| Banerjee, Sayani, Huang, Zheping, Wang, Zhengke, Nakashima, Akitoshi, Saito, Shigeru, Sharma, Surendra, Cheng, Shibin. "Etiological Value of Sterile Inflammation in Preeclampsia: Is It a Non-Infectious Pregnancy Complication?." Frontiers in Cellular and Infection Microbiology, vol. 11, 2021. |
| Nakashima A, Cheng SB, Ikawa M, Yoshimori T, Huber WJ, Menon R, Huang Z, Fierce J, Padbury JF, Sadovsky Y, Saito S, Sharma S. "Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia." Autophagy, vol. 16, no. 10, 2020, pp. 1771-1785. |
| Cheng SB, Nakashima A, Huber WJ, Davis S, Banerjee S, Huang Z, Saito S, Sadovsky Y, Sharma S. "Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors." Cell death & disease, vol. 10, no. 12, 2019, pp. 927. |
| Liu N, Wang L, Yang T, Xiong C, Xu L, Shi Y, Bao W, Chin YE, Cheng SB, Yan H, Qiu A, Zhuang S. "EGF Receptor Inhibition Alleviates Hyperuricemic Nephropathy." Journal of the American Society of Nephrology, vol. 26, no. 11, 2015, pp. 2716-29. |
| Cheng, Shi-Bin, Sharma, Surendra. "Interleukin-10: a pleiotropic regulator in pregnancy." American Journal of Reproductive Immunology, vol. 73, no. 6, 2015, pp. 487-500. |
| Gaudet HM, Cheng SB, Christensen EM, Filardo EJ. "The G-protein coupled estrogen receptor, GPER: The inside and inside-out story." Molecular and cellular endocrinology, vol. 418 Pt 3, 2015, pp. 207-19. |
| Cheng, Shi-Bin, Nakashima, Akitoshi, Sharma, Surendra. "Understanding Pre-Eclampsia Using Alzheimer's Etiology: An Intriguing Viewpoint." Am J Reprod Immunol, vol. 75, no. 3, 2015, pp. 372-381. |
| Cheng SB, Dong J, Pang Y, LaRocca J, Hixon M, Thomas P, Filardo EJ. "Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone." Molecular and cellular endocrinology, vol. 382, no. 2, 2014, pp. 950-9. |
| Kalkunte SS, Neubeck S, Norris WE, Cheng SB, Kostadinov S, Vu Hoang D, Ahmed A, von Eggeling F, Shaikh Z, Padbury J, Berg G, Olofsson A, Markert UR, Sharma S. "Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model." The American Journal of Pathology, vol. 183, no. 5, 2013, pp. 1425-36. |
| Cheng SB, Filardo EJ. "Trans-Golgi Network (TGN) as a regulatory node for β1-adrenergic receptor (β1AR) down-modulation and recycling." Journal of Biological Chemistry, vol. 287, no. 17, 2012, pp. 14178-91. |
| Cheng SB, Quinn JA, Graeber CT, Filardo EJ. "Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway." Journal of Biological Chemistry, vol. 286, no. 25, 2011, pp. 22441-55. |
| Cheng SB, Ferland P, Webster P, Bearer EL. "Herpes simplex virus dances with amyloid precursor protein while exiting the cell." PLoS ONE, vol. 6, no. 3, 2011, pp. e17966. |
| Cheng SB, Graeber CT, Quinn JA, Filardo EJ. "Retrograde transport of the transmembrane estrogen receptor, G-protein-coupled-receptor-30 (GPR30/GPER) from the plasma membrane towards the nucleus." Steroids, vol. 76, no. 9, 2011, pp. 892-6. |
Ongoing research focuses on deciphering the molecular mechanisms of adverse pregnancy outcomes, such as preeclampsia, with particular emphasis on the roles of ER stress, autophagy-lysosome, unfolded protein response, protein misfolding and aggregation, mitochondria, and inflammation, as well as the interaction between trophoblasts and immune cells at the maternal-fetal interface in the pathogenesis of preeclampsia.
Current
COBRE for Reproductive Health 1P20GM121298-01 NIGMS 2017-2022
Project: Novel Mechanism of Protein Misfolding and Aggregation in Preeclampsia
Role: Project Leader
Completed
NIH Supplementary Grant 3P20GM121298 - 04W1 2020-2021
Project: Sweet relief for preeclampsia, a severe pregnancy complication affecting women's health
Total Funding: $367,416/year
Role: Project Leader
COBRE for Perinatal Biology, National Institute of General Medical Sciences, 2015-2016
Pilot Project I: Understanding preeclampsia using Alzheimer’s tools
Role: PI
William and Mary Oh – William and Elsa Zopfi Award, 2016-2017
Preeclampsia as a Prelude for the Onset of Alzheimer's Disease
Role: PI
Deans Awards Brown University, 2015-2016 (Sharma)
Protein Aggregation in Preclampsia: New Mechanism for Deadly Pregnancy Disease
Role: Co-investigator
Rhode Island Foundation (No. 20133983), 2014-2015
Protein Aggregation Response in Preeclampsia: A Novel Mechanistic/Therapeutic Approach
Role: PI
COBRE for Perinatal Biology (5P20RR018728-10), National Institute of General Medical Sciences (8P20GM103537-10; PI: James Padbury)
Pilot Project I: in vivo and in vitro Model of Pre-eclampsia Pathology
Role: PI
Grant-in-Aid for Scientific Research, (Basic Research (C)) (No. 13833006), 2001-2003
Effect of Dioxin prenatal exposure on the behavior of mouse
The Japanese Ministry of Education, Sports, Science, and Technology, Japan
Role: Co-investigator (PI: S. Kuchiiwa)
Research Grant (No. 200100115-14), 2001-2003
Neurotoxic effect of Dioxin
Japan Society for the Promotion of Science, JAPAN
Role: PI
| Year | Degree | Institution |
|---|---|---|
| 2002 | PhD | Kagoshima University |
| 1991 | MS | Sun Yat-sen University |
| 1988 | BS | Wannan Medical College |
| 1988 | MD | Wannan Medical College |
1992, 1993 Excellent Teacher Award, Sun Yat-sen University of Medical Sciences (SUMS), China
1994 Research Project Achievement Award, SUMS, China
1995 Scientific Progress Award, Ministry of Health, China
1999, 2000 Travel Awards, Kagoshima Prefecture International Communication Society, Japan
1999-2000 Scholarship, Ministry of Education, Science and Culture of Japan, Japan
2000 Travel Award, Kato Memorial Bioscience Foundation, Japan
2000-2001 Fellowship, Japan-China Medical Association, Japan
2000, 2002 Publication Award, the Kodama Foundation for Research of Medical Science, Japan
2000-2002 Teaching Assistantship, Faculty of Medicine, Kagoshima University, Japan
2001-2003 Fellowship, Japan Society for the Promotion of Science, Japan
2001-2003 Research Award, Japan Society for the Promotion of Science (No. 200100115-14), Japan
2005 Travel Award, Neuroscience Center of Excellence, LSUHSC, USA
2005 Travel Award, Society of Neuroscience, USA
2006 Excellent Presentation Award, Neuroscience Center of Excellence, LSUHSC, USA
2007 Travel Award, International Herpes Simplex Virus Workshop, North Carolina, USA
2012-pres Member of Editors & Editorial Board, Nephrology Open Journal
2012-pres Member of Editors & Editorial Board, Journal of Tropical Medicine & Surgery
2015 ASRI Post Award, American Society for Reproductive Immunology
2019 Master of Arts ad eundem, Brown Unviversity,
2019-pres Member of Editorial Board, American Journal of Reproductive Immunology
2020-pres Associate Editor, American Journal of Environmental Biology
Department of Pediatrics
Brown University
| Research Scientist. - |
