Advance Modeling of Normal Tissue Complication post Radiotherapy:  The efficacy of radiotherapy is limited by normal tissue toxicity. Dr Saleh has performed studies with colleagues at other institutes to identify correlations between dose to normal structures and late toxicity and in particular; late rectal bleeding in prostate cancer, dryness of mouth (Xerostomia) and difficulty opening the mouth (Trismus) in Head&Neck cancer patients. These studies helped to establish dose limits to certain structures to lower complication rates and improve quality of life for the patients.

Evaluation of Deformable Image Registration (DIR): DIR is a technique used to fuse images from different modalities (PET, CT, MRI) and to align patient scans obtained in different positions for better target definition and soft tissue delineation. Although DIR holds great promise, its use is currently limited in the clinic due to a lack of metrics to quantify the quality of the registration.Dr Saleh developed a quantitative metric to evaluate the performance of deformable registration and its use for dose mapping which is an essential step for Adaptive Radiotherapy.

1. Liu, V. Moiseenko, A. Agranovich, A. Karvat, W. Kwan,  Z. H. Saleh, A. A. Apte, and J. O. Deasy, Normal Tissue Complication Probability (NTCP) Modeling Of Late Rectal Bleeding Following External Beam Radiotherapy For Prostate Cancer: A Test of the QUANTEC-Recommended NTCP Model, Biology-Guided Adaptive Radiotherapy (BIGART), Acta Oncologica. 2010; 49:884-887.
2. Vitali Moiseenko, Ph.D., Jonn Wu, M.D., Allan Hovan, M.D.D., Ziad Saleh, Ph.D.Aditya Apte, PhD., Joseph O. Deasy, Ph.D., Stephen Harrow, M.D., Carman Rabuka, M.D.D., Adam Muggli, D.D.S., and Anna Thompson, M.D. Treatment planning constraints to avoid xerostomia in head and neck radiotherapy: an independent test of QUANTEC criteria using a prospectively collected dataset. Int J Radiat Oncol Biol Phys. 2012 Mar 1; 82(3):1108-14.
3. Rao SD, Saleh ZH (equal co-authorship), Setton J, Tam M, McBride SM, Riaz N, Deasy JO, Lee NY, Dose-volume factors correlating with trismus following chemoradiation for head and neck cancer. Acta Oncol. 2015 Apr 29: 1-6. 
4. Thor, M., Tyagi, N., Hatzoglou, V., Apte, A., Saleh, Z., Riaz, N. ... & Deasy, J. O. (2017). A magnetic resonance imaging-based approach to quantify radiation-induced normal tissue injuries applied to trismus in head and neck cancer. Physics and Imaging in Radiation Oncology, 1, 34-40.
5. Shackleford J.A., Shusharina N., Verberg J., Warmerdam G., Winey B., Neuner M., Steininger P., Arbisser A., Golland P., Lou Y., Paganelli C., Peroni M., Riboldi M., Baroni G., Zaffino P., Spadea M.F., Apte A., Saleh Z., Deasy J.O., Mori S., Kandasamy N., Sharp G.C. Plastimatch 1.6 - Current Capabilities and Future Directions. Int Conf Med Image Comput Comput Assist Interv. 2012 Oct; 15(WS). Workshop on Image-Guidance and Multimodal Dose Planning in Radiation Therapy
6. Saleh ZH, Apte AP, Sharp GC, Shusharina NP, Wang Y, Veeraraghavan H, Thor M, Muren LP, Rao SS, Lee NY, Deasy JO, The distance discordance metric-a novel approach to quantifying spatial uncertainties in intra- and inter-patient deformable image registration. Phys Med Biol. 2014 Feb 7;59(3):733-46
7. Saleh, Z., Thor, M., Apte, A.P., Sharp, G., Tang, X., Veeraraghavan, H., Muren, L. and Deasy, J., 2016. A multiple-image-based method to evaluate the performance of deformable image registration in the pelvis. Physics in Medicine and Biology, 61(16), p.6172.
8. Liu, Y., Saleh, Z., Song, Y., Chan, M., Li, X., Shi, C. ... & Tang, X. (2017). Novel Wavelet-Based Segmentation of Prostate CBCT Images with Implanted Calypso transponders.  International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 6(03), 336.

2001                      Graduate Student Achievement Award, University of Florida

2007                      Graduate Student Research Award, Florida Institute of Technology

2008                      Outstanding Student Paper Award, American Geophysical Union (AGU)

2012                      Young Investigators Award, Radiological and Medical Physics Society (RAMPS)

2014-2018                   Assistant Attending Medical Physicist, Memorial Sloan Kettering Cancer Center, NY 

2014-2018                   Assistant Member (Level-I), Memorial Hospital and Allied Diseases, NY, NY

2018-2018                   Assistant Member, Memorial Hospital and Allied Diseases, NY, NY

2018-present               Associate Medical Physicist, Radiation Oncology, Rhode Island Hospital, RI

2018-present               Assistant Professor of Radiation Oncology, Alpert Medical School, Brown University, RI

2019-present               Adjunct Assistant Professor of Physics, University of Rhode Island, RI