Anne C. HartProfessor of Neuroscience, NIH Graduate Partnership Program (NIH GPP) Director
Dr. Anne Hart obtained her Ph.D. in Neuroscience at UCLA with Dr. S.L. Zipursky working on cell fate specification in the Drosophila eye. She undertook her post-doctoral training in C. elegans genetics with Dr. Josh Kaplan in the Department of Molecular Biology at Massachusetts General Hospital. Dr. Hart joined the Center for Cancer Research at the Massachusetts General Hospital and the Harvard Medical School Department of Pathology as an assistant professor and taught numerous classes in genetics and neuroscience. She moved to the Department of Neuroscience at Brown University in the fall of 2009. She has served as faculty in neuroscience courses at the Marine Biological Laboratories and the Okinawa Institute of Sicence and Technology. Her research focuses on the molecular and cellular mechanisms underlying neurological disease, sensory signaling, sleep, and adaptation to environmental stress.
Kwon DY, Dimitriadi M, Terzic B, Cable C, Hart AC, Chitnis A, Fischbeck KH, Burnett BG. 2013 The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein. Molecular Biology of the Cell 24(12):1863-71 PMCID: PMC3681692
Dimitriadi M, Kye MJ, Kalloo G, Yersak J, Sahin M, Hart AC 2013 The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in Spinal Muscular Atrophy models. Journal of Neuroscience 33(15)6557-62 PMID: 23575853
Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis-Tsakonas S. 2013 Genetic circuitry of Survival motor neuron, the protein underlying spinal muscular atrophy PNAS 110(26):E2371-80 PMID: 23757500
Hyde R, Corkins ME, Somers GA, Hart AC 2011 Genes, Brain and Behavior PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response. Genes, Brain and Behavior 10: 286–298 PMID: 21143768
Walker AK, PhD, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen, M, Yang F,
Niebergall L, Vance D, Tzoneva M, Hart AC, Näär, AM 2011 A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell 147(4):840-52. PMID: 22035958
Dimitriadi M, Sleigh JN, Walker AK, Chang HC-H, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC 2010 Conserved genes act as modifiers of invertebrate SMN loss of function defects. PLoS Genetics 6(10): e1001172 PMID: 21124729
Haspel G, O’Donovan, Hart AC 2010 Motorneurons dedicated to either forward or backward locomotion in the nematode C. elegans.Journal of Neuroscience 30(33):11151 PMID: 20720122
Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM 2010 Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes and Development 24(13):1403-17. PMID: 20595232
Guo ZV, Hart AC, Ramanathan S Optical interrogation of neural circuits in Caenorhabditis elegans Nature Methods 2009 6: 891-96. PMID: 19898486
Jeong H, Then F, Savas J, Tanese N., Hart AC, Krainc D Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation in Huntington’s Disease. Cell 2009 137(1):60-72. PMID: 19345187
Chang HC-H, Dimlich DN, Yokokura T, Mukherjee A, Kankel MW, Sen A, Sridhar V, Fulga TA, Hart, AC, Van Vactor D, Artavanis-Tsakonas S Modeling Spinal Muscular Atrophy in Drosophila 2008 PLoS ONE 3(9):e3209 PMID: 18791638
Komatsu H, Chao MC, Larkins-Ford J, Corkins ME, Somers GA, Tucey T, Dionne HM, White JQ, Wani K, Boxem M, Hart AC OSM-11 facilitates LIN-12 Notch signaling during C. elegans vulval development 2008 PLoS Biology 6(8):e196. PMID: 18700817
Ferkey D, Hyde R, Haspel G, Dionne HM, Hess HA, Suzuki H, Schafer WR, Koelle MR, Hart AC C. elegans G Protein Regulator RGS-3 Controls Sensitivity to Sensory Stimuli 2007 Neuron 53(1):39-5. PMID: 17196529
Voisine C, Varma H, Walker N, Bates EA, Stockwell BR and Hart AC 2007 Identification of Potential Therapeutic Drugs for Huntington's Disease using Caenorhabditis elegansPLoS ONE 6:e504 (ACS Chemical Biology Spotlight paper). PMID: 17551584
Varma H, Cheng R, Voisine C, Hart AC, Stockwell BR 2007 Inhibitors of metabolism rescue cell death in Huntington’s disease models PNAS 104(36):14525-30
Varma H, Voisine C, De Marco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR 2006 Selective inhibitors of death in mutant huntingtin cells Nature Chemical Biology 3(2):99-100.
E.A. Bates, M. Victor, M.J. Alkema, A.K. Jones, Y. Shi, H.R. Horvitz, and A.C. Hart. 2006. Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. Journal of Neuroscience 26: 2830-2838. PMID: 16525063
M.Y. Chao, J. Larkins-Ford, T.M. Tucey, and A.C. Hart. 2005. lin-12 Notch functions in the adult nervous system. BMC Neuroscience 6:45. PMID: 16011804
M.Y. Chao, H. Komatsu, and A.C. Hart. 2004. Feeding status and serotonin rapidly and reversibly modulate a C. elegans chemosensory circuit. PNAS 101:15512-17 (PNAS Track II) PMID: 15492222
H.S. Fukuto, D.M. Ferkey, A.J. Apicella, H. Lans, T. Sharmeen, W. Chen, R.J. Lefkowitz, G. Jansen, W.R. Schafer, and A.C. Hart. 2004. G Protein-Coupled Receptor Kinase Function Is Essential for Chemosensation in C. elegans. Neuron 42: 581-593. PMID: 15157420
Singh K, Huang H, Hart AC. 2013 Do C. elegans sleep? A closer look. Sleep 36(3):307-8 PMID: 23450901
Liu-Yesucevitz L, Bassell G, Gitler A, Hart AC, Klann E, Richter J, Warren S and Wolozin B 2011 Local RNA Translation at the Synapses and in Disease. Journal of Neuroscience 9:31(45):16086-93. PMID:22072660
Hart AC and Chao MY 2010 “from Odors to Behaviors in Caenorhabditis elegans” In: Menini A, editor Neurobiology of Olfaction Boca Raton, FL CRC Press; PMID: 21882435
Dimitriadi M and Hart AC 2010 Neurodegenerative disorders: Insights from the nematode Caenorhabditis elegans Neurobiology of Disease 40:4-11.
Hart AC. 2006. Editor “Behavior” in WormBook, ed. The C. elegans Research Community, WormBook
Voisine C, Hart AC 2004 C. elegans as a model system for Triplet Repeat Diseases. In: Kohwi Y, editor. Methods in Molecular Biology, Trinucleotide Repeat Protocols. Totowa, NJ: Humana Press; 277:141-60.
Anne Hart is a neurobiologist who uses genetic and molecular approaches in the small nematode C. elegans to understand the conserved mechanisms underlying neurodegenerative disease and nervous system function. She focuses on delineating cellular and molecular pathways pertinent to Spinal Muscular Atrophy (SMA), Amyotrophic Lateral Sclerosis and other motor neuon diseases. Dr. Hart also studies the genetic and molecular mechanisms regulating sleep, how animals respond to sensory stimuli, and stress/aging.
Dr. Hart's research has focused primarily on neurodegenerative disease and neuronal signaling using the C. elegans nervous system. Currently, she and her lab members are working on 1) Spinal Muscular Atrophy and on 2) Notch signaling in behavior, sleep, and stress response.
Dr. Hart uses forward and reverse genetic techniques to identify pathways critical for neurodegenerative disease and has established the utility of C. elegans for modeling these human disorders. In the last few years, her laboratory has primarily focused on delineating the cellular and molecular pathways that play critical roles in Spinal Muscular Atrophy (SMA) as part of a collaborative effort with Drs. S. Artavanis-Tsakonas and D. van Vactor. Having multiple C. elegans models of neurodegenerative disease on hand allows both intellectual and practical synergy in characterizing relevant pathological pathways. Dr. Hart's group is currently developing C. elegans models of ALS.
Dr. Hart and her laboratory also undertake behavioral, molecular, and genetic studies to understand how animals respond to changes in the environment. This resulted in the identification of a new family of conserved Notch co-ligands in C. elegans. Current research examines 1) the role of these Notch co-ligands in cell fate specification during development, 2) the role of the Notch pathway in stress resistance/longevity, and 3) the targets of Notch signaling in adult behavior and sleep. Dr. Hart's group originally identified OSM-11 as a protein required for normal adult behavior and they are now addressing neuronal roles for the Notch signaling pathway. The role of Notch signaling in the adult nervous system is poorly understood in any system.
Our work has been funded by the ALS Association, Hereditary Disease Foundation, The Whitehall Foundation, The March of Dimes, The SMA Foundation, the National Institute of General Medical Science, and National Institute of Neurological Disorders and Stroke.
1985-1989 ARCS Scholar and Ursula Mandel Scholar, UCLA.
1988-1991 NRSA Traineeship, Genetics Training Grant, UCLA.
1993-1995 Muscular Dystrophy Assoc. Postdoctoral Fellowship.
1995-1996 Medical Foundation Postdoctoral Fellowship.
1998-2000 Basil O'Connor Award, March of Dimes Foundation
1998-2001 Searle Scholar Program Award
2016 Dean's Award for Excellence in Graduate and/or Postdoctoral Teaching and Mentoring
1996-date Society for Neuroscience
2005-date Genetics Society of America
2007-date PLoS One Editorial Board
2008-date Neuroscience Editorial Board
2009-date Member of Marine Biological Laboratories Corporation
2009-date Member of MBL Science Advisory Council
NEUR 2030 - Advanced Molecular and Cellular Neurobiology I. Fall 2015, Fall 2016.