William Cioffi J. Murray Beardsley Professor of Surgery, Professor of Medical Science, Chair of Surgery

Hospital Appointments

Executive Surgeon-in-Chief, Department of Surgery, The Miriam Hospital, Veterans Affairs Hospital,
Women and Infants Hospital and Memorial Hospital of Rhode Island.

2001-present Surgeon-in-Chief, Department of Surgery
Rhode Island Hospital, Providence, RI

1995-present Active Surgeon
Women & Infants' Hospital, Providence, RI

Brown Affiliations

scholarly work

Safran H, Dipetrillo T, Iannitti D, Quirk D, Akerman P, Cruff D, Cioffi W, Shah S, Ramdin N, Rich T: Gemcitabine, paclitaxel, and radiation for locally advanced pancreatic cancer: a Phase I trial. International Journal of Radiation Oncology, Biology, Physics. 54(1):137-41, 2002 Sep 1.

Song GY, Chung CS, Jarrar D, Cioffi WG, Ayala A: Mechanism of immune dysfunction in sepsis: Inducible nitric-oxide mediated alterations in p38 MAPK activation. J Trauma 53(2):276-83, 2002.

Knoferl MW, Angele MK, Diodato MD, Schwacha MG, Ayala A, Cioffi WG, Bland KI, Chaudry IH: Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate of subsequent sepsis. Ann Surg 235(1):105-12, 2002.

Knoferl MW, Diodato MD, Schwacha MG, Cioffi WG, Bland KI, Chaudry IH: Cyclooxygenase-2-mediated regulation of Kupffer cell interleukin-6 production following trauma-hemorrhage and subsequent sepsis. Shock 16(6):479-83, 2001.

Cioffi WG: Whatís new in burns and metabolism [review]. J Am Coll Surg 192(2):241-254, 2001.

Safran H, Moore T, Iannitti D, DePetrillo T, Akerman P, Cioffi W, Harrington D, Quirk D, Rathore R, Cruff D, Vakharia J, Vora S, Savarese D, Wanebo H: Paclitaxel and concurrent radiation for locally advanced pancreatic cancer. Int J Radiation Oncology Biol Phys 49(5):1275-1279, 2001.

Wang P, BA ZF, Koo DJ, Cioffi WG, Bland KI, Chaudry IH: Continuous resuscitation after hemorrhage and acute fluid replacement improves cardiovascular responses. Surgery 129(5):559- 66, 2001.Rocco Jr TR, Reinert SE, Cioffi WG, Harrington DT, Buczko G, Simms HH: A 9-year, singleinstitution, retrospective review of death rate and prognosis factors in adult respiratory distress syndrome. Ann Surg 233(3):414-422, 2001.Saitoh D, Shirani KZ, Cioffi WG, Kizaki T, Ohmo H, Okada Y, Mason AD Jr, Pruitt BA Jr: Changes in the tissue and plasma superoxide dismutase (SOD) levels in a burned rat model. Tohoku J Experimental Med 193(1):27-36, 2001.

research overview

William G. Cioffi, Jr., M.D. is professor and chair of the Department of Surgery at Brown Medical School. He is a national leader in trauma, critical care, and burns. Throughout his career his major research interests have focused on the host response to injury and include basic science, translational, and clinical research.

research statement

William G. Cioffi, Jr., M.D. is professor and chair of the Department of Surgery at Brown Medical School. He is a national leader in trauma, critical care, and burns. Throughout his career his major research interests have focused on the host response to injury and include basic science, translational, and clinical research.

funded research

ONGOING RESEARCH SUPPORT

National Institutes of Health (NIH)/National Institute on Alcohol Abuse and Alcoholism (NIAAA) #2 R01 AA009892-11A1
Peter Monti (PI)
Role: Collaborator
$2,133,733.
05/10/05 to 04/30/10
"Enhanced MI with alcohol positive trauma patients"
The major goal of this project is to evaluate the efficacy of motivational interviews with significant others, in preventing recidivism among alcohol-positive patients admitted to a trauma service.

NIH / National Institute of General Medical Sciences (NIGMS) #1 T32 GM065085-1A1
Jorge Albina (PI)
Role: Executive Committee, Clinical Coordinator, Research Faculty
$1,201,764.
07/01/2004 to 06/30/09
"Trauma and Inflammation Research Training"
The major goal of this project is to identify, recruit, and train the next generation of Trauma Scientists with particular emphasis in retaining MDs in academic trauma medicine careers.

NIH #5 RO1 HL 073525-02.
Alfred Ayala (PI)
Role: Collaborator
$1,431,210 (direct and indirect costs).
9/1/03-6/30/07
Regulatory mechanisms of acute lung injury.