Shibin Cheng Assistant Professor of Pediatrics (Research)

Brown Affiliations

scholarly work

  1. Kalkunte S.S., Neubeck S, Norris W. E., Cheng, S.B., Kostadinov S, Hoang D. V, Ahmed A, Eggeling F. von, Shaikh Z, Padbury J, Berg G, Olofsson A, Markert  U. R., and Sharma S. (2013) Transthyretin is Dysregulated in Preeclampsia and Its Native Form Prevents the Onset of Disease in a Preclinical Mouse Model, Am J Pathol  183 (5): 1425-36. (PMCID: PMC3814653)   
  2. Cheng, S.B., Dong, J., Pang, Y., LaRocca, J., Hixson, M., Thomas, P. and Filardo, E.J. (2013) Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone. Mol Cell Endocrinol. 382 (2): 950-9. (PMCID: 24239983)
  3. Cheng, S.B. and Filardo, E.D. (2012) Trans-Golgi network (TGN) as a regulatory node for beta1-adrenergic receptor down-modulation and recycling, J Biol Chem 287(17): 14178-91. (PMCID: PMC3340205)
  4. Cheng, S. B., Quinn J., Graeber C.T., and Filardo E.D. (2011) Down-modulation of GPER/GPR30 from the cell surface occurs via a trans-Golgi-proteasome pathway. J Biol Chem 286(25): 22441-55. (PMCID: PMC3121390)
  5. Cheng, S. B., Ferland, P., and Bearer, E.L. (2011) Herpes simplex virus dances with amyloid precursor protein while exiting the cell. PLoS ONE 6(3): e17966.doi: 10.1371/journal.pone.0017966. (PMCID: PMC3069030)
  6. Cheng, S. B., Graeber C.T., Quinn J., and Filardo E.D. (2011) Retrograde transport of the transmembrane estrogen receptor, G-protein-coupled-receptor-30 (GPR30/GPER) from the plasma membrane towards the nucleus. Steroids 76(9):892-6. (PMID: 21354433)
  7. Cheng S. B., Amici S. A., Ren X.Q., McKay S. B., Treuil M. W., Lindstrom J. M., Rao J., and Anand R. Presynaptic targeting of alpha4beta2 nicotinic acetylcholine receptors is regulated by neurexin-1beta. J Biol Chem 2009, 284(35): 23251-9. (PMCID: PMC2749099)
  8. Ren X. Q., Cheng S. B., Treuil M. W., Mukherjee J., Rao J., Lindstrom J. M., and Anand R. Structural determinants of alpha4beta2 nicotinic acetylcholine receptor trafficking. Journal of Neuroscience 2005, 25: 6676-6686. (PMID: 16014729)
  9. Cheng S.B., Kuchiiwa S., Kawachi A., Gao H.Z., Gohshi A., Kozako T., Kuchiiwa T., Nakagawa S. Up-regulation of methionine-like enkephalin immunoreactivity by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin treatment in the forebrain of the Long-Evans rat. J Chem Neuroanat 2003, 25: 73-82. (PMID: 12663056)
  10. Cheng S.B., Kuchiiwa S., Gao H., Kuchiiwa T., Nakagawa S. Dioxin exposure down-regulates nitric oxide synthase and NADPH-d activities in the hypothalamus. Neurosci Lett. 2003, 345: 5-8. (PMID: 12809975)
  11. Cheng S.B., Kuchiiwa S., Gao H., Kuchiiwa T., Nakagawa S. Morphological study of orexin neurons in the hypothalamus of the Long-Evans rat, with special reference to co-expression of orexin and NADPH-diaphorase or nitric oxide synthase activities. Neurosci. Res. 2003, 46: 53-62. (PMID: 12725912)
  12. Cheng S.B., Kuchiiwa S., Nagatomo I., Akasaki Y., Uchida M., Tominaga M., Hashiguchi W., Kuchiiwa T., Nakagawa S. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin pretreatment induces c-Fos expression in the forebrain of the Long-Evans rat, Brain Res 2002, 931 (2): 176-180. (PMID: 11897103)
  13. Cheng S.B., Kuchiiwa S., Kuchiiwa T., Nonaka S., Nakagawa S. Presence of nitric oxide synthase in autonomic and sensory ganglion neurons innervating the lacrimal gland of the cat: an immunofluorescent and retrograde tracer double-labeling study. J Chem Neuroanat 2001, 22(3): 147-155. (PMID: 11522437)
  14. Cheng S.B., Kuchiiwa S., Kuchiiwa T., Nakagawa S. Three novel neuronal pathways to the lacrimal gland of the cat: an investigation with cholera toxin B subunit as a retrograde tracer. Brain Res 2000, 873(1): 160-164. (PMID: 10915825)
  15. Cheng S.B.(corresponding author), Hayakawa T., Kuchiiwa S., Maeda S., Ito H., Seki M., Nakagawa S. Evidence for the collateral innervation of the esophagus and the heart from neurons in the compact formation of the ambiguus nucleus of the rat. Brain Res 1999, 832:171-174. (PMID: 10375665)
  16. Kuchiiwa S., Cheng S.B., Nagatomo I., Akasaki Y., Uchida M., Tominaga M., Hashiguchi W., Kuchiiwa T. In utero and lactational exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin decreases erotonin-immunoreactivity in the raphe nuclei of mice. Neurosci Lett 2002, 317 (2): 73-76. (PMID: 11755243)
  17. Kuchiiwa S., Cheng S.B., Kuchiiwa T. Morphological distinction between the vasomotor neurons and the secretomotor neurons innervating the cat cranio-oro-facial regions. Neurosci Lett 2000, 288(3): 219-222. (PMID: 10889347)
  18. Kozako T., Kawachi A., Cheng S.B., Kuchiiwa S., Motoya T., Nakagawa S., Yamada K.. Role of the vestibular nuclei in endothelin-1-induced barrel rotation in rats. Eur. J. Pharmacol. 2002, 454: 199-207. (PMID: 12421648)

research overview

Ongoing research focuses on dissecting the molecular mechanisms of preeclampsia and roles of tranthyretin in preeclampsia.

funded research

Ongoing funding

Rhode Island Foundation (No. 20133983), 2014-2015

Protein Aggregation Response in Preeclampsia: A Novel Mechanistic/Therapeutic Approach

Role: PI



COBRE for Perinatal Biology (5P20RR018728-10), National Institute of General Medical Sciences (8P20GM103537-10; PI: James Padbury)
Pilot Project I: in vivo and in vitro Model of Pre-eclampsia Pathology

Role: PI (Oct, 2012-Jul, 2013)


Grant-in-Aid for Scientific Research, (Basic Research (C)) (No. 13833006), 2001-2003

Effect of Dioxin prenatal exposure on the behavior of mouse      

The Japanese Ministry of Education, Sports, Science and Technology, Japan

Role: Co-investigator (PI: S. Kuchiiwa)


Research Grant (No. 200100115-14), 2001-2003

Neurotoxic effect of Dioxin

Japan Society for the Promotion of Science, JAPAN

Role: PI