Metastasis, development of resistance to treatments, and tumor relapse are fundamental reasons for most cancer patient-related mortality. In my laboratory, we aim to understand the fundamental biology of cancer progression and, in particular, to comprehend how tumors become highly aggressive, develop resistance to therapies, and eventually become metastatic.
Our research, along with others, has demonstrated that the aberrant activation of a latent embryonic program—known as the epithelial-mesenchymal transition (EMT), makes the cancer cells migratory, invasive, and metastatic (Yang and Mani et al., Cell 2004; Mani & Yang et al., PNAS 2007).
Tumors at the metastatic site tend to appear similar to the primary tumor. Since EMT is necessary for cancer cells to migrate and invade, we demonstrated that the EMT program also provides stem cell properties to differentiated cancer cells (Mani et al., Cell 2008). This ability helps cancer cells to survive in circulation and establish metastasis in the hostile distant microenvironment.
This highly cited and extremely influential article suggested that the tumor can make its own cancer stem cells by activating EMT and also explained the presence of plasticity within the tumor.
Currently, we are pursuing the following areas.
| Fathi M, Martinez-Paniagua M, Rezvan A, Montalvo MJ, Mohanty V, Chen K, Mani SA, Varadarajan N. "Identifying signatures of EV secretion in metastatic breast cancer through functional single-cell profiling." iScience, vol. 26, no. 4, 2023, pp. 106482. |
| Addeo A, Miranda-Morales E, den Hollander P, Friedlaender A, O Sintim H, Wu J, Mani SA, Subbiah V. "RET aberrant cancers and RET inhibitor therapies: Current state-of-the-art and future perspectives." Pharmacology & Therapeutics, vol. 242, 2023, pp. 108344. |
| Wu L, Amjad S, Yun H, Mani S, de Perrot M. "A panel of emerging EMT genes identified in malignant mesothelioma." Scientific reports, vol. 12, no. 1, 2022, pp. 1007. |
| Visal TH, den Hollander P, Cristofanilli M, Mani SA. "Circulating tumour cells in the -omics era: how far are we from achieving the 'singularity'?." Br J Cancer, vol. 127, no. 2, 2022, pp. 173-184. |
| Deshmukh AP, den Hollander P, Kuburich NA, Vasaikar S, Joseph R, Mani SA. "Enrichment of Cancer Stem Cells in a Tumorsphere Assay." Methods in Molecular Biology, vol. 2429, 2022, pp. 501-507. |
| Aouad P, Zhang Y, De Martino F, Stibolt C, Ali S, Ambrosini G, Mani SA, Maggs K, Quinn HM, Sflomos G, Brisken C. "Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence." Nature Communications, vol. 13, no. 1, 2022, pp. 4975. |
| Castaneda, Maria, Hollander, Petra den, Mani, Sendurai A. "Forkhead Box Transcription Factors: Double-Edged Swords in Cancer." Cancer Research, vol. 82, no. 11, 2022, pp. 2057-2065. |
| Kuburich NA, den Hollander P, Deshmukh AP, Vasaikar S, Joseph R, Wicha MS, Mani SA. "In Vitro Quantification of Cancer Stem Cells Using a Mammosphere Formation Assay." Methods in Molecular Biology, vol. 2429, 2022, pp. 509-513. |
| den Hollander P, Joseph R, Vasaikar S, Kuburich NA, Deshmukh AP, Mani SA. "Limiting Dilution Tumor Initiation Assay: An In Vivo Approach for the Study of Cancer Stem Cells." Methods in Molecular Biology, vol. 2429, 2022, pp. 547-554. |
| Castaneda M, den Hollander P, Kuburich NA, Rosen JM, Mani SA. "Mechanisms of cancer metastasis." Seminars in Cancer Biology, vol. 87, 2022, pp. 17-31. |
| Kudaravalli S, den Hollander P, Mani SA. "Role of p38 MAP kinase in cancer stem cells and metastasis." Oncogene, vol. 41, no. 23, 2022, pp. 3177-3185. |
| Martínez-Peña F, Pearson AD, Tang EL, Kuburich NA, Mani SA, Schultz PG, Bollong MJ, Lairson LL. "Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers." European journal of medicinal chemistry, vol. 242, 2022, pp. 114638. |
| Kuburich, Nick A., den Hollander, Petra, Pietz, Jordan T., Mani, Sendurai A. "Vimentin and cytokeratin: Good alone, bad together." Seminars in Cancer Biology, vol. 86, no. Pt 3, 2022, pp. 816-826. |
| Satpathy S, Krug K, Jean Beltran PM, Savage SR, Petralia F, Kumar-Sinha C, Dou Y, Reva B, Kane MH, Avanessian SC, Vasaikar SV, Krek A, Lei JT, Jaehnig EJ, Omelchenko T, Geffen Y, Bergstrom EJ, Stathias V, Christianson KE, Heiman DI, Cieslik MP, Cao S, Song X, Ji J, Liu W, Li K, Wen B, Li Y, Gümüş ZH, Selvan ME, Soundararajan R, Visal TH, Raso MG, Parra ER, Babur Ö, Vats P, Anand S, Schraink T, Cornwell M, Rodrigues FM, Zhu H, Mo CK, Zhang Y, da Veiga Leprevost F, Huang C, Chinnaiyan AM, Wyczalkowski MA, Omenn GS, Newton CJ, Schurer S, Ruggles KV, Fenyö D, Jewell SD, Thiagarajan M, Mesri M, Rodriguez H, Mani SA, Udeshi ND, Getz G, Suh J, Li QK, Hostetter G, Paik PK, Dhanasekaran SM, Govindan R, Ding L, Robles AI, Clauser KR, Nesvizhskii AI, Wang P, Carr SA, Zhang B, Mani DR, Gillette MA, Clinical Proteomic Tumor Analysis Consortium. "A proteogenomic portrait of lung squamous cell carcinoma." Cell, vol. 184, no. 16, 2021, pp. 4348-4371.e40. |
| Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis AK, Huang RYJ, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore GD, Mani SA, Massagué J, Mayor R, McClay D, Mostov KE, Newgreen DF, Nieto MA, Puisieux A, Runyan R, Savagner P, Stanger B, Stemmler MP, Takahashi Y, Takeichi M, Theveneau E, Thiery JP, Thompson EW, Weinberg RA, Williams ED, Xing J, Zhou BP, Sheng G, EMT International Association (TEMTIA). "Author Correction: Guidelines and definitions for research on epithelial-mesenchymal transition." Nature reviews. Molecular cell biology, vol. 22, no. 12, 2021, pp. 834. |
| Bushnell GG, Deshmukh AP, den Hollander P, Luo M, Soundararajan R, Jia D, Levine H, Mani SA, Wicha MS. "Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge." npj Breast Cancer, vol. 7, no. 1, 2021, pp. 66. |
| Joseph, Robiya, Soundararajan, Rama, Vasaikar, Suhas, Yang, Fei, Allton, Kendra L., Tian, Lin, den Hollander, Petra, Isgandarova, Sevinj, Haemmerle, Monika, Mino, Barbara, Zhou, Tieling, Shin, Crystal, Martinez-Paniagua, Melisa, Sahin, Aysegul A., Rodriguez-Canales, Jaime, Gelovani, Juri, Chang, Jeffrey T., Acharya, Ghanashyam, Sood, Anil K., Wistuba, Ignacio I., Gibbons, Don L., Solis, Luisa M., Barton, Michelle C., Varadarajan, Navin, Rosen, Jeffrey M., Zhang, Xiang H., Mani, Sendurai A. "CD8+ T cells inhibit metastasis and CXCL4 regulates its function." British Journal of Cancer, vol. 125, no. 2, 2021, pp. 176-189. |
| Ammassam Veettil R, Marcano DC, Yuan X, Zaheer M, Adumbumkulath A, Lee R, Isenhart LC, Soriano N, Mhatre K, Joseph R, Mani SA, Shin CS, Acharya G. "Dextran Sulfate Polymer Wafer Promotes Corneal Wound Healing." Pharmaceutics, vol. 13, no. 10, 2021. |
| Tripathi SC, Jolly MK, Mani SA, Levine H. "Editorial: Characterizing the Multi-Faceted Dynamics of Tumor Cell Plasticity." Frontiers in molecular biosciences, vol. 7, 2021, pp. 630276. |
| Balcik-Ercin P, Cayrefourcq L, Soundararajan R, Mani SA, Alix-Panabières C. "Epithelial-to-Mesenchymal Plasticity in Circulating Tumor Cell Lines Sequentially Derived from a Patient with Colorectal Cancer." Cancers, vol. 13, no. 21, 2021. |
| Deshmukh, Abhijeet P., Vasaikar, Suhas V., Tomczak, Katarzyna, Tripathi, Shubham, den Hollander, Petra, Arslan, Emre, Chakraborty, Priyanka, Soundararajan, Rama, Jolly, Mohit Kumar, Rai, Kunal, Levine, Herbert, Mani, Sendurai A. "Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing." Proceedings of the National Academy of Sciences, vol. 118, no. 19, 2021. |
| Zhao N, Powell RT, Yuan X, Bae G, Roarty KP, Stossi F, Strempfl M, Toneff MJ, Johnson HL, Mani SA, Jones P, Stephan CC, Rosen JM. "Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition." Nature Communications, vol. 12, no. 1, 2021, pp. 4262. |
| Fathi M, Joseph R, Adolacion JRT, Martinez-Paniagua M, An X, Gabrusiewicz K, Mani SA, Varadarajan N. "Single-Cell Cloning of Breast Cancer Cells Secreting Specific Subsets of Extracellular Vesicles." Cancers, vol. 13, no. 17, 2021. |
| Tarallo S, Pardini B, Fox AH, Ingram H, Taccioli C, Taube JH, Mani SA. "The Non-Coding RNA Journal Club: Highlights on Recent Papers-8." Non-coding RNA, vol. 7, no. 1, 2021. |
| Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, Martin RS, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. "Correction: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression." Oncogene, vol. 39, no. 15, 2020, pp. 3226-3228. |
| Vasaikar SV, Deshmukh AP, den Hollander P, Addanki S, Kuburich NA, Kudaravalli S, Joseph R, Chang JT, Soundararajan R, Mani SA. "EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures." British Journal of Cancer, vol. 124, no. 1, 2020, pp. 259-269. |
| Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis AK, Huang RYJ, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore GD, Mani SA, Massagué J, Mayor R, McClay D, Mostov KE, Newgreen DF, Nieto MA, Puisieux A, Runyan R, Savagner P, Stanger B, Stemmler MP, Takahashi Y, Takeichi M, Theveneau E, Thiery JP, Thompson EW, Weinberg RA, Williams ED, Xing J, Zhou BP, Sheng G, EMT International Association (TEMTIA). "Guidelines and definitions for research on epithelial-mesenchymal transition." Nature reviews. Molecular cell biology, vol. 21, no. 6, 2020, pp. 341-352. |
| Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, San Martin R, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. "UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression." Oncogene, vol. 39, no. 15, 2020, pp. 3089-3101. |
| Jia W, Deshmukh A, Mani SA, Jolly MK, Levine H. "A possible role for epigenetic feedback regulation in the dynamics of the epithelial-mesenchymal transition (EMT)." Phys. Biol., vol. 16, no. 6, 2019, pp. 066004. |
| Vijay, Geraldine Vidhya, Zhao, Na, Den Hollander, Petra, Toneff, Mike J., Joseph, Robiya, Pietila, Mika, Taube, Joseph H., Sarkar, Tapasree R., Ramirez-Pena, Esmeralda, Werden, Steven J., Shariati, Maryam, Gao, Ruli, Sobieski, Mary, Stephan, Clifford C., Sphyris, Nathalie, Miura, Noayuki, Davies, Peter, Chang, Jeffrey T., Soundararajan, Rama, Rosen, Jeffrey M., Mani, Sendurai A. "GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer." Breast Cancer Research, vol. 21, no. 1, 2019, pp. 37. |
| Soundararajan R, Fradette JJ, Konen JM, Moulder S, Zhang X, Gibbons DL, Varadarajan N, Wistuba II, Tripathy D, Bernatchez C, Byers LA, Chang JT, Contreras A, Lim B, Parra ER, Roarty EB, Wang J, Yang F, Barton M, Rosen JM, Mani SA. "Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy." Cancers, vol. 11, no. 5, 2019. |
| Ramirez-Peña, Esmeralda, Arnold, James, Shivakumar, Vinita, Joseph, Robiya, Vidhya Vijay, Geraldine, den Hollander, Petra, Bhangre, Neeraja, Allegakoen, Paul, Prasad, Rishika, Conley, Zachary, Matés, José M., Márquez, Javier, Chang, Jeffrey T., Vasaikar, Suhas, Soundararajan, Rama, Sreekumar, Arun, Mani, Sendurai A. "The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression." Cancers, vol. 11, no. 10, 2019, pp. 1610. |
| Korkut A, Zaidi S, Kanchi RS, Rao S, Gough NR, Schultz A, Li X, Lorenzi PL, Berger AC, Robertson G, Kwong LN, Datto M, Roszik J, Ling S, Ravikumar V, Manyam G, Rao A, Shelley S, Liu Y, Ju Z, Hansel D, de Velasco G, Pennathur A, Andersen JB, O'Rourke CJ, Ohshiro K, Jogunoori W, Nguyen BN, Li S, Osmanbeyoglu HU, Ajani JA, Mani SA, Houseman A, Wiznerowicz M, Chen J, Gu S, Ma W, Zhang J, Tong P, Cherniack AD, Deng C, Resar L, Cancer Genome Atlas Research Network, Weinstein JN, Mishra L, Akbani R. "A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily." Cell Systems, vol. 7, no. 4, 2018, pp. 422-437.e7. |
| Soundararajan R, Paranjape AN, Maity S, Aparicio A, Mani SA. "EMT, stemness and tumor plasticity in aggressive variant neuroendocrine prostate cancers." Biochimica et biophysica acta. Reviews on cancer, vol. 1870, no. 2, 2018, pp. 229-238. |
| Soundararajan R, Aparicio AM, Logothetis CJ, Mani SA, Maity SN. "Function of Tumor Suppressors in Resistance to Antiandrogen Therapy and Luminal Epithelial Plasticity of Aggressive Variant Neuroendocrine Prostate Cancers." Frontiers in Oncology, vol. 8, 2018, pp. 69. |
| Jolly MK, Mani SA, Levine H. "Hybrid epithelial/mesenchymal phenotype(s): The 'fittest' for metastasis?." Biochimica et biophysica acta. Reviews on cancer, vol. 1870, no. 2, 2018, pp. 151-157. |
| Xiao H, Shiu PKT, Shu J, Santulli G, Gheybi MK, Conn SJ, Bogard B, Hubé F, Taube JH, Mani SA, Song L, Calin GA, Zhang S. "The Non-Coding RNA Journal Club: Highlights on Recent Papers-6." Non-coding RNA, vol. 4, no. 3, 2018. |
| Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL. "A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers." Proceedings of the National Academy of Sciences, vol. 114, no. 46, 2017, pp. E9903-E9912. |
| Jia D, Jolly MK, Tripathi SC, Den Hollander P, Huang B, Lu M, Celiktas M, Ramirez-Peña E, Ben-Jacob E, Onuchic JN, Hanash SM, Mani SA, Levine H. "Distinguishing mechanisms underlying EMT tristability." Cancer Convergence, vol. 1, no. 1, 2017, pp. 2. |
| Tian L, Zhang XHF, Mani SA. "Effective models for antimetastatic therapies." Oncotarget, vol. 8, no. 55, 2017, pp. 93295-93296. |
| Tian L, Goldstein A, Wang H, Ching Lo H, Sun Kim I, Welte T, Sheng K, Dobrolecki LE, Zhang X, Putluri N, Phung TL, Mani SA, Stossi F, Sreekumar A, Mancini MA, Decker WK, Zong C, Lewis MT, Zhang XH. "Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming." J. Geophys. Res., vol. 544, no. 7649, 2017, pp. 250-254. |
| Rigoutsos I, Lee SK, Nam SY, Anfossi S, Pasculli B, Pichler M, Jing Y, Rodriguez-Aguayo C, Telonis AG, Rossi S, Ivan C, Catela Ivkovic T, Fabris L, Clark PM, Ling H, Shimizu M, Redis RS, Shah MY, Zhang X, Okugawa Y, Jung EJ, Tsirigos A, Huang L, Ferdin J, Gafà R, Spizzo R, Nicoloso MS, Paranjape AN, Shariati M, Tiron A, Yeh JJ, Teruel-Montoya R, Xiao L, Melo SA, Menter D, Jiang ZQ, Flores ER, Negrini M, Goel A, Bar-Eli M, Mani SA, Liu CG, Lopez-Berestein G, Berindan-Neagoe I, Esteller M, Kopetz S, Lanza G, Calin GA. "N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration." Genome Biology, vol. 18, no. 1, 2017, pp. 98. |
| Yam C, Mani SA, Moulder SL. "Targeting the Molecular Subtypes of Triple Negative Breast Cancer: Understanding the Diversity to Progress the Field." The oncologist, vol. 22, no. 9, 2017, pp. 1086-1093. |
| Taube JH, Sphyris N, Johnson KS, Reisenauer KN, Nesbit TA, Joseph R, Vijay GV, Sarkar TR, Bhangre NA, Song JJ, Chang JT, Lee MG, Soundararajan R, Mani SA. "The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition." Oncotarget, vol. 8, no. 39, 2017, pp. 65548-65565. |
| Achour C, Bogard B, Hubé F, Mani SA, Santulli G, Taube JH. "The Non-Coding RNA Journal Club: Highlights on Recent Papers-5." Non-coding RNA, vol. 3, no. 2, 2017. |
| Chakravarty D, Tiwary CS, Woellner CF, Radhakrishnan S, Vinod S, Ozden S, da Silva Autreto PA, Bhowmick S, Asif S, Mani SA, Galvao DS, Ajayan PM. "3D Porous Graphene by Low-Temperature Plasma Welding for Bone Implants." Adv. Mater., vol. 28, no. 40, 2016, pp. 8959-8967. |
| Zhao W, Prijic S, Urban BC, Tisza MJ, Zuo Y, Li L, Tan Z, Chen X, Mani SA, Chang JT. "Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity." Cancer Research, vol. 76, no. 7, 2016, pp. 2037-49. |
| Gautheret D, Taube JH, Mani SA, Santulli G, Cuerda-Gil D, Slotkin RK, Zhang B, Wang Y, Salzman DW, Weidhaas JB. "Erratum: The Non-Coding RNA Journal Club: Highlights on Recent Papers-4. Non-Coding RNA 2016, 2, 9." Non-coding RNA, vol. 2, no. 4, 2016. |
| Pietilä M, Vijay GV, Soundararajan R, Yu X, Symmans WF, Sphyris N, Mani SA. "FOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition." Scientific reports, vol. 6, 2016, pp. 23070. |
| Svanidze E, Besara T, Ozaydin MF, Tiwary CS, Wang JK, Radhakrishnan S, Mani S, Xin Y, Han K, Liang H, Siegrist T, Ajayan PM, Morosan E. "High hardness in the biocompatible intermetallic compound β-Ti3Au." Science Advances, vol. 2, no. 7, 2016, pp. e1600319. |
| Paranjape AN, Soundararajan R, Werden SJ, Joseph R, Taube JH, Liu H, Rodriguez-Canales J, Sphyris N, Wistuba I, Miura N, Dhillon J, Mahajan N, Mahajan K, Chang JT, Ittmann M, Maity SN, Logothetis C, Tang DG, Mani SA. "Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties." Oncogene, vol. 35, no. 46, 2016, pp. 5963-5976. |
| Dhawan A, Madani Tonekaboni SA, Taube JH, Hu S, Sphyris N, Mani SA, Kohandel M. "Mathematical modelling of phenotypic plasticity and conversion to a stem-cell state under hypoxia." Scientific reports, vol. 6, 2016, pp. 18074. |
| Kwon OJ, Zhang L, Wang J, Su Q, Feng Q, Zhang XH, Mani SA, Paulter R, Creighton CJ, Ittmann MM, Xin L. "Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model." Journal of Clinical Investigation, vol. 126, no. 7, 2016, pp. 2626-41. |
| Boareto M, Jolly MK, Goldman A, Pietilä M, Mani SA, Sengupta S, Ben-Jacob E, Levine H, Onuchic JN. "Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype." Journal of The Royal Society Interface, vol. 13, no. 118, 2016. |
| Werden, S J, Sphyris, N, Sarkar, T R, Paranjape, A N, LaBaff, A M, Taube, J H, Hollier, B G, Ramirez-Peña, E Q, Soundararajan, R, den Hollander, P, Powell, E, Echeverria, G V, Miura, N, Chang, J T, Piwnica-Worms, H, Rosen, J M, Mani, S A. "Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth." Oncogene, vol. 35, no. 46, 2016, pp. 5977-5988. |
| Mitra S, Federico L, Zhao W, Dennison J, Sarkar TR, Zhang F, Takiar V, Cheng KW, Mani S, Lee JS, Mills GB. "Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT." Oncotarget, vol. 7, no. 26, 2016, pp. 40252-40265. |
| Jolly MK, Tripathi SC, Jia D, Mooney SM, Celiktas M, Hanash SM, Mani SA, Pienta KJ, Ben-Jacob E, Levine H. "Stability of the hybrid epithelial/mesenchymal phenotype." Oncotarget, vol. 7, no. 19, 2016, pp. 27067-84. |
| Gautheret D, Taube JH, Mani SA, Santulli G, Cuerda-Gil D, Slotkin RK, Zhang B, Wang Y, Salzman DW, Weidhaas JB. "The Non-Coding RNA Journal Club: Highlights on Recent Papers-4." Non-coding RNA, vol. 2, no. 3, 2016. |
| Toneff, M. J., Sreekumar, A., Tinnirello, A., Hollander, P. Den, Habib, S., Li, S., Ellis, M. J., Xin, L., Mani, S. A., Rosen, J. M. "The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states." BMC Biology, vol. 14, no. 1, 2016, pp. 47. |
| Ashokkumar M, Cristian Chipara A, Tharangattu Narayanan N, Anumary A, Sruthi R, Thanikaivelan P, Vajtai R, Mani SA, Ajayan PM. "Three-Dimensional Porous Sponges from Collagen Biowastes." ACS Appl. Mater. Interfaces, vol. 8, no. 23, 2016, pp. 14836-44. |
| Pietilä M, Ivaska J, Mani SA. "Whom to blame for metastasis, the epithelial-mesenchymal transition or the tumor microenvironment?." Cancer Letters, vol. 380, no. 1, 2016, pp. 359-68. |
| Soundararajan R, Paranjape AN, Barsan V, Chang JT, Mani SA. "A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome." Scientific reports, vol. 5, 2015, pp. 11766. |
| Jolly MK, Jia D, Boareto M, Mani SA, Pienta KJ, Ben-Jacob E, Levine H. "Coupling the modules of EMT and stemness: A tunable 'stemness window' model." Oncotarget, vol. 6, no. 28, 2015, pp. 25161-74. |
| Bhowmik SK, Ramirez-Peña E, Arnold JM, Putluri V, Sphyris N, Michailidis G, Putluri N, Ambs S, Sreekumar A, Mani SA. "EMT-induced metabolite signature identifies poor clinical outcome." Oncotarget, vol. 6, no. 40, 2015, pp. 42651-60. |
| Sphyris N, Sarkar TR, Battula VL, Andreeff M, Mani SA. "GD2 and GD3 synthase: novel drug targets for cancer therapy." Molecular & cellular oncology, vol. 2, no. 3, 2015, pp. e975068. |
| Sarkar TR, Battula VL, Werden SJ, Vijay GV, Ramirez-Peña EQ, Taube JH, Chang JT, Miura N, Porter W, Sphyris N, Andreeff M, Mani SA. "GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer." Oncogene, vol. 34, no. 23, 2015, pp. 2958-67. |
| Cohen EN, Gao H, Anfossi S, Mego M, Reddy NG, Debeb B, Giordano A, Tin S, Wu Q, Garza RJ, Cristofanilli M, Mani SA, Croix DA, Ueno NT, Woodward WA, Luthra R, Krishnamurthy S, Reuben JM. "Inflammation Mediated Metastasis: Immune Induced Epithelial-To-Mesenchymal Transition in Inflammatory Breast Cancer Cells." PLoS ONE, vol. 10, no. 7, 2015, pp. e0132710. |
| Mallampati S, Leng X, Ma H, Zeng J, Li J, Wang H, Lin K, Lu Y, Yang Y, Sun B, Gong Y, Lee JS, Konopleva M, Andreeff M, Arlinghaus RB, Cai Z, Fang B, Shen H, Han X, Hirsch-Ginsberg CF, Gao X, Paranjape AN, Mani SA, Clise-Dwyer K, Sun X. "Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia." Blood, vol. 125, no. 19, 2015, pp. 2968-73. |
| Liu Y, Zhou R, Baumbusch LO, Tsavachidis S, Brewster AM, Do KA, Sahin A, Hortobagyi GN, Taube JH, Mani SA, Aarøe J, Wärnberg F, Børresen-Dale AL, Mills GB, Thompson PA, Bondy ML. "Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer." Breast cancer research and treatment, vol. 143, no. 1, 2014, pp. 189-201. |
| De B, Mandal S, Sau D, Mani S, Chatterjee S, Mondal S, Bhattacharya K, Sil K, Bhattacharya R. "Pentoxifylline Plus Prednisolone versus Pentoxifylline Only for Severe Alcoholic Hepatitis: A Randomized Controlled Clinical Trial." Annals of medical and health sciences research, vol. 4, no. 5, 2014, pp. 810-6. |
| Jolly MK, Huang B, Lu M, Mani SA, Levine H, Ben-Jacob E. "Towards elucidating the connection between epithelial-mesenchymal transitions and stemness." Journal of The Royal Society Interface, vol. 11, no. 101, 2014, pp. 20140962. |
| Krohn A, Ahrens T, Yalcin A, Plönes T, Wehrle J, Taromi S, Wollner S, Follo M, Brabletz T, Mani SA, Claus R, Hackanson B, Burger M. "Tumor cell heterogeneity in Small Cell Lung Cancer (SCLC): phenotypical and functional differences associated with Epithelial-Mesenchymal Transition (EMT) and DNA methylation changes." PLoS ONE, vol. 9, no. 6, 2014, pp. e100249. |
| Malouf GG, Taube JH, Lu Y, Roysarkar T, Panjarian S, Estecio MR, Jelinek J, Yamazaki J, Raynal NJ, Long H, Tahara T, Tinnirello A, Ramachandran P, Zhang XY, Liang S, Mani SA, Issa JP. "Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition." Genome Biology, vol. 14, no. 12, 2013, pp. R144. |
| Yao Y, Suraokar M, Darnay BG, Hollier BG, Shaiken TE, Asano T, Chen CH, Chang BH, Lu Y, Mills GB, Sarbassov D, Mani SA, Abbruzzese JL, Reddy SA. "BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation." Science Signaling, vol. 6, no. 257, 2013, pp. ra2. |
| Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Gafà R, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Le Marchand L, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S, Fodde R, Calin GA. "CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer." Genome Research, vol. 23, no. 9, 2013, pp. 1446-61. |
| Lu J, Ye X, Fan F, Xia L, Bhattacharya R, Bellister S, Tozzi F, Sceusi E, Zhou Y, Tachibana I, Maru DM, Hawke DH, Rak J, Mani SA, Zweidler-McKay P, Ellis LM. "Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1." Cancer Cell, vol. 23, no. 2, 2013, pp. 171-85. |
| Taube JH, Malouf GG, Lu E, Sphyris N, Vijay V, Ramachandran PP, Ueno KR, Gaur S, Nicoloso MS, Rossi S, Herschkowitz JI, Rosen JM, Issa JP, Calin GA, Chang JT, Mani SA. "Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties." Scientific reports, vol. 3, 2013, pp. 2687. |
| Romero-Aburto R, Narayanan TN, Nagaoka Y, Hasumura T, Mitcham TM, Fukuda T, Cox PJ, Bouchard RR, Maekawa T, Kumar DS, Torti SV, Mani SA, Ajayan PM. "Fluorinated graphene oxide; a new multimodal material for biological applications." Adv. Mater., vol. 25, no. 39, 2013, pp. 5632-7. |
| Hollier BG, Tinnirello AA, Werden SJ, Evans KW, Taube JH, Sarkar TR, Sphyris N, Shariati M, Kumar SV, Battula VL, Herschkowitz JI, Guerra R, Chang JT, Miura N, Rosen JM, Mani SA. "FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer." Cancer Research, vol. 73, no. 6, 2013, pp. 1981-92. |
| Zarkoob H, Taube JH, Singh SK, Mani SA, Kohandel M. "Investigating the link between molecular subtypes of glioblastoma, epithelial-mesenchymal transition, and CD133 cell surface protein." PLoS ONE, vol. 8, no. 5, 2013, pp. e64169. |
| Chang JT, Mani SA. "Sheep, wolf, or werewolf: cancer stem cells and the epithelial-to-mesenchymal transition." Cancer Letters, vol. 341, no. 1, 2013, pp. 16-23. |
| Kolonin MG, Evans KW, Mani SA, Gomer RH. "Alternative origins of stroma in normal organs and disease." Stem cell research, vol. 8, no. 2, 2012, pp. 312-23. |
| Giordano A, Gao H, Anfossi S, Cohen E, Mego M, Lee BN, Tin S, De Laurentiis M, Parker CA, Alvarez RH, Valero V, Ueno NT, De Placido S, Mani SA, Esteva FJ, Cristofanilli M, Reuben JM. "Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer." Molecular Cancer Therapeutics, vol. 11, no. 11, 2012, pp. 2526-34. |
| Mego M, Mani SA, Lee BN, Li C, Evans KW, Cohen EN, Gao H, Jackson SA, Giordano A, Hortobagyi GN, Cristofanilli M, Lucci A, Reuben JM. "Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy." International Journal of Cancer, vol. 130, no. 4, 2012, pp. 808-16. |
| Battula VL, Shi Y, Evans KW, Wang RY, Spaeth EL, Jacamo RO, Guerra R, Sahin AA, Marini FC, Hortobagyi G, Mani SA, Andreeff M. "Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis." Journal of Clinical Investigation, vol. 122, no. 6, 2012, pp. 2066-78. |
| Román-Pérez E, Casbas-Hernández P, Pirone JR, Rein J, Carey LA, Lubet RA, Mani SA, Amos KD, Troester MA. "Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients." Breast cancer research : BCR, vol. 14, no. 2, 2012, pp. R51. |
| Narayanan TN, Gupta BK, Vithayathil SA, Aburto RR, Mani SA, Taha-Tijerina J, Xie B, Kaipparettu BA, Torti SV, Ajayan PM. "Hybrid 2D nanomaterials as dual-mode contrast agents in cellular imaging." Adv. Mater., vol. 24, no. 22, 2012, pp. 2992-8. |
| Walia V, Yu Y, Cao D, Sun M, McLean JR, Hollier BG, Cheng J, Mani SA, Rao K, Premkumar L, Elble RC. "Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis." Oncogene, vol. 31, no. 17, 2012, pp. 2237-46. |
| Fan F, Samuel S, Evans KW, Lu J, Xia L, Zhou Y, Sceusi E, Tozzi F, Ye XC, Mani SA, Ellis LM. "Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells." Cancer medicine, vol. 1, no. 1, 2012, pp. 5-16. |
| Guo, Wenjun, Keckesova, Zuzana, Donaher, Joana Liu, Shibue, Tsukasa, Tischler, Verena, Reinhardt, Ferenc, Itzkovitz, Shalev, Noske, Aurelia, Zürrer-Härdi, Ursina, Bell, George, Tam, Wai Leong, Mani, Sendurai A., van Oudenaarden, Alexander, Weinberg, Robert A. "Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State." Cell, vol. 148, no. 5, 2012, pp. 1015-1028. |
| Tong Z, Chakraborty S, Sung B, Koolwal P, Kaur S, Aggarwal BB, Mani SA, Bresalier RS, Batra SK, Guha S. "Epidermal growth factor down-regulates the expression of neutrophil gelatinase-associated lipocalin (NGAL) through E-cadherin in pancreatic cancer cells." Cancer, vol. 117, no. 11, 2011, pp. 2408-18. |
| May CD, Sphyris N, Evans KW, Werden SJ, Guo W, Mani SA. "Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression." Breast cancer research : BCR, vol. 13, no. 1, 2011, pp. 202. |
| Mani SA, Barton MC. "HDAC3 at the fulcrum of an epithelial-mesenchymal balance." Molecular Cell, vol. 43, no. 5, 2011, pp. 697-8. |
| Sphyris N, Mani SA. "pIgR: frenemy of inflammation, EMT, and HCC progression." JNCI Journal of the National Cancer Institute, vol. 103, no. 22, 2011, pp. 1644-5. |
| Taube, Joseph H., Herschkowitz, Jason I., Komurov, Kakajan, Zhou, Alicia Y., Gupta, Supriya, Yang, Jing, Hartwell, Kimberly, Onder, Tamer T., Gupta, Piyush B., Evans, Kurt W., Hollier, Brett G., Ram, Prahlad T., Lander, Eric S., Rosen, Jeffrey M., Weinberg, Robert A., Mani, Sendurai A. "Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes." Proceedings of the National Academy of Sciences, vol. 107, no. 35, 2010, pp. 15449-15454. |
| Blick T, Hugo H, Widodo E, Waltham M, Pinto C, Mani SA, Weinberg RA, Neve RM, Lenburg ME, Thompson EW. "Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer." Journal of mammary gland biology and neoplasia, vol. 15, no. 2, 2010, pp. 235-52. |
| Battula VL, Evans KW, Hollier BG, Shi Y, Marini FC, Ayyanan A, Wang RY, Brisken C, Guerra R, Andreeff M, Mani SA. "Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells." STEM CELLS, vol. 28, no. 8, 2010, pp. 1435-45. |
| Mego M, Mani SA, Cristofanilli M. "Molecular mechanisms of metastasis in breast cancer--clinical applications." Nature reviews. Clinical oncology, vol. 7, no. 12, 2010, pp. 693-701. |
| Lu J, Steeg PS, Price JE, Krishnamurthy S, Mani SA, Reuben J, Cristofanilli M, Dontu G, Bidaut L, Valero V, Hortobagyi GN, Yu D. "Breast cancer metastasis: challenges and opportunities." Cancer Research, vol. 69, no. 12, 2009, pp. 4951-3. |
| Gupta SK, Mishra R, Kusum S, Spedding M, Meiri KF, Gressens P, Mani S. "GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986." Cell death and differentiation, vol. 16, no. 4, 2009, pp. 624-37. |
| Hollier BG, Evans K, Mani SA. "The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies." Journal of mammary gland biology and neoplasia, vol. 14, no. 1, 2009, pp. 29-43. |
| Bloushtain-Qimron N, Yao J, Snyder EL, Shipitsin M, Campbell LL, Mani SA, Hu M, Chen H, Ustyansky V, Antosiewicz JE, Argani P, Halushka MK, Thomson JA, Pharoah P, Porgador A, Sukumar S, Parsons R, Richardson AL, Stampfer MR, Gelman RS, Nikolskaya T, Nikolsky Y, Polyak K. "Cell type-specific DNA methylation patterns in the human breast." Proceedings of the National Academy of Sciences, vol. 105, no. 37, 2008, pp. 14076-81. |
| Onder, Tamer T., Gupta, Piyush B., Mani, Sendurai A., Yang, Jing, Lander, Eric S., Weinberg, Robert A. "Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways." Cancer Research, vol. 68, no. 10, 2008, pp. 3645-3654. |
| Mani, Sendurai A., Guo, Wenjun, Liao, Mai-Jing, Eaton, Elinor Ng., Ayyanan, Ayyakkannu, Zhou, Alicia Y., Brooks, Mary, Reinhard, Ferenc, Zhang, Cheng Cheng, Shipitsin, Michail, Campbell, Lauren L., Polyak, Kornelia, Brisken, Cathrin, Yang, Jing, Weinberg, Robert A. "The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells." Cell, vol. 133, no. 4, 2008, pp. 704-715. |
| Liao MJ, Zhang CC, Zhou B, Zimonjic DB, Mani SA, Kaba M, Gifford A, Reinhardt F, Popescu NC, Guo W, Eaton EN, Lodish HF, Weinberg RA. "Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity." Cancer Research, vol. 67, no. 17, 2007, pp. 8131-8. |
| Huang H, Wang H, Sinz M, Zoeckler M, Staudinger J, Redinbo MR, Teotico DG, Locker J, Kalpana GV, Mani S. "Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole." Oncogene, vol. 26, no. 2, 2007, pp. 258-68. |
| Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, Kutok JL, Hartwell K, Richardson AL, Weinberg RA. "Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers." Proceedings of the National Academy of Sciences, vol. 104, no. 24, 2007, pp. 10069-74. |
| Goel S, Bauer RJ, Desai K, Bulgaru A, Iqbal T, Strachan BK, Kim G, Kaubisch A, Vanhove GF, Goldberg G, Mani S. "Pharmacokinetic and safety study of subcutaneously administered weekly ING-1, a human engineere monoclonal antibody targeting human EpCAM, in patients with advanced solid tumors." Annals of Oncology, vol. 18, no. 10, 2007, pp. 1704-7. |
| Kadirvel R, Sundaram K, Mani S, Samuel S, Elango N, Panneerselvam C. "Supplementation of ascorbic acid and alpha-tocopherol prevents arsenic-induced protein oxidation and DNA damage induced by arsenic in rats." Human & experimental toxicology, vol. 26, no. 12, 2007, pp. 939-46. |
| Yang J, Mani SA, Weinberg RA. "Exploring a new twist on tumor metastasis." Cancer Research, vol. 66, no. 9, 2006, pp. 4549-52. |
| Alarcon-Vargas D, Zhang Z, Agarwal B, Challagulla K, Mani S, Kalpana GV. "Targeting cyclin D1, a downstream effector of INI1/hSNF5, in rhabdoid tumors." Oncogene, vol. 25, no. 5, 2006, pp. 722-34. |
| Gupta PB, Mani S, Yang J, Hartwell K, Weinberg RA. "The evolving portrait of cancer metastasis." Cold Spring Harbor Symposia on Quantitative Biology, vol. 70, 2005, pp. 291-7. |
| Yang, Jing, Mani, Sendurai A, Donaher, Joana Liu, Ramaswamy, Sridhar, Itzykson, Raphael A, Come, Christophe, Savagner, Pierre, Gitelman, Inna, Richardson, Andrea, Weinberg, Robert A. "Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis." Cell, vol. 117, no. 7, 2004, pp. 927-939. |
| Aklilu M, Kindler HL, Donehower RC, Mani S, Vokes EE. "Phase II study of flavopiridol in patients with advanced colorectal cancer." Annals of Oncology, vol. 14, no. 8, 2003, pp. 1270-3. |
| Mani S. "Signalling mechanisms in progesterone-neurotransmitter interactions." J Mol Endocrinol, vol. 30, no. 2, 2003, pp. 127-37. |
| Lu Y, Mani S, Kandimalla ER, Yu D, Agrawal S, States JC, Bregman DB. "The Cockayne syndrome group B DNA repair protein as an anti-cancer target." International Journal of Oncology, vol. 19, no. 6, 2001, pp. 1089-97. |
| Amanatullah DF, Reutens AT, Zafonte BT, Fu M, Mani S, Pestell RG. "Cell-cycle dysregulation and the molecular mechanisms of prostate cancer." Frontiers in Bioscience, vol. 5, 2000, pp. D372-90. |
| Abbott B, Abolins M, Abramov V, Acharya BS, Adams DL, Adams M, Ahn S, Akimov V, Alves GA, Amos N, Anderson EW, Baarmand MM, Babintsev VV, Babukhadia L, Baden A, Baldin B, Banerjee S, Bantly J, Barberis E, Baringer P, Bartlett JF, Bassler U, Belyaev A, Beri SB, Bernardi G, Bertram I, Bezzubov VA, Bhat PC, Bhatnagar V, Bhattacharjee M, Blazey G, Blessing S, Boehnlein A, Bojko NI, Borcherding F, Brandt A, Breedon R, Briskin G, Brock R, Brooijmans G, Bross A, Buchholz D, Buescher V, Burtovoi VS, Butler JM, Carvalho W, Casey D, Casilum Z, Castilla-Valdez H, Chakraborty D, Chan KM, Chekulaev SV, Chen W, Cho DK, Choi S, Chopra S, Choudhary BC, Christenson JH, Chung M, Claes D, Clark AR, Cobau WG, Cochran J, Coney L, Connolly B, Cooper WE, Coppage D, Cullen-Vidal D, Cummings MA, Cutts D, Dahl OI, Davis K, De K, Del Signore K, Demarteau M, Denisov D, Denisov SP, Diehl HT, Diesburg M, Di Loreto G, Draper P, Ducros Y, Dudko LV, Dugad SR, Dyshkant A, Edmunds D, Ellison J, Elvira VD, Engelmann R, Eno S, Eppley G, Ermolov P, Eroshin OV, Estrada J, Evans H, Evdokimov VN, Fahland T, Feher S, Fein D, Ferbel T, Fisk HE, Fisyak Y, Flattum E, Fleuret F, Fortner M, Frame KC, Fuess S, Gallas E, Galyaev AN, Gartung P, Gavrilov V, Genik RJ Jr, Genser K, Gerber CE, Gershtein Y, Gibbard B, Gilmartin R, Ginther G, Gobbi B, Gómez B, Gómez G, Goncharov PI, González Solís JL, Gordon H, Goss LT, Gounder K, Goussiou A, Graf N, Grannis PD, Green DR, Green JA, Greenlee H, Grinstein S, Grudberg P, Grünendahl S, Guglielmo G, Gupta A, Gurzhiev SN, Gutierrez G, Gutierrez P, Hadley NJ, Haggerty H, Hagopian S, Hagopian V, Hahn KS, Hall RE, Hanlet P, Hansen S, Hauptman JM, Hays C, Hebert C, Hedin D, Heinson AP, Heintz U, Heuring T, Hirosky R, Hobbs JD, Hoeneisen B, Hoftun JS, Hsieh F, Ito AS, Jerger SA, Jesik R, Joffe-Minor T, Johns K, Johnson M, Jonckheere A, Jones M, Jöstlein H, Jun SY, Kahn S, Kajfasz E, Karmanov D, Karmgard D, Kehoe R, Kim SK, Klima B, Klopfenstein C, Knuteson B, Ko W, Kohli JM, Koltick D, Kostritskiy AV, Kotcher J, Kotwal AV, Kozelov AV, Kozlovsky EA, Krane J, Krishnaswamy MR, Krzywdzinski S, Kubantsev M, Kuleshov S, Kulik Y, Kunori S, Landsberg G, Leflat A, Lehner F, Li H, Li J, Li QZ, Lima JG, Lincoln D, Linn SL, Linnemann J, Lipton R, Lu JG, Lucotte A, Leuking L, Lundstedt C, Maciel AK, Madaras RJ, Manankov V, Mani S, Mao HS, Markeloff R, Marshall T, Martin MI, Martin RD, Mauritz KM, May B, Mayorov AA, McCarthy R, McDonald J, McKibben T, McMahon T, Melanson HL, Merkin M, Merritt KW, Miao C, Miettinen H, Mincer A, Mishra CS, Mokhov N, Mondal NK, Montgomery HE, Mostafa M, da Motta H, Nagy E, Nang F, Narain M, Narasimham VS, Neal HA, Negret JP, Negroni S, Norman D, Oesch L, Oguri V, Olivier B, Oshima N, Owen D, Padley P, Para A, Parashar N, Partridge R, Parua N, Paterno M, Patwa A, Pawlik B, Perkins J, Peters M, Piegaia R, Piekarz H, Pischalnikov Y, Pope BG, Popkov E, Prosper HB, Protopopescu S, Qian J, Quintas PZ, Raja R, Rajagopalan S, Reay NW, Reucroft S, Rijssenbeek M, Rockwell T, Roco M, Rubinov P, Ruchti R, Rutherfoord J, Santoro A, Sawyer L, Schamberger RD, Schellman H, Schwartzman A, Sculli J, Sen N, Shabalina E, Shankar HC, Shivpuri RK, Shpakov D, Shupe M, Sidwell RA, Singh H, Singh JB, Sirotenko V, Slattery P, Smith E, Smith RP, Snihur R, Snow GR, Snow J, Snyder S, Solomon J, Song XF, Sorín V, Sosebee M, Sotnikova N, Souza M, Stanton NR, Steinbrück G, Stephens RW, Stevenson ML, Stichelbaut F, Stoker D, Stolin V, Stoyanova DA, Strauss M, Streets K, Strovink M, Stutte L, Sznajder A, Tarazi J, Tartaglia M, Thomas TL, Thompson J, Toback D, Trippe TG, Turcot AS, Tuts PM, van Gemmeren P, Vaniev V, Varelas N, Volkov AA, Vorobiev AP, Wahl HD, Warchol J, Watts G, Wayne M, Weerts H, White A, White JT, Wightman JA, Willis S, Wimpenny SJ, Wirjawan JV, Womersley J, Wood DR, Yamada R, Yamin P, Yasuda T, Yip K, Youssef S, Yu J, Yu Y, Zanabria M, Zheng H, Zhou Z, Zhu ZH, Zielinski M, Zieminska D, Zieminski A, Zutshi V, Zverev EG, Zylberstejn A. "Measurement of the W-->taunu production cross section in pp collisions at square root s=1.8 TeV." Phys. Rev. Lett., vol. 84, no. 25, 2000, pp. 5710-5. |
| Abbott B, Abolins M, Abramov V, Acharya BS, Adams DL, Adams M, Akimov V, Alves GA, Amos N, Anderson EW, Baarmand MM, Babintsev VV, Babukhadia L, Baden A, Baldin B, Banerjee S, Bantly J, Barberis E, Baringer P, Bartlett JF, Bassler U, Bean A, Belyaev A, Beri SB, Bernardi G, Bertram I, Bezzubov VA, Bhat PC, Bhatnagar V, Bhattacharjee M, Blazey G, Blessing S, Boehnlein A, Bojko NI, Borcherding F, Brandt A, Breedon R, Briskin G, Brock R, Brooijmans G, Bross A, Buchholz D, Buescher V, Burtovoi VS, Butler JM, Carvalho W, Casey D, Casilum Z, Castilla-Valdez H, Chakraborty D, Chan KM, Chekulaev SV, Chen W, Cho DK, Choi S, Chopra S, Choudhary BC, Christenson JH, Chung M, Claes D, Clark AR, Cobau WG, Cochran J, Coney L, Connolly B, Cooper WE, Coppage D, Cullen-Vidal D, Cummings MA, Cutts D, Dahl OI, Davis K, De K, Del Signore K, Demarteau M, Denisov D, Denisov SP, Diehl HT, Diesburg M, Di Loreto G, Draper P, Ducros Y, Dudko LV, Dugad SR, Dyshkant A, Edmunds D, Ellison J, Elvira VD, Engelmann R, Eno S, Eppley G, Ermolov P, Eroshin OV, Estrada J, Evans H, Evdokimov VN, Fahland T, Feher S, Fein D, Ferbel T, Fisk HE, Fisyak Y, Flattum E, Fleuret F, Fortner M, Frame KC, Fuess S, Gallas E, Galyaev AN, Gartung P, Gavrilov V, Genik RJ Jr, Genser K, Gerber CE, Gershtein Y, Gibbard B, Gilmartin R, Ginther G, Gobbi B, Gómez B, Gómez G, Goncharov PI, González Solís JL, Gordon H, Goss LT, Gounder K, Goussiou A, Graf N, Grannis PD, Green JA, Greenlee H, Grinstein S, Grudberg P, Grünendahl S, Guglielmo G, Gupta A, Gurzhiev SN, Gutierrez G, Gutierrez P, Hadley NJ, Haggerty H, Hagopian S, Hagopian V, Hahn KS, Hall RE, Hanlet P, Hansen S, Hauptman JM, Hays C, Hebert C, Hedin D, Heinson AP, Heintz U, Heuring T, Hirosky R, Hobbs JD, Hoeneisen B, Hoftun JS, Ito AS, Jerger SA, Jesik R, Joffe-Minor T, Johns K, Johnson M, Jonckheere A, Jones M, Jöstlein H, Jun SY, Juste A, Kahn S, Kajfasz E, Karmanov D, Karmgard D, Kehoe R, Kim SK, Klima B, Klopfenstein C, Knuteson B, Ko W, Kohli JM, Kostritskiy AV, Kotcher J, Kotwal AV, Kozelov AV, Kozlovsky EA, Krane J, Krishnaswamy MR, Krzywdzinski S, Kubantsev M, Kuleshov S, Kulik Y, Kunori S, Landsberg G, Leflat A, Lehner F, Li J, Li QZ, Lima JG, Lincoln D, Linn SL, Linnemann J, Lipton R, Lu JG, Lucotte A, Lueking L, Lundstedt C, Maciel AK, Madaras RJ, Manankov V, Mani S, Mao HS, Markeloff R, Marshall T, Martin MI, Martin RD, Mauritz KM, May B, Mayorov AA, McCarthy R, McDonald J, McKibben T, McMahon T, Melanson HL, Merkin M, Merritt KW, Miao C, Miettinen H, Mihalcea D, Mincer A, Mishra CS, Mokhov N, Mondal NK, Montgoemry HE, Mostafa M, da Motta H, Nagy E, Nang F, Narain M, Narasimham VS, Neal HA, Negret JP, Negroni S, Norman D, Oesch L, Oguri V, Olivier B, Oshima N, Padley P, Pan LJ, Para A, Parashar N, Partridge R, Parua N, Paterno M, Patwa A, Pawlik B, Perkins J, Peters M, Piegaia R, Piekarz H, Pope BG, Popkov E, Prosper HB, Protopopescu S, Qian J, Quintas PZ, Raja R, Rajagopalan S, Reay NW, Reucroft S, Rijssenbeek M, Rockwell T, Roco M, Rubinov P, Ruchti R, Rutherfoord J, Santoro A, Sawyer L, Schamberger RD, Schellman H, Schwartzman A, Sculli J, Sen N, Shabalina E, Shankar HC, Shivpuri RK, Shpakov D, Shupe M, Sidwell RA, Singh H, Singh JB, Sirotenko V, Slattery P, Smith E, Smith RP, Snihur R, Snow GR, Snow J, Snyder S, Solomon J, Song XF, Sorín V, Sosebee M, Sotnikova N, Souza M, Stanton NR, Steinbrück G, Stephens RW, Stevenson ML, Stichelbaut F, Stoker D, Stolin V, Stoyanova DA, Strauss M, Streets K, Strovink M, Stutte L, Sznajder A, Tarazi J, Taylor W, Tentindo-Repond S, Thomas TL, Thompson J, Toback D, Trippe TG, Turcot AS, Tuts PM, van Gemmeren P, Vaniev V, Varelas N, Volkov AA, Vorobiev AP, Wahl HD, Wang H, Warchol J, Watts G, Wayne M, Weerts H, White A, White JT, Whiteson D, Wightman JA, Willis S, Wimpenny SJ, Wirjawan JV, Womersley J, Wood DR, Yamada R, Yamin P, Yasuda T, Yip K, Youssef S, Yu J, Yu Z, Zanabria M, Zheng H, Zhou Z, Zhu ZH, Zielinski M, Zieminska D, Zieminski A, Zutshi V, Zverev EG, Zylberstejn A. "Probing Balitsky-Fadin-Kuraev-Lipatov dynamics in the dijet cross section at large rapidity intervals in pp collisions at sqrt[s]=1800 and 630 GeV." Phys. Rev. Lett., vol. 84, no. 25, 2000, pp. 5722-7. |
| Vokes EE, Goh BC, Bertucci D, Vogelzang NJ, Mani S, Ratain MJ. "A Phase I study of raltitrexed and paclitaxel given every 3 weeks to patients with solid tumors." Cancer, vol. 86, no. 3, 1999, pp. 528-32. |
| Vogelzang NJ, Mani S, Schilsky RL, Ansari RH, Taber D, Rhinehart SN, Garcia JC, Meyer SC, Mick R, Brockstein BE, Stadler WM, Ratain MJ, Vokes EE. "Phase II and pharmacodynamic studies of pyrazine diazohydroxide (NSC 361456) in patients with advanced renal and colorectal cancer." Clin Cancer Res , vol. 4, no. 4, 1998, pp. 929-34. |
| O'Malley BW, Schrader WT, Mani S, Smith C, Weigel NL, Conneely OM, Clark JH. "An alternative ligand-independent pathway for activation of steroid receptors." Recent progress in hormone research, vol. 50, 1995, pp. 333-47. |
| Wang Y, Holland JF, Bleiweiss IJ, Melana S, Liu X, Pelisson I, Cantarella A, Stellrecht K, Mani S, Pogo BG. "Detection of mammary tumor virus env gene-like sequences in human breast cancer." Cancer Research, vol. 55, no. 22, 1995, pp. 5173-9. |
| Buzaid AC, Sandler AB, Mani S, Curtis AM, Poo WJ, Bolognia JL, Ariyan S. "Role of computed tomography in the staging of primary melanoma." Journal of Clinical Oncology, vol. 11, no. 4, 1993, pp. 638-43. |
| Year | Degree | Institution |
|---|---|---|
| 2000 | PhD | Indian Institute of Science |
| 1993 | MS | Madurai Kamaraj University |
| 1991 | BS | Madurai Kamaraj University |
| Associate Director for Translational Oncology, Legorteta Cancer Center, The Warren Alpert Medical School. Brown University , 2022- |
| Director, Translational Research Disease Groups, The Warren Alpert Medical School. Brown Univeristy , 2022- |
| Director, Stem Cell Center, The Warren Alpert Medical School. Brown University, 2022- |
| Professor, Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School. Brown Unviersity, 2022- |
