Grants: (Active)
Legorreta Cancer Research Fund (Brown University) 3/1/22 – 2/28/23
Chi3l1 regulation of P53 in Lung Cancer
Role: PI ($ 15,000)
P01 HL114501-01A1 (Choi) 06/01/2021 – 07/31/2026
NIH/NHLBI
Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers
Role: Co-Investigator of Project #2 (Leader, Jack A. Elias, M.D.) ($ 4.3 M)
LC210132 (Department of Defense) 10/01/2021-09/30/2022
Antitumor activity of Kasugamycin in primary and metastatic lung cancer
Role: Co-Investigator (Chun Geun Lee, PI) ($ 150,000)
PR211855 (Department of Defense) 01/01/2202-12/30/2023
Bispecific Targeting of CHI3L1 and PD-1/PD-L1 Axis as a Novel Therapeutic Strategy for Idiopathic Pulmonary Fibrosis
Role: Co-Investigator (Chun Geun Lee, PI) ($ 159,128)
Completed Research Support
Cancer Center Seed Grant, Brown University 11/01/2020-10/31/2021
Blocking anti-Chitinase 3-Like-1 to overcome resistance to immune checkpoint inhibitors in advanced non-small cell lung cancer.
Role: Co-PI (Corresponding PI: Hina Khan) ($25,000)
Brown Research Seed Fund (Covid-19) 05/14/2020-05/15/2021
Chitinase 3-like 1 (Chi3l1), a powerful inhibitor of epithelial cell death, can be used as a biomarker of CoV-2 infection that predicts disease severity and progression.
Role: Co-Investigator (PI: Chun Geun Lee) ($17,000)
BC1700061 (81550110261) NSFC China 1/1/2016-12/31/2017
Cellular signaling pathways for the efficacy evaluation of the plant expressed therapeutic antibody
Role: PI Role: ($67,000)
This grant studied about the efficacy of the plant expressed human antibodies may be affected due to the plant and mammalian various differences in endomembrane system, secretory pathway that are likely to cause changes in antibody glycosylation and other post-translational and secretary modifications. Therefore, understanding the differences between mammalian cell CHO expressed and plant expressed antibodies in interfering the cellular pathways in cancer cells are essential to predict efficacy of antibodies expressed by plants.
2014M560336 Shanghai, China 07/20/14-12/31/2015
The development of plant system for the cost-effective production of Agtuzumab, an Anti-AGR2 antibody involved in tumor Reduction and angiogenesis.
Role: PI ($20,000)
The objective of this study is to provide a novel and alternative plant-based method for the industrial-scale production of Agtuzumab for the tumor reduction and angiogenesis.
NII/ACD/19.309/DBT.PD/2012 New Delhi, India 01/01/2012- 12/27/2013
Molecular Characterization of mRNA transcripts tagged with H-ras in Bubalus bubalis genome.
Role: PI. ($15,000)
This grant studied about epetitive sequences are the major components of the eukaryotic genomes. The association of these repeats with transcribing sequences and their regulation in Bubalus bubalis has remained largely unresolved. This is significant because H-ras repeats owing to their shrinkage and expansion affect gene expression and are implicated in human diseases. In-depth analysis of H-ras gene is hoped to focus the search for elusive ones.
