Expertise/Certifications: Surgical pathology, Gastrointestinal pathology, Clinical Immunology
Office number: 401-606-4467
(Lab Customer Service: 401-793-4242)
Dr. Lu is Assistant Professor of Pathology and Laboratory Medicine at the Warren Alpert School of Medicine at Brown University. He received his M.D. from Shanghai Medical College of Fudan University, Shanghai, China, and his Ph.D. in Molecular and Cellular Biology from the University of Massachusetts at Amherst, MA. He is board-certified in anatomic pathology and clinical pathology by the American Board of Pathology, and has special interests in molecular mechanisms in oncology and gastrointestinal pathology, clinical immunology, and use of technology in pathology education.
|Ji C, Nagaoka K, Zou J, Casulli S, Lu S, Cao KY, Zhang H, Iwagami Y, Carlson RI, Brooks K, Lawrence J, Mueller W, Wands JR, Huang CK. "Chronic ethanol-mediated hepatocyte apoptosis links to decreased TET1 and 5-hydroxymethylcytosine formation." The FASEB Journal, vol. 33, no. 2, 2019, pp. fj201800736R.|
|Zhao CL, Hui Y, Wang LJ, Yang D, Yakirevich E, Mangray S, Huang CK, Lu S. "Alanine-Glyoxylate Aminotransferase 1 (AGXT1) is a Novel Marker for Hepatocellular Carcinomas." Human Pathology, 2018.|
|Huang CK, Iwagami Y, Zou J, Casulli S, Lu S, Nagaoka K, Ji C, Ogawa K, Cao KY, Gao JS, Carlson RI, Wands JR. "Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation." Cancer Letters, vol. 429, 2018, pp. 1-10.|
|Wang Y, Lu S, Xiong J, Singh K, Hui Y, Zhao C, Brodsky AS, Yang D, Jolly G, Ouseph M, Schorl C, DeLellis RA, Resnick MB. "ColXα1 is a stromal component that colocalizes with elastin in the breast tumor extracellular matrix." The journal of pathology. Clinical research, 2018.|
|Hui Y, Lu S, Wang H, Resnick MB, Wang Y. "Discordant HER2 Immunohistochemical Expression and Gene Amplification in Ductal Carcinoma In Situ - Evaluating HER2 in Synchronous In Situ and Invasive Carcinoma." Histopathology, 2018.|
|Acosta-Gonzalez, Gabriel, Ouseph, Madhu, Lombardo, Kara, Lu, Shaolei, Glickman, Jonathan, Resnick, Murray. "Immune environment in serrated lesions of the Colon: intraepithelial lymphocyte density, PD-1, and PD-L1 expression correlate with serrated neoplasia pathway progression." Human Pathology, 2018.|
|Park WKC, Maxwell AWP, Frank VE, Primmer MP, Paul JB, Collins SA, Lombardo KA, Lu S, Borjeson TM, Baird GL, Dupuy DE. "The in vivo performance of a novel thermal accelerant agent used for augmentation of microwave energy delivery within biologic tissues during image-guided thermal ablation: a porcine study." International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, vol. 34, no. 1, 2018, pp. 1-8.|
|Lu, Shaolei, Herzlinger, Michael, Cao, Weibiao, Noble, Lelia, Yang, Dongfang, Shapiro, Jason, Kurtis, Jonathan, LeLeiko, Neal, Resnick, Murray. "Utility of 15(S)-HETE as a Serological Marker for Eosinophilic Esophagitis." Scientific Reports, vol. 8, no. 1, 2018, pp. 14498.|
|Wang, Yihong, Lu, Shaolei, Graves, Theresa, Ouseph, Madhu M., Resnick, Murray B., Yakirevich, Evgeny. "Can Sentinel Lymph Node Biopsy Be Spared in Papillary Carcinoma of the Breast?." Clinical Breast Cancer, vol. 17, no. 2, 2017, pp. 127-133.|
|Hui, Yiang, Quddus, M. Ruhul, Murthy, Jayasimha N., Yang, Dongfang, Sung, C. James, Lu, Shaolei, Resnick, Murray B., Wang, Li Juan. "Human Papillomavirus Genotyping of Incidental Malignant and Premalignant Lesions on Hemorrhoidectomy Specimens." The American Journal of Surgical Pathology, vol. 41, no. 3, 2017, pp. 382-388.|
|Yakirevich E, Lu S, Allen D, Mangray S, Fanion JR, Lombardo KA, Safran H, Resnick MB. "Prognostic significance of IgG4+ plasma cell infiltrates following neoadjuvant chemoradiation therapy for esophageal adenocarcinoma." Human Pathology, vol. 66, 2017, pp. 126-135.|
|Zhao CL, Hui Y, Wang LJ, Lombardo K, Yang D, Mangray S, Yakirevich E, Amin A, Huang CK, Lu S. "T-complex-associated-testis-expressed 3 (TCTE3) is a novel marker for pancreatobiliary carcinomas." Human Pathology, vol. 70, 2017, pp. 62-69.|
|Li J, Lu S, Lombardo K, Monahan R, Amin A. "ARID1A alteration in aggressive urothelial carcinoma and variants of urothelial carcinoma." Human Pathology, vol. 55, 2016, pp. 17-23.|
|Wang Y, Resnick MB, Lu S, Hui Y, Brodsky AS, Yang D, Yakirevich E, Wang L. "Collagen type III α1 as a useful diagnostic immunohistochemical marker for fibroepithelial lesions of the breast." Human Pathology, vol. 57, 2016, pp. 176-181.|
|Wood SM, Gill AJ, Brodsky AS, Lu S, Friedman K, Karashchuk G, Lombardo K, Yang D, Resnick MB. "Fatty acid-binding protein 1 is preferentially lost in microsatellite instable colorectal carcinomas and is immune modulated via the interferon γ pathway." Modern Pathology, vol. 30, no. 1, 2016, pp. 123-133.|
|Friedman K, Brodsky AS, Lu S, Wood S, Gill AJ, Lombardo K, Yang D, Resnick MB. "Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, vol. 29, no. 5, 2016, pp. 528-541.|
|Yakirevich E, Magi-Galluzzi C, Grada Z, Lu S, Resnick MB, Mangray S. "Cadherin 17 Is a Sensitive and Specific Marker for Metanephric Adenoma." The American Journal of Surgical Pathology, vol. 39, no. 4, 2015, pp. 479-486.|
|Snow AN, Mangray S, Lu S, Clubwala R, Li J, Resnick MB, Yakirevich E. "Expression of cadherin 17 in well-differentiated neuroendocrine tumours." Histopathology, vol. 66, no. 7, 2015, pp. 1010-1021.|
|Matoso A, Allen D, Herzlinger M, Ferreira J, Chen S, Lu S, Fabre V, Monahan R, Yang D, Noble L, Mangray S, Resnick MB. "Correlation of ALOX15 expression with eosinophilic or reflux esophagitis in a cohort of pediatric patients with esophageal eosinophilia." Human Pathology, vol. 45, no. 6, 2014, pp. 1205-12.|
|He M, Pepperell JR, Gundogan F, De Paepe ME, Maggio L, Lu S, Kostadinov S, O'Brien B, Delamonte S, Pinar H, Tantravahi U. "Monochorionic twins discordant for mosaic trisomy 14." American journal of medical genetics. Part A, vol. 164A, no. 5, 2014, pp. 1227-33.|
|Taliano RJ, Lu S, Singh K, Mangray S, Tavares R, Noble L, Resnick MB, Yakirevich E. "Calretinin expression in high-grade invasive ductal carcinoma of the breast is associated with basal-like subtype and unfavorable prognosis." Human Pathology, vol. 44, no. 12, 2013, pp. 2743-50.|
|Lu S, Singh K, Mangray S, Tavares R, Noble L, Resnick MB, Yakirevich E. "Claudin expression in high-grade invasive ductal carcinoma of the breast: correlation with the molecular subtype." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, vol. 26, no. 4, 2013, pp. 485-95.|
|Matoso A, Mukkada VA, Lu S, Monahan R, Cleveland K, Noble L, Mangray S, Resnick MB. "Expression microarray analysis identifies novel epithelial-derived protein markers in eosinophilic esophagitis." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, vol. 26, no. 5, 2013, pp. 665-76.|
|Ratanaprasatporn L, Charpentier KP, Resnick M, Lu S, Dupuy D. "Intra-operative microwave ablation of liver malignancies with tumour permittivity feedback control: a prospective ablate and resect study." HPB, vol. 15, no. 12, 2013, pp. 997-1001.|
|Cross-Knorr S, Lu S, Perez K, Guevara S, Brilliant K, Pisano C, Quesenberry PJ, Resnick MB, Chatterjee D. "RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients." BMC cancer, vol. 13, 2013, pp. 463.|
|Lu S, Mukkada VA, Mangray S, Cleveland K, Shillingford N, Schorl C, Brodsky AS, Resnick MB. "MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets." PLoS ONE, vol. 7, no. 7, 2012, pp. e40676.|
|Jiao B, Ma H, Shokhirev MN, Drung A, Yang Q, Shin J, Lu S, Byron M, Kalantry S, Mercurio AM, Lawrence JB, Hoffmann A, Bach I. "Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells." Cell, vol. 149, no. 3, 2012, pp. 630-41.|
|Cellurale C, Girnius N, Jiang F, Cavanagh-Kyros J, Lu S, Garlick DS, Mercurio AM, Davis RJ. "Role of JNK in mammary gland development and breast cancer." Cancer Research, vol. 72, no. 2, 2012, pp. 472-81.|
|Yakirevich E, Samkari A, Holloway MP, Lu S, Singh K, Yu J, Fenton MA, Altura RA. "Total Survivin and acetylated Survivin correlate with distinct molecular subtypes of breast cancer." Human Pathology, vol. 43, no. 6, 2012, pp. 865-73.|
|Goel HL, Bae D, Pursell B, Gouvin LM, Lu S, Mercurio AM. "Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland." Development, vol. 138, no. 14, 2011, pp. 2969-76.|
|Walter O, Prasad M, Lu S, Quinlan RM, Edmiston KL, Khan A. "IMP3 is a novel biomarker for triple negative invasive mammary carcinoma associated with a more aggressive phenotype." Human Pathology, vol. 40, no. 11, 2009, pp. 1528-33.|
|Yang X, Pursell B, Lu S, Chang TK, Mercurio AM. "Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition." Journal of cell science, vol. 122, no. Pt 14, 2009, pp. 2473-80.|
|Lu S, Simin K, Khan A, Mercurio AM. "Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance." Clin Cancer Res , vol. 14, no. 4, 2008, pp. 1050-8.|
|Bae D, Lu S, Taglienti CA, Mercurio AM. "Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2." Journal of Biological Chemistry, vol. 283, no. 42, 2008, pp. 28074-80.|
|Lu S, Becker KA, Hagen MJ, Yan H, Roberts AL, Mathews LA, Schneider SS, Siegelmann HT, MacBeth KJ, Tirrell SM, Blanchard JL, Jerry DJ. "Transcriptional responses to estrogen and progesterone in mammary gland identify networks regulating p53 activity." Endocrinology, vol. 149, no. 10, 2008, pp. 4809-20.|
|Becker KA, Lu S, Dickinson ES, Dunphy KA, Mathews L, Schneider SS, Jerry DJ. "Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF-beta-dependent pathways." Oncogene, vol. 24, no. 42, 2005, pp. 6345-53.|
Lu S, Huang G.
"An experimental study of inhibiting the epidural scar formation following lumbar spinal surgery." Chinese Journal of Orthopaedics, vol. 21, no. 4, 2001, pp. 238-244.
Lu S, Huang G.
"Epidural scar formation and failed back surgery syndrome." Chinese Journal of Orthopaedics, vol. 21, no. 4, 2000, pp. 630-633.
Lu K, Gao X, Cai H, Wen L, Wang Y, Zhang Y, Lu S.
"Use of unilateral external fixation for extremity fractures: a report of 45 cases." Beijing Medicine, vol. 21, 1999, pp. 248.
Xue Q, Huang G, Gao X, Lu S, Wang Y.
"Environmental factors of fall risk in the aged hip fractures: a report of 439 cases." Chinese Journal of Geriatrics , vol. 15, 1996, pp. 276-278.
Rhode Island Foundation (2015-16) Contribution of Hedgehog Signaling Pathway to Intrahepatic Cholangiocarcinoma
Brown Pilot Project Funding for Translational Research (2011-2012) Molecular Characterization of CK5/6 Positive Cells in Breast Carcinoma
Susan G. Komen for the Cure (2006-2009) Contribution of CUTL-1 to Basal Phenotype Breast Cancer.
|2009||MD||Shanghai Medical University|
|2005||PhD||University of Massachusetts, Amherst|
2011 Breast Pathology Award: Best Resident Research in Clinical Sciences, International Society of Breast Pathology