Haley, Sheila

Sheila A Haley

Assistant Professor of Molecular Biology, Cell Biology and Biochemistry (Research)

Overview

The first hurdle a virus encounters prior to virus infection is engagement at the cell surface. In turn, viruses utilize various strategies to overcome this barrier. Virus entry to a host cell is required for a productive viral infection. Interactions between viruses and their cognate receptors on the cell surface determine the route of virus entry. Understanding the interactions between viruses and their host cell receptors is required for a full understanding of the virus invasion process. My research focuses on understanding the mechanism by which JCPyV, a human polyoma virus, engages its target cell(s) in the host, identifying determinants of the tissue tropism of viruses, and pursuing possibilities for specific interference of infection.

Brown Affiliations

Molecular Biology, Cell Biology and Biochemistry

Publications Visualize it

O'Hara, Bethany A., Gee, Gretchen V., Atwood, Walter J., Haley, Sheila A. "Susceptibility of Primary Human Choroid Plexus Epithelial Cells and Meningeal Cells to Infection by JC Virus." Journal of Virology, vol. 92, no. 8, 2018, pp. e00105-18.

Full Text PubMed

Haley, Sheila A., O'Hara, Bethany A., Nelson, Christian D.S., Brittingham, Frances L.P., Henriksen, Kammi J., Stopa, Edward G., Atwood, Walter J. "Human Polyomavirus Receptor Distribution in Brain Parenchyma Contrasts with Receptor Distribution in Kidney and Choroid Plexus." The American Journal of Pathology, vol. 185, no. 8, 2015, pp. 2246-2258.

Full Text PubMed

Haley, Sheila A., Atwood, Walter J. "An animal model for progressive multifocal leukoencephalopathy." Journal of Clinical Investigation, vol. 124, no. 12, 2014, pp. 5103-5106.

Full Text PubMed

Assetta B, Maginnis MS, Gracia Ahufinger I, Haley SA, Gee GV, Nelson CD, O'Hara BA, Allen Ramdial SA, Atwood WJ. "5-HT2 receptors facilitate JC polyomavirus entry." Journal of Virology, vol. 87, no. 24, 2013, pp. 13490-8.

Full Text PubMed

de Paepe ME, Haley SA, Lacourse Z, Mao Q. "Effects of Fas-ligand overexpression on alveolar type II cell growth kinetics in perinatal murine lungs." Pediatric Research, vol. 68, no. 1, 2010, pp. 57-62.

Full Text PubMed

Maginnis MS, Haley SA, Gee GV, Atwood WJ. "Role of N-linked glycosylation of the 5-HT2A receptor in JC virus infection." Journal of Virology, vol. 84, no. 19, 2010, pp. 9677-84.

Full Text PubMed

Haley SA, O'Hara BA, Banerjee R, Atwood WJ. "Unique susceptibility of a human lung carcinoid tumor cell line to infection with BK virus." Virus research, vol. 149, no. 1, 2010, pp. 128-32.

Full Text PubMed

De Paepe ME, Gundavarapu S, Tantravahi U, Pepperell JR, Haley SA, Luks FI, Mao Q. "Fas-ligand-induced apoptosis of respiratory epithelial cells causes disruption of postcanalicular alveolar development." The American Journal of Pathology, vol. 173, no. 1, 2008, pp. 42-56.

Full Text PubMed

Haley SA, Zhao T, Zou L, Klysik JE, Padbury JF, Kochilas LK. "Forced expression of the cell cycle inhibitor p57Kip2 in cardiomyocytes attenuates ischemia-reperfusion injury in the mouse heart." BMC physiology, vol. 8, 2008, pp. 4.

Full Text PubMed

Haley SA, Wessel GM. "Proteolytic cleavage of the cell surface protein p160 is required for detachment of the fertilization envelope in the sea urchin." Developmental Biology, vol. 272, no. 1, 2004, pp. 191-202.

Full Text PubMed

Haley SA, Wessel GM. "Regulated proteolysis by cortical granule serine protease 1 at fertilization." Molecular biology of the cell, vol. 15, no. 5, 2004, pp. 2084-92.

Full Text PubMed

Wessel GM, Brooks JM, Green E, Haley S, Voronina E, Wong J, Zaydfudim V, Conner S. "The biology of cortical granules." International review of cytology, vol. 209, 2001, pp. 117-206.

PubMed

Haley SA, Wessel GM. "The cortical granule serine protease CGSP1 of the sea urchin, Strongylocentrotus purpuratus, is autocatalytic and contains a low-density lipoprotein receptor-like domain." Developmental Biology, vol. 211, no. 1, 1999, pp. 1-10.

Full Text PubMed

Background

Education and Training

Year	Degree	Institution
2001	PhD	Brown University
1990	BS	University of Massachusetts

Researchers@Brown

Researchers@Brown

Sheila A Haley

Assistant Professor of Molecular Biology, Cell Biology and Biochemistry (Research)

Overview

Brown Affiliations

Publications Visualize it

Research

Scholarly Work

Background

Education and Training

Affiliations Visualize it

Teaching

Teaching Overview