Sheila A. HaleyAssistant Professor of Molecular Biology, Cell Biology and Biochemistry (Research)
The first hurdle a virus encounters prior to virus infection is engagement at the cell surface. In turn, viruses utilize various strategies to overcome this barrier. Virus entry to a host cell is required for a productive viral infection. Interactions between viruses and their cognate receptors on the cell surface determine the route of virus entry. Understanding the interactions between viruses and their host cell receptors is required for a full understanding of the virus invasion process. My research focuses on understanding the mechanism by which JCPyV, a human polyoma virus, engages its target cell(s) in the host, identifying determinants of the tissue tropism of viruses, and pursuing possibilities for specific interference of infection.
Haley, S.A., O’Hara, B.A., Nelson, C.D.S., Brittingham, F.L.P., Henriksen, K.J., Stopa, E.G., and Atwood, W.J. Human Polyomavirus JCPyV Receptor Distribution in Brain Parenchyma Contrasts with Receptor Distribution in Kidney and Choroid Plexus. (American Journal of Pathology, in press).
Haley S.A., Atwood W.J., 2014. An animal model for progressive multifocal leukoencephalopathy. J. Clinical Investigation, Nov 17: 1-4. PMID: 25401466
Assetta B., Maginnis M.S., Gracia Ahufinger I., Haley S.A., Gee G.V., Nelson C.D., O'Hara B.A., Allen Ramdial S.A., Atwood W.J., 2013. 5-HT2 receptors facilitate JC polyomavirus entry. Journal of Virology, 87(24):13490-8. PMID: 24089568
Haley, S.A., O’Hara, B.A., Banerjee, R., Atwood, W.J., 2010. Unique Susceptibility of a Human Lung Carcinoid Tumor Cell Line to Infection with BK Virus. Virus Research 149 (1): 128-132. PMID: 20122973
Maginnnis, M.S., Haley, S.A., Gee, G.V., and Atwood, W.J., 2010. Role of N-linked Glycosylation of the 5-HT2A Receptor in JC Virus Infection. Journal of Virology, 84 (19): 9677 – 9684. PMID: 20660194
De Paepe, M.E., Haley, S.A., Lacourse, Z., and Mao, Q., 2010. The Effects of Fas-Ligand Overexpression on Alveolar Type II Cell Growth Kinetics in Perinatal Murine Lungs. Pediatric Research, 68 (1): 57-62. PMID: 20375852