My laboratory is interested in how neural circuits generate sensory perception and behavior. We use a combination of molecular genetic, in vivo imaging, computational and behavioral approaches to determine fundamental functional properties of neural networks in the mouse olfactory cortex. I have joined the Brown Neuroscience Department in January 2018.
A central question in neuroscience is how sensory stimuli are detected and processed by neural circuits in the brain to generate sensory perception and behavior. Our laboratory has recently developed new molecular genetic and viral approaches that allow us to target and manipulate defined neural cell types in the olfactory cortex of mice. We have also characterized, using in vivo two-photon microscopy, electrophysiological recordings and computational approaches, fundamental principles of odor information coding in cortical neural networks. These recent advances open up new opportunities to explore how diverse neural cell types contribute to odor information coding in cortical neural networks, and how this information is transmitted to downstream target areas involved in sensory integration, cognition, and motor control. Finally, we are interested in how learning and experience alter olfactory neural network functions and behavior.
Levin Z, Leary OP, Mora V, Kant S, Brown S, Svokos K, Akbar U, Serre T, Klinge P, Fleischmann A, Ruocco MG. "Cerebrospinal fluid transcripts may predict shunt surgery responses in normal pressure hydrocephalus." Brain, vol. 146, no. 9, 2023, pp. 3747-3759. |
Li RC, Molday LL, Lin CC, Ren X, Fleischmann A, Molday RS, Yau KW. "Low signaling efficiency from receptor to effector in olfactory transduction: A quantified ligand-triggered GPCR pathway." Proceedings of the National Academy of Sciences, vol. 119, no. 32, 2022, pp. e2121225119. |
DuBreuil DM, Lopez Soto EJ, Daste S, Meir R, Li D, Wainger B, Fleischmann A, Lipscombe D. "Heat but not mechanical hypersensitivity depends on voltage-gated CaV2.2 calcium channel activity in peripheral axon terminals innervating skin." Journal of Neuroscience, vol. 41, no. 36, 2021, pp. 7546-7560. |
Zeppilli S, Ackels T, Attey R, Klimpert N, Ritola KD, Boeing S, Crombach A, Schaefer AT, Fleischmann A. "Molecular characterization of projection neuron subtypes in the mouse olfactory bulb." eLife, vol. 10, 2021. |
Meissner-Bernard C, Dembitskaya Y, Venance L, Fleischmann A. "Encoding of Odor Fear Memories in the Mouse Olfactory Cortex." Current Biology, vol. 29, no. 3, 2019, pp. 367-380.e4. |
Roland B, Deneux T, Franks KM, Bathellier B, Fleischmann A. "Odor identity coding by distributed ensembles of neurons in the mouse olfactory cortex." eLife, vol. 6, 2017. |
Abdus-Saboor I, Al Nufal MJ, Agha MV, Ruinart de Brimont M, Fleischmann A, Shykind BM. "An Expression Refinement Process Ensures Singular Odorant Receptor Gene Choice." Current Biology, vol. 26, no. 8, 2016, pp. 1083-90. |
Roland B, Jordan R, Sosulski DL, Diodato A, Fukunaga I, Wickersham I, Franks KM, Schaefer AT, Fleischmann A. "Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'." eLife, vol. 5, 2016. |
Diodato A, Ruinart de Brimont M, Yim YS, Derian N, Perrin S, Pouch J, Klatzmann D, Garel S, Choi GB, Fleischmann A. "Molecular signatures of neural connectivity in the olfactory cortex." Nature Communications, vol. 7, 2016, pp. 12238. |
Abdus-Saboor I, Fleischmann A, Shykind B. "Setting limits: maintaining order in a large gene family." Transcription, vol. 5, no. 3, 2014, pp. e28978. |
Fleischmann A, Abdus-Saboor I, Sayed A, Shykind B. "Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation." PLoS biology, vol. 11, no. 5, 2013, pp. e1001568. |
Angelo K, Rancz EA, Pimentel D, Hundahl C, Hannibal J, Fleischmann A, Pichler B, Margrie TW. "A biophysical signature of network affiliation and sensory processing in mitral cells." J. Geophys. Res., vol. 488, no. 7411, 2012, pp. 375-8. |
Glinka ME, Samuels BA, Diodato A, Teillon J, Feng Mei D, Shykind BM, Hen R, Fleischmann A. "Olfactory deficits cause anxiety-like behaviors in mice." Journal of Neuroscience, vol. 32, no. 19, 2012, pp. 6718-25. |
Choi GB, Stettler DD, Kallman BR, Bhaskar ST, Fleischmann A, Axel R. "Driving opposing behaviors with ensembles of piriform neurons." Cell, vol. 146, no. 6, 2011, pp. 1004-15. |
Fleischmann A, Shykind BM, Sosulski DL, Franks KM, Glinka ME, Mei DF, Sun Y, Kirkland J, Mendelsohn M, Albers MW, Axel R. "Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination." Neuron, vol. 60, no. 6, 2008, pp. 1068-81. |
Gass P, Fleischmann A, Hvalby O, Jensen V, Zacher C, Strekalova T, Kvello A, Wagner EF, Sprengel R. "Mice with a fra-1 knock-in into the c-fos locus show impaired spatial but regular contextual learning and normal LTP." Brain research. Molecular brain research, vol. 130, no. 1-2, 2004, pp. 16-22. |
Fleischmann A, Hvalby O, Jensen V, Strekalova T, Zacher C, Layer LE, Kvello A, Reschke M, Spanagel R, Sprengel R, Wagner EF, Gass P. "Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS." Journal of Neuroscience, vol. 23, no. 27, 2003, pp. 9116-22. |
Fleischmann A, Jochum W, Eferl R, Witowsky J, Wagner EF. "Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogene." Cancer Cell, vol. 4, no. 6, 2003, pp. 477-82. |
Wenzel A, Iseli HP, Fleischmann A, Hafezi F, Grimm C, Wagner EF, Remé CE. "Fra-1 substitutes for c-Fos in AP-1-mediated signal transduction in retinal apoptosis." Journal of neurochemistry, vol. 80, no. 6, 2002, pp. 1089-94. |
Fleischmann A, Hafezi F, Elliott C, Remé CE, Rüther U, Wagner EF. "Fra-1 replaces c-Fos-dependent functions in mice." Genes & Development, vol. 14, no. 21, 2000, pp. 2695-700. |
Sibilia M, Fleischmann A, Behrens A, Stingl L, Carroll J, Watt FM, Schlessinger J, Wagner EF. "The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development." Cell, vol. 102, no. 2, 2000, pp. 211-20. |
BIOL 1630 - Big Data Neuroscience Lab |
NEUR 1630 - Big Data Neuroscience Ideas Lab |
NEUR 1630 - Big Data Neuroscience Lab |
NEUR 1630 - Open-Source Big Data Neuroscience Lab |
NEUR 2010 - Graduate Proseminar in Neuroscience |
NEUR 2020 - Graduate Proseminar in Neuroscience |
NEUR 2040 - Advanced Molecular and Cellular Neurobiology II |