Barbara S. Stonestreet, M.D., is a Professor of Pediatrics at Brown Medical School. She is a Staff Neonatologist at Women & Infants Hospital of Rhode Island. She received her Bachelor's Degree in Biology and German from New York University (New York, New York), and her M.D. from Tufts University (Boston, Massachusetts). Dr. Stonestreet then continued her training in pediatrics at Stanford University School of Medicine (Stanford, California) and Boston University School of Medicine (Boston, Massachusetts). She completed her Fellowship in Neonatal-Perinatal Medicine at Brown University and Women & Infants Hospital of Rhode Island. Dr. Stonestreet has been listed in Best Doctors in America and has served as an active member of the National Institutes of Child Health and Human Development Study Section from 1991-1995. Dr. Stonestreet also served as a member of the Editorial Board of the Journal of Pediatrics from 1990-1997. She is a member of the Society for Pediatric Research, Perinatal Research Society, American Pediatric Society, Society for Neuroscience, and Society for Gynecologic Investigation. Dr. Stonestreet has more than 139 publications in peer-reviewed journals, on various aspects of neonatology and perinatology, including cerebral circulation, fetal blood-brain barrier permeability, and fetal brain injury.
She may be reached at Bstonestreet@wihri.org; 401-274-1122 x 47429.
| Chen X, Zhang J, Kim B, Jaitpal S, Meng SS, Adjepong K, Imamura S, Wake H, Nishibori M, Stopa EG, Stonestreet BS. "High-mobility group box-1 translocation and release after hypoxic ischemic brain injury in neonatal rats." Experimental Neurology, vol. 311, 2019, pp. 1-14. |
| Disdier C, Zhang J, Fukunaga Y, Lim YP, Qiu J, Santoso A, Stonestreet BS. "Alterations in inter-alpha inhibitor protein expression after hypoxic-ischemic brain injury in neonatal rats." International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, vol. 65, 2018, pp. 54-60. |
| Disdier C, Chen X, Kim JE, Threlkeld SW, Stonestreet BS. "Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period." Brain sciences, vol. 8, no. 6, 2018. |
| Chen X, Patra A, Sadowska GB, Stonestreet BS. "Ischemic-Reperfusion Injury Increases Matrix Metalloproteinases and Tissue Metalloproteinase Inhibitors in Fetal Sheep Brain." Developmental Neuroscience, vol. 40, no. 3, 2018, pp. 234-245. |
| Chen X, Hovanesian V, Naqvi S, Lim YP, Tucker R, Donahue JE, Stopa EG, Stonestreet BS. "Systemic infusions of anti-interleukin-1β neutralizing antibodies reduce short-term brain injury after cerebral ischemia in the ovine fetus." Brain, Behavior, and Immunity, vol. 67, 2018, pp. 24-35. |
| Threlkeld, Steven W., Lim, Yow-Pin, La Rue, Molly, Gaudet, Cynthia, Stonestreet, Barbara S. "Immuno-modulator inter-alpha inhibitor proteins ameliorate complex auditory processing deficits in rats with neonatal hypoxic-ischemic brain injury." Brain, Behavior, and Immunity, vol. 64, 2017, pp. 173-179. |
| Threlkeld SW, Lim YP, La Rue M, Gaudet C, Stonestreet BS. "Immuno-modulator inter-alpha inhibitor proteins ameliorate complex auditory processing deficits in rats with neonatal hypoxic-ischemic brain injury." Psychoneuroendocrinology, vol. 64, 2017, pp. 173-179. |
| Spasova, Mariya S., Chen, Xiaodi, Sadowska, Grazyna B., Horton, Edward R., Lim, Yow-Pin, Stonestreet, Barbara S. "Ischemia reduces inter-alpha inhibitor proteins in the brain of the ovine fetus." Developmental Neurobiology, vol. 77, no. 6, 2017, pp. 726-737. |
| Spasova MS, Chen X, Sadowska GB, Horton ER, Lim YP, Stonestreet BS. "Ischemia reduces inter-alpha inhibitor proteins in the brain of the ovine fetus." Developmental Neurobiology, vol. 77, no. 6, 2017, pp. 726-737. |
| Patra A, Chen X, Sadowska GB, Zhang J, Lim YP, Padbury JF, Banks WA, Stonestreet BS. "Neutralizing anti-interleukin-1β antibodies reduce ischemia-related interleukin-1β transport across the blood-brain barrier in fetal sheep." Neuroscience, vol. 346, 2017, pp. 113-125. |
| Gaudet, Cynthia M., Lim, Yow-Pin, Stonestreet, Barbara S., Threlkeld, Steven W. "Effects of age, experience and inter-alpha inhibitor proteins on working memory and neuronal plasticity after neonatal hypoxia-ischemia." Behavioural Brain Research, vol. 302, 2016, pp. 88-99. |
| Mirza H, Laptook AR, Oh W, Vohr BR, Stoll BJ, Kandefer S, Stonestreet BS, Generic Database Subcommittee of the NICHD Neonatal Research Network. "Effects of indomethacin prophylaxis timing on intraventricular haemorrhage and patent ductus arteriosus in extremely low birth weight infants." Archives of Disease in Childhood - Fetal and Neonatal Edition, vol. 101, no. 5, 2016, pp. F418-22. |
| Chen, X., Rivard, L., Naqvi, S., Nakada, S., Padbury, J.F., Sanchez-Esteban, J., Stopa, E.G., Lim, Y.-P., Stonestreet, B.S. "Expression and localization of Inter-alpha Inhibitors in rodent brain." Neuroscience, vol. 324, 2016, pp. 69-81. |
| Malaeb, Shadi N., Stonestreet, Barbara S. "Postnatal glucocorticoid-induced hypomyelination, gliosis, and neurologic deficits are dose-dependent, preparation-specific, and reversible." Experimental Neurology, vol. 278, 2016, pp. 1-3. |
| Malaeb SN, Stonestreet BS. "Postnatal glucocorticoid-induced hypomyelination, gliosis, and neurologic deficits are dose-dependent, preparation-specific, and reversible." Experimental Neurology, vol. 278, 2016, pp. 1-3. |
| Zhang J, Sadowska GB, Chen X, Park SY, Kim JE, Bodge CA, Cummings E, Lim YP, Makeyev O, Besio WG, Gaitanis J, Banks WA, Stonestreet BS. "Anti-IL-6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus." The FASEB Journal, vol. 29, no. 5, 2015, pp. 1739-53. |
| Sadowska GB, Chen X, Zhang J, Lim YP, Cummings EE, Makeyev O, Besio WG, Gaitanis J, Padbury JF, Banks WA, Stonestreet BS. "Interleukin-1β transfer across the blood-brain barrier in the ovine fetus." Journal of Cerebral Blood Flow & Metabolism, vol. 35, no. 9, 2015, pp. 1388-95. |
| Chen X, Sadowska GB, Zhang J, Kim JE, Cummings EE, Bodge CA, Lim YP, Makeyev O, Besio WG, Gaitanis J, Threlkeld SW, Banks WA, Stonestreet BS. "Neutralizing anti-interleukin-1β antibodies modulate fetal blood-brain barrier function after ischemia." Neurobiology of disease, vol. 73, 2015, pp. 118-29. |
| Sadowska GB, Ahmedli N, Chen X, Stonestreet BS. "Ontogeny of tight junction protein expression in the ovine cerebral cortex during development." Neuroscience, vol. 310, 2015, pp. 422-9. |
| Sadowska GB, Ahmedli N, Chen X, Stonestreet BS. "Ontogeny of tight junction protein expression in the ovine cerebral cortex during development." Neuroscience, vol. 310, 2015, pp. 422-9. |
| Threlkeld SW, Gaudet CM, La Rue ME, Dugas E, Hill CA, Lim YP, Stonestreet BS. "Effects of inter-alpha inhibitor proteins on neonatal brain injury: Age, task and treatment dependent neurobehavioral outcomes." Experimental Neurology, vol. 261, 2014, pp. 424-33. |
| Virgintino D, Girolamo F, Rizzi M, Ahmedli N, Sadowska GB, Stopa EG, Zhang J, Stonestreet BS. "Ischemia/Reperfusion-induced neovascularization in the cerebral cortex of the ovine fetus." Journal of Neuropathology and Experimental Neurology, vol. 73, no. 6, 2014, pp. 495-506. |
| Sadowska GB, Stonestreet BS. "Maternal treatment with glucocorticoids modulates gap junction protein expression in the ovine fetal brain." Neuroscience, vol. 275, 2014, pp. 248-58. |
| Spasova, M. S., Sadowska, G. B., Threlkeld, S. W., Lim, Y.-P., Stonestreet, B. S. "Ontogeny of inter-alpha inhibitor proteins in ovine brain and somatic tissues." Experimental Biology and Medicine, vol. 239, no. 6, 2014, pp. 724-736. |
| Spasova MS, Sadowska GB, Threlkeld SW, Lim YP, Stonestreet BS. "Ontogeny of inter-alpha inhibitor proteins in ovine brain and somatic tissues." Experimental Biology and Medicine, vol. 239, no. 6, 2014, pp. 724-36. |
| Cohen SS, Stonestreet BS. "Sex differences in behavioral outcome following neonatal hypoxia ischemia: Insights from a clinical meta-analysis and a rodent model of induced hypoxic ischemic injury." Experimental Neurology, vol. 256, 2014, pp. 70-3. |
| Malaeb SN, Stonestreet BS. "Steroids and injury to the developing brain: net harm or net benefit?." Clinics in Perinatology, vol. 41, no. 1, 2014, pp. 191-208. |
| Chaaban, H., Malaeb, S., Stonestreet, B. S. "Core Concepts: Intestinal Perfusion in the Perinatal Period." NeoReviews, vol. 14, no. 7, 2013, pp. e332-e339. |
| Cohen SS, Min M, Cummings EE, Chen X, Sadowska GB, Sharma S, Stonestreet BS. "Effects of interleukin-6 on the expression of tight junction proteins in isolated cerebral microvessels from yearling and adult sheep." Neuroimmunomodulation, vol. 20, no. 5, 2013, pp. 264-73. |
| Chen X, Threlkeld SW, Cummings EE, Sadowska GB, Lim YP, Padbury JF, Sharma S, Stonestreet BS. "In-vitro validation of cytokine neutralizing antibodies by testing with ovine mononuclear splenocytes." Journal of comparative pathology, vol. 148, no. 2-3, 2013, pp. 252-8. |
| Mirza H, Oh W, Laptook A, Vohr B, Tucker R, Stonestreet BS. "Indomethacin prophylaxis to prevent intraventricular hemorrhage: association between incidence and timing of drug administration." The Journal of Pediatrics, vol. 163, no. 3, 2013, pp. 706-10.e1. |
| Stonestreet BS, Sadowska GB, Hanumara RC, Petrache M, Petersson KH, Patlak CS. "Comparative effects of glucose- and mannitol-induced osmolar stress on blood-brain barrier function in ovine fetuses and lambs." Journal of Cerebral Blood Flow & Metabolism, vol. 32, no. 1, 2012, pp. 115-26. |
| Malaeb, S. N., Cohen, S. S., Virgintino, D., Stonestreet, B. S. "Core Concepts: Development of the Blood-Brain Barrier." NeoReviews, vol. 13, no. 4, 2012, pp. e241-e250. |
| Sommers R, Stonestreet BS, Oh W, Laptook A, Yanowitz TD, Raker C, Mercer J. "Hemodynamic effects of delayed cord clamping in premature infants." Pediatrics, vol. 129, no. 3, 2012, pp. e667-72. |
| Chaaban H, Stonestreet BS. "Intestinal hemodynamics and oxygenation in the perinatal period." Seminars in Perinatology, vol. 36, no. 4, 2012, pp. 260-8. |
| Chen X, Threlkeld SW, Cummings EE, Juan I, Makeyev O, Besio WG, Gaitanis J, Banks WA, Sadowska GB, Stonestreet BS. "Ischemia-reperfusion impairs blood-brain barrier function and alters tight junction protein expression in the ovine fetus." Neuroscience, vol. 226, 2012, pp. 89-100. |
| Sadowska GB, Threlkeld SW, Flangini A, Sharma S, Stonestreet BS. "Ontogeny and the effects of in utero brain ischemia on interleukin-1β and interleukin-6 protein expression in ovine cerebral cortex and white matter." International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, vol. 30, no. 6, 2012, pp. 457-63. |
| Kim CR, Sadowska GB, Newton SA, Merino M, Petersson KH, Padbury JF, Stonestreet BS. "Na+,K+-ATPase activity and subunit protein expression: ontogeny and effects of exogenous and endogenous steroids on the cerebral cortex and renal cortex of sheep." Reproductive sciences (Thousand Oaks, Calif.), vol. 18, no. 4, 2011, pp. 359-73. |
| Su, S. W., Stonestreet, B. S. "Core Concepts: Neonatal Glomerular Filtration Rate." NeoReviews, vol. 11, no. 12, 2010, pp. e714-e721. |
| Sadowska GB, Malaeb SN, Stonestreet BS. "Maternal glucocorticoid exposure alters tight junction protein expression in the brain of fetal sheep." AJP: Heart and Circulatory Physiology, vol. 298, no. 1, 2010, pp. H179-88. |
| Threlkeld SW, Lynch JL, Lynch KM, Sadowska GB, Banks WA, Stonestreet BS. "Ovine proinflammatory cytokines cross the murine blood-brain barrier by a common saturable transport mechanism." Neuroimmunomodulation, vol. 17, no. 6, 2010, pp. 405-10. |
| Malaeb SN, Hovanesian V, Sarasin MD, Hartmann SM, Sadowska GB, Stonestreet BS. "Effects of maternal antenatal glucocorticoid treatment on apoptosis in the ovine fetal cerebral cortex." Journal of neuroscience research, vol. 87, no. 1, 2009, pp. 179-89. |
| Stonestreet, Barbara. "Intraventricular hemorrhage in premature infants." Cerebrospinal Fluid Research, vol. 6, no. Suppl 1, 2009, pp. S3. |
| Mehter NS, Sadowska GB, Malaeb SN, Stonestreet BS. "Na+, K+-ATPase activity and subunit isoform protein abundance: effects of antenatal glucocorticoids in the frontal cerebral cortex and renal cortex of ovine fetuses." Reproductive sciences (Thousand Oaks, Calif.), vol. 16, no. 3, 2009, pp. 294-307. |
| Duncan AR, Sadowska GB, Stonestreet BS. "Ontogeny and the effects of exogenous and endogenous glucocorticoids on tight junction protein expression in ovine cerebral cortices." Brain Research, vol. 1303, 2009, pp. 15-25. |
| Sadowska GB, Stopa EG, Stonestreet BS. "Ontogeny of connexin 32 and 43 expression in the cerebral cortices of ovine fetuses, newborns, and adults." Brain Research, vol. 1255, 2009, pp. 51-6. |
| Malaeb SN, Sadowska GB, Stonestreet BS. "Effects of maternal treatment with corticosteroids on tight junction protein expression in the cerebral cortex of the ovine fetus with and without exposure to in utero brain ischemia." Brain Research, vol. 1160, 2007, pp. 11-9. |
| Stonestreet BS, Sadowska GB, Leeman J, Hanumara RC, Petersson KH, Patlak CS. "Effects of acute hyperosmolality on blood-brain barrier function in ovine fetuses and lambs." American journal of physiology. Regulatory, integrative and comparative physiology, vol. 291, no. 4, 2006, pp. R1031-9. |
| Sadowska GB, Patlak CS, Petersson KH, Stonestreet BS. "Effects of multiple courses of antenatal corticosteroids on blood-brain barrier permeability in the ovine fetus." Journal of the Society for Gynecologic Investigation, vol. 13, no. 4, 2006, pp. 248-55. |
| Kim CR, Sadowska GB, Petersson KH, Merino M, Sysyn GD, Padbury JF, Stonestreet BS. "Effects of postnatal steroids on Na+/K+-ATPase activity and alpha1- and beta1-subunit protein expression in the cerebral cortex and renal cortex of newborn lambs." Reprod. Fertil. Dev., vol. 18, no. 4, 2006, pp. 413-23. |
| Gray S, Stonestreet BS, Thamotharan S, Sadowska GB, Daood M, Watchko J, Devaskar SU. "Skeletal muscle glucose transporter protein responses to antenatal glucocorticoids in the ovine fetus." The Journal of endocrinology, vol. 189, no. 2, 2006, pp. 219-29. |
| Pua ZJ, Stonestreet BS, Cullen A, Shahsafaei A, Sadowska GB, Sunday ME. "Histochemical analyses of altered fetal lung development following single vs multiple courses of antenatal steroids." The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, vol. 53, no. 12, 2005, pp. 1469-79. |
| Ron NP, Kazianis JA, Padbury JF, Brown CM, McGonnigal BG, Sysyn GD, Sadowska GB, Stonestreet BS. "Ontogeny and the effects of corticosteroid pretreatment on aquaporin water channels in the ovine cerebral cortex." Reprod. Fertil. Dev., vol. 17, no. 5, 2005, pp. 535-42. |
| Petersson KH, Pinar H, Stopa EG, Sadowska GB, Hanumara RC, Stonestreet BS. "Effects of exogenous glucose on brain ischemia in ovine fetuses." Pediatric Research, vol. 56, no. 4, 2004, pp. 621-9. |
| Stonestreet BS, Watkins S, Petersson KH, Sadowska GB. "Effects of multiple courses of antenatal corticosteroids on regional brain and somatic tissue water content in ovine fetuses." Journal of the Society for Gynecologic Investigation, vol. 11, no. 3, 2004, pp. 166-74. |
| Stonestreet BS, Petersson KH, Sadowska GB, Patlak CS. "Regulation of brain water during acute glucose-induced hyperosmolality in ovine fetuses, lambs, and adults." Journal of Applied Physiology, vol. 96, no. 2, 2004, pp. 553-60. |
| Wharton KN, Pinar H, Stonestreet BS, Tucker R, McLean KR, Wallach M, Vohr BR. "Severe umbilical cord inflammation-a predictor of periventricular leukomalacia in very low birth weight infants." Early human development, vol. 77, no. 1-2, 2004, pp. 77-87. |
| Stonestreet BS, Elitt CM, Markowitz J, Petersson KH, Sadowska GB. "Effects of antenatal corticosteroids on regional brain and non-neural tissue water content in the ovine fetus." Journal of the Society for Gynecologic Investigation, vol. 10, no. 2, 2003, pp. 59-66. |
| Elitt CM, Sadowska GB, Stopa EG, Pinar H, Petersson KH, Stonestreet BS. "Effects of antenatal steroids on ischemic brain injury in near-term ovine fetuses." Early human development, vol. 73, no. 1-2, 2003, pp. 1-15. |
| Stonestreet BS, Oen-Hsiao JM, Petersson KH, Sadowska GB, Patlak CS. "Regulation of brain water during acute hyperosmolality in ovine fetuses, lambs, and adults." Journal of Applied Physiology, vol. 94, no. 4, 2003, pp. 1491-500. |
| Kerzner LS, Stonestreet BS, Wu KY, Sadowska G, Malee MP. "Antenatal dexamethasone: effect on ovine placental 11beta-hydroxysteroid dehydrogenase type 2 expression and fetal growth." Pediatric Research, vol. 52, no. 5, 2002, pp. 706-12. |
| Hai CM, Sadowska G, Francois L, Stonestreet BS. "Maternal dexamethasone treatment alters myosin isoform expression and contractile dynamics in fetal arteries." AJP: Heart and Circulatory Physiology, vol. 283, no. 5, 2002, pp. H1743-9. |
| Petersson KH, Pinar H, Stopa EG, Faris RA, Sadowska GB, Hanumara RC, Stonestreet BS. "White matter injury after cerebral ischemia in ovine fetuses." Pediatric Research, vol. 51, no. 6, 2002, pp. 768-76. |
| Burgess GH, Oh W, Brann BS 4th, Brubakk AM, Stonestreet BS. "Effects of phenobarbital on cerebral blood flow velocity after endotracheal suctioning in premature neonates." Archives of Pediatrics & Adolescent Medicine, vol. 155, no. 6, 2001, pp. 723-7. |
| Sysyn GD, Petersson KH, Patlak CS, Sadowska GB, Stonestreet BS. "Effects of postnatal dexamethasone on blood-brain barrier permeability and brain water content in newborn lambs." American journal of physiology. Regulatory, integrative and comparative physiology, vol. 280, no. 2, 2001, pp. R547-53. |
| Goldstein M, Rehan VK, Oh W, Stonestreet BS. "Cerebral and intestinal perfusion and metabolism in normocythemic hyperviscous hypoxic newborn pigs." Journal of Applied Physiology, vol. 88, no. 6, 2000, pp. 2107-15. |
| McGowan JE, Sysyn G, Petersson KH, Sadowska GB, Mishra OP, Delivoria-Papadopoulos M, Stonestreet BS. "Effect of dexamethasone treatment on maturational changes in the NMDA receptor in sheep brain." Journal of Neuroscience, vol. 20, no. 19, 2000, pp. 7424-9. |
| Stonestreet BS, McKnight AJ, Sadowska G, Petersson KH, Oen JM, Patlak CS. "Effects of duration of positive-pressure ventilation on blood-brain barrier function in premature lambs." Journal of Applied Physiology, vol. 88, no. 5, 2000, pp. 1672-7. |
| Stonestreet BS, Sadowska GB, McKnight AJ, Patlak C, Petersson KH. "Exogenous and endogenous corticosteroids modulate blood-brain barrier development in the ovine fetus." American journal of physiology. Regulatory, integrative and comparative physiology, vol. 279, no. 2, 2000, pp. R468-77. |
| Stonestreet BS, Petersson KH, Sadowska GB, Pettigrew KD, Patlak CS. "Antenatal steroids decrease blood-brain barrier permeability in the ovine fetus." The American journal of physiology, vol. 276, no. 2 Pt 2, 1999, pp. R283-9. |
| Stonestreet BS, Petersson KH, Sadowska GB, Pettigrew KD, Patlak CS. "Antenatal steroids decrease blood-brain barrier permeability in the ovine fetus." American journal of physiology. Regulatory, integrative and comparative physiology, vol. 276, no. 2, 1999, pp. R283-R289. |
| Kleinman ME, Oh W, Stonestreet BS. "Comparison of intravenous and endotracheal epinephrine during cardiopulmonary resuscitation in newborn piglets." Critical care medicine, vol. 27, no. 12, 1999, pp. 2748-54. |
| Yanowitz TD, Yao AC, Pettigrew KD, Werner JC, Oh W, Stonestreet BS. "Postnatal hemodynamic changes in very-low-birthweight infants." Journal of Applied Physiology, vol. 87, no. 1, 1999, pp. 370-80. |
| Yanowitz TD, Yao AC, Werner JC, Pettigrew KD, Oh W, Stonestreet BS. "Effects of prophylactic low-dose indomethacin on hemodynamics in very low birth weight infants." The Journal of Pediatrics, vol. 132, no. 1, 1998, pp. 28-34. |
| Stonestreet BS, Ocampo SS, Oh W. "Reductions in cardiac output in hypoxic young pigs: systemic and regional perfusion and oxygen metabolism." Journal of Applied Physiology, vol. 85, no. 3, 1998, pp. 874-82. |
| Alemany CA, Oh W, Stonestreet BS. "Effects of nitric oxide synthesis inhibition on mesenteric perfusion in young pigs." The American journal of physiology, vol. 272, no. 3 Pt 1, 1997, pp. G612-6. |
| Papparella A, DeLuca FG, Oyer CE, Pinar H, Stonestreet BS. "Ischemia-reperfusion injury in the intestines of newborn pigs." Pediatric Research, vol. 42, no. 2, 1997, pp. 180-8. |
| Kim CR, Oh W, Stonestreet BS. "Magnesium is a cerebrovasodilator in newborn piglets." The American journal of physiology, vol. 272, no. 1 Pt 2, 1997, pp. H511-6. |
| Stonestreet BS, Boyle LD, Papparella A, Berard DJ. "Circulatory and metabolic effects of alpha-adrenergic blockade in the hyperinsulinemic ovine fetus." Journal of the Society for Gynecologic Investigation, vol. 3, no. 5, 1996, pp. 241-9. |
| Stonestreet BS, Patlak CS, Pettigrew KD, Reilly CB, Cserr HF. "Ontogeny of blood-brain barrier function in ovine fetuses, lambs, and adults." The American journal of physiology, vol. 271, no. 6 Pt 2, 1996, pp. R1594-601. |
| Stonestreet BS, Widness JA, Berard DJ. "Circulatory and metabolic effects of hypoxia in the hyperinsulinemic ovine fetus." Pediatric Research, vol. 38, no. 1, 1995, pp. 67-75. |
| Stonestreet BS, Barefield ES, Piva D, Goldstein M. "Effects of hypercarbia on autoregulation of brain blood flow and cerebral metabolism in newborn piglets." Reprod. Fertil. Dev., vol. 7, no. 5, 1995, pp. 1381-7. |
| Coyle MG, Oh W, Petersson KH, Stonestreet BS. "Effects of indomethacin on brain blood flow, cerebral metabolism, and sagittal sinus prostanoids after hypoxia." The American journal of physiology, vol. 269, no. 4 Pt 2, 1995, pp. H1450-9. |
| Lee C, Stonestreet BS, Oh W, Outerbridge EW, Cashore WJ. "Postnatal maturation of the blood-brain barrier for unbound bilirubin in newborn piglets." Brain Research, vol. 689, no. 2, 1995, pp. 233-8. |
| Brann BS 4th, Mayfield SR, Goldstein M, Oh W, Stonestreet BS. "Cardiovascular effects of hypoxia/hypercarbia and tension pneumothorax in newborn piglets." Critical care medicine, vol. 22, no. 9, 1994, pp. 1453-60. |
| Papparella A, Berard D, Stonestreet BS. "Circulatory and metabolic effects of anemia in hyperinsulinemic ovine fetuses." The American journal of physiology, vol. 266, no. 1 Pt 2, 1994, pp. H250-7. |
| Schiff DE, Stonestreet BS. "Central venous catheters in low birth weight infants: incidence of related complications." Journal of perinatology : official journal of the California Perinatal Association, vol. 13, no. 2, 1993, pp. 153-8. |
| Stonestreet BS, Le E, Berard DJ. "Circulatory and metabolic effects of beta-adrenergic blockade in the hyperinsulinemic ovine fetus." The American journal of physiology, vol. 265, no. 4 Pt 2, 1993, pp. H1098-106. |
| Zola EM, Gunkel JH, Chan RK, Lim MO, Knox I, Feldman BH, Denson SE, Stonestreet BS, Mitchell BR, Wyza MM. "Comparison of three dosing procedures for administration of bovine surfactant to neonates with respiratory distress syndrome." The Journal of Pediatrics, vol. 122, no. 3, 1993, pp. 453-9. |
| Coyle MG, Oh W, Stonestreet BS. "Effects of indomethacin on brain blood flow and cerebral metabolism in hypoxic newborn piglets." The American journal of physiology, vol. 264, no. 1 Pt 2, 1993, pp. H141-9. |
| Levitsky LL, Stonestreet BS, Mink K, Zheng Q. "Glutamine carbon disposal and net glutamine uptake in fetuses of fed and fasted ewes." The American journal of physiology, vol. 265, no. 5 Pt 1, 1993, pp. E722-7. |
| Malone TA, Stonestreet BS, Goddard M, Sicard R, Werner JC, Oh W. "Atrial natriuretic peptide in newborn piglets with a patent ductus arteriosus." Developmental pharmacology and therapeutics, vol. 19, no. 2-3, 1992, pp. 155-60. |
| Stonestreet BS, Burgess GH, Cserr HF. "Blood-brain barrier integrity and brain water and electrolytes during hypoxia/hypercapnia and hypotension in newborn piglets." Brain Research, vol. 590, no. 1-2, 1992, pp. 263-70. |
| Barefield ES, Oh W, Stonestreet BS. "Group B Streptococcus-induced acidosis in newborn swine: regional oxygen transport and lactate flux." Journal of Applied Physiology, vol. 72, no. 1, 1992, pp. 272-7. |
| Georgieff MK, Kassner RJ, Radmer WJ, Berard DJ, Doshi SR, Stonestreet BS. "The effect of in utero insulin exposure on tissue iron status in fetal rats." Pediatric Research, vol. 31, no. 1, 1992, pp. 64-7. |
| Monin P, Stonestreet BS, Oh W. "Hyperventilation restores autoregulation of cerebral blood flow in postictal piglets." Pediatric Research, vol. 30, no. 3, 1991, pp. 294-8. |
| Stonestreet BS. "Effects of prolonged fetal hyperinsulinemia on plasma catecholamines, circulation and oxygen metabolism in utero." Developmental pharmacology and therapeutics, vol. 15, no. 1, 1990, pp. 35-44. |
| Malone TA, Stonestreet BS, Goddard M, Oh W. "Hemodynamic changes in a term newborn piglet model of patent ductus arteriosus." American journal of perinatology, vol. 7, no. 2, 1990, pp. 184-8. |
| Calvert SA, Widness JA, Oh W, Stonestreet BS. "The effects of acute uterine ischemia on fetal circulation." Pediatric Research, vol. 27, no. 6, 1990, pp. 552-6. |
| Stonestreet BS, Ogburn PL Jr, Goldstein M, Oh W, Widness JA. "Effects of chronic fetal hyperinsulinemia on plasma arachidonic acid and prostaglandin concentrations." American Journal of Obstetrics and Gynecology, vol. 161, no. 4, 1989, pp. 894-9. |
| Stonestreet BS, Piasecki GJ, Susa JB, Jackson BT. "Effects of insulin infusion on plasma catecholamine concentration in fetal sheep." American Journal of Obstetrics and Gynecology, vol. 160, no. 3, 1989, pp. 740-5. |
| Stonestreet BS, Goldstein M, Oh W, Widness JA. "Effects of prolonged hyperinsulinemia on erythropoiesis in fetal sheep." The American journal of physiology, vol. 257, no. 5 Pt 2, 1989, pp. R1199-204. |
| Mayfield SR, Shaul PW, Oh W, Stonestreet BS. "Gastrointestinal blood flow and oxygen delivery during environmental cold stress: effect of anaemia." Journal of developmental physiology, vol. 12, no. 4, 1989, pp. 219-23. |
| Lee C, Oh W, Stonestreet BS, Cashore WJ. "Permeability of the blood brain barrier for 125I-albumin-bound bilirubin in newborn piglets." Pediatric Research, vol. 25, no. 5, 1989, pp. 452-6. |
| Mayfield SR, Stonestreet BS, Shaul PW, Brubakk AM, Susa J, Oh W. "Plasma catecholamine concentrations of newborn piglets in thermoneutral and cold environments." Journal of developmental physiology, vol. 11, no. 6, 1989, pp. 331-4. |
| Mayfield SR, Oh W, Piva DL, Stonestreet BS. "Postprandial gastrointestinal blood flow and oxygen consumption during environmental cold stress." The American journal of physiology, vol. 256, no. 2 Pt 1, 1989, pp. G364-8. |
| Ogburn PL Jr, Goldstein M, Walker J, Stonestreet BS. "Prolonged hyperinsulinemia reduces plasma fatty acid levels in the major lipid groups in fetal sheep." American Journal of Obstetrics and Gynecology, vol. 161, no. 3, 1989, pp. 728-32. |
| Georgieff MK, Widness JA, Mills MM, Stonestreet BS. "The effect of prolonged intrauterine hyperinsulinemia on iron utilization in fetal sheep." Pediatric Research, vol. 26, no. 5, 1989, pp. 467-9. |
| Goldstein M, Stonestreet BS, Brann BS 4th, Oh W. "Cerebral cortical blood flow and oxygen metabolism in normocythemic hyperviscous newborn piglets." Pediatric Research, vol. 24, no. 4, 1988, pp. 486-9. |
| Mayfield SR, Shaul PW, Oh W, Stonestreet BS. "Anemia blunts the thermogenic response to environmental cold stress in newborn piglets." Pediatric Research, vol. 21, no. 5, 1987, pp. 482-6. |
| Szabo JS, Mayfield SR, Oh W, Stonestreet BS. "Postprandial gastrointestinal blood flow and oxygen consumption: effects of hypoxemia in neonatal piglets." Pediatric Research, vol. 21, no. 1, 1987, pp. 93-8. |
| Brubakk AM, Oh W, Stonestreet BS. "Prolonged hypercarbia in the awake newborn piglet: effect on brain blood flow and cardiac output." Pediatric Research, vol. 21, no. 1, 1987, pp. 29-33. |
| Brann BS 4th, Stonestreet BS, Oh W, Cashore WJ. "The in vivo effect of bilirubin and sulfisoxazole on cerebral oxygen, glucose, and lactate metabolism in newborn piglets." Pediatric Research, vol. 22, no. 2, 1987, pp. 135-40. |
| Mayfield SR, Stonestreet BS, Brubakk AM, Shaul PW, Oh W. "Regional blood flow in newborn piglets during environmental cold stress." The American journal of physiology, vol. 251, no. 3 Pt 1, 1986, pp. G308-13. |
| Burgess GH, Stonestreet BS, Cashore WJ, Oh W. "Brain bilirubin deposition and brain blood flow during acute urea-induced hyperosmolality in newborn piglets." Pediatric Research, vol. 19, no. 6, 1985, pp. 537-42. |
| Szabo JS, Stonestreet BS, Oh W. "Effects of hypoxemia on gastrointestinal blood flow and gastric emptying in the newborn piglet." Pediatric Research, vol. 19, no. 5, 1985, pp. 466-71. |
| Nowicki PT, Hansen NB, Stonestreet BS, Yao AC, Oh W. "The effect of blood volume expansion on gastrointestinal oxygenation in piglets." Pediatric Research, vol. 19, no. 3, 1985, pp. 268-71. |
| Burgess GH, Oh W, Bratlid D, Brubakk AM, Cashore WJ, Stonestreet BS. "The effects of brain blood flow on brain bilirubin deposition in newborn piglets." Pediatric Research, vol. 19, no. 7, 1985, pp. 691-6. |
| Brubakk AM, Bratlid D, Oh W, Yao AC, Stonestreet BS. "Atropine prevents increases in brain blood flow during hypertension in newborn piglets." Pediatric Research, vol. 18, no. 11, 1984, pp. 1121-6. |
| Rosenkrantz TS, Stonestreet BS, Hansen NB, Nowicki P, Oh W. "Cerebral blood flow in the newborn lamb with polycythemia and hyperviscosity." The Journal of Pediatrics, vol. 104, no. 2, 1984, pp. 276-80. |
| Nowicki PT, Oh W, Yao A, Hansen NB, Stonestreet BS. "Effect of polycythemia on gastrointestinal blood flow and oxygenation in piglets." The American journal of physiology, vol. 247, no. 3 Pt 1, 1984, pp. G220-5. |
| Nowicki PT, Hansen NB, Oh W, Stonestreet BS. "Gastrointestinal blood flow and oxygen consumption in the newborn lamb: effect of chronic anemia and acute hypoxia." Pediatric Research, vol. 18, no. 5, 1984, pp. 420-5. |
| Hansen NB, Brubakk AM, Bratlid D, Oh W, Stonestreet BS. "The effects of variations in PaCO2 on brain blood flow and cardiac output in the newborn piglet." Pediatric Research, vol. 18, no. 11, 1984, pp. 1132-6. |
| Stonestreet BS, Laptook AR, Siegel SR, Oh W. "The renal response to acute asphyxia in spontaneously breathing newborn lambs." Early human development, vol. 9, no. 4, 1984, pp. 347-61. |
| Laptook AR, Stonestreet BS, Oh W. "Brain blood flow and O2 delivery during hemorrhagic hypotension in the piglet." Pediatric Research, vol. 17, no. 1, 1983, pp. 77-80. |
| Warburton D, Bell EF, Stonestreet BS, Oh W. "Echocardiographic effects of high and low volumes of maintenance fluid administration in low-birth-weight infants." Developmental pharmacology and therapeutics, vol. 6, no. 1, 1983, pp. 45-54. |
| Stonestreet BS, Nowicki PT, Hansen NB, Petit R, Oh W. "Effect of aminophylline on brain blood flow in the newborn piglet." Developmental pharmacology and therapeutics, vol. 6, no. 4, 1983, pp. 248-58. |
| Hansen NB, Oh W, LaRochelle F, Stonestreet BS. "Effects of maternal ritodrine administration on neonatal renal function." The Journal of Pediatrics, vol. 103, no. 5, 1983, pp. 774-80. |
| Nowicki PT, Stonestreet BS, Hansen NB, Yao AC, Oh W. "Gastrointestinal blood flow and oxygen consumption in awake newborn piglets: effect of feeding." The American journal of physiology, vol. 245, no. 5 Pt 1, 1983, pp. G697-702. |
| Stonestreet BS, Hansen NB, Laptook AR, Oh W. "Glucocorticoid accelerates renal functional maturation in fetal lambs." Early human development, vol. 8, no. 3-4, 1983, pp. 331-41. |
| Stonestreet BS, Bell EF, Warburton D, Oh W. "Renal response in low-birth-weight neonates. Results of prolonged intake of two different amounts of fluid and sodium." American journal of diseases of children (1960), vol. 137, no. 3, 1983, pp. 215-9. |
| Laptook AR, Stonestreet BS, Oh W. "The effect of carotid artery ligation on brain blood flow in newborn piglets." Brain Research, vol. 276, no. 1, 1983, pp. 51-4. |
| Hansen NB, Stonestreet BS, Rosenkrantz TS, Oh W. "Validity of Doppler measurements of anterior cerebral artery blood flow velocity: correlation with brain blood flow in piglets." Pediatrics, vol. 72, no. 4, 1983, pp. 526-31. |
| Laptook A, Stonestreet BS, Oh W. "Autoregulation of brain blood flow in the newborn piglet: regional differences in flow reduction during hypotension." Early human development, vol. 6, no. 1, 1982, pp. 99-107. |
| Stonestreet BS, Laptook A, Schanler R, Oh W. "Hemodynamic responses to asphyxia in spontaneously breathing newborn term and premature lamb." Early human development, vol. 7, no. 1, 1982, pp. 81-97. |
| Laptook A, Stonestreet BS, Oh W. "The effects of different rates of plasmanate infusions upon brain blood flow after asphyxia and hypotension in newborn piglets." The Journal of Pediatrics, vol. 100, no. 5, 1982, pp. 791-6. |
| Cashore WJ, Peter G, Lauermann M, Stonestreet BS, Oh W. "Clostridia colonization and clostridial toxin in neonatal necrotizing enterocolitis." The Journal of Pediatrics, vol. 98, no. 2, 1981, pp. 308-11. |
| Bell EF, Warburton D, Stonestreet BS, Oh W. "Effect of fluid administration on the development of symptomatic patent ductus arteriosus and congestive heart failure in premature infants." New England Journal of Medicine, vol. 302, no. 11, 1980, pp. 598-604. |
| Cowett RM, Susa JB, Warburton D, Stonestreet B, Schwartz R, Oh W. "Endogenous posthepatic insulin secretion and metabolic clearance rates in the neonatal lamb." Pediatric Research, vol. 14, no. 12, 1980, pp. 1391-4. |
| Stonestreet BS, Rubin L, Pollak A, Cowett RM, Oh W. "Renal functions of low birth weight infants with hyperglycemia and glucosuria produced by glucose infusions." Pediatrics, vol. 66, no. 4, 1980, pp. 561-7. |
| Cowett RM, Oh W, Pollak A, Schwartz R, Stonestreet BS. "Glucose disposal of low birth weight infants: steady state hyperglycemia produced by constant intravenous glucose infusion." Pediatrics, vol. 63, no. 3, 1979, pp. 389-96. |
| Bell EF, Warburton D, Stonestreet BS, Oh W. "High-volume fluid intake predisposes premature infants to necrotising enterocolitis." The Lancet, vol. 2, no. 8133, 1979, pp. 90. |
| Pollak A, Susa JB, Stonestreet BS, Schwartz R, Oh W. "Phosphoenolpyruvate carboxykinase in experimental intrauterine growth retardation in rats." Pediatric Research, vol. 13, no. 3, 1979, pp. 175-7. |
| Stonestreet BS, Bell EF, Oh W. "Validity of endogenous creatinine clearance in low birthweight infants." Pediatric Research, vol. 13, no. 9, 1979, pp. 1012-4. |
| Boyle R, Nelson JS, Stonestreet BS, Peter G, Oh W. "Alterations in stool flora resulting from oral kanamycin prophylaxis of necrotizing enterocolitis." The Journal of Pediatrics, vol. 93, no. 5, 1978, pp. 857-61. |
| Boyle RJ, Chandler BD, Stonestreet BS, Oh W. "Early identification of sepsis in infants with respiratory distress." Pediatrics, vol. 62, no. 5, 1978, pp. 744-50. |
| Stonestreet BS, Oh W. "Plasma creatinine levels in low-birth-weight infants during the first three months of life." Pediatrics, vol. 61, no. 5, 1978, pp. 788-9. |
| Ross BS, Pollak A, Oh W. "The pharmacologic effects of furosemide therapy in the low-birth-weight infant." The Journal of Pediatrics, vol. 92, no. 1, 1978, pp. 149-52. |
| Ross BS, Peter G, Dempsey JM, Oh W. "Klebsiella pneumoniae nosocomial epidemic in an intensive care nursery due to contaminated intravenous fluid." American journal of diseases of children (1960), vol. 131, no. 6, 1977, pp. 712. |
| Ross B, Cowett RM, Oh W. "Renal functions of low birth weight infants during the first two months of life." Pediatric Research, vol. 11, no. 11, 1977, pp. 1162-4. |
Dr. Stonestreet is a staff neonatologist at Women and Infants Infants; in addition, she coordinates the department weekly Perinatal Management Conference.
Dr. Stonestreet has been involved in studies to understand brain development and the pathogenesis of brain injury in the fetus and neonate.
Malaeb, S.N., Sadowska, G. B., and Stonestreet, B.S. Effects of maternal treatment with corticosteroids on tight junction protein expression in the ovine fetal cerebral cortex with and without exposure to in-utero brain ischemia. Brain Res. 1160C: 11-19, 2007.
Stonestreet, B.S., Sadowska, G.B., Leeman, J., Hanumara, R.C., Petersson, K.H., Patlak, C.S. Effects of acute hyperosmolality on blood-brain barrier function in ovine fetuses and lambs. Am J Physiol. Regul. Integr. Comp. Physiol. 18 (4): 413-423, 2006.
Sadowska, G. B., Patlak, C.S., Petersson, K.H., Stonestreet, B.S. Effects of multiple courses of antenatal corticosteroids on blood-brain barrier permeability in the ovine fetus. J. Soc. Gynecol. Investig. 13 (4): 248-255, 2006.
Kim, CR., Sadowska, G.B., Petersson, K.H., Merino, M., Sysyn, G.D., Padbury, J.F., and Stonestreet, B.S. Effects of postnatal steroids on Na+, K+-ATPase activity and α1- and β1-subunit protein expression in the cerebral cortex and renal cortes of newborn lambs. Reprod. Fert. Dev. 18 (4): 413-423, 2006.
Gray, S., Stonestreet, B.S., Thamotharan, S., Sadowska, G.B., Daood, M., Watchko, J., and Devaskar, S.U. Skeletal muscle glucose transporter protein responses to antenatal glucocorticoids in the ovine fetus. J. Endocrinol. 189: 219-229, 2006.
Pua, Z.J., Stonestreet, B.S., Cullen, A., Shahsafaei, A., Sadowska, G.B., and Sunday, M.E. Histochemical analyses of altered fetal lung development following single vs multiple courses of antenatal steroids. J. Histochem. Cytochem. 53 (12): 1469-1479, 2005.
Ron, N.P., Kazianis, J.A., Padbury, J.F., Brown, C.M., McGonnigal, B.G., Sysyn, G.S., Sadowska, G.B., Stonestreet, B.S. Ontogeny and the effects of corticosteroid pretreatment on aquaporin water channels in the ovine cerebral cortex. Reprod. Fertil. Dev. 17(5): 535-542, 2005.
| Year | Degree | Institution |
|---|---|---|
| 1972 | MD | Tufts University |
| 1967 | BA | New York University |
| Fellow | The Warren Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, neonatology | 1975-1978 | Providence, RI |
| Senior Resident | Boston University School of Medicine, Boston City Hospital, Pediatrics | 1974-1975 | Boston, MA |
| Junior Resident | Stanford University School of Medicine, Pediatrics | 1973-1974 | Stanford, CA |
| Intern | Stanford University School of Medicine, Pediatrics | 1972-1973 | Stanford, CA |
| Name | Title |
|---|---|
| Bath, Kevin | Associate Professor of Cognitive, Linguistic and Psychological Sciences |
| Fallon, Justin | Professor of Medical Science, Professor of Psychiatry and Human Behavior |
| Lim, Yow-Pin | Adjunct Professor of Pathology and Laboratory Medicine |
| Padbury, James | William and Mary Oh - William and Elsa Zopfi Professor of Pediatrics for Perinatal Research |
| Sadowska, Grazyna | Instructor in Pediatrics (Research) |
| Sharma, Surendra | Professor of Pathology and Laboratory Medicine (Research), Professor of Pediatrics (Research) |
| Walsh, Edward | Associate Professor of Brain Science (Research) |
| Certification | American Board of Pediatrics, Neonatal-perinatal medicine | 1983- | #1315 |
| Medical License | Rhode Island | 1978- | #CMD 5375 |
| Certification | American Board of Pediatrics, General pediatrics | 1977- | #20685 |
| Medical License | Massachusetts | 1974- | #58916 |
| Medical License | California | 1974- | #GO27189 |
| Program Director, Fellowship in Neonatal-Perinatal Medicine. Women & Infants Hospital of Rhode Island, 1995-Present |
| Physician. Rhode Island Hospital, 1992-Present |
| Associate Physician. Rhode Island Hospital, 1985-1992 |
| Scientific Staff. Roger Williams Medical Center, 1978-1984 |
| Assistant Physician. Rhode Island Hospital, 1978-1985 |
| Staff Neonatologist. Women & Infants Hospital of Rhode Island, 1978-Present |
