|
Luczak MW, Zhitkovich A.
"Monoubiquitinated γ-H2AX: Abundant product and specific biomarker for non-apoptotic DNA double-strand breaks." Toxicology and Applied Pharmacology, vol. 355, 2018, pp. 238-246.
|
|
Krawic C, Zhitkovich A.
"Toxicological Antagonism among Welding Fume Metals: Inactivation of Soluble Cr(VI) by Iron." Chemical Research in Toxicology, vol. 31, no. 11, 2018, pp. 1172-1184.
|
|
Ortega-Atienza S, Krawic C, Watts L, McCarthy C, Luczak MW, Zhitkovich A.
"20S immunoproteasomes remove formaldehyde-damaged cytoplasmic proteins suppressing caspase-independent cell death." Scientific reports, vol. 7, no. 1, 2017, pp. 654.
|
|
Luczak MW, Zhitkovich A.
"Nickel-induced HIF-1α promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cells." Toxicology and Applied Pharmacology, vol. 331, 2017, pp. 94-100.
|
|
Krawic, Casey, Luczak, Michal W., Zhitkovich, Anatoly.
"Variation in Extracellular Detoxification Is a Link to Different Carcinogenicity among Chromates in Rodent and Human Lungs." Chemical Research in Toxicology, vol. 30, no. 9, 2017, pp. 1720-1729.
|
|
Ortega-Atienza S, Wong VC, DeLoughery Z, Luczak MW, Zhitkovich A.
"ATM and KAT5 safeguard replicating chromatin against formaldehyde damage." Nucleic acids research, vol. 44, no. 1, 2016, pp. 198-209.
|
|
Ortega-Atienza S, Rubis B, McCarthy C, Zhitkovich A.
"Formaldehyde Is a Potent Proteotoxic Stressor Causing Rapid Heat Shock Transcription Factor 1 Activation and Lys48-Linked Polyubiquitination of Proteins." The American Journal of Pathology, vol. 186, no. 11, 2016, pp. 2857-2868.
|
|
Rubis, Blazej, Zhitkovich, Anatoly.
"Abstract 2563: Modulation of DNA damage responses and cytotoxicity of bleomycin by vitamin C." Cancer Research, vol. 75, no. 15 Supplement, 2015, pp. 2563-2563.
|
|
Luczak, Michal W., Green, Samantha E., Zhitkovich, Anatoly.
"Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics." Environ Health Perspect, vol. 124, no. 1, 2015, pp. 61-6.
|
|
DeLoughery, Z., Luczak, M. W., Ortega-Atienza, S., Zhitkovich, A.
"DNA Double-Strand Breaks by Cr(VI) Are Targeted to Euchromatin and Cause ATR-Dependent Phosphorylation of Histone H2AX and Its Ubiquitination." Toxicological Sciences, vol. 143, no. 1, 2015, pp. 54-63.
|
|
Ortega-Atienza, Sara, Green, Samantha E., Zhitkovich, Anatoly.
"Proteasome activity is important for replication recovery, CHK1 phosphorylation and prevention of G2 arrest after low-dose formaldehyde." Toxicology and Applied Pharmacology, vol. 286, no. 2, 2015, pp. 135-141.
|
|
Sawant A, Kothandapani A, Zhitkovich A, Sobol RW, Patrick SM.
"Role of mismatch repair proteins in the processing of cisplatin interstrand cross-links." DNA Repair, vol. 35, 2015, pp. 126-36.
|
|
DeLoughery Z, Luczak MW, Zhitkovich A.
"Monitoring Cr intermediates and reactive oxygen species with fluorescent probes during chromate reduction." Chemical Research in Toxicology, vol. 27, no. 5, 2014, pp. 843-51.
|
|
Rodrigues, Carlos F., Val, Mariana, Rodrigues, Inês P., Ferreira, Susana, Botelho, Filomena, Ramalho, José, Zhitkovich, Anatoly, Carreira, Isabel M., Alpoim, Carmen.
"Abstract 2603: Cancer stem cells and dedifferentiation: the stromal match-point." Cancer Research, vol. 73, no. 8 Supplement, 2013, pp. 2603-2603.
|
|
Morse JL, Luczak MW, Zhitkovich A.
"Chromium(VI) causes interstrand DNA cross-linking in vitro but shows no hypersensitivity in cross-link repair-deficient human cells." Chemical Research in Toxicology, vol. 26, no. 10, 2013, pp. 1591-8.
|
|
Zhitkovich, Anatoly, Wong, Victor, Morse, Jessica.
"Noncanonical activation of ATR-p53 axis by DNA–protein crosslinks controls cell death responses to formaldehyde." Toxicology Letters, vol. 221, 2013, pp. S130.
|
|
Wong VC, Morse JL, Zhitkovich A.
"p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells." Toxicology and Applied Pharmacology, vol. 269, no. 3, 2013, pp. 233-9.
|
|
Luczak MW, Zhitkovich A.
"Role of direct reactivity with metals in chemoprotection by N-acetylcysteine against chromium(VI), cadmium(II), and cobalt(II)." Free Radical Biology and Medicine, vol. 65, 2013, pp. 262-9.
|
|
Green SE, Luczak MW, Morse JL, DeLoughery Z, Zhitkovich A.
"Uptake, p53 pathway activation, and cytotoxic responses for Co(II) and Ni(II) in human lung cells: implications for carcinogenicity." Toxicological Sciences, vol. 136, no. 2, 2013, pp. 467-77.
|
|
Zhitkovich, Anatoly, Reynolds, Mindy, Armknecht, Susan.
"Dual role of ascorbate in chromium genotoxicity." Toxicology Letters, vol. 211, 2012, pp. S72.
|
|
Wong V, Armknecht S, Zhitkovich A.
"Metabolism of Cr(VI) by ascorbate but not glutathione is a low oxidant-generating process." Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), vol. 26, no. 2-3, 2012, pp. 192-6.
|
|
Wong VC, Cash HL, Morse JL, Lu S, Zhitkovich A.
"S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde." Cell Cycle, vol. 11, no. 13, 2012, pp. 2526-37.
|
|
Reynolds M, Armknecht S, Johnston T, Zhitkovich A.
"Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levels." Mutagenesis, vol. 27, no. 4, 2012, pp. 437-43.
|
|
Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt R, Kane AB.
"Bioavailability, Intracellular Mobilization of Nickel, and HIF-1 Activation in Human Lung Epithelial Cells Exposed to Metallic Nickel and Nickel Oxide Nanoparticles." Toxicological Sciences, vol. 124, no. 1, 2011, pp. 138-148.
|
|
Zhitkovich A.
"Chromium in drinking water: sources, metabolism, and cancer risks." Chemical Research in Toxicology, vol. 24, no. 10, 2011, pp. 1617-29.
|
|
Macfie A, Hagan E, Zhitkovich A.
"Mechanism of DNA-protein cross-linking by chromium." Chemical Research in Toxicology, vol. 23, no. 2, 2010, pp. 341-7.
|
|
Zecevic A, Hagan E, Reynolds M, Poage G, Johnston T, Zhitkovich A.
"XPA impacts formation but not proteasome-sensitive repair of DNA-protein cross-links induced by chromate." Mutagenesis, vol. 25, no. 4, 2010, pp. 381-8.
|
|
Pietruska JR, Johnston T, Zhitkovich A, Kane AB.
"XRCC1 deficiency sensitizes human lung epithelial cells to genotoxicity by crocidolite asbestos and Libby amphibole." Environ Health Perspect, vol. 118, no. 12, 2010, pp. 1707-13.
|
|
Reynolds MF, Peterson-Roth EC, Bespalov IA, Johnston T, Gurel VM, Menard HL, Zhitkovich A.
"Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimers." Cancer Research, vol. 69, no. 3, 2009, pp. 1071-9.
|
|
Zecevic A, Menard H, Gurel V, Hagan E, DeCaro R, Zhitkovich A.
"WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts." Cell Cycle, vol. 8, no. 17, 2009, pp. 2769-78.
|
|
Salnikow K, Zhitkovich A.
"Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium." Chemical Research in Toxicology, vol. 21, no. 1, 2008, pp. 28-44.
|
|
Guttmann D, Poage G, Johnston T, Zhitkovich A.
"Reduction with glutathione is a weakly mutagenic pathway in chromium(VI) metabolism." Chemical Research in Toxicology, vol. 21, no. 11, 2008, pp. 2188-94.
|
|
Bartley, Elizabeth, Rouzer, Carol A., Zhitkovich, Anatoly.
"Spotlight." Chemical Research in Toxicology, vol. 21, no. 2, 2008, pp. 274-275.
|
|
Branco R, Chung AP, Johnston T, Gurel V, Morais P, Zhitkovich A.
"The chromate-inducible chrBACF operon from the transposable element TnOtChr confers resistance to chromium(VI) and superoxide." Journal of bacteriology, vol. 190, no. 21, 2008, pp. 6996-7003.
|
|
Reynolds M, Stoddard L, Bespalov I, Zhitkovich A.
"Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G2 phase by mismatch repair." Nucleic acids research, vol. 35, no. 2, 2007, pp. 465-76.
|
|
Liu, X., Gurel, V., Morris, D., Murray, D. W., Zhitkovich, A., Kane, A. B., Hurt, R. H.
"Bioavailability of Nickel in Single-Wall Carbon Nanotubes." Adv. Mater., vol. 19, no. 19, 2007, pp. 2790-2796.
|
|
Reynolds M, Zhitkovich A.
"Cellular vitamin C increases chromate toxicity via a death program requiring mismatch repair but not p53." Carcinogenesis, vol. 28, no. 7, 2007, pp. 1613-20.
|
|
Karaczyn A, Ivanov S, Reynolds M, Zhitkovich A, Kasprzak KS, Salnikow K.
"Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel." Journal of cellular biochemistry, vol. 97, no. 5, 2006, pp. 1025-35.
|
|
Messer J, Reynolds M, Stoddard L, Zhitkovich A.
"Causes of DNA single-strand breaks during reduction of chromate by glutathione in vitro and in cells." Free Radical Biology and Medicine, vol. 40, no. 11, 2006, pp. 1981-92.
|
|
Quievryn G, Messer J, Zhitkovich A.
"Lower mutagenicity but higher stability of Cr-DNA adducts formed during gradual chromate activation with ascorbate." Carcinogenesis, vol. 27, no. 11, 2006, pp. 2316-21.
|
|
Zhitkovich A.
"Importance of chromium-DNA adducts in mutagenicity and toxicity of chromium(VI)." Chemical Research in Toxicology, vol. 18, no. 1, 2005, pp. 3-11.
|
|
Zhitkovich, Anatoly, Peterson-Roth, Elizabeth, Reynolds, Mindy.
"Killing of Chromium-Damaged Cells by Mismatch Repair and its Relevance to Carcinogenesis." Cell Cycle, vol. 4, no. 8, 2005, pp. 4050-4052.
|
|
Zhitkovich A, Peterson-Roth E, Reynolds M.
"Killing of chromium-damaged cells by mismatch repair and its relevance to carcinogenesis." Cell Cycle, vol. 4, no. 8, 2005, pp. 1050-2.
|
|
Peterson-Roth E, Reynolds M, Quievryn G, Zhitkovich A.
"Mismatch repair proteins are activators of toxic responses to chromium-DNA damage." Molecular and Cellular Biology, vol. 25, no. 9, 2005, pp. 3596-607.
|
|
Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS.
"Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress." Journal of Biological Chemistry, vol. 279, no. 39, 2004, pp. 40337-44.
|
|
Dickinson DA, Warnes GR, Quievryn G, Messer J, Zhitkovich A, Rubitski E, Aubrecht J.
"Differentiation of DNA reactive and non-reactive genotoxic mechanisms using gene expression profile analysis." Mutation research, vol. 549, no. 1-2, 2004, pp. 29-41.
|
|
Reynolds M, Peterson E, Quievryn G, Zhitkovich A.
"Human nucleotide excision repair efficiently removes chromium-DNA phosphate adducts and protects cells against chromate toxicity." Journal of Biological Chemistry, vol. 279, no. 29, 2004, pp. 30419-24.
|
|
Quievryn G, Peterson E, Messer J, Zhitkovich A.
"Genotoxicity and mutagenicity of chromium(VI)/ascorbate-generated DNA adducts in human and bacterial cells." Biochemistry, vol. 42, no. 4, 2003, pp. 1062-70.
|
|
Quievryn G, Messer J, Zhitkovich A.
"Carcinogenic chromium(VI) induces cross-linking of vitamin C to DNA in vitro and in human lung A549 cells." Biochemistry, vol. 41, no. 9, 2002, pp. 3156-67.
|
|
Zhitkovich A, Quievryn G, Messer J, Motylevich Z.
"Reductive activation with cysteine represents a chromium(III)-dependent pathway in the induction of genotoxicity by carcinogenic chromium(VI)." Environ Health Perspect, vol. 110 Suppl 5, 2002, pp. 729-31.
|
|
Zhitkovich A, Song Y, Quievryn G, Voitkun V.
"Non-oxidative mechanisms are responsible for the induction of mutagenesis by reduction of Cr(VI) with cysteine: role of ternary DNA adducts in Cr(III)-dependent mutagenesis." Biochemistry, vol. 40, no. 2, 2001, pp. 549-60.
|
|
Quievryn G, Goulart M, Messer J, Zhitkovich A.
"Reduction of Cr (VI) by cysteine: significance in human lymphocytes and formation of DNA damage in reactions with variable reduction rates." Molecular and Cellular Biochemistry, vol. 222, no. 1-2, 2001, pp. 107-18.
|
|
Quievryn G, Zhitkovich A.
"Loss of DNA-protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function." Carcinogenesis, vol. 21, no. 8, 2000, pp. 1573-80.
|
|
Zhitkovich A, Shrager S, Messer J.
"Reductive metabolism of Cr(VI) by cysteine leads to the formation of binary and ternary Cr--DNA adducts in the absence of oxidative DNA damage." Chemical Research in Toxicology, vol. 13, no. 11, 2000, pp. 1114-24.
|
|
Voitkun V, Zhitkovich A.
"Analysis of DNA-protein crosslinking activity of malondialdehyde in vitro." Mutation research, vol. 424, no. 1-2, 1999, pp. 97-106.
|
|
Zhitkovich A, Voitkun V, Kluz T, Costa M.
"Utilization of DNA-protein cross-links as a biomarker of chromium exposure." Environ Health Perspect, vol. 106 Suppl 4, 1998, pp. 969-74.
|
|
Lipskaia LA, Zhitkovich AV, Vasiukhin VI, Tsvetkov AG, Sal'nikov KV.
"[The participation of endonuclease in the formation of extrachromosomal DNA and the possible mechanisms of the occurrence of gene amplification]." Tsitologiia, vol. 35, no. 1, 1993, pp. 70-8.
|
|
Konoplia EF, Voĭtkun VA, Zhitkovich AV, Miliutin AA.
"[Effect of phorbol esters and amiloride on the radiation-induced interphase death of thymocytes]." Doklady Akademii nauk / [Rossiiskaia akademii nauk], vol. 324, no. 2, 1992, pp. 452-5.
|
|
Egutkin GG, Zhitkovich AV.
"[The evaluation of the age-related characteristics of the structural status of the plasma membrane lipid phase in rat fatty tissue by using the method of inductive-resonance energy transfer]." Nauchnye doklady vysshei shkoly. Biologicheskie nauki, no. 8, 1990, pp. 30-8.
|
|
Konoplia EF, Luksha GL, Detinkin ON, Zhitkovich AV, Gavrilin MA, Montik VI, Fil'chenkov GN.
"[The mechanisms of the realization of the effect of glucocorticoids in aging]." Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, vol. 76, no. 9, 1990, pp. 1224-31.
|
|
Konoplia EF, Detinkin ON, Zhitkovich AV.
"[Stability of DNA-protein complexes in cell nuclei of the rat liver during aging]." Voprosy meditsinskoi khimii, vol. 35, no. 2, 1989, pp. 78-82.
|
|
Konoplia EF, Detinkin ON, Zhitkovich AV.
"[Study of the age-related features of the structural state of rat liver cell chromatin using micrococcal nuclease and circular dichroism]." Biokhimiia (Moscow, Russia), vol. 53, no. 11, 1988, pp. 1876-82.
|
