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Yihong Wang Assistant Professor of Pathology and Laboratory Medicine

Expertise/Certifications: Breast Pathology, Surgical Pathology, Anatomic Pathology, Clinical Pathology
Office number: 444-5169
(Lab Customer Service: 401-793-4242)

Dr. Wang is on the faculty of Pathology and Laboratory Medicine at the Warren Alpert School of Medicine at Brown University, and leads the breast pathology section for Lifespan Laboratories.  She obtained her MD from Shandong Medical University, and her PhD from Ohio University.  After a post-doctoral fellowship in genomics, she completed her pathology residency at Harvard University (Beth Israel Deaconess Medical Center), including a fellowship in breast pathology (BIDMC).  Dr. Wang has particular interests in the pathobiology of breast cancer and personalized diagnostics. She is currently working on miRNA expression profiles in breast cancer and their relationship to response to therapies. 

Prior academic appointments:
Assistant Professor of Pathology, Albert Einstein College of Medicine, New York, NY
Attending Pathologist, Montefiore Medical Center, New York, NY

Brown Affiliations

scholarly work

Zhou C, Cohen D, Wang Y, Lee H, Mondelblatt A, Tsai T, Aguirre A, Connolly J and Fujimoto J. Integrated Optical Coherence Tomography and microscopy for Ex-vivo Multi-scare Evaluation of Human Breast Pathology. Cancer Res, 2010, 70 (24), 10071-9.

Genega EM, Ghebremichael M, Najarian R, Fu Y, Wang Y, Argani P, Grisanzio C and Signoretti S. Carbonic Anhydrase IX expression in renal neoplasms: correlation with tumor type and grade. Am J Clin Pathol, 2010, 134 (6), 873-9

Tung N, Wang Y, Collins LC, Kaplan J, Li H, Gelman R, Comander AH, Gallagher B, Fetten K, Krag K, Stoeckert KA, Legare RD, Sgroi D, Ryan PD, Garber JE, Schnitt SJ. Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features. Breast Cancer Res. 2010, 12 (1), R12

Zhou C, Wang Y, Aguirre A, Tsai T, Cohen D, Connolly J and Fujimoto J. Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography (OCT) and Optical Coherence Microscopy (OCM). J Biomed Optics, 2010, 15(1)

Zhou C, Tsai T, Adler D, Lee H, Cohen D, Mondelblatt A, Wang Y, Connolly J, and Fujimoto J. Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells.  Optics letters 2010, 35(5

Dialani V, Hines N, Wang Y and Slanetz P. Breast schwannoma. Case Report in Medicine, 2011, v2011, Feb 9

Tamimi RM, Colditz GA, Wang Y, Collins LC, Hu R, Rosner B, Irie HY, Connolly JL, Schnitt SJ. Expression of IGF1R in normal breast tissue and subsequent risk of breast cancer. Breast Cancer Res Treat. 2011, 128(1), 243-50

Zerbini LF, de Vasconcellos JF, Czibere A, Wang Y, Paccez JD, Gu X, Zhou JR, Libermann TA. JunD-mediated repression of GADD45alpha and gamma regulates escape from cell death in prostate cancer. Cell Cycle, 2011 Aug 1, 10 (15).

Wang Y, Zhu C, and Whitney K. Bilateral cribriform atypical ductal proliferation in male beast; a mimicker of female cribriform atypical ductal hyperplasia?  Histopathology, 2011, 59 (1), 148-150

Lee H, Zhou C, Cohen DW, Mondelblatt AE, Wang Y, Aguirre AD, Shen D, Sheikine Y, Fujimoto JG and Connolly JL. Integrated Optical Coherence Tomography and Optical Coherence Microscopy Imaging of Ex Vivo Human Renal Tissues. Journal of Urology, 2012, 187 (2), 691-9

Kaplan JS, Schnitt SJ, Collins LC, Wang Y, Garber JE, Montgomery K, West RB, Krag K, Fetten K, Lincoln A, Tung NM. Pathologic Features and Immunophenotype of Estrogen Receptor-positive Breast Cancers in BRCA1 Mutation Carriers. American Journal of Surgical Pathology 2012, 36 (10), 1483-8

Chao SK, Wang Y* , Verdier-Pinard P, Yang CH, Liu L,  Rodriguez-Gabin A, McDaid HM, and Horwitz SB. Characterization of an Immunohistochemistry-compatible beta V tubulin antibody specific for the human isotype. * co-first author. 2012, 69, 566-76 

research overview

 Dr. Wang has particular interests in the pathobiology of breast cancer and personalized diagnostics. She is currently working on miRNA expression profiles in breast cancer and their relationship to response to therapies. 

research statement

Expression Profile of MicroRNA Analysis with Correlation to Response from Breast Cancer treated with Neoadjuvant Chemotherapy
We are evaluating the expression profile of miRNA's in pre-treated tumor samples in the neoadjuvant setting.  By studying the differential expression of miRNA's of breast cancers and the clinical response to treatment, we plan to develp predictors of clinical responses to different therapies. 

Clinical and Radiologic Follow-up Study for Breast Biopsy Diagnosis of Radial Scar (Radial Sclerosing Lesion) without other Atypia
Radial scars/radial sclerosing lesions (RS/RSL) are benign breast lesions that my be detected by mammography and simulate breast cancer.  In collaborative studies with surgeons and radiologists, we are working to determine the best clinical approaches to RS/RSL.