Shipra Vaishnava is an assistant professor in the department of Molecular Microbiology and Immunology at Brown University. She studies how we maintain peaceful relations with 100 trillion bacteria in our intestine. Her lab uses unique in-vivotools such as germ-free mouse models in combination with a broad array of genetic, cell biological and biochemical approaches to explore the interactions between intestinal bacteria and our immune system. Dr. Vaishnava completed a PhD at the University of Georgia and a post-doctoral fellowship at University of Texas Southwestern Medical Center before coming to Brown.
|Iyer N, Vaishnava S. "Alcohol Lowers Your (Intestinal) Inhibitions." Cell Host & Microbe, vol. 19, no. 2, 2016, pp. 131-3.|
|Vaishnava S. "The Intestinal Mucus Layer Comes of Age." Trends in Immunology, vol. 37, no. 1, 2016, pp. 3-4.|
|Derebe, Mehabaw G, Zlatkov, Clare M, Gattu, Sureka, Ruhn, Kelly A, Vaishnava, Shipra, Diehl, Gretchen E, MacMillan, John B, Williams, Noelle S, Hooper, Lora V. "Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection." eLife, vol. 3, 2014.|
|Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, Ley R, Wakeland EK, Hooper LV. "The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine." Science, vol. 334, no. 6053, 2014, pp. 255-8.|
|Raetz, Megan, Hwang, Sun-hee, Wilhelm, Cara L, Kirkland, Donna, Benson, Alicia, Sturge, Carolyn R, Mirpuri, Julie, Vaishnava, Shipra, Hou, Baidong, DeFranco, Anthony L, Gilpin, Christopher J, Hooper, Lora V, Yarovinsky, Felix. "Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells." Nature Immunology, vol. 14, no. 2, 2012, pp. 136-142.|
|Reiff SB, Vaishnava S, Striepen B. "The HU protein is important for apicoplast genome maintenance and inheritance in Toxoplasma gondii." Eukaryotic cell, vol. 11, no. 7, 2012, pp. 905-15.|
|Vaishnava S, Hooper LV. "Eat your carrots! T cells are RARing to go." Immunity, vol. 34, no. 3, 2011, pp. 290-2.|
|Ismail, A. S., Severson, K. M., Vaishnava, S., Behrendt, C. L., Yu, X., Benjamin, J. L., Ruhn, K. A., Hou, B., DeFranco, A. L., Yarovinsky, F., Hooper, L. V. " intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface." Proceedings of the National Academy of Sciences, vol. 108, no. 21, 2011, pp. 8743-8748.|
|Duerkop, Breck A., Vaishnava, Shipra, Hooper, Lora V. "Immune Responses to the Microbiota at the Intestinal Mucosal Surface." Immunity, vol. 31, no. 3, 2009, pp. 368-376.|
|Mukherjee S, Vaishnava S, Hooper LV. "Multi-layered regulation of intestinal antimicrobial defense." Cellular and molecular life sciences : CMLS, vol. 65, no. 19, 2008, pp. 3019-27.|
|Vaishnava S, Behrendt CL, Ismail AS, Eckmann L, Hooper LV. "Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface." Proceedings of the National Academy of Sciences, vol. 105, no. 52, 2008, pp. 20858-63.|
|Vaishnava S, Hooper LV. "Alkaline phosphatase: keeping the peace at the gut epithelial surface." Cell Host & Microbe, vol. 2, no. 6, 2007, pp. 365-7.|
|Gubbels MJ, Vaishnava S, Boot N, Dubremetz JF, Striepen B. "A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus." Journal of cell science, vol. 119, no. Pt 11, 2006, pp. 2236-45.|
|Gaji RY, Zhang D, Breathnach CC, Vaishnava S, Striepen B, Howe DK. "Molecular genetic transfection of the coccidian parasite Sarcocystis neurona." Molecular and biochemical parasitology, vol. 150, no. 1, 2006, pp. 1-9.|
|Vaishnava S, Striepen B. "The cell biology of secondary endosymbiosis--how parasites build, divide and segregate the apicoplast." Molecular Microbiology, vol. 61, no. 6, 2006, pp. 1380-7.|
|Vaishnava S, Morrison DP, Gaji RY, Murray JM, Entzeroth R, Howe DK, Striepen B. "Plastid segregation and cell division in the apicomplexan parasite Sarcocystis neurona." Journal of cell science, vol. 118, no. Pt 15, 2005, pp. 3397-407.|
|White, Michael W., Jerome, Maria E., Vaishnava, Shipra, Guerini, Michael, Behnke, Michael, Striepen, Boris. "Genetic rescue of a Toxoplasma gondii conditional cell cycle mutant." Molecular Microbiology, vol. 55, no. 4, 2004, pp. 1060-1071.|
Disruption of interactions between host immune system and resident microbiota can have profound consequences for host health. As a result studying the role of immune system in regulating microbiota and the molecular mechanisms by which microbiota shape host immunity are currently a central question in the field of biomedical science.
Vaishnava lab focuses on following areas of research to gain a better understanding of complex and dynamic nature of host- microbe interaction at the intestinal mucosal surface:
1. Role of adaptive immunity in regulating host-microbe interaction.
Intestinal microbiota provides a strong selective pressure for the host to evolve adaptive immunity. However little is known about the adaptive immune mechanisms that work in concert with the innate immune effectors to maintain the physical separation of host and microbiota and limit subepithelial bacterial penetration. We are interested in studying the role of adaptive immunity in regulating composition and geographical location of the intestinal bacteria.
2. Bacteria regulated vitamin A metabolism.
Complex communities of bacteria inhabit the mammalian intestines that are continuously interacting with the host. These interactions play a critical role in shaping host immunity. Mechanisms by which intestinal bacteria guide the development of mucosal immune response are not well understood. A key factor in orchestrating mucosal immune responses in the intestine is retinoic acid (RA), a metabolite of vitamin A (retinol). Currently not much is known about whether and how bacteria regulate vitamin A metabolism in the intestinal mucosa. Our goal is to define the molecular mechanism by which gut bacteria modulate vitamin A metabolism in the intestine and how this regulates RAR signaling dependent immune function in the mucosal tissues.
3. Stratification of bacterial communities within the intestinal mucus layer.
Intestinal bacteria play a critical role in regulating the metabolic potential of the host and greatly influences host biochemistry and susceptibility to disease. Moreover it has been shown that certain bacteria or their products exert powerful effects on immune cell differentiation whereas other species have no effect. The molecular basis for the differential ability of commensal species to trigger distinct immune developmental and metabolic pathways is yet to be determined. Our hypothesis is that this differential ability might be determined by the location of particular bacterial species with respect to the host epithelial surface. Our goal is to determine how bacterial communities are stratified within the intestinal lumen in order to better understand how they might influence host physiology and susceptibility to disease.
|2005||PhD||University of Georgia|
|1999||MS||Maharaja Sayajirao University|
|Post-doctoral fellow||UT Southwestern Medical Center, Dallas, immunology||2006-2011||Dallas|
Molecular Microbiology and Immunology Department
Molecular and Cellular Biology
|BIOL 1250 - Host-microbiome Interactions in Health and Disease|
|BIOL 1600 - Development of Vaccines to Infectious Diseases|