Dr. Wen is an Assistant Professor (Research) of Medicine at the Alpert Medical School of Brown University within the Division of Hematology/Oncology at Rhode Island Hospital. He is also working as a Director of the Extracellular Vesicle Core at COBRE Center for Stem Cells and Aging in Rhode Island Hospital. His research focuses on extracellular vesicle biology and hematopoietic stem cell biology. Currently, he is studying the biological functions of extracellular vesicles, focusing on the role of mesenchymal stem cell-derived extracellular vesicles in the reversal of radiation damage on hematopoietic stem cells and the digestive system. He also is investigating the clinical significance and mechanism of action of extracellular vesicles in oncology patients with leukemia or lung carcinoma.
| Wen S, Dooner M, Papa E, Del Tatto M, Pereira M, Borgovan T, Cheng Y, Goldberg L, Liang O, Camussi G, Quesenberry P. "Biodistribution of Mesenchymal Stem Cell-Derived Extracellular Vesicles in a Radiation Injury Bone Marrow Murine Model." International Journal of Molecular Sciences, vol. 20, no. 21, 2019. |
| Tapparo M, Bruno S, Collino F, Togliatto G, Deregibus MC, Provero P, Wen S, Quesenberry PJ, Camussi G. "Renal Regenerative Potential of Extracellular Vesicles Derived from miRNA-Engineered Mesenchymal Stromal Cells." International Journal of Molecular Sciences, vol. 20, no. 10, 2019. |
| Dooner MS, Stewart C, Deng Y, Papa E, Pereira M, Del Tatto M, Johnson S, Wen S, Amaral A, Aliotta J, Quesenberry PJ, Goldberg LR. "Daily rhythms influence the ability of lung-derived extracellular vesicles to modulate bone marrow cell phenotype." PLoS ONE, vol. 13, no. 11, 2018, pp. e0207444. |
| Aliotta JM, Pereira M, Wen S, Dooner MS, Del Tatto M, Papa E, Cheng Y, Goldberg L, Ventetuolo CE, Liang O, Klinger JR, Quesenberry PJ. "Bone Marrow Endothelial Progenitor Cells Are the Cellular Mediators of Pulmonary Hypertension in the Murine Monocrotaline Injury Model." STEM CELLS Translational Medicine, vol. 6, no. 7, 2017, pp. 1595-1606. |
| Collino F, Pomatto M, Bruno S, Lindoso RS, Tapparo M, Sicheng W, Quesenberry P, Camussi G. "Exosome and Microvesicle-Enriched Fractions Isolated from Mesenchymal Stem Cells by Gradient Separation Showed Different Molecular Signatures and Functions on Renal Tubular Epithelial Cells." Stem cell reviews and reports, vol. 13, no. 2, 2017, pp. 226-243. |
| Bruno S, Tapparo M, Collino F, Chiabotto G, Deregibus MC, Soares Lindoso R, Neri F, Kholia S, Giunti S, Wen S, Quesenberry P, Camussi G. "Renal Regenerative Potential of Different Extracellular Vesicle Populations Derived from Bone Marrow Mesenchymal Stromal Cells." Tissue engineering. Part A, vol. 23, no. 21-22, 2017, pp. 1262-1273. |
| Aliotta JM, Pereira M, Wen S, Dooner MS, Del Tatto M, Papa E, Goldberg LR, Baird GL, Ventetuolo CE, Quesenberry PJ, Klinger JR. "Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice." Cardiovascular research, vol. 110, no. 3, 2016, pp. 319-30. |
| Wen S, Dooner M, Cheng Y, Papa E, Del Tatto M, Pereira M, Deng Y, Goldberg L, Aliotta J, Chatterjee D, Stewart C, Carpanetto A, Collino F, Bruno S, Camussi G, Quesenberry P. "Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells." Leukemia, vol. 30, no. 11, 2016, pp. 2221-2231. |
| Aliotta JM, Pereira M, Sears EH, Dooner MS, Wen S, Goldberg LR, Quesenberry PJ. "Lung-derived exosome uptake into and epigenetic modulation of marrow progenitor/stem and differentiated cells." Journal of Extracellular Vesicles, vol. 4, 2015, pp. 26166. |
| Quesenberry PJ, Aliotta J, Camussi G, Abdel-Mageed AB, Wen S, Goldberg L, Zhang HG, Tetta C, Franklin J, Coffey RJ, Danielson K, Subramanya V, Ghiran I, Das S, Chen CC, Pusic KM, Pusic AD, Chatterjee D, Kraig RP, Balaj L, Dooner M. "Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium." Journal of Extracellular Vesicles, vol. 4, 2015, pp. 27575. |
| Quesenberry PJ, Goldberg LR, Aliotta JM, Dooner MS, Pereira MG, Wen S, Camussi G. "Cellular phenotype and extracellular vesicles: basic and clinical considerations." Stem Cells and Development, vol. 23, no. 13, 2014, pp. 1429-36. |
| Nisimova L, Wen S, Cross-Knorr S, Rogers AB, Moss SF, Chatterjee D. "Role of Raf kinase inhibitor protein in Helicobacter pylori-mediated signaling in gastric cancer." Critical Reviews in Oncogenesis, vol. 19, no. 6, 2014, pp. 469-81. |
| Tang X, Wen S, Zheng D, Tucker L, Cao L, Pantazatos D, Moss SF, Ramratnam B. "Acetylation of drosha on the N-terminus inhibits its degradation by ubiquitination." PLoS ONE, vol. 8, no. 8, 2013, pp. e72503. |
| Ruiz VE, Sachdev M, Zhang S, Wen S, Moss SF. "Isolating, immunophenotyping and ex vivo stimulation of CD4+ and CD8+ gastric lymphocytes during murine Helicobacter pylori infection." Journal of immunological methods, vol. 384, no. 1-2, 2012, pp. 157-63. |
| Wen S, So Y, Singh K, Slingerland JM, Resnick MB, Zhang S, Ruiz V, Moss SF. "Promotion of cytoplasmic mislocalization of p27 by Helicobacter pylori in gastric cancer." Oncogene, vol. 31, no. 14, 2012, pp. 1771-80. |
| Moen EL, Wen S, Anwar T, Cross-Knorr S, Brilliant K, Birnbaum F, Rahaman S, Sedivy JM, Moss SF, Chatterjee D. "Regulation of RKIP function by Helicobacter pylori in gastric cancer." PLoS ONE, vol. 7, no. 5, 2012, pp. e37819. |
| Zhao Y, Liu Z, Yu S, Wen S, Hammarstrom L, Rabbani H. "Construction of a High Efficiency PCR Products Cloning T Vector Using pGEM-5zf (+)." Avicenna journal of medical biotechnology, vol. 1, no. 1, 2009, pp. 37-9. |
| Wen S, Moss SF. "Helicobacter pylori virulence factors in gastric carcinogenesis." Cancer Letters, vol. 282, no. 1, 2009, pp. 1-8. |
| Wen S, Felley CP, Kessler V, Michetti P, Pan-Hammarström Q. "Comment on "Resistin-like molecule beta (RELMbeta/FIZZ2) is highly expressed in the ileum of SAMP1/YitFc mice and is associated with initiation of ileitis"." The Journal of Immunology, vol. 180, no. 4, 2008, pp. 2009; author reply 2009-10. |
| Wen S, Velin D, Felley CP, Du L, Michetti P, Pan-Hammarström Q. "Expression of Helicobacter pylori virulence factors and associated expression profiles of inflammatory genes in the human gastric mucosa." Infection and Immunity, vol. 75, no. 11, 2007, pp. 5118-26. |
| Pan-Hammarström Q, Wen S, Hammarström L. "Cytokine gene expression profiles in human lymphocytes induced by a formula of traditional Chinese medicine, vigconic VI-28." Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, vol. 26, no. 9, 2006, pp. 628-36. |
| Pan-Hammarström Q, Lähdesmäki A, Zhao Y, Du L, Zhao Z, Wen S, Ruiz-Perez VL, Dunn-Walters DK, Goodship JA, Hammarström L. "Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation." Journal of Experimental Medicine, vol. 203, no. 1, 2006, pp. 99-110. |
| Zhao Y, Pan-Hammarström Q, Zhao Z, Wen S, Hammarström L. "Selective IgG2 deficiency due to a point mutation causing abnormal splicing of the Cgamma2 gene." International immunology, vol. 17, no. 1, 2005, pp. 95-101. |
| Wen S, Felley CP, Bouzourene H, Reimers M, Michetti P, Pan-Hammarström Q. "Inflammatory gene profiles in gastric mucosa during Helicobacter pylori infection in humans." The Journal of Immunology, vol. 172, no. 4, 2004, pp. 2595-606. |
| Pan-Hammarström Q, Wen S, Ghanaat-Pour H, Solders G, Forsberg H, Hammarström L. "Lack of correlation between the reduction of serum immunoglobulin concentration and the CTG repeat expansion in patients with type 1 dystrophia [correction of Dystrofia] myotonica." Journal of neuroimmunology, vol. 144, no. 1-2, 2003, pp. 100-4. |
1 Grant title: Effect of moveable niches vesicles on the development and mitigation of bone marrow failure
Role: Principal Investigator
Agency: Rhode Island Foundation
Period: 07/01/19-06/30/2020
2. NIH/NIGMS 1P20GM119943 COBRE Stem Cells and Aging (PI: Peter Quesenberry)
Pilot Project: Mesenchymal stem cell-derived vesicles therapy for mitigation of acute radiation syndromes
Role: Pilot project Principal Investigator
Period: 07/01/2017-06/31/2020
3.Extracellular Vesicle Core at COBRE Center for Stem Cells and Aging (PI: Peter Quesenberry)
Role: Core director
Period: 07/01/2019-present
4. Herbert Savit 49 Endowed Research Fellowship Fund
Pilot Project: The fundamental properties of hematopoietic stem cells are influenced by progression through the cell cycle
Role: Principal Investigator
Period 2019-present
5.Grant title: Basic Aspects of Hematopoietic Stem Cells and Aging
Principal Investigator: Peter Quesenberry
Role: Research Scientist
Agency: NIH/NIDDK:1RO1DK112808-01A1
Period:9/15/2017-6/30/2020
6. Grant title: Reversal of aplastic anemia by mesenchymal stem cell-derived extracellular vesicles
Role: Principal Investigator
Agency: Aplastic Anemia & MDS International Foundation
Period: 07/01/15-07/01/17
7, Grant title: Regulation of renal and bone marrow injury by extracellular vesicle non- coding RNA
Role:Co – Investigator
Principal Investigator: Peter Quesenberry
Agency: NIH 5UH2TR000880
Period: 08/01/13-07/31/18
| Year | Degree | Institution |
|---|---|---|
| 2007 | PhD | Karolinska Institute |
| 1997 | MS | Guangzhou University of Chinese Medicine (廣州中醫葯大學) |
| 1992 | MD | Sun Yat-sen University |
