In the area of Intrauterine growth restriction (IUGR): Using an animal model, I have demonstrated that the fetus with IUGR has reduced hepatic glycogen content, which increases their risk for low blood sugar during the neonatal period.
In infants of diabetic mothers, I have demonstrated fetal hyperinsulinemia as the major factor for the increased problems during the newborn period, including being born too large, low blood glucose, respiratory distress, and failure. I have also demonstrated that being born too large predisposes them to a higher incidence of obesity in the adolescent period as well as diabetes.
In very low birth weight infants, and in collaboration with 15 other centers within the Neonatal Research Network, we have evaluated the use of several interventions: surfactant, vit A to prevent chronic lung disease, and the use of inhaled nitric oxide for newborns with persistent pulmonary hypertension. All of these data have been published in several journals listed on my CV.