William Oldham, MD, PhD, ATSF is Director of Research and Innovation for the Pulmonary, Critical Care, and Sleep Medicine division at Brown University Health. His laboratory investigates how cellular metabolic reprogramming contributes to the lung diseases pulmonary hypertension and pulmonary fibrosis by studying in vitro and in vivo model systems using state-of-the-art analytical techniques, including metabolomics, stable isotope tracing, extracellular flux analyses, systems biology, and network medicine. By improving understanding of cell metabolism, his lab aims to develop new therapeutic strategies for the treatment lung diseases.
Dr. Oldham received his MD and PhD in Pharmacology from Vanderbilt University where he studied the mechanisms of receptor-mediated heterotrimeric G protein activation under the mentorship of Dr. Heidi Hamm. He completed clinical training in internal medicine, pulmonary disease, and critical care medicine at Massachusetts General Hospital and Harvard Medical School. As a post-doctoral fellow with Dr. Joseph Loscalzo, he investigated how cell metabolism responds to redox stress.
Currently, the primary interests of his laboratory are (1) identifying the metabolic requirements for extracellular matrix synthesis in fibrotic diseases, (2) characterizing the role of metabolic reprogramming in pulmonary cell differentiation following injury, (3) understanding the role of the MYC transcription factor in sustaining hypoxic cells, and (4) developing a small molecule therapeutic for ischemia-reperfusion injury.
His work is funded by the National Heart, Lung, and Blood Institute of the National Institutes of Health.
| Yang JS, Morris AJ, Kamizaki K, Chen J, Stark J, Oldham WM, Nakamura T, Mishima E, Loscalzo J, Minami Y, Conrad M, Henry WS, Hsu VW. "ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1." Cell, vol. 188, no. 10, 2025, pp. 2569-2585.e20. |
| Torrino S, Oldham WM, Tejedor AR, Burgos IS, Nasr L, Rachedi N, Fraissard K, Chauvet C, Sbai C, O'Hara BP, Abélanet S, Brau F, Favard C, Clavel S, Collepardo-Guevara R, Espinosa JR, Ben-Sahra I, Bertero T. "Mechano-dependent sorbitol accumulation supports biomolecular condensate." Cell, vol. 188, no. 2, 2025, pp. 447-464.e20. |
| Oldham WM. "Targeting Cardiac Fibrosis With a Vaccine Against Fibroblast Activation Protein." Circulation research, vol. 136, no. 1, 2025, pp. 41-43. |
| Singh N, Oldham WM. "Targeting type-2 inflammation in pulmonary hypertension: lessons from a novel model." American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 328, no. 5, 2025, pp. L669-L670. |
| Xiao W, Shrimali N, Vigder N, Oldham WM, Clish CB, He H, Wong SJ, Wertheim BM, Arons E, Haigis MC, Leopold JA, Loscalzo J. "Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells." Nature metabolism, vol. 6, no. 11, 2024, pp. 2138-2156. |
| Rachedi NS, Tang Y, Tai YY, Zhao J, Chauvet C, Grynblat J, Akoumia KKF, Estephan L, Torrino S, Sbai C, Ait-Mouffok A, Latoche JD, Al Aaraj Y, Brau F, Abélanet S, Clavel S, Zhang Y, Guillermier C, Kumar NVG, Tavakoli S, Mercier O, Risbano MG, Yao ZK, Yang G, Ouerfelli O, Lewis JS, Montani D, Humbert M, Steinhauser ML, Anderson CJ, Oldham WM, Perros F, Bertero T, Chan SY. "Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness." Cell Metabolism, vol. 36, no. 6, 2024, pp. 1335-1350.e8. |
| Tamura T, Cheng C, Villaseñor-Altamirano AB, Yamada K, Ikeda K, Hayashida K, Menon JA, Chen XD, Chung H, Varon J, Chen J, Choi J, Cullen AM, Guo J, Lin X, Olenchock BA, Pinilla-Vera MA, Manandhar R, Sheikh MDA, Hou PC, Lawler PR, Oldham WM, Seethala RR, Immunology of Cardiac Arrest Network (I-CAN), Baron RM, Bohula EA, Morrow DA, Blumberg RS, Chen F, Merriam LT, Weissman AJ, Brenner MB, Chen X, Ichinose F, Kim EY. "Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation." Science Translational Medicine, vol. 16, no. 776, 2024, pp. eadq5796. |
| McGarrity S, Ziehr DR, Austin-Tse CA, Wein MN, Chivukula RR, Oldham WM. "Exercise Intolerance and Low Cardiac Filling Pressures in a Woman With a Novel eNOS Mutation." Circulation. Genomic and precision medicine, vol. 17, no. 5, 2024, pp. e004741. |
| Oldham WM. "Exploring the Molecular Signatures of Pulmonary Vascular Lesions." Am J Respir Crit Care Med, vol. 210, no. 3, 2024, pp. 256-257. |
| Philip N, Yun X, Pi H, Murray S, Hill Z, Fonticella J, Perez P, Zhang C, Pathmasiri W, Sumner S, Servinsky L, Jiang H, Huetsch JC, Oldham WM, Visovatti S, Leary PJ, Gharib SA, Brittain E, Simpson CE, Le A, Shimoda LA, Suresh K. "Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension." American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 326, no. 3, 2024, pp. L252-L265. |
| Kamiya M, Carter H, Espindola MS, Doyle TJ, Lee JS, Merriam LT, Zhang F, Kawano-Dourado L, Sparks JA, Hogaboam CM, Moore BB, Oldham WM, Kim EY. "Immune mechanisms in fibrotic interstitial lung disease." Cell, vol. 187, no. 14, 2024, pp. 3506-3530. |
| Nguyen HN, Jeong Y, Kim Y, Kamiya M, Kim Y, Athar H, Castaldi PJ, Hersh CP, Menon JA, Wong J, Chan I, Oldham WM, Padera RF, Sharma NS, Sholl LM, Vivero M, Watts GFM, Knipe RS, Black KE, Hariri LP, Yun JH, Merriam LT, Yuan K, Kim EY, Brenner MB. "Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis." Proceedings of the National Academy of Sciences, vol. 121, no. 50, 2024, pp. e2401899121. |
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Oldham WM.
"New Agents in Pulmonary Disease." Brigham Intensive Review of Internal Medicine, edited by Singh AK, Loscalzo J, Philadelphia, Elsevier, 2024, pp. 470-476.
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Wertheim B, Maron BA, Oldham WM.
"Pulmonary Hypertension." Brigham Intensive Review of Internal Medicine, edited by Singh AK, Loscalzo J, Philadelphia, Elsevier, 2024, pp. 1028-1038.
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| Li G, Huang H, Wu Y, Shu C, Hwang N, Li Q, Zhao R, Lam HC, Oldham WM, Ei-Chemaly S, Agrawal PB, Tian J, Liu X, Perrella MA. "Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes." Basic research in cardiology, vol. 119, no. 1, 2024, pp. 151-168. |
| Chakraborty A, Bandyopadhaya A, Singh VK, Kovacic F, Cha S, Oldham WM, Tzika AA, Rahme LG. "The bacterial quorum sensing signal 2'-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection." eLife, vol. 13, 2024. |
| Wang RS, Huang S, Waldo SW, Hess E, Gokhale M, Johnson SW, Zeder K, Choudhary G, Leopold JA, Oldham WM, Kovacs G, Freiberg MS, Tedford RJ, Maron BA, Brittain EL. "Elevated Pulmonary Arterial Compliance Is Associated with Survival in Pulmonary Hypertension: Results from a Novel Network Medicine Analysis." Am J Respir Crit Care Med, vol. 208, no. 3, 2023, pp. 312-321. |
| Diaz-Cuadros M, Miettinen TP, Skinner OS, Sheedy D, Díaz-García CM, Gapon S, Hubaud A, Yellen G, Manalis SR, Oldham WM, Pourquié O. "Metabolic regulation of species-specific developmental rates." Nature, vol. 613, no. 7944, 2023, pp. 550-557. |
| Copeland CA, Olenchock BA, Ziehr D, McGarrity S, Leahy K, Young JD, Loscalzo J, Oldham WM. "MYC overrides HIF-1α to regulate proliferating primary cell metabolism in hypoxia." eLife, vol. 12, 2023. |
| Wertheim BM, Wang RS, Guillermier C, Hütter CV, Oldham WM, Menche J, Steinhauser ML, Maron BA. "Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension." JCI insight, vol. 8, no. 4, 2023. |
| Tamura T, Cheng C, Chen W, Merriam LT, Athar H, Kim YH, Manandhar R, Amir Sheikh MD, Pinilla-Vera M, Varon J, Hou PC, Lawler PR, Oldham WM, Seethala RR, Tesfaigzi Y, Immunology of Cardiac Arrest Network (I-CAN), Weissman AJ, Baron RM, Ichinose F, Berg KM, Bohula EA, Morrow DA, Chen X, Kim EY. "Single-cell transcriptomics reveal a hyperacute cytokine and immune checkpoint axis after cardiac arrest in patients with poor neurological outcome." Med (New York, N.Y.), vol. 4, no. 7, 2023, pp. 432-456.e6. |
| He H, Mulhern RM, Oldham WM, Xiao W, Lin YD, Liao R, Loscalzo J. "L-2-Hydroxyglutarate Protects Against Cardiac Injury via Metabolic Remodeling." Circulation research, vol. 131, no. 7, 2022, pp. 562-579. |
| Xiao W, Oldham WM, Priolo C, Pandey AK, Loscalzo J. "Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism." Circulation research, vol. 129, no. 1, 2021, pp. 9-29. |
| Maron BA, Wang RS, Shevtsov S, Drakos SG, Arons E, Wever-Pinzon O, Huggins GS, Samokhin AO, Oldham WM, Aguib Y, Yacoub MH, Rowin EJ, Maron BJ, Maron MS, Loscalzo J. "Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes." Nature Communications, vol. 12, no. 1, 2021, pp. 873. |
| Oldham WM, Hess E, Waldo SW, Humbert M, Choudhary G, Maron BA. "Integrating haemodynamics identifies an extreme pulmonary hypertension phenotype." European Respiratory Journal, vol. 58, no. 2, 2021. |
| Lee LY, Oldham WM, He H, Wang R, Mulhern R, Handy DE, Loscalzo J. "Interferon-γ Impairs Human Coronary Artery Endothelial Glucose Metabolism by Tryptophan Catabolism and Activates Fatty Acid Oxidation." Circulation, vol. 144, no. 20, 2021, pp. 1612-1628. |
| Torrino S, Grasset EM, Audebert S, Belhadj I, Lacoux C, Haynes M, Pisano S, Abélanet S, Brau F, Chan SY, Mari B, Oldham WM, Ewald AJ, Bertero T. "Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis." Cell Metabolism, vol. 33, no. 7, 2021, pp. 1342-1357.e10. |
| Oldham WM, Hemnes AR, Aldred MA, Barnard J, Brittain EL, Chan SY, Cheng F, Cho MH, Desai AA, Garcia JGN, Geraci MW, Ghiassian SD, Hall KT, Horn EM, Jain M, Kelly RS, Leopold JA, Lindstrom S, Modena BD, Nichols WC, Rhodes CJ, Sun W, Sweatt AJ, Vanderpool RR, Wilkins MR, Wilmot B, Zamanian RT, Fessel JP, Aggarwal NR, Loscalzo J, Xiao L. "NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review." Journal of the American College of Cardiology, vol. 77, no. 16, 2021, pp. 2040-2052. |
| Singh I, Oliveira RKF, Naeije R, Oldham WM, Faria-Urbina M, Waxman AB, Systrom DM. "Systemic vascular distensibility relates to exercise capacity in connective tissue disease." Rheumatology (Oxford, England), vol. 60, no. 3, 2021, pp. 1429-1434. |
| Mehta AK, Cheney EM, Hartl CA, Pantelidou C, Oliwa M, Castrillon JA, Lin JR, Hurst KE, de Oliveira Taveira M, Johnson NT, Oldham WM, Kalocsay M, Berberich MJ, Boswell SA, Kothari A, Johnson S, Dillon DA, Lipschitz M, Rodig S, Santagata S, Garber JE, Tung N, Yélamos J, Thaxton JE, Mittendorf EA, Sorger PK, Shapiro GI, Guerriero JL. "Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer." Nature cancer, vol. 2, no. 1, 2021, pp. 66-82. |
| Sauer CM, Gómez J, Botella MR, Ziehr DR, Oldham WM, Gavidia G, Rodríguez A, Elbers P, Girbes A, Bodi M, Celi LA. "Understanding critically ill sepsis patients with normal serum lactate levels: results from U.S. and European ICU cohorts." Scientific reports, vol. 11, no. 1, 2021, pp. 20076. |
| Singh, Inderjit, Oldham, William M., Rahaghi, Farbod Nick. "Precision Medicine in Pulmonary Hypertension." Respiratory Medicine, 2020, pp. 241-255. |
| Kim EY, Oldham WM. "Innate T cells in the intensive care unit." Molecular immunology, vol. 105, 2019, pp. 213-223. |
| Sternschein RM, Oldham WM. "Paradoxical Embolization via Large Pulmonary Arteriovenous Malformation." Am J Respir Crit Care Med, vol. 200, no. 5, 2019, pp. 29-30. |
| Singh I, Oliveira RKF, Naeije R, Rahaghi FN, Oldham WM, Systrom DM, Waxman AB. "Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodeling in Pulmonary Hypertension." Chest, vol. 156, no. 4, 2019, pp. 724-732. |
| Guarino VA, Oldham WM, Loscalzo J, Zhang YY. "Reaction rate of pyruvate and hydrogen peroxide: assessing antioxidant capacity of pyruvate under biological conditions." Scientific reports, vol. 9, no. 1, 2019, pp. 19568. |
| Bertero T, Oldham WM, Grasset EM, Bourget I, Boulter E, Pisano S, Hofman P, Bellvert F, Meneguzzi G, Bulavin DV, Estrach S, Feral CC, Chan SY, Bozec A, Gaggioli C. "Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy." Cell Metabolism, vol. 29, no. 1, 2019, pp. 124-140.e10. |
| Verwer EE, Kavanagh TR, Mischler WJ, Feng Y, Takahashi K, Wang S, Shoup TM, Neelamegam R, Yang J, Guehl NJ, Ran C, Massefski W, Cui Y, El-Chemaly S, Sadow PM, Oldham WM, Kijewski MF, El Fakhri G, Normandin MD, Priolo C. "[(18)F]Fluorocholine and [(18)F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM." Clin Cancer Res , vol. 24, no. 23, 2018, pp. 5925-5938. |
| Yang JS, Hsu JW, Park SY, Li J, Oldham WM, Beznoussenko GV, Mironov AA, Loscalzo J, Hsu VW. "GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis." Nature, vol. 561, no. 7722, 2018, pp. 263-267. |
| Musri MM, Coll-Bonfill N, Maron BA, Peinado VI, Wang RS, Altirriba J, Blanco I, Oldham WM, Tura-Ceide O, García-Lucio J, de la Cruz-Thea B, Meister G, Loscalzo J, Barberà JA. "MicroRNA Dysregulation in Pulmonary Arteries from Chronic Obstructive Pulmonary Disease. Relationships with Vascular Remodeling." American Journal of Respiratory Cell and Molecular Biology, vol. 59, no. 4, 2018, pp. 490-499. |
| Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. "NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension." Science Translational Medicine, vol. 10, no. 445, 2018. |
| Oldham WM, Oliveira RKF, Wang RS, Opotowsky AR, Rubins DM, Hainer J, Wertheim BM, Alba GA, Choudhary G, Tornyos A, MacRae CA, Loscalzo J, Leopold JA, Waxman AB, Olschewski H, Kovacs G, Systrom DM, Maron BA. "Network Analysis to Risk Stratify Patients with Exercise Intolerance." Circulation research, vol. 122, no. 6, 2018, pp. 864-876. |
| Fessel JP, Oldham WM. "Nicotine Adenine Dinucleotides: The Redox Currency of the Cell." Antioxidants & redox signaling, vol. 28, no. 3, 2018, pp. 165-166. |
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Wertheim B, Maron BA, Oldham WM.
"Pulmonary Hypertension." Brigham Intensive Review of Internal Medicine, edited by Singh AK, Loscalzo J, Philadelphia, Elsevier, 2018, pp. 906-916.
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| Fessel JP, Oldham WM. "Pyridine Dinucleotides from Molecules to Man." Antioxidants & redox signaling, vol. 28, no. 3, 2018, pp. 180-212. |
| Wang RS, Oldham WM, Maron BA, Loscalzo J. "Systems Biology Approaches to Redox Metabolism in Stress and Disease States." Antioxidants & redox signaling, vol. 29, no. 10, 2018, pp. 953-972. |
| Oldham WM. "The Long Noncoding RNA LnRPT Puts the Brakes on Pulmonary Artery Smooth Muscle Cell Proliferation." American Journal of Respiratory Cell and Molecular Biology, vol. 58, no. 2, 2018, pp. 138-139. |
| Lam HC, Baglini CV, Lope AL, Parkhitko AA, Liu HJ, Alesi N, Malinowska IA, Ebrahimi-Fakhari D, Saffari A, Yu JJ, Pereira A, Khabibullin D, Ogorek B, Nijmeh J, Kavanagh T, Handen A, Chan SY, Asara JM, Oldham WM, Diaz-Meco MT, Moscat J, Sahin M, Priolo C, Henske EP. "p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis." Cancer Research, vol. 77, no. 12, 2017, pp. 3255-3267. |
| Lam HC, Liu HJ, Baglini CV, Filippakis H, Alesi N, Nijmeh J, Du H, Lope AL, Cottrill KA, Handen A, Asara JM, Kwiatkowski DJ, Ben-Sahra I, Oldham WM, Chan SY, Henske EP. "Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells." Oncotarget, vol. 8, no. 39, 2017, pp. 64714-64727. |
| Maron BA, Stephens TE, Farrell LA, Oldham WM, Loscalzo J, Leopold JA, Lewis GD. "Elevated pulmonary arterial and systemic plasma aldosterone levels associate with impaired cardiac reserve capacity during exercise in left ventricular systolic heart failure patients: A pilot study." The Journal of Heart and Lung Transplantation, vol. 35, no. 3, 2016, pp. 342-351. |
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Oldham WM, Loscalzo J.
"Pharmacology of Vascular Tone." Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, edited by Golan DE, Tashjian AH, Armstrong EJ, Philadelphia, Lippincott Williams & Wilkins, 2016, pp. 385-402.
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| Fessel, Joshua P., Oldham, William M. "Pulmonary Hypertension as a Metabolic Disease." Pulmonary Hypertension, 2016, pp. 135-145. |
| Oldham WM, Loscalzo J. "Quantification of 2-Hydroxyglutarate Enantiomers by Liquid Chromatography-mass Spectrometry." BIO-PROTOCOL, vol. 6, no. 16, 2016. |
| Oldham WM, Lewis GD, Opotowsky AR, Waxman AB, Systrom DM. "Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing." Pulmonary Circulation, vol. 6, no. 1, 2016, pp. 55-62. |
| Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan J 3rd, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggioli C, Loscalzo J, Fessel J, Chan SY. "Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension." Journal of Clinical Investigation, vol. 126, no. 9, 2016, pp. 3313-35. |
| Oldham WM, Clish CB, Yang Y, Loscalzo J. "Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress." Cell Metabolism, vol. 22, no. 2, 2015, pp. 291-303. |
| Berry NC, Manyoo A, Oldham WM, Stephens TE, Goldstein RH, Waxman AB, Tracy JA, Leary PJ, Leopold JA, Kinlay S, Opotowsky AR, Systrom DM, Maron BA. "Protocol for exercise hemodynamic assessment: performing an invasive cardiopulmonary exercise test in clinical practice." Pulmonary Circulation, vol. 5, no. 4, 2015, pp. 610-8. |
| Wang RS, Oldham WM, Loscalzo J. "Network-based association of hypoxia-responsive genes with cardiovascular diseases." New Journal of Physics, vol. 16, no. 10, 2014, pp. 105014. |
| Maron BA, Oldham WM, Chan SY, Vargas SO, Arons E, Zhang YY, Loscalzo J, Leopold JA. "Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis." Circulation, vol. 130, no. 2, 2014, pp. 168-79. |
| Ciampa EJ, Hunt AA, Arneson KO, Mordes DA, Oldham WM, Vin Woo K, Owens DA, Cannon MD, Dermody TS. "A workshop on leadership for MD/PhD students." Medical Education Online, vol. 16, 2011. |
| Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E. "Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity." Science Signaling, vol. 3, no. 121, 2010, pp. ra37. |
| Preininger AM, Funk MA, Oldham WM, Meier SM, Johnston CA, Adhikary S, Kimple AJ, Siderovski DP, Hamm HE, Iverson TM. "Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits." Biochemistry, vol. 48, no. 12, 2009, pp. 2630-42. |
| Oldham WM, Hamm HE. "Heterotrimeric G protein activation by G-protein-coupled receptors." Nature reviews. Molecular cell biology, vol. 9, no. 1, 2008, pp. 60-71. |
| Oldham WM, Hamm HE. "How do receptors activate G proteins?." Advances in protein chemistry, vol. 74, 2007, pp. 67-93. |
| Oldham WM, Van Eps N, Preininger AM, Hubbell WL, Hamm HE. "Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins." Proceedings of the National Academy of Sciences, vol. 104, no. 19, 2007, pp. 7927-32. |
| "Signal Transduction in the Retina." [], 2007. |
| Preininger AM, Henage LG, Oldham WM, Yoon EJ, Hamm HE, Brown HA. "Direct modulation of phospholipase D activity by Gbetagamma." Molecular pharmacology, vol. 70, no. 1, 2006, pp. 311-8. |
| Oldham WM, Van Eps N, Preininger AM, Hubbell WL, Hamm HE. "Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins." Nature Structural & Molecular Biology, vol. 13, no. 9, 2006, pp. 772-7. |
| Van Eps N, Oldham WM, Hamm HE, Hubbell WL. "Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway." Proceedings of the National Academy of Sciences, vol. 103, no. 44, 2006, pp. 16194-9. |
| Oldham WM, Hamm HE. "Structural basis of function in heterotrimeric G proteins." Quarterly reviews of biophysics, vol. 39, no. 2, 2006, pp. 117-66. |
| Kwong J, Roundabush FL, Hutton Moore P, Montague M, Oldham W, Li Y, Chin LS, Li L. "Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis." Journal of cell science, vol. 113 ( Pt 12), 2000, pp. 2273-84. |
| Year | Degree | Institution |
|---|---|---|
| 2008 | MD | Vanderbilt University |
| 2006 | PhD | Vanderbilt University |
| 2001 | BS | University of North Carolina at Chapel Hill |
