Graduate Program Director for the Biotechnology Graduate Program, Professor of Medical Science, Professor of Engineering

Overview

Dr. Edith Mathiowitz is a full Professor of Medical Science and Engineering at Brown University in the Department of Molecular Pharmacology, Physiology & Biotechnology.  She is also the Director of the Biotechnology Graduate Program.  Her extensive experience includes development of polymers that are used in drug and gene delivery systems and tissue engineering applications, including stem cell recruitment. Following her undergraduate degree in physical chemistry and graduate school at the Weizmann institute of science, Dr. Mathiowitz trained as a postdoctoral associate with Professor Robert Langer.

Dr. Mathiowitz directs an interdisciplinary laboratory that focuses on developing smart delivery systems based on bioadhesive polymers, which enhance the non- specific interaction with intestinal mucosa by inducing reversible secondary bonds and prolonging the residence time of traditional and novel oral dosage forms.  She has been a pioneer in the area of nanomedicine by developing spontaneously forming biodegradable nanoparticles that in contrast to traditional thinking that mucosal barrier will prevent those particles from even passing the mucosal tissue.  They can be engineered by combining hydrophobic polymers with high concentration of carboxylic acid, penetrate mucosal barriers and deliver active biologics.  These nanoparticles are being used as cancer vaccines as well as for the oral delivery of peptides and proteins.  In addition, she has experience with polymers, vascular grafts and micro/nanoencapsulation. What characterize her work is using combination of basic scientific concepts in interfacial biophysics and applying them to improving health.

During her post doc, she submitted with Professor Langer seven patent applications of which 20 patents were issued and have subsequently been licensed to many startup companies.  Her work at Enzytec generated four issued patents that form the basis for the Prolease delivery systems, injectable proteins such as growth hormones. Dr. Mathiowitz’s laboratory serves as a focal point for many inventions and as an incubator for several start-up companies. Some have licensed her technologies. Technologies she has developed have formed the foundation for the launch of four biotechnology companies, two of which Dr. Mathiowitz is a Founder:  Spherics, Inc. – Founder; Perosphere, Inc. – Co-Founder.  Dr. Mathiowitz was the Editor of The Encyclopedia of Controlled Drug Delivery Systems (1999) and serves as an editorial board member for several journals.  In 2005, she was co-Chair of the Controlled Release Society, an international society dealing with drug delivery. To date, Dr. Mathiowitz has authored 120 publications, over 75 patents, and an edited book on bioadhesion; her work has been published in over 120 conference proceedings and abstracts. Her work at Brown University has generated about 56 patent applications of which 40 were issued as patents and have been the basis for two start-up companies and have been licensed to others.

Brown Affiliations

Research Areas

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