MW, Goumnerova L, Manley P, Chi SN, Marcus KJ, Manzanera AG, Polanco MLS, Guzik BW, Aguilar-Cordova E, Diaz-Montero CM, DiPatri AJ, Tomita T, Lulla R, Greenspan L, Aguilar LK, Goldman S. "Phase I study of gene-mediated cytotoxic immunotherapy with AdV-tk as adjuvant to surgery and radiation for pediatric malignant glioma and recurrent ependymoma." Neuro-Oncology, vol. 21, no. 4, 2019, pp. 537-546. |
| Katagi H, Louis N, Unruh D, Sasaki T, He X, Zhang A, Ma Q, Piunti A, Shimazu Y, Lamano JB, Carcaboso AM, Tian X, Seluanov A, Gorbunova V, Laurie KL, Kondo A, Wadhwani NR, Lulla R, Goldman S, Venneti S, Becher OJ, Zou L, Shilatifard A, Hashizume R. "Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma." Clin Cancer Res , vol. 25, no. 18, 2019, pp. 5572-5583. |
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"Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma. 2019." 2019.
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| Dobson THW, Tao RH, Swaminathan J, Maegawa S, Shaik S, Bravo-Alegria J, Sharma A, Kennis B, Yang Y, Callegari K, Haltom AR, Taylor P, Kogiso M, Qi L, Khatua S, Goldman S, Lulla RR, Fangusaro J, MacDonald TJ, Li XN, Hawkins C, Rajaram V, Gopalakrishnan V. "Transcriptional repressor REST drives lineage stage-specific chromatin compaction at <i>Ptch1</i> and increases AKT activation in a mouse model of medulloblastoma." Science Signaling, vol. 12, no. 565, 2019. |
| Huang T, Garcia R, Qi J, Lulla R, Horbinski C, Behdad A, Wadhwani N, Shilatifard A, James C, Saratsis AM. "Detection of histone H3 K27M mutation and post-translational modifications in pediatric diffuse midline glioma via tissue immunohistochemistry informs diagnosis and clinical outcomes." Oncotarget, vol. 9, no. 98, 2018, pp. 37112-37124. |
| Choi DK, Pillay-Smiley N, Marzec S, Wadhwani NR, DiPatri AJ, Tomita T, Lulla RR. "Primary Central Nervous System Malignant Melanoma in Children: A Case Series and Review of the Literature." Journal of Pediatric Hematology/Oncology, vol. 40, no. 8, 2018, pp. 616-619. |
| Marini BL, Benitez LL, Zureick AH, Salloum R, Gauthier AC, Brown J, Wu YM, Robinson DR, Kumar C, Lonigro R, Vats P, Cao X, Kasaian K, Anderson B, Mullan B, Chandler B, Linzey JR, Camelo-Piragua SI, Venneti S, McKeever PE, McFadden KA, Lieberman AP, Brown N, Shao L, Leonard MAS, Junck L, McKean E, Maher CO, Garton HJL, Muraszko KM, Hervey-Jumper S, Mulcahy-Levy JM, Green A, Hoffman LM, Dorris K, Vitanza NA, Wang J, Schwartz J, Lulla R, Smiley NP, Bornhorst M, Haas-Kogan DA, Robertson PL, Chinnaiyan AM, Mody R, Koschmann C. "Blood-brain barrier-adapted precision medicine therapy for pediatric brain tumors." Translational Research, vol. 188, 2017, pp. 27.e1-27.e14. |
| Finelt N, Lulla RR, Melin-Aldana H, Ruth JS, Lin FY, Su JM, Pourciau CY, Hunt RD, Kenner-Bell BM. "Bumps in the Road: Panniculitis in Children and Adolescents Treated with Vemurafenib." Pediatric dermatology, vol. 34, no. 3, 2017, pp. 337-341. |
| Huang TY, Piunti A, Lulla RR, Qi J, Horbinski CM, Tomita T, James CD, Shilatifard A, Saratsis AM. "Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma." Acta neuropathologica communications, vol. 5, no. 1, 2017, pp. 28. |
| Shaik S, Kennis B, Maegawa S, Schadler K, Yanwen Y, Callegari K, Lulla RR, Goldman S, Nazarian J, Rajaram V, Fangusaro J, Gopalakrishnan V. "REST upregulates gremlin to modulate diffuse intrinsic pontine glioma vasculature." Oncotarget, vol. 9, no. 4, 2017, pp. 5233-5250. |
| Piunti A, Hashizume R, Morgan MA, Bartom ET, Horbinski CM, Marshall SA, Rendleman EJ, Ma Q, Takahashi YH, Woodfin AR, Misharin AV, Abshiru NA, Lulla RR, Saratsis AM, Kelleher NL, James CD, Shilatifard A. "Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas." Nature Medicine, vol. 23, no. 4, 2017, pp. 493-500. |
| Ladomersky E, Genet M, Zhai L, Gritsina G, Lauing KL, Lulla RR, Fangusaro J, Lenzen A, Kumthekar P, Raizer JJ, Binder DC, James CD, Wainwright DA. "Improving vaccine efficacy against malignant glioma." Oncoimmunology, vol. 5, no. 8, 2016, pp. e1196311. |
| Hashizume R, Zhang A, Mueller S, Prados MD, Lulla RR, Goldman S, Saratsis AM, Mazar AP, Stegh AH, Cheng SY, Horbinski C, Haas-Kogan DA, Sarkaria JN, Waldman T, James CD. "Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth." Neuro-Oncology, vol. 18, no. 11, 2016, pp. 1519-1528. |
| Torchia J, Golbourn B, Feng S, Ho KC, Sin-Chan P, Vasiljevic A, Norman JD, Guilhamon P, Garzia L, Agamez NR, Lu M, Chan TS, Picard D, de Antonellis P, Khuong-Quang DA, Planello AC, Zeller C, Barsyte-Lovejoy D, Lafay-Cousin L, Letourneau L, Bourgey M, Yu M, Gendoo DMA, Dzamba M, Barszczyk M, Medina T, Riemenschneider AN, Morrissy AS, Ra YS, Ramaswamy V, Remke M, Dunham CP, Yip S, Ng HK, Lu JQ, Mehta V, Albrecht S, Pimentel J, Chan JA, Somers GR, Faria CC, Roque L, Fouladi M, Hoffman LM, Moore AS, Wang Y, Choi SA, Hansford JR, Catchpoole D, Birks DK, Foreman NK, Strother D, Klekner A, Bognár L, Garami M, Hauser P, Hortobágyi T, Wilson B, Hukin J, Carret AS, Van Meter TE, Hwang EI, Gajjar A, Chiou SH, Nakamura H, Toledano H, Fried I, Fults D, Wataya T, Fryer C, Eisenstat DD, Scheinemann K, Fleming AJ, Johnston DL, Michaud J, Zelcer S, Hammond R, Afzal S, Ramsay DA, Sirachainan N, Hongeng S, Larbcharoensub N, Grundy RG, Lulla RR, Fangusaro JR, Druker H, Bartels U, Grant R, Malkin D, McGlade CJ, Nicolaides T, Tihan T, Phillips J, Majewski J, Montpetit A, Bourque G, Bader GD, Reddy AT, Gillespie GY, Warmuth-Metz M, Rutkowski S, Tabori U, Lupien M, Brudno M, Schüller U, Pietsch T, Judkins AR, Hawkins CE, Bouffet E, Kim SK, Dirks PB, Taylor MD, Erdreich-Epstein A, Arrowsmith CH, De Carvalho DD, Rutka JT, Jabado N, Huang A. "Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors." Cancer Cell, vol. 30, no. 6, 2016, pp. 891-908. |
| Lulla, Rishi R., Saratsis, Amanda Muhs, Hashizume, Rintaro. "Mutations in chromatin machinery and pediatric high-grade glioma." Science Advances, vol. 2, no. 3, 2016, pp. e1501354. |
| Lulla RR, Goldman S, Yamada T, Beattie CW, Bressler L, Pacini M, Pollack IF, Fisher PG, Packer RJ, Dunkel IJ, Dhall G, Wu S, Onar A, Boyett JM, Fouladi M. "Phase I trial of p28 (NSC745104), a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in pediatric patients with recurrent or progressive central nervous system tumors: A Pediatric Brain Tumor Consortium Study." Neuro-Oncology, vol. 18, no. 9, 2016, pp. 1319-25. |
| Iqbal A, Eckerdt F, Bell J, Nakano I, Giles FJ, Cheng SY, Lulla RR, Goldman S, Platanias LC. "Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition." Oncotarget, vol. 7, no. 22, 2016, pp. 33192-201. |
| Malchenko S, Sredni ST, Hashimoto H, Kasai A, Nagayasu K, Xie J, Margaryan NV, Seiriki K, Lulla RR, Seftor RE, Pachman LM, Meltzer HY, Hendrix MJ, Soares MB. "A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells." PLoS ONE, vol. 10, no. 3, 2015, pp. e0121707. |
| Aw-Zoretic J, Wadhwani NR, Lulla RR, Ryan ME. "Erratum to: Imaging findings of anaplastic astrocytoma in a child with maple syrup urine disease: a case report." Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, vol. 31, no. 9, 2015, pp. 1631. |
| Aw-Zoretic J, Wadhwani NR, Lulla RR, Ryan ME. "Imaging findings of anaplastic astrocytoma in a child with maple syrup urine disease: a case report." Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, vol. 31, no. 9, 2015, pp. 1625-9. |
| Merino DM, Shlien A, Villani A, Pienkowska M, Mack S, Ramaswamy V, Shih D, Tatevossian R, Novokmet A, Choufani S, Dvir R, Ben-Arush M, Harris BT, Hwang EI, Lulla R, Pfister SM, Achatz MI, Jabado N, Finlay JL, Weksberg R, Bouffet E, Hawkins C, Taylor MD, Tabori U, Ellison DW, Gilbertson RJ, Malkin D. "Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups." Clin Cancer Res , vol. 21, no. 1, 2015, pp. 184-92. |
| Torchia J, Picard D, Lafay-Cousin L, Hawkins CE, Kim SK, Letourneau L, Ra YS, Ho KC, Chan TS, Sin-Chan P, Dunham CP, Yip S, Ng HK, Lu JQ, Albrecht S, Pimentel J, Chan JA, Somers GR, Zielenska M, Faria CC, Roque L, Baskin B, Birks D, Foreman N, Strother D, Klekner A, Garami M, Hauser P, Hortobágyi T, Bognár L, Wilson B, Hukin J, Carret AS, Van Meter TE, Nakamura H, Toledano H, Fried I, Fults D, Wataya T, Fryer C, Eisenstat DD, Scheineman K, Johnston D, Michaud J, Zelcer S, Hammond R, Ramsay DA, Fleming AJ, Lulla RR, Fangusaro JR, Sirachainan N, Larbcharoensub N, Hongeng S, Barakzai MA, Montpetit A, Stephens D, Grundy RG, Schüller U, Nicolaides T, Tihan T, Phillips J, Taylor MD, Rutka JT, Dirks P, Bader GD, Warmuth-Metz M, Rutkowski S, Pietsch T, Judkins AR, Jabado N, Bouffet E, Huang A. "Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis." The Lancet Oncology, vol. 16, no. 5, 2015, pp. 569-82. |
| Packer RJ, Rood BR, Turner DC, Stewart CF, Fisher M, Smith C, Young-Pouissant T, Goldman S, Lulla R, Banerjee A, Pollack I, Kun L, Onar-Thomas A, Wu S, Boyett JM, Fouladi M. "Phase I and pharmacokinetic trial of PTC299 in pediatric patients with refractory or recurrent central nervous system tumors: a PBTC study." J Neurooncol, vol. 121, no. 1, 2015, pp. 217-24. |
| Brower JV, Gans S, Hartsell WF, Goldman S, Fangusaro JR, Patel N, Lulla RR, Smiley NP, Chang JH, Gondi V. "Proton therapy and helical tomotherapy result in reduced dose deposition to the pancreas in the setting of cranio-spinal irradiation for medulloblastoma: implications for reduced risk of diabetes mellitus in long-term survivors." Acta oncologica (Stockholm, Sweden), vol. 54, no. 4, 2015, pp. 563-6. |
| Eckerdt F, Beauchamp E, Bell J, Iqbal A, Su B, Fukunaga R, Lulla RR, Goldman S, Platanias LC. "Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells." Oncotarget, vol. 5, no. 18, 2014, pp. 8442-51. |
| Rao VK, Haridas A, Nguyen TT, Lulla R, Wainwright MS, Goldstein JL. "Symptomatic cerebral vasospasm following resection of a medulloblastoma in a child." Neurocritical Care, vol. 18, no. 1, 2013, pp. 84-8. |
| Lulla RR, Costa FF, Bischof JM, Chou PM, de F Bonaldo M, Vanin EF, Soares MB. "Identification of Differentially Expressed MicroRNAs in Osteosarcoma." Sarcoma, vol. 2011, 2011, pp. 732690. |
| Costa FF, Bischof JM, Vanin EF, Lulla RR, Wang M, Sredni ST, Rajaram V, Bonaldo Mde F, Wang D, Goldman S, Tomita T, Soares MB. "Identification of microRNAs as potential prognostic markers in ependymoma." PLoS ONE, vol. 6, no. 10, 2011, pp. e25114. |
| Lulla RR, Thompson AA, Liem RI. "Elevated soluble transferrin receptor levels reflect increased erythropoietic drive rather than iron deficiency in pediatric sickle cell disease." Pediatric Blood & Cancer, vol. 55, no. 1, 2010, pp. 141-4. |
| Kondo A, Goldman S, Lulla RR, Mania-Farnell B, Vanin EF, Sredni ST, Rajaram V, Soares MB, Tomita T. "Longitudinal assessment of regional directed delivery in a rodent malignant glioma model." Journal of neurosurgery. Pediatrics, vol. 4, no. 6, 2009, pp. 592-8. |
| Patel D, Piotrowski ZH, Lulla RR. "Multiple births among adolescent women in Illinois." The Journal of reproductive medicine, vol. 42, no. 12, 1997, pp. 779-84. |
| Year | Degree | Institution |
|---|---|---|
| 2010 | MS | Northwestern University |
| 2003 | MD | Boston University School of Medicine |
| 1999 | BA | Boston University |
