Robert Reenan trained as a graduate student in the laboratory of Dr. Richard Kolodner at Harvard Medical School where he studied the process of DNA repair in yeast, discovering genes that would become important in human cancer. He then pursued post-doctoral work in the Laboratory of Genetics at University of Wisconsin-Madison under Dr. Barry Ganetzky. There, he started a lifelong love affair with behavioral neurogenetics studying, in particular, ion channel genes in the fruit fly. He began his independent career at the University of Connecticut Medical School in the Department of Genetics where he discovered the process of RNA editing in the nervous system of the fly. Reenan joined the faculty at Brown University in the summer of 2006.
| Silvestrini MJ, Johnson JR, Kumar AV, Thakurta TG, Blais K, Neill ZA, Marion SW, St Amand V, Reenan RA, Lapierre LR. "Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan." Cell Reports, vol. 23, no. 7, 2018, pp. 1915-1921. |
| McKerrow, Wilson H., Savva, Yiannis A., Rezaei, Ali, Reenan, Robert A., Lawrence, Charles E. "Predicting RNA hyper-editing with a novel tool when unambiguous alignment is impossible." BMC Genomics, vol. 18, no. 1, 2017. |
| Savva YA, Laurent GS, Reenan RA. "Genome-Wide Analysis of A-to-I RNA Editing." Methods in Molecular Biology, vol. 1358, 2016, pp. 255-68. |
| Savva YA, Rezaei A, St Laurent G, Reenan RA. "Reprogramming, Circular Reasoning and Self versus Non-self: One-Stop Shopping with RNA Editing." Frontiers in Genetics, vol. 7, 2016, pp. 100. |
| Reenan R. "Correcting mutations by RNA repair." New England Journal of Medicine, vol. 370, no. 2, 2014, pp. 172-4. |
| Rieder LE, Savva YA, Reyna MA, Chang YJ, Dorsky JS, Rezaei A, Reenan RA. "Dynamic response of RNA editing to temperature in Drosophila." BMC biology, vol. 13, 2014, pp. 1. |
| Birkenfeld, Andreas L., Samuel, Varman T., Shulman, Gerald I., De Cabo, Rafael, Reenan, Robert A., Zhu, Chen-Tseh, Helfand, Stephen. "I'm not Dead Yet: Flies and Mice." Biophysical Journal, vol. 106, no. 2, 2014, pp. 12a. |
| Savva YA, Reenan RA. "Identification of evolutionarily meaningful information within the mammalian RNA editing landscape." Genome Biology, vol. 15, no. 1, 2014, pp. 103. |
| Zhu CT, Chang C, Reenan RA, Helfand SL. "Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion." Aging, vol. 6, no. 1, 2014, pp. 58-69. |
| Schutte RJ, Schutte SS, Algara J, Barragan EV, Gilligan J, Staber C, Savva YA, Smith MA, Reenan R, O'Dowd DK. "Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current." Journal of Neurophysiology, vol. 112, no. 4, 2014, pp. 903-12. |
| Juliano CE, Reich A, Liu N, Götzfried J, Zhong M, Uman S, Reenan RA, Wessel GM, Steele RE, Lin H. "PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells." Proceedings of the National Academy of Sciences, vol. 111, no. 1, 2014, pp. 337-42. |
| St Laurent G, Tackett MR, Nechkin S, Shtokalo D, Antonets D, Savva YA, Maloney R, Kapranov P, Lawrence CE, Reenan RA. "Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila." Nature Structural & Molecular Biology, vol. 20, no. 11, 2013, pp. 1333-9. |
| Gell SL, Reenan RA. "Mutations to the piRNA pathway component aubergine enhance meiotic drive of segregation distorter in Drosophila melanogaster." Genetics, vol. 193, no. 3, 2013, pp. 771-84. |
| Savva YA, Jepson JE, Chang YJ, Whitaker R, Jones BC, St Laurent G, Tackett MR, Kapranov P, Jiang N, Du G, Helfand SL, Reenan RA. "RNA editing regulates transposon-mediated heterochromatic gene silencing." Nature Communications, vol. 4, 2013, pp. 2745. |
| Rieder LE, Staber CJ, Hoopengardner B, Reenan RA. "Tertiary structural elements determine the extent and specificity of messenger RNA editing." Nature Communications, vol. 4, 2013, pp. 2232. |
| Sun L, Gilligan J, Staber C, Schutte RJ, Nguyen V, O'Dowd DK, Reenan R. "A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure." Journal of Neuroscience, vol. 32, no. 41, 2012, pp. 14145-55. |
| Savva YA, Jepson JE, Sahin A, Sugden AU, Dorsky JS, Alpert L, Lawrence C, Reenan RA. "Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila." Nature Communications, vol. 3, 2012, pp. 790. |
| Garber G, Smith LA, Reenan RA, Rogina B. "Effect of sodium channel abundance on Drosophila development, reproductive capacity and aging." Fly, vol. 6, no. 1, 2012, pp. 57-67. |
| Ryan MY, Maloney R, Fineberg JD, Reenan RA, Horn R. "RNA editing in eag potassium channels: biophysical consequences of editing a conserved S6 residue." Channels, vol. 6, no. 6, 2012, pp. 443-52. |
| Savva YA, Rieder LE, Reenan RA. "The ADAR protein family." Genome Biology, vol. 13, no. 12, 2012, pp. 252. |
| Rieder LE, Reenan RA. "The intricate relationship between RNA structure, editing, and splicing." Seminars in cell & developmental biology, vol. 23, no. 3, 2012, pp. 281-8. |
| Jepson JE, Savva YA, Yokose C, Sugden AU, Sahin A, Reenan RA. "Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets." Journal of Biological Chemistry, vol. 286, no. 10, 2011, pp. 8325-37. |
| Bhogal B, Jepson JE, Savva YA, Pepper AS, Reenan RA, Jongens TA. "Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein." Nature Neuroscience, vol. 14, no. 12, 2011, pp. 1517-24. |
| Staber CJ, Gell S, Jepson JE, Reenan RA. "Perturbing A-to-I RNA editing using genetics and homologous recombination." Methods in Molecular Biology, vol. 718, 2011, pp. 41-73. |
| Pittendrigh BR, Berenbaum MR, Seufferheld MJ, Margam VM, Strycharz JP, Yoon KS, Sun W, Reenan R, Lee SH, Clark JM. "Simplify, simplify: Lifestyle and compact genome of the body louse provide a unique functional genomics opportunity." Communicative & integrative biology, vol. 4, no. 2, 2011, pp. 188-91. |
| Jepson JE, Savva YA, Jay KA, Reenan RA. "Visualizing adenosine-to-inosine RNA editing in the Drosophila nervous system." Nature methods, vol. 9, no. 2, 2011, pp. 189-94. |
| Horn R, Reenan R. "Channels get in an HUFA: RNA editing gets them out of a jam." EMBO J, vol. 29, no. 13, 2010, pp. 2097-8. |
| Ryan, Mary Y., Maloney, Rachel, Fineberg, Jeffrey, Reenan, Robert A., Horn, Richard. "Lysine Versus Arginine: RNA Editing In The Eag Potassium Channel." Biophysical Journal, vol. 98, no. 3, 2010, pp. 116a. |
| Colina, Claudia, Palavicini, Juan Pablo, Srikumar, Deepa, Holmgren, Miguel, Rosenthal, Joshua J. C. "Regulation of Na+/K+ ATPase Transport Velocity by RNA Editing." PLoS biology, vol. 8, no. 11, 2010, pp. e1000540. |
| Jepson JE, Reenan RA. "Unraveling pleiotropic functions of A-to-I RNA editing in Drosophila." Fly, vol. 4, no. 2, 2010, pp. 154-8. |
| Jepson JE, Reenan RA. "Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila." Journal of Biological Chemistry, vol. 284, no. 45, 2009, pp. 31391-400. |
| St Laurent G 3rd, Savva YA, Reenan R. "Enhancing non-coding RNA information content with ADAR editing." Neuroscience Letters, vol. 466, no. 2, 2009, pp. 89-98. |
| Ryan, Mary Y., Maloney, Rachel, Reenan, Robert A., Horn, Richard. "Functional Consequences of RNA Editing of the eag Potassium Channel." Biophysical Journal, vol. 96, no. 3, 2009, pp. 191a. |
| Ingleby L, Maloney R, Jepson J, Horn R, Reenan R. "Regulated RNA editing and functional epistasis in Shaker potassium channels." The Journal of general physiology, vol. 133, no. 1, 2009, pp. 17-27. |
| Reenan RA, Rogina B. "Acquired temperature-sensitive paralysis as a biomarker of declining neuronal function in aging Drosophila." Aging Cell, vol. 7, no. 2, 2008, pp. 179-86. |
| Ryan MY, Maloney R, Reenan R, Horn R. "Characterization of five RNA editing sites in Shab potassium channels." Channels, vol. 2, no. 3, 2008, pp. 202-9. |
| Jepson JE, Reenan RA. "RNA editing in regulating gene expression in the brain." Biochimica et biophysica acta, vol. 1779, no. 8, 2008, pp. 459-70. |
| Tedford HW, Maggio F, Reenan RA, King G. "A model genetic system for testing the in vivo function of peptide toxins." Peptides, vol. 28, no. 1, 2007, pp. 51-6. |
| Sixsmith J, Reenan RA. "Comparative genomic and bioinformatic approaches for the identification of new adenosine-to-inosine substrates." Methods in enzymology, vol. 424, 2007, pp. 245-64. |
| Drosophila 12 Genomes Consortium, Clark AG, Eisen MB, Smith DR, Bergman CM, Oliver B, Markow TA, Kaufman TC, Kellis M, Gelbart W, Iyer VN, Pollard DA, Sackton TB, Larracuente AM, Singh ND, Abad JP, Abt DN, Adryan B, Aguade M, Akashi H, Anderson WW, Aquadro CF, Ardell DH, Arguello R, Artieri CG, Barbash DA, Barker D, Barsanti P, Batterham P, Batzoglou S, Begun D, Bhutkar A, Blanco E, Bosak SA, Bradley RK, Brand AD, Brent MR, Brooks AN, Brown RH, Butlin RK, Caggese C, Calvi BR, Bernardo de Carvalho A, Caspi A, Castrezana S, Celniker SE, Chang JL, Chapple C, Chatterji S, Chinwalla A, Civetta A, Clifton SW, Comeron JM, Costello JC, Coyne JA, Daub J, David RG, Delcher AL, Delehaunty K, Do CB, Ebling H, Edwards K, Eickbush T, Evans JD, Filipski A, Findeiss S, Freyhult E, Fulton L, Fulton R, Garcia AC, Gardiner A, Garfield DA, Garvin BE, Gibson G, Gilbert D, Gnerre S, Godfrey J, Good R, Gotea V, Gravely B, Greenberg AJ, Griffiths-Jones S, Gross S, Guigo R, Gustafson EA, Haerty W, Hahn MW, Halligan DL, Halpern AL, Halter GM, Han MV, Heger A, Hillier L, Hinrichs AS, Holmes I, Hoskins RA, Hubisz MJ, Hultmark D, Huntley MA, Jaffe DB, Jagadeeshan S, Jeck WR, Johnson J, Jones CD, Jordan WC, Karpen GH, Kataoka E, Keightley PD, Kheradpour P, Kirkness EF, Koerich LB, Kristiansen K, Kudrna D, Kulathinal RJ, Kumar S, Kwok R, Lander E, Langley CH, Lapoint R, Lazzaro BP, Lee SJ, Levesque L, Li R, Lin CF, Lin MF, Lindblad-Toh K, Llopart A, Long M, Low L, Lozovsky E, Lu J, Luo M, Machado CA, Makalowski W, Marzo M, Matsuda M, Matzkin L, McAllister B, McBride CS, McKernan B, McKernan K, Mendez-Lago M, Minx P, Mollenhauer MU, Montooth K, Mount SM, Mu X, Myers E, Negre B, Newfeld S, Nielsen R, Noor MA, O'Grady P, Pachter L, Papaceit M, Parisi MJ, Parisi M, Parts L, Pedersen JS, Pesole G, Phillippy AM, Ponting CP, Pop M, Porcelli D, Powell JR, Prohaska S, Pruitt K, Puig M, Quesneville H, Ram KR, Rand D, Rasmussen MD, Reed LK, Reenan R, Reily A, Remington KA, Rieger TT, Ritchie MG, Robin C, Rogers YH, Rohde C, Rozas J, Rubenfield MJ, Ruiz A, Russo S, Salzberg SL, Sanchez-Gracia A, Saranga DJ, Sato H, Schaeffer SW, Schatz MC, Schlenke T, Schwartz R, Segarra C, Singh RS, Sirot L, Sirota M, Sisneros NB, Smith CD, Smith TF, Spieth J, Stage DE, Stark A, Stephan W, Strausberg RL, Strempel S, Sturgill D, Sutton G, Sutton GG, Tao W, Teichmann S, Tobari YN, Tomimura Y, Tsolas JM, Valente VL, Venter E, Venter JC, Vicario S, Vieira FG, Vilella AJ, Villasante A, Walenz B, Wang J, Wasserman M, Watts T, Wilson D, Wilson RK, Wing RA, Wolfner MF, Wong A, Wong GK, Wu CI, Wu G, Yamamoto D, Yang HP, Yang SP, Yorke JA, Yoshida K, Zdobnov E, Zhang P, Zhang Y, Zimin AV, Baldwin J, Abdouelleil A, Abdulkadir J, Abebe A, Abera B, Abreu J, Acer SC, Aftuck L, Alexander A, An P, Anderson E, Anderson S, Arachi H, Azer M, Bachantsang P, Barry A, Bayul T, Berlin A, Bessette D, Bloom T, Blye J, Boguslavskiy L, Bonnet C, Boukhgalter B, Bourzgui I, Brown A, Cahill P, Channer S, Cheshatsang Y, Chuda L, Citroen M, Collymore A, Cooke P, Costello M, D'Aco K, Daza R, De Haan G, DeGray S, DeMaso C, Dhargay N, Dooley K, Dooley E, Doricent M, Dorje P, Dorjee K, Dupes A, Elong R, Falk J, Farina A, Faro S, Ferguson D, Fisher S, Foley CD, Franke A, Friedrich D, Gadbois L, Gearin G, Gearin CR, Giannoukos G, Goode T, Graham J, Grandbois E, Grewal S, Gyaltsen K, Hafez N, Hagos B, Hall J, Henson C, Hollinger A, Honan T, Huard MD, Hughes L, Hurhula B, Husby ME, Kamat A, Kanga B, Kashin S, Khazanovich D, Kisner P, Lance K, Lara M, Lee W, Lennon N, Letendre F, LeVine R, Lipovsky A, Liu X, Liu J, Liu S, Lokyitsang T, Lokyitsang Y, Lubonja R, Lui A, MacDonald P, Magnisalis V, Maru K, Matthews C, McCusker W, McDonough S, Mehta T, Meldrim J, Meneus L, Mihai O, Mihalev A, Mihova T, Mittelman R, Mlenga V, Montmayeur A, Mulrain L, Navidi A, Naylor J, Negash T, Nguyen T, Nguyen N, Nicol R, Norbu C, Norbu N, Novod N, O'Neill B, Osman S, Markiewicz E, Oyono OL, Patti C, Phunkhang P, Pierre F, Priest M, Raghuraman S, Rege F, Reyes R, Rise C, Rogov P, Ross K, Ryan E, Settipalli S, Shea T, Sherpa N, Shi L, Shih D, Sparrow T, Spaulding J, Stalker J, Stange-Thomann N, Stavropoulos S, Stone C, Strader C, Tesfaye S, Thomson T, Thoulutsang Y, Thoulutsang D, Topham K, Topping I, Tsamla T, Vassiliev H, Vo A, Wangchuk T, Wangdi T, Weiand M, Wilkinson J, Wilson A, Yadav S, Young G, Yu Q, Zembek L, Zhong D, Zimmer A, Zwirko Z, Jaffe DB, Alvarez P, Brockman W, Butler J, Chin C, Gnerre S, Grabherr M, Kleber M, Mauceli E, MacCallum I. "Evolution of genes and genomes on the Drosophila phylogeny." J. Geophys. Res., vol. 450, no. 7167, 2007, pp. 203-18. |
| Jepson JE, Reenan RA. "Genetic approaches to studying adenosine-to-inosine RNA editing." Methods in enzymology, vol. 424, 2007, pp. 265-87. |
| Sattelle DB, Jones AK, Sattelle BM, Matsuda K, Reenan R, Biggin PC. "Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster." BioEssays : news and reviews in molecular, cellular and developmental biology, vol. 27, no. 4, 2005, pp. 366-76. |
| Reenan RA. "Molecular determinants and guided evolution of species-specific RNA editing." J. Geophys. Res., vol. 434, no. 7031, 2005, pp. 409-13. |
| Keegan LP, Brindle J, Gallo A, Leroy A, Reenan RA, O'Connell MA. "Tuning of RNA editing by ADAR is required in Drosophila." EMBO J, vol. 24, no. 12, 2005, pp. 2183-93. |
| Bhalla T, Rosenthal JJ, Holmgren M, Reenan R. "Control of human potassium channel inactivation by editing of a small mRNA hairpin." Nature Structural & Molecular Biology, vol. 11, no. 10, 2004, pp. 950-6. |
| Pedra, Joao H.F, Hostetler, Andrew, Gaffney, Patrick J, Reenan, Robert A, Pittendrigh, Barry R. "Hyper-susceptibility to deltamethrin in parats-1 DDT resistant Drosophila melanogaster." Pesticide Biochemistry and Physiology, vol. 78, no. 1, 2004, pp. 58-66. |
| Park JW, Parisky K, Celotto AM, Reenan RA, Graveley BR. "Identification of alternative splicing regulators by RNA interference in Drosophila." Proceedings of the National Academy of Sciences, vol. 101, no. 45, 2004, pp. 15974-9. |
| Hoopengardner B, Bhalla T, Staber C, Reenan R. "Nervous system targets of RNA editing identified by comparative genomics." Science, vol. 301, no. 5634, 2003, pp. 832-6. |
| Grauso M, Reenan RA, Culetto E, Sattelle DB. "Novel putative nicotinic acetylcholine receptor subunit genes, Dalpha5, Dalpha6 and Dalpha7, in Drosophila melanogaster identify a new and highly conserved target of adenosine deaminase acting on RNA-mediated A-to-I pre-mRNA editing." Genetics, vol. 160, no. 4, 2002, pp. 1519-33. |
| Reenan RA. "The RNA world meets behavior: A-->I pre-mRNA editing in animals." Trends in Genetics, vol. 17, no. 2, 2001, pp. 53-6. |
| Palladino MJ, Keegan LP, O'Connell MA, Reenan RA. "A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity." Cell, vol. 102, no. 4, 2000, pp. 437-49. |
| Palladino MJ, Keegan LP, O'Connell MA, Reenan RA. "dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing." RNA, vol. 6, no. 7, 2000, pp. 1004-18. |
| Rogina B, Reenan RA, Nilsen SP, Helfand SL. "Extended life-span conferred by cotransporter gene mutations in Drosophila." Science, vol. 290, no. 5499, 2000, pp. 2137-40. |
| Martin RL, Pittendrigh B, Liu J, Reenan R, ffrench-Constant R, Hanck DA. "Point mutations in domain III of a Drosophila neuronal Na channel confer resistance to allethrin." Insect biochemistry and molecular biology, vol. 30, no. 11, 2000, pp. 1051-9. |
| Hanrahan CJ, Palladino MJ, Ganetzky B, Reenan RA. "RNA editing of the Drosophila para Na(+) channel transcript. Evolutionary conservation and developmental regulation." Genetics, vol. 155, no. 3, 2000, pp. 1149-60. |
| Reenan RA, Hanrahan CJ, Ganetzky B. "The mle(napts) RNA helicase mutation in drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing." Neuron, vol. 25, no. 1, 2000, pp. 139-49. |
| Hanrahan CJ, Palladino MJ, Bonneau LJ, Reenan RA. "RNA editing of a Drosophila sodium channel gene." Annals of the New York Academy of Sciences, vol. 868, 1999, pp. 51-66. |
| Warmke JW, Reenan RA, Wang P, Qian S, Arena JP, Wang J, Wunderler D, Liu K, Kaczorowski GJ, Van der Ploeg LH, Ganetzky B, Cohen CJ. "Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology." The Journal of general physiology, vol. 110, no. 2, 1997, pp. 119-33. |
| Pittendrigh B, Reenan R, ffrench-Constant RH, Ganetzky B. "Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides." Molecular & general genetics : MGG, vol. 256, no. 6, 1997, pp. 602-10. |
| Alani E, Reenan RA, Kolodner RD. "Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae." Genetics, vol. 137, no. 1, 1994, pp. 19-39. |
| Reenan RA, Kolodner RD. "Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions." Genetics, vol. 132, no. 4, 1992, pp. 975-85. |
| Reenan RA, Kolodner RD. "Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins." Genetics, vol. 132, no. 4, 1992, pp. 963-73. |
Leila E Rieder, Yiannis A Savva, Matthew A Reyna, Yao-Jen Chang, Jacquelyn S Dorsky, Ali Rezaei and Robert A Reenan (2015) Dynamic response of RNA editing to temperature in Drosophila BMC Biology 2015, 13:1
Schutte RJ, Schutte SS, Algara J, Barragan EV, Gilligan J, Staber C, Savva YA, Smith MA, Reenan R, O'Dowd DK. (2014) Knock-in Model of Dravet Syndrome revelas a constitutive and conditional reduction in sodium current. J Neurophysiol. 112(4):903-912.
Savva YA, Reenan RA. (2014) Identification of evolutionarily meaningful information within the mammalian RNA editng landscape. Genome Biol. 2014 Jan 28;15(1):103.
Reenan, RA (2014) Correcting mutations by RNA repair. New England Journal of Medicine. 370(2):172-174.
Zhu C, Chang C, Reenan RA, and Helfand SL. (2014) Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion. Aging. 6(1):58-69.
Gell SL and Reenan RA. (2013) Mutations to the piRNA Pathway Component aubergine Enhance Meiotic Drive of Segregation Distorter in Drosophila melanogaster. Genetics. 193(3):771-784.
Rieder LE,Staber CJ,Barry Hoopengardner B. & Reenan RA. (2013) Tertiary structural elements determine the extent and specificity of messenger RNA editing. Nature Communications 4:2232 doi:10.1038/ncomms3232
St Laurent G, Tackett MR, Nechkin S, Shtokalo D, Antonets D, Savva SA, Maloney R, Kapranov P, Lawrence CE and RA Reenan. (2013) Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila. Nature Structural & Molecular Biology 20(11):1333-9.
Savva YA, Jepson JEC, Chang Y, Whitaker R, Jones BC, St Laurent G, Tackett MR, Kapranov P, Jiang N, Du G, Helfand SL, and
Reenan RA. (2013) RNA editing regulates transposon-mediated heterochromatic gene silencing.
Nature Communications 4:2745 doi:10.1038/ncomms3745
Juliano CE, Reich A, Liu N, Götzfried J, Zhong M, Uman S, Reenan RA, Wessel GM, Steele RE, Lin H. (2013) PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells. Proc Natl Acad Sci U S A. 111(1):337-42.
Rieder LE, Reenan RA. (2012) The intricate relationship between RNA structure, editing, and splicing. Semin Cell Dev Biol. 23(3):281-288.
Jepson JE, Savva YA, Jay KA, Reenan RA. (2012) Visualizing adenosine-to-inosine RNA editing in the Drosophila nervous system. Nature Methods 9(2):189-194.
Garber G, Smith LA, Reenan R, Rogina B. (2012) Effect of sodium channel abundance on Drosophila development, reproductive capacity and aging. Fly 6(1):57-67.
Savva YA, Jepson JE, Sahin A, Sugden AU, Dorsky JS, Alpert L, Lawrence C, Reenan RA. (2012) Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila. Nature Communications 3:790 doi:10.1038/ncomms1789
Sun L, Gilligan J, Staber C, Schutte RJ, Nguyen V, O'Dowd DK, Reenan R. (2012) A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure. J Neurosci. 32(41):14145-14155.
Ryan MY, Maloney R, Fineberg JD, Reenan RA, Horn R. (2012) RNA editing in eag potassium channels: Biophysical consequences of editing a conserved S6 residue. Channels 6(6):443-452.
Savva YA, Rieder LE, Reenan RA. (2012) The ADAR protein family. Genome Biology 13(12):252
Staber, C.J., Gell, S., Jepson, J.E. and Reenan, R.A. (2011) Perturbing A-to-I RNA Editing Using Genetics and Homologous Recombination. Methods Mol Biol 718:41-73.
Jepson JE, Savva YA, Yokose C, Sugden AU, Sahin A, Reenan RA. (2011) Engineered alterations in RNA editing modulate complex behavior in Drosophila: REGULATORY DIVERSITY OF ADENOSINE DEAMINASE ACTING ON RNA (ADAR) TARGETS. J Biol Chem. 286(10):8325-37.
Pittendrigh BR, Berenbaum MR, Seufferheld MJ, Margam VM, Strycharz JP, Yoon KS, Sun W, Reenan R, Lee SH, Clark JM. (2011) Simplify, simplify: Lifestyle and compact genome of the body louse provide a unique functional genomics opportunity. Commun Integr Biol. 4(2):188-91.
Bhogal B, Jepson JE, Savva YA, Pepper AS, Reenan RA, Jongens TA. (2011) Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein. Nature Neuroscience. 14(12):1517-1524.
Jepson, J.E. and Reenan, R.A. (2010) Unraveling pleiotropic functions of A-to-I RNA editing in Drosophila. Fly 4(2):154-158.
Horn, R. and Reenan, R. (2010) Channels get in an HUFA: RNA editing gets them out of a jam. EMBO J. 29(13):2097-8.
Ingleby, I., Maloney, R., Jepson, J., Horn, R. and Reenan, R. (2009) Regulated RNA editing and functional epistasis in Shaker potassium channels. J. Gen. Phys. 133(1):17-27.
St. Laurent, G., Savva, Y.A and Reenan R. (2009) Enhancing non-coding RNA information content with ADAR editing. Neuroscience Letters 466:89-98.
Jepson, J.E. and Reenan, R.A. (2009) Adenosine-to-inosine genetic recoding is required in the adult-stage nervous system for coordinated behavior in Drosophila. J Biol Chem. 284:31391-31400.
Jepson, J.E. and Reenan, R. (2008) RNA editing in regulating gene expression in the brain. Biochim Biophys Acta. 1779:459-470.
Reenan, R. and Rogina, B. (2008) Acquired temperature-sensitive paralysis as a biomarker of declining neuronal function in aging Drosophila. Aging Cell. 7(2):179-186.
Ryan, M.Y., Maloney, R., Reenan, R. and R. Horn. (2008) Characterization of five RNA editing sites in Shab potassium channels. Channels 2:3, 202-209.
Sixsmith, J. and R.A. Reenan (2007) Comparative genomic and bioinformatic approaches for the identification of new adenosine-to-inosine substrates. Methods in Enzymology 424:245-264.
Jepson, J. and R.A. Reenan (2007) Genetic approaches to studying adenosine-to-insosine RNA editing. Methods in Enzymology 424 :265-287.
Drosophila Comparative Genome Sequencing and Analysis Consortium (2007) Evolution of genes and genomes in the context of the Drosophila phylogeny. Nature 450:203-218.
H.W. Tedford, F. Maggio, R.A. Reenan and G. King. (2007) A model genetic system for testing the in vivo function of peptide toxins. Peptides 28(1):51-56
L.P. Keegan, J. Brindle, A. Gallo, A. Leroy, R.A. Reenan and M.A.O'Connell. (2005) Tuning of RNA editing by ADAR is required in Drosophila. EMBO Journal 24(12): 2183-2193.
R.A. Reenan (2005) Molecular determinants and guided evolution of species-specific RNA editing. Nature 434: 409-413.
D. B. Sattelle, A. K. Jones, B. M. Sattelle, K. Matsuda, R.A. Reenan and P. C. Biggin (2005) Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster. Bioessays 27: 366-376.
J.W. Park, K. Parisky, A.M. Celotto, R.A. Reenan and B.R. Graveley (2004). Identification of alternative splicing regulators by RNA interference in Drosophila. P.N.A.S 101:15974-15979.
T. Bhalla, J. Rosenthal, M. Holmgren and R.A. Reenan (2004) Control of human potassium channel inactivation by editing of a small mRNA hairpin. Nature Structural and Molecular Biology 11:950-956
J. Pedra, A. Hostetler, P. Gaffney, R.A. Reenan and B. Pittendrigh. (2004) Hyper-susceptibility to deltamethrin in parats1 DDT resistant Drosophila melanogaster. Pesticide Biochemistry and Physiology 78:58-66.
B. Hoopengardner, T. Bhalla, C. Staber, and R.A. Reenan. (2003) Nervous System Targets of RNA Editing Identified By Comparative Genomics. Science 301:832-836.
M. Grauso, R.A. Reenan, E. Culetto, D.B. Sattelle. (2002) Novel Putative Nicotinic Acetylcholine Receptor Subunit Genes, D_5, D_6 and D_7, in Drosophila melanogaster Identify a New and Highly Conserved Target of Adenosine Deaminase Acting on RNA-Mediated A-to-I Pre-mRNA Editing. Genetics 160(4):1519-1533
R.A. Reenan (2001) The RNA World Meets Behavior: A-to-I Pre-mRNA Editing in Animals. Trends in Genetics 17(2):53-55.
M.J. Palladino, L.P. Keegan, M.A. O'Connell and R.A. Reenan (2000) A-to-I pre-mRNA Editing In Drosophila is Primarily Involved in Adult Nervous System Function and Integrity. Cell 102:437-449.
R.L. Martin, B. Pittendrigh, J. Liu, R.A. Reenan, R. ffrench-Constant and D.A. Hanck. (2000) Point Mutations in Domain III of a Drosophila Neuronal Na+ Channel Confer Resistance to Allethrin. Insect Biochem. and Mol. Biol. 30: 1051-1059.
M.J. Palladino, L.P. Keegan, M.A. O'Connell and R.A. Reenan (2000) dADAR, a Drosophila Double-stranded RNA-specific Adenosine Deaminase is Highly Developmentally Regulated and is Itself a Target for RNA Editing. RNA 6:1004
C.J. Hanrahan, M.J. Palladino, B. Ganetzky and R.A. Reenan (2000) RNA Editing of the Drosophila para Na+ Channel Transcript: Evolutionary Conservation and Developmental Regulation. Genetics 155:1149-1160.
Reenan, R.A., Hanrahan, C.J. and Ganetzky, B. (2000) The mlenapts RNA Helicase Mutation in Drosophila Results in a Splicing Catastrophe of the para Na+ Channel Transcript in a Region of RNA editing. Neuron 25: 139-149.
B. Rogina, R.A. Reenan, Nilsen, S.P. and S.L. Helfand (2000) Extended Life Span Conferred by Cotransporter Gene Mutations in Drosophila. Science 290:2137-2140.
| Year | Degree | Institution |
|---|---|---|
| 1991 | PhD | Harvard University |
| 1984 | AB | University of Missouri at Columbia |
| Name | Title |
|---|---|
| Lawrence, Charles | Professor of Applied Mathematics (Research), Professor Emeritus of Applied Mathematics |
| BIOL 0470 - Genetics |
| BIOL 1540 - Molecular Genetics |
| BIOL 2150 - Scientific Communication |
| BIOL 2340 - Neurogenetics and Disease |
