Robert W. Sobol is a Professor in the Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University and was also recently named the Associate Director for basic research and co-leader of the Cancer Biology Program at the Legorreta Cancer Center at Brown University. In these roles, he leads efforts toward continued growth of the department and of the basic science programs at the Legorreta Cancer Center.
At Brown, my lab’s research will focus on the role of the DNA base excision repair pathway in the regulation of PARP activation and the response to replication stress, and the identification of novel targets to overcome PARP-inhibitor resistance. We are also working on the development of novel biological tools and assays to evaluate PARP-activation, genotoxic stress, and gene-environment interactions and the utilization of these novel tools for the analysis of tumor response, the response to industrial pollutants, and the discovery of molecules that inhibit cellular repair. Further, my lab has a translational focus on how these PARP-dependent DNA damage response pathways impact tumor cell survival, genotoxicity, cellular aging, and response to chemo- and immune checkpoint-based therapies.
| Almeida KH, Andrews ME, Sobol RW. "AP endonuclease 1: Biological updates and advances in activity analysis." Methods in enzymology, vol. 705, 2024, pp. 347-376. |
| Quiñones JL, Tang M, Fang Q, Sobol RW, Demple B. "C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks." DNA Repair, vol. 143, 2024, pp. 103756. |
| Acharya G, Mani C, Sah N, Saamarthy K, Young R, Reedy MB, Sobol RW, Palle K. "CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer." Cell death discovery, vol. 10, no. 1, 2024, pp. 278. |
| Ge J, Ngo LP, Kaushal S, Tay IJ, Thadhani E, Kay JE, Mazzucato P, Chow D, Fessler J, Weingeist DM, Sobol RW, Samson LD, Floyd SR, Engelward BP. "CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176-103202]." DNA Repair, vol. 138, 2024, pp. 103677. |
| Pandya P, Vendetti FP, El-Ghoubaira J, Pathak S, Deppas JJ, Jones R, Columbus AV, Zhang Y, Ivanov D, Huang Z, MacDonald KM, Harding SM, Buj R, Aird KM, Beumer JH, Sobol RW, Bakkenist CJ. "Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy." bioRxiv : the preprint server for biology, 2024. |
| Almohdar D, Gulkis M, Ortiz A, Tang Q, Sobol RW, Çağlayan M. "Impact of polβ/XRCC1 Interaction Variants on the Efficiency of Nick Sealing by DNA Ligase IIIα in the Base Excision Repair Pathway." Journal of molecular biology, vol. 436, no. 4, 2024, pp. 168410. |
| Yan S, Gaddameedhi S, Sobol RW. "Inspiring basic and applied research in genome integrity mechanisms: Dedication to Samuel H. Wilson." Environmental and molecular mutagenesis, vol. 65 Suppl 1, no. Suppl 1, 2024, pp. 4-8. |
| Sobol RW. "Mouse models to explore the biological and organismic role of DNA polymerase beta." Environmental and molecular mutagenesis, vol. 65 Suppl 1, no. Suppl 1, 2024, pp. 57-71. |
| Saville, Kate M., Al-Rahahleh, Rasha Q., Siddiqui, Aisha H., Andrews, Morgan E., Roos, Wynand P., Koczor, Christopher A., Andrews, Joel F., Hayat, Faisal, Migaud, Marie E., Sobol, Robert W. "Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity." DNA Repair, vol. 140, 2024, pp. 103700. |
| Al-Rahahleh RQ, Sobol RW. "Poly-ADP-ribosylation dynamics, signaling, and analysis." Environmental and molecular mutagenesis, 2024. |
| Lin CH, Chin Y, Zhou M, Sobol RW, Hung MC, Tan M. "Protein lipoylation: mitochondria, cuproptosis, and beyond." Trends in biochemical sciences, vol. 49, no. 8, 2024, pp. 729-744. |
| Kratz A, Kim M, Kelly MR, Zheng F, Koczor CA, Li J, Ono K, Qin Y, Churas C, Chen J, Pillich RT, Park J, Modak M, Collier R, Licon K, Pratt D, Sobol RW, Krogan NJ, Ideker T. "A multi-scale map of protein assemblies in the DNA damage response." Cell Systems, 2023. |
| Das D, Duncton MAJ, Georgiadis TM, Pellicena P, Clark J, Sobol RW, Georgiadis MM, King-Underwood J, Jobes DV, Chang C, Gao Y, Deacon AM, Wilson DM 3rd. "A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1." International Journal of Molecular Sciences, vol. 24, no. 23, 2023. |
| Koczor CA, Thompson MK, Sharma N, Prakash A, Sobol RW. "Polβ/XRCC1 heterodimerization dictates DNA damage recognition and basal Polβ protein levels without interfering with mouse viability or fertility." DNA Repair, vol. 123, 2023, pp. 103452. |
| Koczor CA, Saville KM, Al-Rahahleh RQ, Andrews JF, Li J, Sobol RW. "Quantitative Analysis of Nuclear Poly(ADP-Ribose) Dynamics in Response to Laser-Induced DNA Damage." Methods in Molecular Biology, vol. 2609, 2023, pp. 43-59. |
| Chin Y, Gumilar KE, Li XG, Tjokroprawiro BA, Lu CH, Lu J, Zhou M, Sobol RW, Tan M. "Targeting HSF1 for cancer treatment: mechanisms and inhibitor development." Theranostics, vol. 13, no. 7, 2023, pp. 2281-2300. |
| Sobol RW. "WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency." Proceedings of the National Academy of Sciences, vol. 120, no. 2, 2023, pp. e2219963120. |
| Li J, Beiser A, Dey NB, Takeda S, Saha LK, Hirota K, Parker LL, Carter M, Arrieta MI, Sobol RW. "A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage." NAR genomics and bioinformatics, vol. 4, no. 3, 2022, pp. lqac065. |
| Mancuso P, Tricarico R, Bhattacharjee V, Cosentino L, Kadariya Y, Jelinek J, Nicolas E, Einarson M, Beeharry N, Devarajan K, Katz RA, Dorjsuren DG, Sun H, Simeonov A, Giordano A, Testa JR, Davidson G, Davidson I, Larue L, Sobol RW, Yen TJ, Bellacosa A. "Correction to: Thymine DNA glycosylase as a novel target for melanoma." Oncogene, vol. 41, no. 23, 2022, pp. 3300-3301. |
| Fujii S, Sobol RW, Fuchs RP. "Double-strand breaks: When DNA repair events accidentally meet." DNA Repair, vol. 112, 2022, pp. 103303. |
| Yan S, Zhao J, Kemp M, Sobol RW. "Editorial: Mechanistic studies of genome integrity, environmental health, and cancer etiology." Frontiers in Cell and Developmental Biology, vol. 10, 2022, pp. 1026326. |
| Koczor CA, Haider AJ, Saville KM, Li J, Andrews JF, Beiser AV, Sobol RW. "Live Cell Detection of Poly(ADP-Ribose) for Use in Genetic and Genotoxic Compound Screens." Cancers, vol. 14, no. 15, 2022. |
| Li J, Koczor CA, Saville KM, Hayat F, Beiser A, McClellan S, Migaud ME, Sobol RW. "Overcoming Temozolomide Resistance in Glioblastoma via Enhanced NAD(+) Bioavailability and Inhibition of Poly-ADP-Ribose Glycohydrolase." Cancers, vol. 14, no. 15, 2022. |
| Li J, Garavaglia S, Ye Z, Moretti A, Belyaeva OV, Beiser A, Ibrahim M, Wilk A, McClellan S, Klyuyeva AV, Goggans KR, Kedishvili NY, Salter EA, Wierzbicki A, Migaud ME, Mullett SJ, Yates NA, Camacho CJ, Rizzi M, Sobol RW. "A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells." Communications biology, vol. 4, no. 1, 2021, pp. 1420. |
| Ge J, Ngo LP, Kaushal S, Tay IJ, Thadhani E, Kay JE, Mazzucato P, Chow DN, Fessler JL, Weingeist DM, Sobol RW, Samson LD, Floyd SR, Engelward BP. "CometChip enables parallel analysis of multiple DNA repair activities." DNA Repair, vol. 106, 2021, pp. 103176. |
| Thompson MK, Sobol RW, Prakash A. "Exploiting DNA Endonucleases to Advance Mechanisms of DNA Repair." Biology, vol. 10, no. 6, 2021. |
| Li J, M Saville K, Ibrahim M, Zeng X, McClellan S, Angajala A, Beiser A, Andrews JF, Sun M, Koczor CA, Clark J, Hayat F, Makarov MV, Wilk A, Yates NA, Migaud ME, Sobol RW. "NAD(+) bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells." NAR cancer, vol. 3, no. 4, 2021, pp. zcab044. |
| Snyder NW, O'Brien J, Singh B, Buchan G, Arroyo AD, Liu X, Bostwick A, Varner EL, Angajala A, Sobol RW, Blair IA, Mesaros C, Wendell SG. "Primary saturation of α, β-unsaturated carbonyl containing fatty acids does not abolish electrophilicity." Chemico-biological interactions, vol. 350, 2021, pp. 109689. |
| Kim JH, Jeong K, Li J, Murphy JM, Vukadin L, Stone JK, Richard A, Tran J, Gillespie GY, Flemington EK, Sobol RW, Lim SS, Ahn EE. "SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity." Nature Communications, vol. 12, no. 1, 2021, pp. 5551. |
| Koczor CA, Saville KM, Andrews JF, Clark J, Fang Q, Li J, Al-Rahahleh RQ, Ibrahim M, McClellan S, Makarov MV, Migaud ME, Sobol RW. "Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD(+)/SIRT6 axis." Cell Reports, vol. 37, no. 5, 2021, pp. 109917. |
| Wilk A, Hayat F, Cunningham R, Li J, Garavaglia S, Zamani L, Ferraris DM, Sykora P, Andrews J, Clark J, Davis A, Chaloin L, Rizzi M, Migaud M, Sobol RW. "Extracellular NAD(+) enhances PARP-dependent DNA repair capacity independently of CD73 activity." Scientific reports, vol. 10, no. 1, 2020, pp. 651. |
| Saville KM, Clark J, Wilk A, Rogers GD, Andrews JF, Koczor CA, Sobol RW. "NAD(+)-mediated regulation of mammalian base excision repair." DNA Repair, vol. 93, 2020, pp. 102930. |
| Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ. "Regulation of ALT-associated homology-directed repair by polyADP-ribosylation." Nature Structural & Molecular Biology, vol. 27, no. 12, 2020, pp. 1152-1164. |
| Liu Z, Zhang W, Phillips JB, Arora R, McClellan S, Li J, Kim JH, Sobol RW, Tan M. "Immunoregulatory protein B7-H3 regulates cancer stem cell enrichment and drug resistance through MVP-mediated MEK activation." Oncogene, vol. 38, no. 1, 2019, pp. 88-102. |
| Rai P, Sobol RW. "Mechanisms of MTH1 inhibition-induced DNA strand breaks: The slippery slope from the oxidized nucleotide pool to genotoxic damage." DNA Repair, vol. 77, 2019, pp. 18-26. |
| Sannai M, Doneddu V, Giri V, Seeholzer S, Nicolas E, Yip SC, Bassi MR, Mancuso P, Cortellino S, Cigliano A, Lurie R, Ding H, Chernoff J, Sobol RW, Yen TJ, Bagella L, Bellacosa A. "Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1." DNA Repair, vol. 82, 2019, pp. 102687. |
| Fang Q, Andrews J, Sharma N, Wilk A, Clark J, Slyskova J, Koczor CA, Lans H, Prakash A, Sobol RW. "Stability and sub-cellular localization of DNA polymerase β is regulated by interactions with NQO1 and XRCC1 in response to oxidative stress." Nucleic acids research, vol. 47, no. 12, 2019, pp. 6269-6286. |
| Mancuso P, Tricarico R, Bhattacharjee V, Cosentino L, Kadariya Y, Jelinek J, Nicolas E, Einarson M, Beeharry N, Devarajan K, Katz RA, Dorjsuren DG, Sun H, Simeonov A, Giordano A, Testa JR, Davidson G, Davidson I, Larue L, Sobol RW, Yen TJ, Bellacosa A. "Thymine DNA glycosylase as a novel target for melanoma." Oncogene, vol. 38, no. 19, 2019, pp. 3710-3728. |
| Sykora P, Chiari Y, Heaton A, Moreno N, Glaberman S, Sobol RW. "Application of the CometChip platform to assess DNA damage in field-collected blood samples from turtles." Environmental and molecular mutagenesis, vol. 59, no. 4, 2018, pp. 322-333. |
| Sonavane M, Sykora P, Andrews JF, Sobol RW, Gassman NR. "Camptothecin Efficacy to Poison Top1 Is Altered by Bisphenol A in Mouse Embryonic Fibroblasts." Chemical Research in Toxicology, vol. 31, no. 6, 2018, pp. 510-519. |
| Li J, Svilar D, McClellan S, Kim JH, Ahn EE, Vens C, Wilson DM 3rd, Sobol RW. "DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity." Oncotarget, vol. 9, no. 60, 2018, pp. 31719-31743. |
| Sykora P, Witt KL, Revanna P, Smith-Roe SL, Dismukes J, Lloyd DG, Engelward BP, Sobol RW. "Next generation high throughput DNA damage detection platform for genotoxic compound screening." Scientific reports, vol. 8, no. 1, 2018, pp. 2771. |
| Ding L, Dean-Ben XL, Burton NC, Sobol RW, Ntziachristos V, Razansky D. "Constrained Inversion and Spectral Unmixing in Multispectral Optoacoustic Tomography." IEEE transactions on medical imaging, vol. 36, no. 8, 2017, pp. 1676-1685. |
| Golato T, Brenerman B, McNeill DR, Li J, Sobol RW, Wilson DM 3rd. "Development of a Cell-Based Assay for Measuring Base Excision Repair Responses." Scientific reports, vol. 7, no. 1, 2017, pp. 13007. |
| Sawant A, Floyd AM, Dangeti M, Lei W, Sobol RW, Patrick SM. "Differential role of base excision repair proteins in mediating cisplatin cytotoxicity." DNA Repair, vol. 51, 2017, pp. 46-59. |
| Sykora P, Kanno S, Akbari M, Kulikowicz T, Baptiste BA, Leandro GS, Lu H, Tian J, May A, Becker KA, Croteau DL, Wilson DM 3rd, Sobol RW, Yasui A, Bohr VA. "DNA Polymerase Beta Participates in Mitochondrial DNA Repair." Molecular and Cellular Biology, vol. 37, no. 16, 2017. |
| Bigarella CL, Li J, Rimmelé P, Liang R, Sobol RW, Ghaffari S. "FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage." Journal of Biological Chemistry, vol. 292, no. 7, 2017, pp. 3005-3015. |
| Soll JM, Sobol RW, Mosammaparast N. "Regulation of DNA Alkylation Damage Repair: Lessons and Therapeutic Opportunities." Trends in biochemical sciences, vol. 42, no. 3, 2017, pp. 206-218. |
| Nagel ZD, Engelward BP, Brenner DJ, Begley TJ, Sobol RW, Bielas JH, Stambrook PJ, Wei Q, Hu JJ, Terry MB, Dilworth C, McAllister KA, Reinlib L, Worth L, Shaughnessy DT. "Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease." Mutation research, vol. 800-802, 2017, pp. 14-28. |
| Braganza A, Li J, Zeng X, Yates NA, Dey NB, Andrews J, Clark J, Zamani L, Wang XH, St Croix C, O'Sullivan R, Garcia-Exposito L, Brodsky JL, Sobol RW. "UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase." Journal of Biological Chemistry, vol. 292, no. 6, 2017, pp. 2470-2484. |
| Srivas R, Shen JP, Yang CC, Sun SM, Li J, Gross AM, Jensen J, Licon K, Bojorquez-Gomez A, Klepper K, Huang J, Pekin D, Xu JL, Yeerna H, Sivaganesh V, Kollenstart L, van Attikum H, Aza-Blanc P, Sobol RW, Ideker T. "A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy." Molecular Cell, vol. 63, no. 3, 2016, pp. 514-25. |
| Li H, Gu L, Zhong Y, Chen Y, Zhang L, Zhang AR, Sobol RW, Chen T, Li J. "Administration of polysaccharide from Panax notoginseng prolonged the survival of H22 tumor-bearing mice." OncoTargets and therapy, vol. 9, 2016, pp. 3433-41. |
| Simonelli V, Leuzzi G, Basile G, D'Errico M, Fortini P, Franchitto A, Viti V, Brown AR, Parlanti E, Pascucci B, Palli D, Giuliani A, Palombo F, Sobol RW, Dogliotti E. "Crosstalk between mismatch repair and base excision repair in human gastric cancer." Oncotarget, vol. 8, no. 49, 2016, pp. 84827-84840. |
| Moretti A, Li J, Donini S, Sobol RW, Rizzi M, Garavaglia S. "Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid." Scientific reports, vol. 6, 2016, pp. 35710. |
| Fouquerel E, Lormand J, Bose A, Lee HT, Kim GS, Li J, Sobol RW, Freudenthal BD, Myong S, Opresko PL. "Oxidative guanine base damage regulates human telomerase activity." Nature Structural & Molecular Biology, vol. 23, no. 12, 2016, pp. 1092-1100. |
| Godin SK, Zhang Z, Herken BW, Westmoreland JW, Lee AG, Mihalevic MJ, Yu Z, Sobol RW, Resnick MA, Bernstein KA. "The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products." Nucleic acids research, vol. 44, no. 17, 2016, pp. 8199-215. |
| Wendell SG, Golin-Bisello F, Wenzel S, Sobol RW, Holguin F, Freeman BA. "15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids." Journal of Biological Chemistry, vol. 290, no. 9, 2015, pp. 5868-80. |
| Wang J, Li J, Santana-Santos L, Shuda M, Sobol RW, Van Houten B, Qian W. "A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi-1." Molecular oncology, vol. 9, no. 2, 2015, pp. 488-502. |
| Shen JP, Srivas R, Gross A, Li J, Jaehnig EJ, Sun SM, Bojorquez-Gomez A, Licon K, Sivaganesh V, Xu JL, Klepper K, Yeerna H, Pekin D, Qiu CP, van Attikum H, Sobol RW, Ideker T. "Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition." Oncotarget, vol. 6, no. 34, 2015, pp. 35755-69. |
| Quiñones JL, Thapar U, Yu K, Fang Q, Sobol RW, Demple B. "Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivo." Proceedings of the National Academy of Sciences, vol. 112, no. 28, 2015, pp. 8602-7. |
| Chandran UR, Luthra S, Santana-Santos L, Mao P, Kim SH, Minata M, Li J, Benos PV, DeWang M, Hu B, Cheng SY, Nakano I, Sobol RW. "Gene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells." Genomics data, vol. 5, 2015, pp. 333-336. |
| Brown MF, Leibowitz BJ, Chen D, He K, Zou F, Sobol RW, Beer-Stolz D, Zhang L, Yu J. "Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis." Cell death & disease, vol. 6, no. 4, 2015, pp. e1729. |
| Sawant A, Kothandapani A, Zhitkovich A, Sobol RW, Patrick SM. "Role of mismatch repair proteins in the processing of cisplatin interstrand cross-links." DNA Repair, vol. 35, 2015, pp. 126-36. |
| Fouquerel E, Sobol RW. "ARTD1 (PARP1) activation and NAD(+) in DNA repair and cell death." DNA Repair, vol. 23, 2014, pp. 27-32. |
| Fouquerel E, Goellner EM, Yu Z, Gagné JP, Barbi de Moura M, Feinstein T, Wheeler D, Redpath P, Li J, Romero G, Migaud M, Van Houten B, Poirier GG, Sobol RW. "ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion." Cell Reports, vol. 8, no. 6, 2014, pp. 1819-1831. |
| Agnihotri S, Burrell K, Buczkowicz P, Remke M, Golbourn B, Chornenkyy Y, Gajadhar A, Fernandez NA, Clarke ID, Barszczyk MS, Pajovic S, Ternamian C, Head R, Sabha N, Sobol RW, Taylor MD, Rutka JT, Jones C, Dirks PB, Zadeh G, Hawkins C. "ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents." Cancer Discovery, vol. 4, no. 10, 2014, pp. 1198-213. |
| Choi YJ, Li H, Son MY, Wang XH, Fornsaglio JL, Sobol RW, Lee M, Vijg J, Imholz S, Dollé ME, van Steeg H, Reiling E, Hasty P. "Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair." PLoS ONE, vol. 9, no. 1, 2014, pp. e86358. |
| Fang Q, Inanc B, Schamus S, Wang XH, Wei L, Brown AR, Svilar D, Sugrue KF, Goellner EM, Zeng X, Yates NA, Lan L, Vens C, Sobol RW. "HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β." Nature Communications, vol. 5, 2014, pp. 5513. |
| Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. "Mitochondria, energetics, epigenetics, and cellular responses to stress." Environ Health Perspect, vol. 122, no. 12, 2014, pp. 1271-8. |
| Lan L, Nakajima S, Wei L, Sun L, Hsieh CL, Sobol RW, Bruchez M, Van Houten B, Yasui A, Levine AS. "Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin." Nucleic acids research, vol. 42, no. 4, 2014, pp. 2330-45. |
| Bennett GR, Peters R, Wang XH, Hanne J, Sobol RW, Bundschuh R, Fishel R, Yoder KE. "Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference." PLoS ONE, vol. 9, no. 7, 2014, pp. e103164. |
| Li J, Braganza A, Sobol RW. "Base excision repair facilitates a functional relationship between Guanine oxidation and histone demethylation." Antioxidants & redox signaling, vol. 18, no. 18, 2013, pp. 2429-43. |
| Kothandapani A, Sawant A, Dangeti VS, Sobol RW, Patrick SM. "Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity." Nucleic acids research, vol. 41, no. 15, 2013, pp. 7332-43. |
| Joshi K, Banasavadi-Siddegowda Y, Mo X, Kim SH, Mao P, Kig C, Nardini D, Sobol RW, Chow LM, Kornblum HI, Waclaw R, Beullens M, Nakano I. "MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells." STEM CELLS, vol. 31, no. 6, 2013, pp. 1051-63. |
| Mao P, Joshi K, Li J, Kim SH, Li P, Santana-Santos L, Luthra S, Chandran UR, Benos PV, Smith L, Wang M, Hu B, Cheng SY, Sobol RW, Nakano I. "Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3." Proceedings of the National Academy of Sciences, vol. 110, no. 21, 2013, pp. 8644-9. |
| Williams K, Sobol RW. "Mutation research/fundamental and molecular mechanisms of mutagenesis: special issue: DNA repair and genetic instability." Mutation research, vol. 743-744, 2013, pp. 1-3. |
| Nagaria P, Svilar D, Brown AR, Wang XH, Sobol RW, Wyatt MD. "SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress." Mutation research, vol. 743-744, 2013, pp. 26-32. |
| Iyer P, Srinivasan A, Singh SK, Mascara GP, Zayitova S, Sidone B, Fouquerel E, Svilar D, Sobol RW, Bobola MS, Silber JR, Gold B. "Synthesis and characterization of DNA minor groove binding alkylating agents." Chemical Research in Toxicology, vol. 26, no. 1, 2013, pp. 156-68. |
| Svilar D, Dyavaiah M, Brown AR, Tang JB, Li J, McDonald PR, Shun TY, Braganza A, Wang XH, Maniar S, St Croix CM, Lazo JS, Pollack IF, Begley TJ, Sobol RW. "Alkylation sensitivity screens reveal a conserved cross-species functionome." Molecular Cancer Research, vol. 10, no. 12, 2012, pp. 1580-96. |
| Sobol RW. "For MutY, it's all about the OG." Chemistry & Biology, vol. 19, no. 3, 2012, pp. 313-4. |
| Sobol RW. "Genome instability caused by a germline mutation in the human DNA repair gene POLB." PLOS Genetics, vol. 8, no. 11, 2012, pp. e1003086. |
| Srinivasan A, Wang L, Cline CJ, Xie Z, Sobol RW, Xie XQ, Gold B. "Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors." Biochemistry, vol. 51, no. 31, 2012, pp. 6246-59. |
| Svilar D, Vens C, Sobol RW. "Quantitative, real-time analysis of base excision repair activity in cell lysates utilizing lesion-specific molecular beacons." Journal of visualized experiments : JoVE, no. 66, 2012, pp. e4168. |
| Goellner EM, Svilar D, Almeida KH, Sobol RW. "Targeting DNA polymerase ß for therapeutic intervention." Current molecular pharmacology, vol. 5, no. 1, 2012, pp. 68-87. |
| Li J, Luthra S, Wang XH, Chandran UR, Sobol RW. "Transcriptional profiling reveals elevated Sox2 in DNA polymerase ß null mouse embryonic fibroblasts." American journal of cancer research, vol. 2, no. 6, 2012, pp. 699-713. |
| Lisovich A, Chandran UR, Lyons-Weiler MA, LaFramboise WA, Brown AR, Jakacki RI, Pollack IF, Sobol RW. "A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples." BMC medical genomics, vol. 4, 2011, pp. 14. |
| Svilar D, Goellner EM, Almeida KH, Sobol RW. "Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage." Antioxidants & redox signaling, vol. 14, no. 12, 2011, pp. 2491-507. |
| Li H, Wang P, Sun Q, Ding WX, Yin XM, Sobol RW, Stolz DB, Yu J, Zhang L. "Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1." Cancer Research, vol. 71, no. 10, 2011, pp. 3625-34. |
| Pollack IF, Hamilton RL, Sobol RW, Nikiforova MN, Lyons-Weiler MA, LaFramboise WA, Burger PC, Brat DJ, Rosenblum MK, Holmes EJ, Zhou T, Jakacki RI, Children's Oncology Group. "IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group." Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, vol. 27, no. 1, 2011, pp. 87-94. |
| Langevin SM, Stone RA, Bunker CH, Lyons-Weiler MA, LaFramboise WA, Kelly L, Seethala RR, Grandis JR, Sobol RW, Taioli E. "MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck." Cancer, vol. 117, no. 7, 2011, pp. 1454-62. |
| Tang JB, Svilar D, Trivedi RN, Wang XH, Goellner EM, Moore B, Hamilton RL, Banze LA, Brown AR, Sobol RW. "N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide." Neuro-Oncology, vol. 13, no. 5, 2011, pp. 471-86. |
| Kothandapani A, Dangeti VS, Brown AR, Banze LA, Wang XH, Sobol RW, Patrick SM. "Novel role of base excision repair in mediating cisplatin cytotoxicity." Journal of Biological Chemistry, vol. 286, no. 16, 2011, pp. 14564-74. |
| Goellner EM, Grimme B, Brown AR, Lin YC, Wang XH, Sugrue KF, Mitchell L, Trivedi RN, Tang JB, Sobol RW. "Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair." Cancer Research, vol. 71, no. 6, 2011, pp. 2308-17. |
| Yoder KE, Espeseth A, Wang XH, Fang Q, Russo MT, Lloyd RS, Hazuda D, Sobol RW, Fishel R. "The base excision repair pathway is required for efficient lentivirus integration." PLoS ONE, vol. 6, no. 3, 2011, pp. e17862. |
| Mutamba JT, Svilar D, Prasongtanakij S, Wang XH, Lin YC, Dedon PC, Sobol RW, Engelward BP. "XRCC1 and base excision repair balance in response to nitric oxide." DNA Repair, vol. 10, no. 12, 2011, pp. 1282-93. |
| Tang JB, Goellner EM, Wang XH, Trivedi RN, St Croix CM, Jelezcova E, Svilar D, Brown AR, Sobol RW. "Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage." Molecular Cancer Research, vol. 8, no. 1, 2010, pp. 67-79. |
| Asagoshi K, Liu Y, Masaoka A, Lan L, Prasad R, Horton JK, Brown AR, Wang XH, Bdour HM, Sobol RW, Taylor JS, Yasui A, Wilson SH. "DNA polymerase beta-dependent long patch base excision repair in living cells." DNA Repair, vol. 9, no. 2, 2010, pp. 109-19. |
| Langevin SM, Stone RA, Bunker CH, Grandis JR, Sobol RW, Taioli E. "MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index." Carcinogenesis, vol. 31, no. 5, 2010, pp. 864-70. |
| Pollack IF, Hamilton RL, Sobol RW, Nikiforova MN, Nikiforov YE, Lyons-Weiler MA, LaFramboise WA, Burger PC, Brat DJ, Rosenblum MK, Gilles FH, Yates AJ, Zhou T, Cohen KJ, Finlay JL, Jakacki RI, Children's Oncology Group. "Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant gliomas: a report from the Children's Oncology Group." Pediatric Blood & Cancer, vol. 55, no. 6, 2010, pp. 1066-71. |
| Jelezcova E, Trivedi RN, Wang XH, Tang JB, Brown AR, Goellner EM, Schamus S, Fornsaglio JL, Sobol RW. "Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage." Mutation research, vol. 686, no. 1-2, 2010, pp. 57-67. |
| Ueda R, Kohanbash G, Sasaki K, Fujita M, Zhu X, Kastenhuber ER, McDonald HA, Potter DM, Hamilton RL, Lotze MT, Khan SA, Sobol RW, Okada H. "Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1." Proceedings of the National Academy of Sciences, vol. 106, no. 26, 2009, pp. 10746-51. |
| Jones LE Jr, Ying L, Hofseth AB, Jelezcova E, Sobol RW, Ambs S, Harris CC, Espey MG, Hofseth LJ, Wyatt MD. "Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase." Carcinogenesis, vol. 30, no. 12, 2009, pp. 2123-9. |
| Yoshizawa K, Jelezcova E, Brown AR, Foley JF, Nyska A, Cui X, Hofseth LJ, Maronpot RM, Wilson SH, Sepulveda AR, Sobol RW. "Gastrointestinal hyperplasia with altered expression of DNA polymerase beta." PLoS ONE, vol. 4, no. 8, 2009, pp. e6493. |
| Taioli E, Ragin C, Wang XH, Chen J, Langevin SM, Brown AR, Gollin SM, Garte S, Sobol RW. "Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation." BMC Cancer, vol. 9, 2009, pp. 354. |
| Sobol RW. "CHIPping away at base excision repair." Molecular Cell, vol. 29, no. 4, 2008, pp. 413-5. |
| Kronenberg G, Harms C, Sobol RW, Cardozo-Pelaez F, Linhart H, Winter B, Balkaya M, Gertz K, Gay SB, Cox D, Eckart S, Ahmadi M, Juckel G, Kempermann G, Hellweg R, Sohr R, Hörtnagl H, Wilson SH, Jaenisch R, Endres M. "Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase." Journal of Neuroscience, vol. 28, no. 28, 2008, pp. 7219-30. |
| Trivedi RN, Wang XH, Jelezcova E, Goellner EM, Tang JB, Sobol RW. "Human methyl purine DNA glycosylase and DNA polymerase beta expression collectively predict sensitivity to temozolomide." Molecular pharmacology, vol. 74, no. 2, 2008, pp. 505-16. |
| Allen D, Herbert DC, McMahan CA, Rotrekl V, Sobol RW, Wilson SH, Walter CA. "Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice." Biology of Reproduction, vol. 79, no. 5, 2008, pp. 824-31. |
| Almeida KH, Sobol RW. "A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification." DNA Repair, vol. 6, no. 6, 2007, pp. 695-711. |
| Sobol RW. "DNA polymerase beta null mouse embryonic fibroblasts harbor a homozygous null mutation in DNA polymerase iota." DNA Repair, vol. 6, no. 1, 2007, pp. 3-7. |
| Chiosea S, Jelezcova E, Chandran U, Luo J, Mantha G, Sobol RW, Dacic S. "Overexpression of Dicer in precursor lesions of lung adenocarcinoma." Cancer Research, vol. 67, no. 5, 2007, pp. 2345-50. |
| Pollack IF, Hamilton RL, Sobol RW, Burnham J, Yates AJ, Holmes EJ, Zhou T, Finlay JL. "O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort." Journal of Clinical Oncology, vol. 24, no. 21, 2006, pp. 3431-7. |
| Chiosea S, Jelezcova E, Chandran U, Acquafondata M, McHale T, Sobol RW, Dhir R. "Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma." The American Journal of Pathology, vol. 169, no. 5, 2006, pp. 1812-20. |
| Trivedi RN, Almeida KH, Fornsaglio JL, Schamus S, Sobol RW. "The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death." Cancer Research, vol. 65, no. 14, 2005, pp. 6394-400. |
| Endres M, Biniszkiewicz D, Sobol RW, Harms C, Ahmadi M, Lipski A, Katchanov J, Mergenthaler P, Dirnagl U, Wilson SH, Meisel A, Jaenisch R. "Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase." Journal of Clinical Investigation, vol. 113, no. 12, 2004, pp. 1711-21. |
| Cabelof DC, Guo Z, Raffoul JJ, Sobol RW, Wilson SH, Richardson A, Heydari AR. "Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens." Cancer Research, vol. 63, no. 18, 2003, pp. 5799-807. |
| Sobol RW, Kartalou M, Almeida KH, Joyce DF, Engelward BP, Horton JK, Prasad R, Samson LD, Wilson SH. "Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses." Journal of Biological Chemistry, vol. 278, no. 41, 2003, pp. 39951-9. |
| Sobol RW, Foley JF, Nyska A, Davidson MG, Wilson SH. "Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice." DNA Repair, vol. 2, no. 5, 2003, pp. 609-22. |
| Lavrik OI, Kolpashchikov DM, Prasad R, Sobol RW, Wilson SH. "Binary system for selective photoaffinity labeling of base excision repair DNA polymerases." Nucleic acids research, vol. 30, no. 14, 2002, pp. e73. |
| Horton JK, Baker A, Berg BJ, Sobol RW, Wilson SH. "Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage." DNA Repair, vol. 1, no. 4, 2002, pp. 317-33. |
| Sobol RW, Watson DE, Nakamura J, Yakes FM, Hou E, Horton JK, Ladapo J, Van Houten B, Swenberg JA, Tindall KR, Samson LD, Wilson SH. "Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress." Proceedings of the National Academy of Sciences, vol. 99, no. 10, 2002, pp. 6860-5. |
| Tomicic MT, Thust R, Sobol RW, Kaina B. "DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage." Cancer Research, vol. 61, no. 20, 2001, pp. 7399-403. |
| Sobol RW, Wilson SH. "Mammalian DNA beta-polymerase in base excision repair of alkylation damage." Progress in nucleic acid research and molecular biology, vol. 68, 2001, pp. 57-74. |
| Lavrik OI, Prasad R, Sobol RW, Horton JK, Ackerman EJ, Wilson SH. "Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair." Journal of Biological Chemistry, vol. 276, no. 27, 2001, pp. 25541-8. |
| Raaphorst GP, Cybulski SE, Sobol R, Ng CE. "The response of human breast tumour cell lines with altered polymerase beta levels to cisplatin and radiation." Anticancer research, vol. 21, no. 3B, 2001, pp. 2079-83. |
| Wilson SH, Sobol RW, Beard WA, Horton JK, Prasad R, Vande Berg BJ. "DNA polymerase beta and mammalian base excision repair." Cold Spring Harbor Symposia on Quantitative Biology, vol. 65, 2000, pp. 143-55. |
| Sobol RW, Prasad R, Evenski A, Baker A, Yang XP, Horton JK, Wilson SH. "The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity." J. Geophys. Res., vol. 405, no. 6788, 2000, pp. 807-10. |
| Ochs K, Sobol RW, Wilson SH, Kaina B. "Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage." Cancer Research, vol. 59, no. 7, 1999, pp. 1544-51. |
| Fortini P, Pascucci B, Parlanti E, Sobol RW, Wilson SH, Dogliotti E. "Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells." Biochemistry, vol. 37, no. 11, 1998, pp. 3575-80. |
| Biade S, Sobol RW, Wilson SH, Matsumoto Y. "Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA." Journal of Biological Chemistry, vol. 273, no. 2, 1998, pp. 898-902. |
| Robbins I, Mitta G, Vichier-Guerre S, Sobol R, Ubysz A, Rayner B, Lebleu B. "Selective mRNA degradation by antisense oligonucleotide-2,5A chimeras: involvement of RNase H and RNase L." Biochimie, vol. 80, no. 8-9, 1998, pp. 711-20. |
| Chen KH, Yakes FM, Srivastava DK, Singhal RK, Sobol RW, Horton JK, Van Houten B, Wilson SH. "Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines." Nucleic acids research, vol. 26, no. 8, 1998, pp. 2001-7. |
| Sobol RW, Horton JK, Kühn R, Gu H, Singhal RK, Prasad R, Rajewsky K, Wilson SH. "Requirement of mammalian DNA polymerase-beta in base-excision repair." J. Geophys. Res., vol. 379, no. 6561, 1996, pp. 183-6. |
| Sobol RW, Henderson EE, Kon N, Shao J, Hitzges P, Mordechai E, Reichenbach NL, Charubala R, Schirmeister H, Pfleiderer W. "Inhibition of HIV-1 replication and activation of RNase L by phosphorothioate/phosphodiester 2',5'-oligoadenylate derivatives." Journal of Biological Chemistry, vol. 270, no. 11, 1995, pp. 5963-78. |
| Suhadolnik RJ, Reichenbach NL, Hitzges P, Sobol RW, Peterson DL, Henry B, Ablashi DV, Müller WE, Schröder HC, Carter WA. "Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome." Clinical Infectious Diseases, vol. 18 Suppl 1, 1994, pp. S96-104. |
| Sobol RW, Charubala R, Pfleiderer W, Suhadolnik RJ. "Chemical synthesis and biological characterization of phosphorothioate analogs of 2', 5'-3'-deoxyadenylate trimer." Nucleic acids research, vol. 21, no. 10, 1993, pp. 2437-43. |
| Sobol RW, Fisher WL, Reichenbach NL, Kumar A, Beard WA, Wilson SH, Charubala R, Pfleiderer W, Suhadolnik RJ. "HIV-1 reverse transcriptase: inhibition by 2',5'-oligoadenylates." Biochemistry, vol. 32, no. 45, 1993, pp. 12112-8. |
| Kumar A, Kim HR, Sobol RW, Becerra SP, Lee BJ, Hatfield DL, Suhadolnik RJ, Wilson SH. "Mapping of nucleic acid binding in proteolytic domains of HIV-1 reverse transcriptase." Biochemistry, vol. 32, no. 29, 1993, pp. 7466-74. |
| Müller WE, Weiler BE, Charubala R, Pfleiderer W, Leserman L, Sobol RW, Suhadolnik RJ, Schröder HC. "Cordycepin analogues of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase." Biochemistry, vol. 30, no. 8, 1991, pp. 2027-33. |
| Hubbell HR, Sheetz PC, Iogal SS, Brodsky I, Kariko K, Li SW, Suhadolnik RJ, Sobol RW. "Heterogeneous nuclear RNA from hairy cell leukemia patients activates 2',5'-oligoadenylate synthetase." Anticancer research, vol. 11, no. 5, 1991, pp. 1927-32. |
| Sobol RW, Suhadolnik RJ, Kumar A, Lee BJ, Hatfield DL, Wilson SH. "Localization of a polynucleotide binding region in the HIV-1 reverse transcriptase: implications for primer binding." Biochemistry, vol. 30, no. 44, 1991, pp. 10623-31. |
| Kanou M, Ohomori H, Nagai K, Yokoyama S, Suhadolnik RJ, Sobol R Jr, Takaku H. "Purine 8-substitution modulates the ribonuclease L binding and activation abilities of 2',5'-oligoadenylates." Biochemical and Biophysical Research Communications, vol. 176, no. 2, 1991, pp. 769-74. |
| Suhadolnik RJ, Li SW, Sobol RW, Varnum JM. "2',5' A synthetase: allosteric activation by fructose 1,6-bisphosphate." Biochemical and Biophysical Research Communications, vol. 169, no. 3, 1990, pp. 1198-203. |
| Kanou M, Ohomori H, Takaku H, Yokoyama S, Kawai G, Suhadolnik RJ, Sobol R Jr. "Chemical synthesis and biological activities of analogues of 2',5'-oligoadenylates containing 8-substituted adenosine derivatives." Nucleic acids research, vol. 18, no. 15, 1990, pp. 4439-46. |
| Charachon G, Sobol RW, Bisbal C, Salehzada T, Silhol M, Charubala R, Pfleiderer W, Lebleu B, Suhadolnik RJ. "Phosphorothioate analogues of (2'-5')(A)4: agonist and antagonist activities in intact cells." Biochemistry, vol. 29, no. 10, 1990, pp. 2550-6. |
| Montefiori DC, Sobol RW Jr, Li SW, Reichenbach NL, Suhadolnik RJ, Charubala R, Pfleiderer W, Modliszewski A, Robinson WE Jr, Mitchell WM. "Phosphorothioate and cordycepin analogues of 2',5'-oligoadenylate: inhibition of human immunodeficiency virus type 1 reverse transcriptase and infection in vitro." Proceedings of the National Academy of Sciences, vol. 86, no. 18, 1989, pp. 7191-4. |
| Suhadolnik RJ, Karikó K, Sobol RW Jr, Li SW, Reichenbach NL, Haley BE. "2- and 8-azido photoaffinity probes. 1. Enzymatic synthesis, characterization, and biological properties of 2- and 8-azido photoprobes of 2-5A and photolabeling of 2-5A binding proteins." Biochemistry, vol. 27, no. 24, 1988, pp. 8840-6. |
| Suhadolnik RJ, Li SW, Sobol RW Jr, Haley BE. "2- and 8-azido photoaffinity probes. 2. Studies on the binding process of 2-5A synthetase by photosensitive ATP analogues." Biochemistry, vol. 27, no. 24, 1988, pp. 8846-51. |
| Karikó K, Li SW, Sobol RW Jr, Suhadolnik RJ, Charubala R, Pfleiderer W. "Phosphorothioate analogues of 2',5'-oligoadenylate. Activation of 2',5'-oligoadenylate-dependent endoribonuclease by 2',5'-phosphorothioate cores and 5'-monophosphates." Biochemistry, vol. 26, no. 22, 1987, pp. 7136-42. |
| Karikó K, Sobol RW Jr, Suhadolnik L, Li SW, Reichenbach NL, Suhadolnik RJ, Charubala R, Pfleiderer W. "Phosphorothioate analogues of 2',5'-oligoadenylate. Enzymatically synthesized 2',5'-phosphorothioate dimer and trimer: unequivocal structural assignment and activation of 2',5'-oligoadenylate-dependent endoribonuclease." Biochemistry, vol. 26, no. 22, 1987, pp. 7127-35. |
| Year | Degree | Institution |
|---|---|---|
| 1991 | PhD | Temple University |
| 1987 | MA | Temple University |
| 1982 | BS | Allegheny College |
