The research in my laboratory aims to understand the biological consequences of DNA damage. Using the tools of chemistry and biology we probe the effects of DNA modification at the molecular level. We are particularly interested in the role of oxidative DNA damage and its contributions to cancer and neurological disorders such as Huntington's disease.
The Delaney lab aims to unravel the connections between DNA damage and disease. Using the methods and tools of biochemistry, synthetic chemistry, molecular biology, toxicology and biophysics we probe the effects of DNA damage from the molecular to the cellular level. As a chemistry lab, we exploit our abilities to synthesize DNA lesions and study their properties within well-defined systems. For instance, we are interested in determining the type and frequency of mutations caused by individual DNA lesions. Another focus of the lab is on understanding how chemically modifying DNA affects its overall structure and how those modifications influence the inheritance of genetic information.
2004-2007 - Damon Runyon Postdoctoral Fellowship
2008 - Brown University Richard B. Salomon Faculty Research Award
2009 - Brown University NSF ADVANCE Career Development Award
2010-2015 - NIH/NIEHS Outstanding New Environmental Scientist Award
2011-2013 - Philip J. Bray Award for Excellence in Undergraduate Teaching in the Physical Sciences
American Chemical Society
CHEM 0090 - Kitchen Chemistry. Fall 2016.
CHEM 0350 - Organic Chemistry. Spring 2016, Spring 2017.