Stephanie L. Graff, MD FACP FASCO is the Director of the Breast Oncology Program at Brown University Health Cancer Institute, and co-leader of the Breast Cancer Translational Research Disease Group. She is active across numerous professional organizations in oncology, including the American Society of Clinical Oncology (ASCO) where she is a 2020 graduate of the prestigious Leadership Development Program and has previously served on the Joint Certifications Committee, Professional Development Committee and Research Community Forum; and is active in SWOG and Alliance--both part of the National Clinical Trials Network (NCTN). Dr. Graff is on the steering committee for the American Cancer Society's National Breast Cancer Round Table. Dr. Graff is a leader on social media @DrSGraff and a sought-after public speaker and a contributing author of the Dr. Susan Love Breast Book, 7th Edition.
Dr. Graff also enjoys narrative medicine and serves as faculty in the Arts & Medicine Track and is on the Art of Oncology Editorial Board for Journal of Clinical Oncology, among other scientific editorial roles. She volunteers on the Board of Directors for the Dempsey Center.
Research interests include oncology drug development and clinical trials, hormone-receptor positive breast cancer, triple negative breast cancer, metastatic breast cancer, breast cancer genomics, health disparities, women in medicine, and rare breast cancers including male breast cancer, pregnancy-associated breast cancer, pre-menopausal breast cancer, among others.
| Wang Y, Liu L, Graff SL, Cheng L. "Locoregional event or dyssynchronous distant metastasis: clinicopathological and molecular analysis of contralateral axillary lymph node metastasis in breast cancer patients." Histopathology, vol. 86, no. 3, 2025, pp. 472-477. |
| Strandberg J, Louie A, Lee S, Hahn M, Srinivasan P, George A, De La Cruz A, Zhang L, Hernandez Borrero L, Huntington KE, De La Cruz P, Seyhan AA, Koffer PP, Wazer DE, DiPetrillo TA, Graff SL, Azzoli CG, Rounds SI, Klein-Szanto AJ, Tavora F, Yakirevich E, Abbas AE, Zhou L, El-Deiry WS. "TRAIL agonists rescue mice from radiation-induced lung, skin or esophageal injury." Journal of Clinical Investigation, vol. 135, no. 5, 2025. |
| Graff SL, Tinianov S, Kalinsky K. "Nailing down" risk and improving outcomes in early-stage breast cancer." JNCI Journal of the National Cancer Institute, 2024. |
| Kalinsky K, Bianchini G, Hamilton E, Graff SL, Park KH, Jeselsohn R, Demirci U, Martin M, Layman RM, Hurvitz SA, Sammons S, Kaufman PA, Muñoz M, Lai JI, Knoderer H, Sandoval C, Chawla AR, Nguyen B, Zhou Y, Ravenberg E, Litchfield LM, Smyth L, Wander SA. "Abemaciclib Plus Fulvestrant in Advanced Breast Cancer After Progression on CDK4/6 Inhibition: Results From the Phase III postMONARCH Trial." Journal of Clinical Oncology, 2024, pp. JCO2402086. |
| Graff SL, Principe J, Galvin AM, Fenton MA, Strenger R, Salama L, Bansal R, Dizon DS, Begnoche MH. "Evaluating Patient Experience in a Multidisciplinary Breast Cancer Clinic: A Prospective Study." Journal of Women's Health, vol. 33, no. 1, 2024, pp. 39-44. |
| Ali A, Graff SL. "Exploring DESTINY: the Past, Present, and Future of Trastuzumab Deruxtecan." Current Oncology Reports, vol. 26, no. 1, 2024, pp. 1-9. |
| Kim KW, Lopresti M, Graff SL, Witherby S, Dizon DS, Fenton MA. "Fulfilling the Role of a Parent While Undergoing Treatment for Cancer: A Review of the Literature and the Potential Impact of Childcare Support on Cancer Outcomes." American Journal of Clinical Oncology, 2024. |
| Bansal R, Adeyelu T, Elliott A, Tan AR, Ribeiro JR, Meisel J, Oberley MJ, Graff SL, Sledge GW Jr, Grilley-Olson JE, Sammons SL, Rosenberger LH. "Genomic Landscape of Malignant Phyllodes Tumors Identifies Subsets for Targeted Therapy." JCO precision oncology, vol. 8, 2024, pp. e2400289. |
| Graff SL, McGinn C, Showalter JR. "Improving Outcomes for Women With Metastatic HER(2)-Positive and HER(2)-Low Breast Cancer." Journal of the advanced practitioner in oncology, vol. 15, no. 3, 2024, pp. 187-190. |
| Graff SL, Freeman EC, Roach M, Wilson R, Cagle C, Lunsford S, Maravic MC, Fairley R, Gullatte M, Stemland J, Wochal P, Katz J, Hoffner B, Scott JM, May SG. "Investigating the Salience of Clinical Meaningfulness and Clinically Meaningful Outcomes in Metastatic Breast Cancer Care Delivery." JCO Oncology Practice, 2024, pp. OP2400228. |
| Vaz SC, Woll JPP, Cardoso F, Groheux D, Cook GJR, Ulaner GA, Jacene H, Rubio IT, Schoones JW, Peeters MV, Poortmans P, Mann RM, Graff SL, Dibble EH, de Geus-Oei LF. "Joint EANM-SNMMI guideline on the role of 2-[(18)F]FDG PET/CT in no special type breast cancer : (endorsed by the ACR, ESSO, ESTRO, EUSOBI/ESR, and EUSOMA)." European Journal of Nuclear Medicine and Molecular Imaging, 2024. |
| Groheux, David, Vaz, Sofia C., Ulaner, Gary A., Cook, Gary J. R., Woll, John Patrick Pilkington, Mann, Ritse M., Poortmans, Philip, Cardoso, Fatima, Jacene, Heather, Graff, Stephanie L., Rubio, Isabel T., Peeters, Marie-Jeanne Vrancken, Dibble, Elizabeth H., de Geus-Oei, Lioe-Fee. "Joint EANM-SNMMI guidelines on the role of 2-[18F]FDG PET/CT in no special type breast cancer: differences and agreements with European and American guidelines." European Journal of Nuclear Medicine and Molecular Imaging, 2024. |
| Hsiehchen D, Elliott A, Xiu J, Seeber A, El-Deiry W, Antonarakis ES, Graff SL, Hall MJ, Borghaei H, Hoon DSB, Liu SV, Ma PC, McKay RR, Wise-Draper T, Marshall J, Sledge GW, Spetzler D, Zhu H. "Mutation burden and anti-PD-1 outcomes are not universally associated with immune cell infiltration or lymphoid activation." Cancer Cell, vol. 42, no. 12, 2024, pp. 1985-1987. |
| Liu L, Graff SL, Wang Y. "New Emerging Therapies Targeting PI3K/AKT/mTOR/PTEN Pathway in Hormonal Receptor-Positive and HER2-Negative Breast Cancer-Current State and Molecular Pathology Perspective." Cancers, vol. 17, no. 1, 2024. |
| Lambertini M, Blondeaux E, Agostinetto E, Hamy AS, Kim HJ, Di Meglio A, Bernstein Molho R, Hilbers F, Pogoda K, Carrasco E, Punie K, Bajpai J, Ignatiadis M, Moore HCF, Phillips KA, Toss A, Rousset-Jablonski C, Peccatori FA, Renaud T, Ferrari A, Paluch-Shimon S, Fruscio R, Cui W, Wong SM, Vernieri C, Ruddy KJ, Dieci MV, Matikas A, Rozenblit M, Villarreal-Garza C, De Marchis L, Del Mastro L, Puglisi F, Del Pilar Estevez-Diz M, Rodriguez-Wallberg KA, Mrinakova B, Meister S, Livraghi L, Clatot F, Yerushalmi R, De Angelis C, Sánchez-Bayona R, Meattini I, Cichowska-Cwalinska N, Berlière M, Salama M, De Giorgi U, Sonnenblick A, Chiodi C, Lee YJ, Maria C, Azim HA Jr, Boni L, Partridge AH, BRCA BCY Collaboration. "Pregnancy After Breast Cancer in Young BRCA Carriers: An International Hospital-Based Cohort Study." JAMA, vol. 331, no. 1, 2024, pp. 49-59. |
| Wang Y, Liu L, Graff SL, Cheng L. "Recent advancements in biomarkers and molecular diagnostics in hormonal receptor-positive breast cancer." Histopathology, 2024. |
| Kareff SA, Trabolsi A, Krause HB, Samec T, Elliott A, Rodriguez E, Olazagasti C, Watson DC, Bustos MA, Hoon DSB, Graff SL, Antonarakis ES, Goel S, Sledge G, Lopes G. "The Genomic, Transcriptomic, and Immunologic Landscape of HRAS Mutations in Solid Tumors." Cancers, vol. 16, no. 8, 2024. |
| Muquith M, Espinoza M, Elliott A, Xiu J, Seeber A, El-Deiry W, Antonarakis ES, Graff SL, Hall MJ, Borghaei H, Hoon DSB, Liu SV, Ma PC, McKay RR, Wise-Draper T, Marshall J, Sledge GW, Spetzler D, Zhu H, Hsiehchen D. "Tissue-specific thresholds of mutation burden associated with anti-PD-1/L1 therapy benefit and prognosis in microsatellite-stable cancers." Nature cancer, 2024. |
| Turner NC, Oliveira M, Howell SJ, Dalenc F, Cortes J, Gomez Moreno HL, Hu X, Jhaveri K, Krivorotko P, Loibl S, Morales Murillo S, Okera M, Park YH, Sohn J, Toi M, Tokunaga E, Yousef S, Zhukova L, de Bruin EC, Grinsted L, Schiavon G, Foxley A, Rugo HS, CAPItello-291 Study Group. "Capivasertib in Hormone Receptor-Positive Advanced Breast Cancer." New England Journal of Medicine, vol. 388, no. 22, 2023, pp. 2058-2070. |
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Dr. Susan M. Love, Elizabeth Love. Dr. Stephanie L. Graff, Dr. Lauren A. Green.
Dr. Susan Love's Breast Book. Hachette, 2023.
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| Graff SL, Subbiah IM, Markham MJ, Matt-Amaral LB, Close JL, Griffith KA, Jagsi R. "Frequency, barriers, outcomes, and consequences of reporting sexual harassment in clinical oncology." JNCI cancer spectrum, vol. 7, no. 1, 2023. |
| Goetz MP, Bagegni NA, Batist G, Brufsky A, Cristofanilli MA, Damodaran S, Daniel BR, Fleming GF, Gradishar WJ, Graff SL, Grosse Perdekamp MT, Hamilton E, Lavasani S, Moreno-Aspitia A, O'Connor T, Pluard TJ, Rugo HS, Sammons SL, Schwartzberg LS, Stover DG, Vidal GA, Wang G, Warner E, Yerushalmi R, Plourde PV, Portman DJ, Gal-Yam EN. "Lasofoxifene versus fulvestrant for ER+/HER2- metastatic breast cancer with an ESR1 mutation: results from the randomized, phase II ELAINE 1 trial." Annals of Oncology, vol. 34, no. 12, 2023, pp. 1141-1151. |
| Graff SL, Yan F, Abdou Y. "Newly Approved and Emerging Agents in HER2-Positive Metastatic Breast Cancer." Clinical Breast Cancer, 2023. |
| Vaz SC, Graff SL, Ferreira AR, Debiasi M, de Geus-Oei LF. "PET/CT in Patients with Breast Cancer Treated with Immunotherapy." Cancers, vol. 15, no. 9, 2023. |
| Fenton MA, Tarantino P, Graff SL. "Sequencing Antibody Drug Conjugates in Breast Cancer: Exploring Future Roles." Current oncology (Toronto, Ont.), vol. 30, no. 12, 2023, pp. 10211-10223. |
| Haddad SA, Dizon DS, Graff SL. "Sequencing systemic therapy in hormone-receptor positive metastatic breast cancer: a modern paradigm." Chinese clinical oncology, vol. 12, no. 4, 2023, pp. 42. |
| Majmudar S, Graff SL, Kays M, Braz BX, Matt-Amaral L, Markham MJ, Subbiah IM, Bergsland E, Jain S. "The Careers and Professional Well-Being of Women Oncologists During the COVID-19 Pandemic: Responding for Tomorrow." Journal of Medical Internet Research, vol. 25, 2023, pp. e47784. |
| Sagaityte, Emilija, Dowd, Richard S., Lane, Kendall, Graff, Stephanie L., Toms, Steven A. "The Role of RNA Epitranscriptomics and the RNA Fat Mass and Obesity-Associated Demethylase in Triple Negative Breast Cancer." Advances in Breast Cancer Research, vol. 12, no. 02, 2023, pp. 27-50. |
| Wang Y, Hacking SM, Li Z, Graff SL, Yang D, Tan L, Liu F, Zhang T, Zhao Z, Luo S, Du P, Jia S, Cheng L. "Triple-negative Breast Carcinoma With Apocrine and Histiocytoid Features: A Clinicopathologic and Molecular Study of 18 Cases." The American Journal of Surgical Pathology, vol. 47, no. 9, 2023, pp. 1011-1018. |
| Freedman RA, Graff SL, Somerfield MR, Telli ML, Wolff AC, Giordano SH. "Adjuvant Abemaciclib Plus Endocrine Therapy in the Treatment of High-Risk Early Breast Cancer: ASCO Guideline Rapid Recommendation Update Q and A." JCO Oncology Practice, 2022, pp. OP2200140. |
| Subbiah IM, Markham MJ, Graff SL, Matt-Amaral LB, Close JL, Griffith KA, Jagsi R. "Incidence, Nature, and Consequences of Oncologists' Experiences With Sexual Harassment." Journal of Clinical Oncology, 2022, pp. JCO2102574. |
| Graff SL. "People Like Us." Journal of Clinical Oncology, 2022, pp. JCO2201835. |
| Chidharla A, Utengen A, Attai DJ, Drake EK, van Londen GJ, Subbiah IM, Henry E, Murphy M, Barry MM, Manochakian R, Moerdler S, Loeb S, Graff SL, Leyfman Y, Thompson MA, Markham MJ. "Social Media and Professional Development for Oncology Professionals." JCO Oncology Practice, 2022, pp. OP2100761. |
| Anampa-Guzmán A, Freeman-Daily J, Fisch M, Lou E, Pennell NA, Painter CA, Sparacio D, Lewis MA, Karmo M, Anderson PF, Graff SL, Collaboration for Outcomes using Social Media in Oncology. "The Rise of the Expert Patient in Cancer: From Backseat Passenger to Co-navigator." JCO Oncology Practice, 2022, pp. OP2100763. |
| Cortés J, Kim SB, Chung WP, Im SA, Park YH, Hegg R, Kim MH, Tseng LM, Petry V, Chung CF, Iwata H, Hamilton E, Curigliano G, Xu B, Huang CS, Kim JH, Chiu JWY, Pedrini JL, Lee C, Liu Y, Cathcart J, Bako E, Verma S, Hurvitz SA, DESTINY-Breast03 Trial Investigators. "Trastuzumab Deruxtecan versus Trastuzumab Emtansine for Breast Cancer." New England Journal of Medicine, vol. 386, no. 12, 2022, pp. 1143-1154. |
| Graff SL, Wildes T, Duma N, Dizon DS, LoConte NK, Mitchell E, Murphy MC, Perez EA, Temkin SM, Kunz PL, Winkfield KM. "Understanding Modern Medical Centers: Beyond Simone-Intersectional Maxims for a New Era." Journal of Clinical Oncology, 2022, pp. JCO2201060. |
| Motzer R, Alekseev B, Rha SY, Porta C, Eto M, Powles T, Grünwald V, Hutson TE, Kopyltsov E, Méndez-Vidal MJ, Kozlov V, Alyasova A, Hong SH, Kapoor A, Alonso Gordoa T, Merchan JR, Winquist E, Maroto P, Goh JC, Kim M, Gurney H, Patel V, Peer A, Procopio G, Takagi T, Melichar B, Rolland F, De Giorgi U, Wong S, Bedke J, Schmidinger M, Dutcus CE, Smith AD, Dutta L, Mody K, Perini RF, Xing D, Choueiri TK, CLEAR Trial Investigators. "Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma." New England Journal of Medicine, vol. 384, no. 14, 2021, pp. 1289-1300. |
| Powles T, Csőszi T, Özgüroğlu M, Matsubara N, Géczi L, Cheng SY, Fradet Y, Oudard S, Vulsteke C, Morales Barrera R, Fléchon A, Gunduz S, Loriot Y, Rodriguez-Vida A, Mamtani R, Yu EY, Nam K, Imai K, Homet Moreno B, Alva A, KEYNOTE-361 Investigators. "Pembrolizumab alone or combined with chemotherapy versus chemotherapy as first-line therapy for advanced urothelial carcinoma (KEYNOTE-361): a randomised, open-label, phase 3 trial." The Lancet Oncology, vol. 22, no. 7, 2021, pp. 931-945. |
| Bardia A, Hurvitz SA, Tolaney SM, Loirat D, Punie K, Oliveira M, Brufsky A, Sardesai SD, Kalinsky K, Zelnak AB, Weaver R, Traina T, Dalenc F, Aftimos P, Lynce F, Diab S, Cortés J, O'Shaughnessy J, Diéras V, Ferrario C, Schmid P, Carey LA, Gianni L, Piccart MJ, Loibl S, Goldenberg DM, Hong Q, Olivo MS, Itri LM, Rugo HS, ASCENT Clinical Trial Investigators. "Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer." New England Journal of Medicine, vol. 384, no. 16, 2021, pp. 1529-1541. |
| Denduluri N, Somerfield MR, Chavez-MacGregor M, Comander AH, Dayao Z, Eisen A, Freedman RA, Gopalakrishnan R, Graff SL, Hassett MJ, King TA, Lyman GH, Maupin GR, Nunes R, Perkins CL, Telli ML, Trudeau ME, Wolff AC, Giordano SH. "Selection of Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer: ASCO Guideline Update." Journal of Clinical Oncology, vol. 39, no. 6, 2021, pp. 685-693. |
| Graff SL. "Treatment of Premenopausal Women: Finding the Right-Sized Endocrine Therapy." JCO Oncology Practice, 2021, pp. OP2100720. |
| Woitowich NC, Graff SL, Swaroop M, Jain S. "Gender-Specific Conferences and Symposia: A Putative Support Structure for Female Physicians." Journal of Women's Health, vol. 29, no. 8, 2020, pp. 1136-1141. |
| Graff SL, Holder JM, Sears LE, Kurbegov D. "Increase in Genetic Counseling and Testing Referrals After Breast Cancer Pathway Implementation." JCO Oncology Practice, vol. 16, no. 12, 2020, pp. e1481-e1488. |
| Ersek JL, Graff SL, Arena FP, Denduluri N, Kim ES. "Critical Aspects of a Sustainable Clinical Research Program in the Community-Based Oncology Practice." American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Meeting, vol. 39, 2019, pp. 176-184. |
| Duma N, Durani U, Woods CB, Kankeu Fonkoua LA, Cook JM, Wee C, Fuentes HE, Gonzalez-Velez M, Murphy MC, Jain S, Marshall AL, Graff SL, Knoll MA. "Evaluating Unconscious Bias: Speaker Introductions at an International Oncology Conference." Journal of Clinical Oncology, vol. 37, no. 36, 2019, pp. 3538-3545. |
| LaCasce A, Graff S, Gao J, Close J, Boulmay B. "Preparing Fellows for Graduation: Perspectives on Career Guidance." American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Meeting, vol. 39, 2019, pp. 609-614. |
| Graff SL. "The Cattle Don't Care." Journal of Clinical Oncology, vol. 37, no. 13, 2019, pp. 1136-1138. |
| Cook JW, Dillmon M, Graff SL, Pentz RD, Srivastava R, Close JL. "Caring for Colleagues and Loved Ones With Cancer." American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Meeting, vol. 38, 2018, pp. 903-908. |
| Graff SL, Close J, Cole S, Matt-Amaral L, Beg R, Markham MJ. "Impact of Closed Facebook Group Participation on Female Hematology/Oncology Physicians." Journal of Oncology Practice, vol. 14, no. 12, 2018, pp. e758-e769. |
| Ghosh A, Sarkar S, Banerjee S, Behbod F, Tawfik O, McGregor D, Graff S, Banerjee SK. "MIND model for triple-negative breast cancer in syngeneic mice for quick and sequential progression analysis of lung metastasis." PLoS ONE, vol. 13, no. 5, 2018, pp. e0198143. |
| Gupta V, Haque I, Chakraborty J, Graff S, Banerjee S, Banerjee SK. "Racial disparity in breast cancer: can it be mattered for prognosis and therapy." Journal of cell communication and signaling, vol. 12, no. 1, 2018, pp. 119-132. |
| Denduluri N, Chavez-MacGregor M, Telli ML, Eisen A, Graff SL, Hassett MJ, Holloway JN, Hurria A, King TA, Lyman GH, Partridge AH, Somerfield MR, Trudeau ME, Wolff AC, Giordano SH. "Selection of Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer: ASCO Clinical Practice Guideline Focused Update." Journal of Clinical Oncology, vol. 36, no. 23, 2018, pp. 2433-2443. |
| Year | Degree | Institution |
|---|---|---|
| 2004 | MD | University of Missouri |
| 2003 | BA | University of Missouri |
