Derek M. SteinAssociate Professor of Physics and Associate Professor of Engineering
Prof. Stein joined the Physics Department at Brown in the fall of 2006, following postdoctoral work at the Kavli Institute of Nanoscience at the Delft University of Technology in the Netherlands. He obtained his Ph.D. in Applied Physics from Harvard University in 2003, and his B.Sc. from McGill University in 1997. Prof. Stein's research has focused on the study of single biomolecules, and the use of nanofabricated structures to manipulate them.
"Stiff filamentous virus translocations through solid-state nanopores", Angus McMullen, Hendrick W. de Haan, Jay X. Tang and Derek Stein, Nature Communications, 5, 4171 (2014).
"Statistics of DNA Capture by a Solid-State Nanopore", Mirna Mihovilovic, Nicholas Hagerty, and Derek Stein, Physical Review Letters, 110, 028102 (2013).
"Controlling the Conformations and Transport of DNA by Free Energy Landscaping", Elijah Shelton, Zhijun Jiang, Shutong Wang and Derek Stein, Applied Physics Letters, 99, 263112 (2011).
"Charge Regulation in Nanopore Ionic Field-Effect Transistors", Zhijun Jiang and Derek Stein, Physical Review E, 83, 031203 (2011).
"Electro-ﬂuidic Gating of a Chemically Reactive Surface", Zhijun Jiang and Derek Stein, Langmuir, 26, 8161-8173 (2010).
"Electrokinetic Concentration of DNA polymers in Nanoﬂuidic Channels", Derek Stein, Zeno Deurvorst, Frank H.J. van der Heyden, Wiepke J.A. Koopmans and Cees Dekker, Nano Letters, 10, 765-772 (2010).
"Fabrication of nanopores with embedded annular electrodes and transverse CNT electrodes", Zhijun Jiang, Mirna Mihovilovic, Jason Chan and Derek Stein, Journal of Physics: Condensed Matter, 22, 454114 (2010)
"Pressure-Driven DNA Transport Across an Artificial Nanotopography", Jackson Travis del Bonis-O'Donnell, Walter Reisner, and Derek Stein, New Journal of Physics 11, 075032 (2009).
"Slip-enhanced electrokinetic energy conversion in nanofludic channels", Yongqiang Ren and Derek Stein, Nanotechnology 19, 195707 (2008).
"Pressure-driven transport of confined DNA polymers in fluidic channels", Derek Stein, Frank H.J. van der Heyden, Wiepke J.A. Koopmans and Cees Dekker, PNAS 103, 15853 (2006).
"Surface-charge-governed ion transport in nanofluidic channels", Derek Stein, Maarten Kruithof and Cees Dekker, Physical Review Letters 93, 035901 (2004).
"DNA molecules and configurations in a solid-state nanopore microscope", Jiali Li, Marc Gershow, Derek Stein, Eric Brandin and Jene A. Golovchenko, Nature Materials 2, 611 (2003).
"Ion Beam Sculpting Time Scales", Derek Stein, Jiali Li and Jene A. Golovchenko, Physical Review Letters 89, 276106 (2002).
"Ion beam sculpting at nanometre length scales", Jiali Li, Derek Stein, Ciaran McMullan, Daniel Branton, Michael J. Aziz and Jene A. Golovchenko, Nature 412, 166 (2001).
Bio-nanoscience and single-molecule biophysics. I am interested in using nanostructures to study the structure and behavior of individual biological molecules, the fundamental building blocks of life.
Biomolecules such as deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and proteins are the fundamental machinery of life. Individual biomolecules can now be studied at their natural, molecular length scales using nanofabricated tools such as solid-state nanopores and nanofluidic devices. These recent advances highlight two important ideas: First, the behavior of biomolecules on the nanoscale represents an important and largely unexplored regime in which interesting new physics can dominate. Second, nanostructures can achieve exceptional sensitivity in the study of molecular biophysics that may ultimately revolutionize diagnostic applications.
Our research is focused on developing and implementing new tools for the study of individual biomolecules, while exploring new physics in these nanoscale systems.
NSF, "Electro-fluidics for single-molecule biophysics", $405,000 awarded for 09/2008 - 08/2011.
Intel, "Electronic DNA barcode sequencing", $130,000 awarded for 01/2009-12/2010.
NSF, "CAREER: Probing the Sequence and Dynamics of Single DNA Molecules Using Solid-State Nanopores, Optical Tweezers, and Binding Proteins", $400,000 awarded for 08/2009 - 07/2014.
NIH, "Sequencing by Nanopore Mass Spectrometry", $896,000 awarded for 09/2009 - 08/2012 (PI, with co-PIs Peter Weber and Carthene Bazemore-Walker).
I am interested in teaching biophysics from the perspective of a Physicist. My fascination with life has grown with an appreciation of the physical laws that constrain it. The emerging study of biology at the level of single molecules highlights how ingeniously and effectively living systems overcome the challenges thrown at them. As a teacher, I seek to share my amazement of life, while building a solid understanding of the physics that underlie biology.
PHYS 0030 - Basic Physics. Fall 2015, Fall 2016.
PHYS 0114 - The Science and Technology of Energy. Spring 2014, Spring 2016.