Eric M. Morrow received his PhD in genetics and neurodevelopment at Harvard University. He received his MD degree from the Health Science Training Program at Massachusetts Institute of Technology and Harvard Medical School. During this medical training, Morrow developed a strong interest in the scientific challenges posed by childhood neuropsychiatric disorders. He conducted further clinical and scientific training in neurology and psychiatry at Harvard Medical School. Morrow was Massachusetts General Hospital Rappaport Neuroscience Scholar and Assistant Professor at Harvard Medical School prior to coming to Brown. His research focuses on normal molecular mechanisms of brain development, and genetic perturbations that underlie disorders of human cognitive development. At Brown, Morrow's research bridges between the Department of Molecular Biology, Cell Biology & Biochemistry and the Department of Psychiatry & Human Behavior, where he directs the Developmental Disorders Genetics Research Program (DDGRP).
Molecular Biology, Cell Biology and Biochemistry
Neuroscience
Psychiatry and Human Behavior
Robert J. and Nancy D. Carney Institute for Brain Science
Center for Translational Neuroscience
Hassenfeld Child Health Innovation Institute: Autism Precision Medicine Program
Developmental Disorders Genetics Research Program (DDGRP)
| Lizarraga SB, Ma L, Maguire AM, van Dyck LI, Wu Q, Ouyang Q, Kavanaugh BC, Nagda D, Livi LL, Pescosolido MF, Schmidt M, Alabi S, Cowen MH, Brito-Vargas P, Hoffman-Kim D, Gamsiz Uzun ED, Schlessinger A, Jones RN, Morrow EM. "Human neurons from Christianson syndrome iPSCs reveal mutation-specific responses to rescue strategies." Science Translational Medicine, vol. 13, no. 580, 2021. |
| McCormick CEB, Kavanaugh BC, Sipsock D, Righi G, Oberman LM, Moreno De Luca D, Gamsiz Uzun ED, Best CR, Jerskey BA, Quinn JG, Jewel SB, Wu PC, McLean RL, Levine TP, Tokadjian H, Perkins KA, Clarke EB, Dunn B, Gerber AH, Tenenbaum EJ, Anders TF, Rhode Island Consortium for Autism Research and Treatment (RI-CART)., Sheinkopf SJ, Morrow EM. "Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study." Autism Research, vol. 13, no. 3, 2020, pp. 474-488. |
| Moreno-De-Luca, Daniel, Kavanaugh, Brian C., Best, Carrie R., Sheinkopf, Stephen J., Phornphutkul, Chanika, Morrow, Eric M. "Clinical Genetic Testing in Autism Spectrum Disorder in a Large Community-Based Population Sample." JAMA Psychiatry, 2020. |
| Schmitz-Abe K, Sanchez-Schmitz G, Doan RN, Hill RS, Chahrour MH, Mehta BK, Servattalab S, Ataman B, Lam AN, Morrow EM, Greenberg ME, Yu TW, Walsh CA, Markianos K. "Homozygous deletions implicate non-coding epigenetic marks in Autism spectrum disorder." Scientific reports, vol. 10, no. 1, 2020, pp. 14045. |
| Satterstrom FK, Kosmicki JA, Wang J, Breen MS, De Rubeis S, An JY, Peng M, Collins R, Grove J, Klei L, Stevens C, Reichert J, Mulhern MS, Artomov M, Gerges S, Sheppard B, Xu X, Bhaduri A, Norman U, Brand H, Schwartz G, Nguyen R, Guerrero EE, Dias C, Autism Sequencing Consortium., iPSYCH-Broad Consortium., Betancur C, Cook EH, Gallagher L, Gill M, Sutcliffe JS, Thurm A, Zwick ME, Børglum AD, State MW, Cicek AE, Talkowski ME, Cutler DJ, Devlin B, Sanders SJ, Roeder K, Daly MJ, Buxbaum JD. "Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism." Cell, 2020. |
| Pescosolido MF, Kavanaugh BC, Pochet N, Schmidt M, Jerskey BA, Rogg JM, De Jager PL, Young-Pearse TL, Liu JS, Morrow EM. "Complex Neurological Phenotype in Female Carriers of <i>NHE6</i> Mutations." Molecular neuropsychiatry, vol. 5, no. 2, 2019, pp. 98-108. |
| Ouyang Q, Joesch-Cohen L, Mishra S, Riaz HA, Schmidt M, Morrow EM. "Functional Assessment <i>In Vivo</i> of the Mouse Homologue of the Human Ala-9-Ser NHE6 Variant." eNeuro, 2019. |
| Ouyang Q, Kavanaugh BC, Joesch-Cohen L, Dubois B, Wu Q, Schmidt M, Baytas O, Pastore SF, Harripaul R, Mishra S, Hussain A, Kim KH, Holler-Managan YF, Ayub M, Mir A, Vincent JB, Liu JS, Morrow EM. "GPT2 mutations in autosomal recessive developmental disability: extending the clinical phenotype and population prevalence estimates." Human Genetics, vol. 138, no. 10, 2019, pp. 1183-1200. |
| Warren EB, Morrow EM. "Mitochondrial Function in 22q11 Deletion Syndrome." Neuron, vol. 102, no. 6, 2019, pp. 1089-1091. |
| Morrow, Eric M. "Paternal sperm DNA mosaicism and recurrence risk of autism in families." Nature Medicine, vol. 26, no. 1, 2019, pp. 26-28. |
| Morrow EM, Pescosolido MF, Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A. "Christianson Syndrome." 2018. |
| Schwede, Matthew, Nagpal, Shailender, Gandal, Michael J., Parikshak, Neelroop N., Mirnics, Karoly, Geschwind, Daniel H., Morrow, Eric M. "Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex." Journal of Neurodevelopmental Disorders, vol. 10, no. 1, 2018, pp. 18. |
| Baytaş O, Morrow EM. "The Role of Mitochondrial Glutamate Metabolism in Cognitive Development and Disease." Neuropsychopharmacology, vol. 43, no. 1, 2018, pp. 229-230. |
| Gerber, Alan H., McCormick, Carolyn E. B., Levine, Todd P., Morrow, Eric M., Anders, Thomas F., Sheinkopf, Stephen J. "Brief Report: Factors Influencing Healthcare Satisfaction in Adults with Autism Spectrum Disorder." Journal of Autism and Developmental Disorders, vol. 47, no. 6, 2017, pp. 1896-1903. |
| Wink LK, Pedapati EV, Adams R, Erickson CA, Pedersen KA, Morrow EM, Kaplan D, Siegel M, Autism and Developmental Disorders Inpatient Research Collaborative (ADDIRC). "Characterization of Medication Use in a Multicenter Sample of Pediatric Inpatients with Autism Spectrum Disorder." Journal of Autism and Developmental Disorders, 2017. |
| van Dyck LI, Morrow EM. "Genetic control of postnatal human brain growth." Current opinion in neurology, vol. 30, no. 1, 2017, pp. 114-124. |
| Ma L, Ouyang Q, Werthmann GC, Thompson HM, Morrow EM. "Live-cell Microscopy and Fluorescence-based Measurement of Luminal pH in Intracellular Organelles." Frontiers in Cell and Developmental Biology, vol. 5, 2017, pp. 71. |
| Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium. "Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia." Molecular autism, vol. 8, 2017, pp. 21. |
| Xu M, Ouyang Q, Gong J, Pescosolido MF, Pruett BS, Mishra S, Schmidt M, Jones RN, Gamsiz Uzun ED, Lizarraga SB, Morrow EM. "Mixed Neurodevelopmental and Neurodegenerative Pathology in Nhe6-Null Mouse Model of Christianson Syndrome." eNeuro, vol. 4, no. 6, 2017. |
| Weiner DJ, Wigdor EM, Ripke S, Walters RK, Kosmicki JA, Grove J, Samocha KE, Goldstein JI, Okbay A, Bybjerg-Grauholm J, Werge T, Hougaard DM, Taylor J, iPSYCH-Broad Autism Group., Psychiatric Genomics Consortium Autism Group., Skuse D, Devlin B, Anney R, Sanders SJ, Bishop S, Mortensen PB, Børglum AD, Smith GD, Daly MJ, Robinson EB. "Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders." Nature Genetics, vol. 49, no. 7, 2017, pp. 978-985. |
| Righi G, Benevides J, Mazefsky C, Siegel M, Sheinkopf SJ, Morrow EM, Autism and Developmental Disabilities Inpatient Research Collaborative (ADDIRC). "Predictors of Inpatient Psychiatric Hospitalization for Children and Adolescents with Autism Spectrum Disorder." Journal of Autism and Developmental Disorders, 2017. |
| Yeo RA, Ryman SG, van den Heuvel MP, de Reus MA, Jung RE, Pommy J, Mayer AR, Ehrlich S, Schulz SC, Morrow EM, Manoach D, Ho BC, Sponheim SR, Calhoun VD. "Graph Metrics of Structural Brain Networks in Individuals with Schizophrenia and Healthy Controls: Group Differences, Relationships with Intelligence, and Genetics." Journal of the International Neuropsychological Society, vol. 22, no. 2, 2016, pp. 240-9. |
| Doan RN, Bae BI, Cubelos B, Chang C, Hossain AA, Al-Saad S, Mukaddes NM, Oner O, Al-Saffar M, Balkhy S, Gascon GG, Homozygosity Mapping Consortium for Autism., Nieto M, Walsh CA. "Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior." Cell, vol. 167, no. 2, 2016, pp. 341-354.e12. |
| Ouyang, Qing, Nakayama, Tojo, Baytas, Ozan, Davidson, Shawn M., Yang, Chendong, Schmidt, Michael, Lizarraga, Sofia B., Mishra, Sasmita, EI-Quessny, Malak, Niaz, Saima, Gul Butt, Mirrat, Imran Murtaza, Syed, Javed, Afzal, Chaudhry, Haroon Rashid, Vaughan, Dylan J., Hill, R. Sean, Partlow, Jennifer N., Yoo, Seung-Yun, Lam, Anh-Thu N., Nasir, Ramzi, Al-Saffar, Muna, Barkovich, A. James, Schwede, Matthew, Nagpal, Shailender, Rajab, Anna, DeBerardinis, Ralph J., Housman, David E., Mochida, Ganeshwaran H., Morrow, Eric M. "Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features." Proceedings of the National Academy of Sciences, vol. 113, no. 38, 2016, pp. E5598-E5607. |
| Chaste P, Klei L, Sanders SJ, Hus V, Murtha MT, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Mane SM, Martin DM, Morrow EM, Walsh CA, Sutcliffe JS, Lese Martin C, Beaudet AL, Lord C, State MW, Cook EH Jr, Devlin B. "A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?." Biological Psychiatry, vol. 77, no. 9, 2015, pp. 775-84. |
| Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R. "Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders." Stem Cell Reports, vol. 5, no. 6, 2015, pp. 933-45. |
| Gamsiz ED, Sciarra LN, Maguire AM, Pescosolido MF, van Dyck LI, Morrow EM. "Discovery of Rare Mutations in Autism: Elucidating Neurodevelopmental Mechanisms." Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, vol. 12, no. 3, 2015, pp. 553-71. |
| Howe, Yamini J., O’Rourke, Julia A., Yatchmink, Yvette, Viscidi, Emma W., Jones, Richard N., Morrow, Eric M. "Female Autism Phenotypes Investigated at Different Levels of Language and Developmental Abilities." J Autism Dev Disord, vol. 45, no. 11, 2015, pp. 3537-3549. |
| Sanders SJ, He X, Willsey AJ, Ercan-Sencicek AG, Samocha KE, Cicek AE, Murtha MT, Bal VH, Bishop SL, Dong S, Goldberg AP, Jinlu C, Keaney JF 3rd, Klei L, Mandell JD, Moreno-De-Luca D, Poultney CS, Robinson EB, Smith L, Solli-Nowlan T, Su MY, Teran NA, Walker MF, Werling DM, Beaudet AL, Cantor RM, Fombonne E, Geschwind DH, Grice DE, Lord C, Lowe JK, Mane SM, Martin DM, Morrow EM, Talkowski ME, Sutcliffe JS, Walsh CA, Yu TW, Autism Sequencing Consortium., Ledbetter DH, Martin CL, Cook EH, Buxbaum JD, Daly MJ, Devlin B, Roeder K, State MW. "Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci." Neuron, vol. 87, no. 6, 2015, pp. 1215-1233. |
| Maier R, Moser G, Chen GB, Ripke S, Cross-Disorder Working Group of the Psychiatric Genomics Consortium., Coryell W, Potash JB, Scheftner WA, Shi J, Weissman MM, Hultman CM, Landén M, Levinson DF, Kendler KS, Smoller JW, Wray NR, Lee SH. "Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder." The American Journal of Human Genetics, vol. 96, no. 2, 2015, pp. 283-94. |
| Morrow EM. "MicroRNAs in Copy Number Variants in Schizophrenia: Misregulation of Genome-wide Gene Expression Programs." Biological Psychiatry, vol. 77, no. 2, 2015, pp. 93-4. |
| Young-Pearse TL, Morrow EM. "Modeling developmental neuropsychiatric disorders with iPSC technology: challenges and opportunities." Current opinion in neurobiology, vol. 36, 2015, pp. 66-73. |
| Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium. "Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways." Nature Neuroscience, vol. 18, no. 2, 2015, pp. 199-209. |
| Morrow, Eric M. "Quantifying the Effects of Rare Variants in Pedigrees." JAMA Psychiatry, vol. 72, no. 2, 2015, pp. 106. |
| Siegel M, Smith KA, Mazefsky C, Gabriels RL, Erickson C, Kaplan D, Morrow EM, Wink L, Santangelo SL, Autism and Developmental Disorders Inpatient Research Collaborative (ADDIRC). "The autism inpatient collection: methods and preliminary sample description." Molecular autism, vol. 6, 2015, pp. 61. |
| Lizarraga, Sofia B., Morrow, Eric M. "Uncovering a Role for SK2 in Angelman Syndrome." Cell Reports, vol. 12, no. 3, 2015, pp. 359-360. |
| Howe YJ, Yatchmink Y, Viscidi EW, Morrow EM. "Ascertainment and gender in autism spectrum disorders." Journal of the American Academy of Child & Adolescent Psychiatry, vol. 53, no. 6, 2014, pp. 698-700. |
| McLean RL, Johnson Harrison A, Zimak E, Joseph RM, Morrow EM. "Executive function in probands with autism with average IQ and their unaffected first-degree relatives." Journal of the American Academy of Child & Adolescent Psychiatry, vol. 53, no. 9, 2014, pp. 1001-9. |
| Pescosolido MF, Schwede M, Johnson Harrison A, Schmidt M, Gamsiz ED, Chen WS, Donahue JP, Shur N, Jerskey BA, Phornphutkul C, Morrow EM. "Expansion of the clinical phenotype associated with mutations in activity-dependent neuroprotective protein." Journal of Medical Genetics, vol. 51, no. 9, 2014, pp. 587-9. |
| Schwede M, Garbett K, Mirnics K, Geschwind DH, Morrow EM. "Genes for endosomal NHE6 and NHE9 are misregulated in autism brains." Molecular Psychiatry, vol. 19, no. 3, 2014, pp. 277-9. |
| Pescosolido MF, Stein DM, Schmidt M, El Achkar CM, Sabbagh M, Rogg JM, Tantravahi U, McLean RL, Liu JS, Poduri A, Morrow EM. "Genetic and phenotypic diversity of NHE 6 mutations in Christianson syndrome." Annals of neurology, vol. 76, no. 4, 2014, pp. 581-93. |
| Yeo RA, Gangestad SW, Walton E, Ehrlich S, Pommy J, Turner JA, Liu J, Mayer AR, Schulz SC, Ho BC, Bustillo JR, Wassink TH, Sponheim SR, Morrow EM, Calhoun VD. "Genetic influences on cognitive endophenotypes in schizophrenia." Schizophrenia research, vol. 156, no. 1, 2014, pp. 71-5. |
| Stein DM, Gerber A, Morrow EM. "Inaugural Christianson Syndrome Association conference: families meeting for the first time." Journal of Neurodevelopmental Disorders, vol. 6, no. 1, 2014, pp. 13. |
| Chaste P, Sanders SJ, Mohan KN, Klei L, Song Y, Murtha MT, Hus V, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Lord C, Mane SM, Martin DM, Morrow EM, Walsh CA, Sutcliffe JS, State MW, Martin CL, Devlin B, Beaudet AL, Cook EH Jr, Kim SJ. "Modest impact on risk for autism spectrum disorder of rare copy number variants at 15q11.2, specifically breakpoints 1 to 2." Autism Research, vol. 7, no. 3, 2014, pp. 355-62. |
| Harrison AJ, Zimak EH, Sheinkopf SJ, Manji KP, Morrow EM. "Observation-centered Approach to ASD Assessment in Tanzania." Intellectual and Developmental Disabilities, vol. 52, no. 5, 2014, pp. 330-347. |
| De Rubeis S, He X, Goldberg AP, Poultney CS, Samocha K, Cicek AE, Kou Y, Liu L, Fromer M, Walker S, Singh T, Klei L, Kosmicki J, Shih-Chen F, Aleksic B, Biscaldi M, Bolton PF, Brownfeld JM, Cai J, Campbell NG, Carracedo A, Chahrour MH, Chiocchetti AG, Coon H, Crawford EL, Curran SR, Dawson G, Duketis E, Fernandez BA, Gallagher L, Geller E, Guter SJ, Hill RS, Ionita-Laza J, Jimenz Gonzalez P, Kilpinen H, Klauck SM, Kolevzon A, Lee I, Lei I, Lei J, Lehtimäki T, Lin CF, Ma'ayan A, Marshall CR, McInnes AL, Neale B, Owen MJ, Ozaki N, Parellada M, Parr JR, Purcell S, Puura K, Rajagopalan D, Rehnström K, Reichenberg A, Sabo A, Sachse M, Sanders SJ, Schafer C, Schulte-Rüther M, Skuse D, Stevens C, Szatmari P, Tammimies K, Valladares O, Voran A, Li-San W, Weiss LA, Willsey AJ, Yu TW, Yuen RK, DDD Study., Homozygosity Mapping Collaborative for Autism., UK10K Consortium., Cook EH, Freitag CM, Gill M, Hultman CM, Lehner T, Palotie A, Schellenberg GD, Sklar P, State MW, Sutcliffe JS, Walsh CA, Scherer SW, Zwick ME, Barett JC, Cutler DJ, Roeder K, Devlin B, Daly MJ, Buxbaum JD. "Synaptic, transcriptional and chromatin genes disrupted in autism." J. Geophys. Res., vol. 515, no. 7526, 2014, pp. 209-15. |
| Viscidi, E. W., Johnson, A. L., Spence, S. J., Buka, S. L., Morrow, E. M., Triche, E. W. "The association between epilepsy and autism symptoms and maladaptive behaviors in children with autism spectrum disorder." Autism, vol. 18, no. 8, 2014, pp. 996-1006. |
| Gerber A, Morrow E, Sheinkopf SJ, Anders T. "The Rhode Island Consortium for Autism Research and Treatment (RI-CART): a new statewide autism collaborative." Rhode Island medical journal (2013), vol. 97, no. 5, 2014, pp. 31-4. |
| Aguiar, Derek, Morrow, Eric, Istrail, Sorin. "Tractatus: An Exact and Subquadratic Algorithm for Inferring Identical-by-Descent Multi-shared Haplotype Tracts." Automata, Languages and Programming, 2014, pp. 1-17. |
| Chaste P, Klei L, Sanders SJ, Murtha MT, Hus V, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Lord C, Mane SM, Lese Martin C, Martin DM, Morrow EM, Walsh CA, Sutcliffe JS, State MW, Devlin B, Cook EH Jr, Kim SJ. "Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait." Biological Psychiatry, vol. 74, no. 8, 2013, pp. 576-84. |
| Minhas HM, Pescosolido MF, Schwede M, Piasecka J, Gaitanis J, Tantravahi U, Morrow EM. "An unbalanced translocation involving loss of 10q26.2 and gain of 11q25 in a pedigree with autism spectrum disorder and cerebellar juvenile pilocytic astrocytoma." American journal of medical genetics. Part A, vol. 161A, no. 4, 2013, pp. 787-91. |
| Ouyang Q, Lizarraga SB, Schmidt M, Yang U, Gong J, Ellisor D, Kauer JA, Morrow EM. "Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development." Neuron, vol. 80, no. 1, 2013, pp. 97-112. |
| Viscidi EW, Triche EW, Pescosolido MF, McLean RL, Joseph RM, Spence SJ, Morrow EM. "Clinical characteristics of children with autism spectrum disorder and co-occurring epilepsy." PLoS ONE, vol. 8, no. 7, 2013, pp. e67797. |
| Pescosolido, Matthew F., Gamsiz, Ece D., Nagpal, Shailender, Morrow, Eric M. "Distribution of Disease-Associated Copy Number Variants Across Distinct Disorders of Cognitive Development." Journal of the American Academy of Child & Adolescent Psychiatry, vol. 52, no. 4, 2013, pp. 414-430.e14. |
| Cross-Disorder Group of the Psychiatric Genomics Consortium., Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayés M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DH, Bloss CS, Boehnke M, Boomsma DI, Breen G, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne EM, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Friedl M, Frisén L, Gallagher L, Gejman PV, Georgieva L, Gershon ES, Geschwind DH, Giegling I, Gill M, Gordon SD, Gordon-Smith K, Green EK, Greenwood TA, Grice DE, Gross M, Grozeva D, Guan W, Gurling H, De Haan L, Haines JL, Hakonarson H, Hallmayer J, Hamilton SP, Hamshere ML, Hansen TF, Hartmann AM, Hautzinger M, Heath AC, Henders AK, Herms S, Hickie IB, Hipolito M, Hoefels S, Holmans PA, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hultman CM, Hus V, Ingason A, Ising M, Jamain S, Jones EG, Jones I, Jones L, Tzeng JY, Kähler AK, Kahn RS, Kandaswamy R, Keller MC, Kennedy JL, Kenny E, Kent L, Kim Y, Kirov GK, Klauck SM, Klei L, Knowles JA, Kohli MA, Koller DL, Konte B, Korszun A, Krabbendam L, Krasucki R, Kuntsi J, Kwan P, Landén M, Långström N, Lathrop M, Lawrence J, Lawson WB, Leboyer M, Ledbetter DH, Lee PH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu C, Lohoff FW, Loo SK, Lord C, Lowe JK, Lucae S, MacIntyre DJ, Madden PA, Maestrini E, Magnusson PK, Mahon PB, Maier W, Malhotra AK, Mane SM, Martin CL, Martin NG, Mattheisen M, Matthews K, Mattingsdal M, McCarroll SA, McGhee KA, McGough JJ, McGrath PJ, McGuffin P, McInnis MG, McIntosh A, McKinney R, McLean AW, McMahon FJ, McMahon WM, McQuillin A, Medeiros H, Medland SE, Meier S, Melle I, Meng F, Meyer J, Middeldorp CM, Middleton L, Milanova V, Miranda A, Monaco AP, Montgomery GW, Moran JL, Moreno-De-Luca D, Morken G, Morris DW, Morrow EM, Moskvina V, Muglia P, Mühleisen TW, Muir WJ, Müller-Myhsok B, Murtha M, Myers RM, Myin-Germeys I, Neale MC, Nelson SF, Nievergelt CM, Nikolov I, Nimgaonkar V, Nolen WA, Nöthen MM, Nurnberger JI, Nwulia EA, Nyholt DR, O'Dushlaine C, Oades RD, Olincy A, Oliveira G, Olsen L, Ophoff RA, Osby U, Owen MJ, Palotie A, Parr JR, Paterson AD, Pato CN, Pato MT, Penninx BW, Pergadia ML, Pericak-Vance MA, Pickard BS, Pimm J, Piven J, Posthuma D, Potash JB, Poustka F, Propping P, Puri V, Quested DJ, Quinn EM, Ramos-Quiroga JA, Rasmussen HB, Raychaudhuri S, Rehnström K, Reif A, Ribasés M, Rice JP, Rietschel M, Roeder K, Roeyers H, Rossin L, Rothenberger A, Rouleau G, Ruderfer D, Rujescu D, Sanders AR, Sanders SJ, Santangelo SL, Sergeant JA, Schachar R, Schalling M, Schatzberg AF, Scheftner WA, Schellenberg GD, Scherer SW, Schork NJ, Schulze TG, Schumacher J, Schwarz M, Scolnick E, Scott LJ, Shi J, Shilling PD, Shyn SI, Silverman JM, Slager SL, Smalley SL, Smit JH, Smith EN, Sonuga-Barke EJ, St Clair D, State M, Steffens M, Steinhausen HC, Strauss JS, Strohmaier J, Stroup TS, Sutcliffe JS, Szatmari P, Szelinger S, Thirumalai S, Thompson RC, Todorov AA, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Van Os J, Vicente AM, Vieland VJ, Vincent JB, Visscher PM, Walsh CA, Wassink TH, Watson SJ, Weissman MM, Werge T, Wienker TF, Wijsman EM, Willemsen G, Williams N, Willsey AJ, Witt SH, Xu W, Young AH, Yu TW, Zammit S, Zandi PP, Zhang P, Zitman FG, Zöllner S, Devlin B, Kelsoe JR, Sklar P, Daly MJ, O'Donovan MC, Craddock N, Sullivan PF, Smoller JW, Kendler KS, Wray NR, International Inflammatory Bowel Disease Genetics Consortium (IIBDGC). "Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs." Nature Genetics, vol. 45, no. 9, 2013, pp. 984-94. |
| Gamsiz ED, Viscidi EW, Frederick AM, Nagpal S, Sanders SJ, Murtha MT, Schmidt M, Simons Simplex Collection Genetics Consortium, Triche EW, Geschwind DH, State MW, Istrail S, Cook EH Jr, Devlin B, Morrow EM. "Intellectual disability is associated with increased runs of homozygosity in simplex autism." The American Journal of Human Genetics, vol. 93, no. 1, 2013, pp. 103-9. |
| Marano RM, Mercurio L, Kanter R, Doyle R, Abuelo D, Morrow EM, Shur N. "Risk assessment models in genetics clinic for array comparative genomic hybridization: Clinical information can be used to predict the likelihood of an abnormal result in patients." Journal of pediatric genetics, vol. 2, no. 1, 2013, pp. 25-31. |
| Abrahams BS, Arking DE, Campbell DB, Mefford HC, Morrow EM, Weiss LA, Menashe I, Wadkins T, Banerjee-Basu S, Packer A. "SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs)." Molecular autism, vol. 4, no. 1, 2013, pp. 36. |
| Yeo RA, Gangestad SW, Liu J, Ehrlich S, Thoma RJ, Pommy J, Mayer AR, Schulz SC, Wassink TH, Morrow EM, Bustillo JR, Sponheim SR, Ho BC, Calhoun VD. "The impact of copy number deletions on general cognitive ability and ventricle size in patients with schizophrenia and healthy control subjects." Biological Psychiatry, vol. 73, no. 6, 2013, pp. 540-5. |
| Yu TW, Chahrour MH, Coulter ME, Jiralerspong S, Okamura-Ikeda K, Ataman B, Schmitz-Abe K, Harmin DA, Adli M, Malik AN, D'Gama AM, Lim ET, Sanders SJ, Mochida GH, Partlow JN, Sunu CM, Felie JM, Rodriguez J, Nasir RH, Ware J, Joseph RM, Hill RS, Kwan BY, Al-Saffar M, Mukaddes NM, Hashmi A, Balkhy S, Gascon GG, Hisama FM, LeClair E, Poduri A, Oner O, Al-Saad S, Al-Awadi SA, Bastaki L, Ben-Omran T, Teebi AS, Al-Gazali L, Eapen V, Stevens CR, Rappaport L, Gabriel SB, Markianos K, State MW, Greenberg ME, Taniguchi H, Braverman NE, Morrow EM, Walsh CA. "Using whole-exome sequencing to identify inherited causes of autism." Neuron, vol. 77, no. 2, 2013, pp. 259-73. |
| Sofos E, Pescosolido MF, Quintos JB, Abuelo D, Gunn S, Hovanes K, Morrow EM, Shur N. "A novel familial 11p15.4 microduplication associated with intellectual disability, dysmorphic features, and obesity with involvement of the ZNF214 gene." American journal of medical genetics. Part A, vol. 158A, no. 1, 2012, pp. 50-8. |
| Klei L, Sanders SJ, Murtha MT, Hus V, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Lord C, Mane SM, Martin CL, Martin DM, Morrow EM, Walsh CA, Melhem NM, Chaste P, Sutcliffe JS, State MW, Cook EH Jr, Roeder K, Devlin B. "Common genetic variants, acting additively, are a major source of risk for autism." Molecular autism, vol. 3, no. 1, 2012, pp. 9. |
| Aguiar D, Halldórsson BV, Morrow EM, Istrail S. "DELISHUS: an efficient and exact algorithm for genome-wide detection of deletion polymorphism in autism." Bioinformatics, vol. 28, no. 12, 2012, pp. i154-62. |
| Mefford HC, Rosenfeld JA, Shur N, Slavotinek AM, Cox VA, Hennekam RC, Firth HV, Willatt L, Wheeler P, Morrow EM, Cook J, Sullivan R, Oh A, McDonald MT, Zonana J, Keller K, Hannibal MC, Ball S, Kussmann J, Gorski J, Zelewski S, Banks V, Smith W, Smith R, Paull L, Rosenbaum KN, Amor DJ, Silva J, Lamb A, Eichler EE. "Further clinical and molecular delineation of the 15q24 microdeletion syndrome." Journal of Medical Genetics, vol. 49, no. 2, 2012, pp. 110-8. |
| Gamsiz, Ece D., Ouyang, Qing, Schmidt, Michael, Nagpal, Shailender, Morrow, Eric M. "Genome-wide transcriptome analysis in murine neural retina using high-throughput RNA sequencing." Genomics, vol. 99, no. 1, 2012, pp. 44-51. |
| Pescosolido MF, Yang U, Sabbagh M, Morrow EM. "Lighting a path: genetic studies pinpoint neurodevelopmental mechanisms in autism and related disorders." Dialogues in Clinical Neuroscience, vol. 14, no. 3, 2012, pp. 239-52. |
| Lizarraga SB, Coser KR, Sabbagh M, Morrow EM. "Methods for study of neuronal morphogenesis: ex vivo RNAi electroporation in embryonic murine cerebral cortex." Journal of visualized experiments : JoVE, no. 63, 2012, pp. e3621. |
| Johnson HM, Gaitanis J, Morrow EM. "Genetics in autism diagnosis: adding molecular subtypes to neurobehavioral diagnoses." Medicine and health, Rhode Island, vol. 94, no. 5, 2011, pp. 124-6. |
| Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha MT, Moreno-De-Luca D, Chu SH, Moreau MP, Gupta AR, Thomson SA, Mason CE, Bilguvar K, Celestino-Soper PB, Choi M, Crawford EL, Davis L, Wright NR, Dhodapkar RM, DiCola M, DiLullo NM, Fernandez TV, Fielding-Singh V, Fishman DO, Frahm S, Garagaloyan R, Goh GS, Kammela S, Klei L, Lowe JK, Lund SC, McGrew AD, Meyer KA, Moffat WJ, Murdoch JD, O'Roak BJ, Ober GT, Pottenger RS, Raubeson MJ, Song Y, Wang Q, Yaspan BL, Yu TW, Yurkiewicz IR, Beaudet AL, Cantor RM, Curland M, Grice DE, Günel M, Lifton RP, Mane SM, Martin DM, Shaw CA, Sheldon M, Tischfield JA, Walsh CA, Morrow EM, Ledbetter DH, Fombonne E, Lord C, Martin CL, Brooks AI, Sutcliffe JS, Cook EH Jr, Geschwind D, Roeder K, Devlin B, State MW. "Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism." Neuron, vol. 70, no. 5, 2011, pp. 863-85. |
| Moreno-De-Luca D, SGENE Consortium, Mulle JG, Simons Simplex Collection Genetics Consortium, Kaminsky EB, Sanders SJ, GeneSTAR, Myers SM, Adam MP, Pakula AT, Eisenhauer NJ, Uhas K, Weik L, Guy L, Care ME, Morel CF, Boni C, Salbert BA, Chandrareddy A, Demmer LA, Chow EW, Surti U, Aradhya S, Pickering DL, Golden DM, Sanger WG, Aston E, Brothman AR, Gliem TJ, Thorland EC, Ackley T, Iyer R, Huang S, Barber JC, Crolla JA, Warren ST, Martin CL, Ledbetter DH. "Deletion 17q12 is a recurrent copy number variant that confers high risk of autism and schizophrenia." The American Journal of Human Genetics, vol. 87, no. 5, 2010, pp. 618-30. |
| Ching MS, Shen Y, Tan WH, Jeste SS, Morrow EM, Chen X, Mukaddes NM, Yoo SY, Hanson E, Hundley R, Austin C, Becker RE, Berry GT, Driscoll K, Engle EC, Friedman S, Gusella JF, Hisama FM, Irons MB, Lafiosca T, LeClair E, Miller DT, Neessen M, Picker JD, Rappaport L, Rooney CM, Sarco DP, Stoler JM, Walsh CA, Wolff RR, Zhang T, Nasir RH, Wu BL, Children's Hospital Boston Genotype Phenotype Study Group. "Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders." Am. J. Med. Genet., vol. 153B, no. 4, 2010, pp. 937-47. |
| Morrow, Eric M. "Genomic Copy Number Variation in Disorders of Cognitive Development." Journal of the American Academy of Child & Adolescent Psychiatry, vol. 49, no. 11, 2010, pp. 1091-1104. |
| Morrow EM. "Genomic copy number variation in disorders of cognitive development." Journal of the American Academy of Child & Adolescent Psychiatry, vol. 49, no. 11, 2010, pp. 1091-104. |
| Ehrlich S, Morrow EM, Roffman JL, Wallace SR, Naylor M, Bockholt HJ, Lundquist A, Yendiki A, Ho BC, White T, Manoach DS, Clark VP, Calhoun VD, Gollub RL, Holt DJ. "The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults." NeuroImage, vol. 53, no. 3, 2010, pp. 992-1000. |
| Weiss LA, Arking DE, Gene Discovery Project of Johns Hopkins & the Autism Consortium, Daly MJ, Chakravarti A. "A genome-wide linkage and association scan reveals novel loci for autism." J. Geophys. Res., vol. 461, no. 7265, 2009, pp. 802-8. |
| Walsh CA, Morrow EM, Rubenstein JL. "Autism and brain development." Cell, vol. 135, no. 3, 2008, pp. 396-400. |
| Morrow EM, Yoo SY, Flavell SW, Kim TK, Lin Y, Hill RS, Mukaddes NM, Balkhy S, Gascon G, Hashmi A, Al-Saad S, Ware J, Joseph RM, Greenblatt R, Gleason D, Ertelt JA, Apse KA, Bodell A, Partlow JN, Barry B, Yao H, Markianos K, Ferland RJ, Greenberg ME, Walsh CA. "Identifying autism loci and genes by tracing recent shared ancestry." Science, vol. 321, no. 5886, 2008, pp. 218-23. |
| Morrow EM, Kane A, Goff DC, Walsh CA. "Sequence analysis of P21-activated kinase 3 (PAK3) in chronic schizophrenia with cognitive impairment." Schizophrenia research, vol. 106, no. 2-3, 2008, pp. 265-7. |
| Morrow EM, Chen CM, Cepko CL. "Temporal order of bipolar cell genesis in the neural retina." Neural development, vol. 3, 2008, pp. 2. |
| LEVINE, JOHN B., MORROW, ERIC M., BERDICHEVSKY, YEVGENY, MARTIN, GILLES E. "BK ca Channel in Autism and Mental Retardation." American Journal of Psychiatry, vol. 164, no. 6, 2007, pp. 977-978. |
| Levine JB, Morrow EM, Berdichevsky Y, Martin GE. "BKca channel in autism and mental retardation." American Journal of Psychiatry, vol. 164, no. 6, 2007, pp. 977-8; author reply 978-9. |
| Morrow EM, Lafayette JM, Bromfield EB, Fricchione G. "Postictal psychosis: presymptomatic risk factors and the need for further investigation of genetics and pharmacotherapy." Annals of general psychiatry, vol. 5, 2006, pp. 9. |
| Morrow EM, Smoller JW. "The interface of genetics and clinical psychiatry. Introduction." Harvard review of psychiatry, vol. 14, no. 2, 2006, pp. 45-6. |
| Morrow EM, Furukawa T, Raviola E, Cepko CL. "Synaptogenesis and outer segment formation are perturbed in the neural retina of Crx mutant mice." BMC neuroscience, vol. 6, 2005, pp. 5. |
| Cai L, Morrow EM, Cepko CL. "Misexpression of basic helix-loop-helix genes in the murine cerebral cortex affects cell fate choices and neuronal survival." Development, vol. 127, no. 14, 2000, pp. 3021-30. |
| Furukawa T, Mukherjee S, Bao ZZ, Morrow EM, Cepko CL. "rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells." Neuron, vol. 26, no. 2, 2000, pp. 383-94. |
| Morrow EM, Furukawa T, Lee JE, Cepko CL. "NeuroD regulates multiple functions in the developing neural retina in rodent." Development, vol. 126, no. 1, 1999, pp. 23-36. |
| Furukawa T, Morrow EM, Li T, Davis FC, Cepko CL. "Retinopathy and attenuated circadian entrainment in Crx-deficient mice." Nature Genetics, vol. 23, no. 4, 1999, pp. 466-70. |
| Morrow EM, Belliveau MJ, Cepko CL. "Two phases of rod photoreceptor differentiation during rat retinal development." Journal of Neuroscience, vol. 18, no. 10, 1998, pp. 3738-48. |
| Morrow EM, Furukawa T, Cepko CL. "Vertebrate photoreceptor cell development and disease." Trends in cell biology, vol. 8, no. 9, 1998, pp. 353-8. |
| Furukawa T, Morrow EM, Cepko CL. "Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation." Cell, vol. 91, no. 4, 1997, pp. 531-41. |
Neurodevelopmental disorders such as autism and intellectual disability are common and cause profound morbidity in populations worldwide. The associated costs to society are high and that to families are immeasurable. Intellectual disability (ID, formerly mental retardation), the most common developmental disability, occurs in 2% of people, and ranks first in the US as a cause of lifelong disability (National Center for Health Statistics U.S., 1996). Autism spectrum disorders (ASDs) occur in approximately 1 in 200 children. ID occurs in up to 50% of children with ASD and epilepsy occurs in approximately 25% of children affected by ASD.
The Morrow lab investigates the genetic and molecular mechanisms underlying disorders of cognitive development. The long-term aim of this research is to establish a basic foundation for improved genetic diagnoses and treatment interventions designed to enhance cognitive and functional gains for patients. Because these disorders are highly genetic and in order to identify core molecular mechanisms, genome-wide "forward genetic" strategies to identify genetic mutations have been a principal focus. In complement to this, molecular and neurodevelopmental studies of identified pathways are underway.
Research in the Morrow lab thereby follows two synergistic approaches: 1) human genetic studies in patient and control samples; 2) molecular neurodevelopment studies of identified pathways. In the first approach, the lab has a strong interest in rare genetic variation, including both genomic copy number and sequence changes. Our own data and that from the field as a whole have demonstrated a large and increasing number of heterogeneous loci in developmental disorders. Through extensive regional and international collaboration, we are establishing large datasets of genome-wide microarray data which are studied using new bioinformatic strategies. In molecular studies, we are focusing on neurodevelopmental mechanisms whereby these heterogeneous genes and loci appear to converge, which includes mechanisms involved in synaptic maturation. We are developing experimental models for studying disease genes and mutations in this process. In both our genetic and mechanistic studies, we are also implementing next generation sequencing technologies, as these new methods now provide a power in genomic analysis which has been previously unattainable. Whereby several genetic loci under study have also been implicated in schizophrenia (another neuropsychiatric disorder with developmental and cognitive features), the lab is working through collaboration to understand the role that pathways of interest may play in this condition as well.
Research in the Morrow lab bridges campus and medical school efforts at Brown. The Morrow lab is located at the Laboratories for Molecular Medicine at 70 Ship Street. The Lab partners with the Developmental Disorders Genetics Research Program (DDGRP) in the Department of Psychiatry and Human Behavior, which occupies patient-oriented research space at Bradley Hospital in East Providence. Significant efforts are underway to establish a multi-site collaborative for study of genetics of developmental disorders across the lifespan through the DDGRP and other centers at the Alpert Medical School of Brown University and in Rhode Island.
Ongoing Research Support
Brown University, Research Seed Award (MPI: Morrow, E.M.; Moreno-De-Luca, D.; Uzun, E.D.)
01/15/2021-06/30/2022
"Engineering genetic models for translational research in autism and schizophrenia"
Falk Medical Research Trust Catalyst Award (PI: Morrow, E.M.)
11/30/2020-11/29/2021
"Development of a Preventative Treatment for a Novel Neurometabolic Disorder in Childhood"
NIH/NIA/NINDS R01 NS113141 (PI: Morrow, E.M.)
09/15/2019-06/30/2024
"Neurodegenerative mechanisms in Christianson syndrome and NHE6-related disorders"
NIH/NIMH, R01 MH105442 (PI: Morrow, E.M.)
09/16/2014-05/31/2021 (NCE)
"Mechanisms of circuit failure and treatments in patient-derived neurons in autism"
Previous Research Support
NIH/NIMH, R01 MH102418 (PI: Morrow, E.M.)
04/01/2015-02/29/2020
"Autism-linked endosomal mechanisms in neuronal arborization and connectivity"
Simons Foundation Autism Research Initiative (PI: Morrow, E.M.)
10/01/2018-09/30/2019
"Analysis of UBE3A- and NHE6-mutant Cells to Determine Social Communication Gene Networks"
Brown University/Carney Institute for Brain Science, Carney Innovation Award (MPI: Morrow, E.M.; Moreno-De-Luca, D.)
10/01/2018-09/30/2019
"Development of Experimental Models for Rare Genetic Disorders in Autism and Schizophrenia"
Brain & Behavior Research Foundation, NARSAD Independent Investigator Grant (PI: Morrow, E.M.)
09/15/2017-09/14/2019
"Genetic Investigation of Mitochondrial Metabolism in Circuit Development and Behavior"
NIH/NIMH, R21 MH115392 (PI: Morrow, E.M.)
09/18/2017-08/31/2019
"Convergent Cellular Mechanisms Governed by UBE3A and NHEs in Neurons"
Angelman Syndrome Foundation, General Research Grant (PI: Morrow, E.M.)
09/01/2017-08/31/2019
"Shared Cellular Mechanisms in Angelman Syndrome and Christianson Syndrome"
Simons Foundation Autism Research Initiative and Nancy Lurie Marks Family Foundation for Autism Research (PI: Siegel, M.; Co-I: Morrow, E.M.)
10/01/2015-09/30/2018
"Autism Inpatient Collection: Phase II"
Brown University, Research Seed Award (PI: Morrow, E.M.)
01/01/2017-06/30/2018
"Mechanisms in mitochondrial metabolism in brain development and health"
Simons Foundation Autism Research Initiative (PI: Morrow, E.M.)
04/01/2013-03/31/2017
"Population and Genetics Study of Autism and Intellectual Disability"
NIH/NINDS, R13 NS093882 (MPI: Morrow, E.M.; Walkley, S.U.)
07/15/2015-06/30/2016
"Support for the 1st International Basic Science and Clinical Conference on Christianson Syndrome"
Brown University, Research Seed Award (MPI: Morrow, E.M.; Istrail, S.)
07/01/2014-06/30/2016
"Genome-wide Sequence Analysis in Severe Autism and Intellectual Disability"
The Company of Biologists, Scientific Meeting Grant (PI: Morrow, E.M.)
05/01/2015-10/31/2015
"Disease Models and Endosomal Mechanisms in Christianson Syndrome"
Simons Foundation Autism Research Initiative and Nancy Lurie Marks Family Foundation for Autism Research (PI: Siegel, M.; Co-I: Morrow, E.M.)
10/01/2013-09/30/2015
"Autism and Developmental Disorders Inpatient Research Collaborative: Phenotyping of the Severely Affected Autism Population"
Burroughs Wellcome Fund, Career Award for Medical Scientists (PI: Morrow, E.M.)
09/01/2007-08/31/2015
"Identification of autism genes in special founder populations using high-density SNP microarrays"
NIH/NIGMS, P20 GM103645 (PI: Sanes, J.N.; Project PI: Morrow, E.M.)
08/15/2013-07/31/2018
Centers of Biomedical Research Excellence (COBRE) Center for Central Nervous System Function
"Genetic-imaging study of obsessive compulsive behavior in autism"
Simons Foundation Autism Research Initiative and Nancy Lurie Marks Family Foundation for Autism Research (PI: Morrow, E.M.)
07/01/2012-06/30/2014
"Role of Endosomal NHE6 in Brain Connectivity and Autism"
Rhode Island Hospital Institutional Funds (PI: Quesenberry, P.; Project PI: Morrow, E.M.)
03/01/2011-02/28/2014
"Stem cell pilot: Human induced pluripotent stem cell (iPSC) technology applied to brain disease"
NIH/NCRR, P20 RR018728 (PI: Padbury, J.; Project PI: Morrow, E.M.)
08/01/2011-07/31/2013
Perinatal Medicine Center of Biomedical Research Excellence (COBRE)
"Trafficking Mechanisms in Axonal Growth in Embryonic and Perinatal Development"
Simons Foundation Autism Research Initiative (Site PI: Morrow, E.M.)
07/01/2011-06/30/2012
"A Genome-Wide Search for Autism Genes in the Simons Simplex Collection (SSC): The Illumina Genetic Analysis Team"
NIH/NIMH, K23 MH080954 (PI: Morrow, E.M.)
09/15/2007-08/31/2012
"Genetic investigation of cognitive development in autistic spectrum disorders"
Mentor: Christopher A. Walsh MD PhD; Co-Mentors: Mark Daly PhD, Sorin Istrail PhD
Collaborative Translational Genetics in Autism (Project 3 PI: Morrow, E.M.)
Fidelity Foundation
12/01/2008-03/01/2011
National Alliance for Research on Schizophrenia and Depression, NARSAD Young Investigator Grant (PI: Morrow, E.M.)
08/01/2007-06/30/2009
Charles H. Hood Foundation, Child Health Research Award (PI: Morrow, E.M.)
08/01/2007-07/31/2009
"Genetics of autism spectrum disorders"
Jerome Lyle Rappaport Family Foundation, Massachusetts General Hospital Rappaport Neuroscience Scholar (PI: Morrow, E.M.)
07/01/2007-06/30/2008
Genetics
Books and Book Chapters
Derek Aguiar, Eric Morrow, and Sorin Istrail. "Tractatus: An Exact and Subquadratic Algorithm for Inferring Identical-by-Descent Multi-shared Haplotype Tracts" In: Roded Sharan, ed. Research in Computational Molecular Biology. Springer International Publishing. Lecture Notes in Computer Science Vol. 8394, 2014, 1-17.
Eric M. Morrow and Christopher A. Walsh. "Isolate Populations and Rare Variation in Autism Spectrum Disorders" In: David Amaral, Daniel Geschwind, and Geraldine Dawson, eds. Autism Spectrum Disorders. Oxford: Oxford University Press. 2011, 766-775.
Journal Articles and Reviews
Schmitz-Abe, K., Sanchez-Schmitz, G., Doan, R.N., Hill, R.S., Chahrour, M.H., Mehta, B.K., Servattalab, S., Ataman, B., Lam, A.N., Morrow, E.M., Greenberg, M.E., Yu, T.W., Walsh, C.A., and Markianos, K. (2020). Homozygous deletions implicate non-coding epigenetic marks in Autism Spectrum Disorder. Sci Rep 10: 14045 (PMID: 32820185; PMCID: PMC7441318).
Moreno-De-Luca, D., Kavanaugh, B.C., Best, C.R., Sheinkopf, S.J., Phornphutkul, C., and Morrow, E.M. (2020). Clinical genetic testing in Autism Spectrum Disorder in a large community-based population sample. JAMA Psychiatry 77: 979-981 (PMID: 32401282; PMCID: PMC7221847).
Satterstrom, F.K., Kosmicki, J.A., Wang, J., Breen, M.S., De Rubeis, S., An, J.Y., Peng, M., Collins, R., Grove, J., Klei, L., Stevens, C., Reichert, J., Mulhern, M.S., Artomov, M., Gerges, S., Sheppard, B., Xu, X., Bhaduri, A., Norman, U., Brand, H., Schwartz, G., Nguyen, R., Guerrero, E.E., Dias, C.; Autism Sequencing Consortium; iPSYCH-Broad Consortium, Betancur, C., Cook, E.H., Gallagher, L., Gill, M., Sutcliffe, J.S., Thurm, A., Zwick, M.E., Børglum, A.D., State, M.W., Cicek, A.E., Talkowski, M.E., Cutler, D.J., Devlin, B., Sanders, S.J., Roeder, K., Daly, M.J., and Buxbaum, J.D. (2020). Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism. Cell 180: 568-584.e23 (PMID: 31981491; PMCID: PMC7250485).
Morrow, E.M. (2020). Paternal sperm DNA mosaicism and recurrence risk of autism in families. Nat Med 26: 26-28 (PMID: 31873313). (Invited News and Views)
Warren, E.B. and Morrow, E.M. (2019). Mitochondrial function in 22q11 deletion syndrome. Neuron 102: 1089-1091 (PMID: 31220439). (Invited Preview)
Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium (2017). Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Mol Autism 8: 21 (PMID: 28540026; PMCID: PMC5441062).
van Dyck, L.I. and Morrow, E.M. (2017). Genetic control of postnatal human brain growth. Curr Opin Neurol 30: 114-124 (PMID: 27898583; PMCID: PMC5340196).
Doan, R.N., Bae, B.I., Cubelos, B., Chang, C., Hossain, A.A., Al-Saad, S., Mukaddes, N.M., Oner, O., Al-Saffar, M., Balkhy, S., Gascon, G.G.; Homozygosity Mapping Consortium for Autism, Nieto, M., and Walsh, C.A. (2016). Mutations in human accelerated regions disrupt cognition and social behavior. Cell 167: 341-354.e12 (PMID: 27667684; PMCID: PMC5063026).
Sanders, S.J., He, X., Willsey, A.J., Ercan-Sencicek, A.G., Samocha, K.E., Cicek, A.E., Murtha, M.T., Bal, V.H., Bishop, S.L., Dong, S., Goldberg, A.P., Jinlu, C., Keaney, J.F. 3rd, Klei, L., Mandell, J.D., Moreno-De-Luca, D., Poultney, C.S., Robinson, E.B., Smith, L., Solli-Nowlan, T., Su, M.Y., Teran, N.A., Walker, M.F., Werling, D.M., Beaudet, A.L., Cantor, R.M., Fombonne, E., Geschwind, D.H., Grice, D.E., Lord, C., Lowe, J.K., Mane, S.M., Martin, D.M., Morrow, E.M., Talkowski, M.E., Sutcliffe, J.S., Walsh, C.A., Yu, T.W.; Autism Sequencing Consortium, Ledbetter, D.H., Martin, C.L., Cook, E.H., Buxbaum, J.D., Daly, M.J., Devlin, B., Roeder, K., and State, M.W. (2015). Insights into Autism Spectrum Disorder genomic architecture and biology from 71 risk loci. Neuron 87: 1215-1233 (PMID: 26402605; PMCID: PMC4624267).
Morrow, E.M. (2015). MicroRNAs in copy number variants in schizophrenia: Misregulation of genome-wide gene expression programs. Biol Psychiatry 77: 93-94 (PMID: 25524307). (Invited Editorial)
Morrow, E.M. (2015). Quantifying the effects of rare variants in pedigrees: How far does the apple fall from the tree? JAMA Psychiatry 72: 106-107 (PMID: 25493613). (Invited Editorial)
Maier, R., Moser, G., Chen, G.B., Ripke, S.; Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Coryell, W., Potash, J.B., Scheftner, W.A., Shi, J., Weissman, M.M., Hultman, C.M., Landén, M., Levinson, D.F., Kendler, K.S., Smoller, J.W., Wray, N.R., and Lee, S.H. (2015). Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. Am J Hum Genet 96: 283-294 (PMID: 25640677; PMCID: PMC4320268).
Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium (2015). Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci 18: 199-209 (PMID: 25599223; PMCID: PMC4378867).
Chaste, P., Klei, L., Sanders, S.J., Hus, V., Murtha, M.T., Lowe, J.K., Willsey, A.J., Moreno-De-Luca, D., Yu, T.W., Fombonne, E., Geschwind, D., Grice, D.E., Ledbetter, D.H., Mane, S.M., Martin, D.M., Morrow, E.M., Walsh, C.A., Sutcliffe, J.S., Lese Martin, C., Beaudet, A.L., Lord, C., State, M.W., Cook, E.H. Jr., and Devlin, B. (2015). A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity? Biol Psychiatry 77: 775-784 (PMID: 25534755; PMCID: PMC437912).
De Rubeis, S., He, X., Goldberg, A.P., Poultney, C.S., Samocha, K., Cicek, A.E., Kou, Y., Liu, L., Fromer, M., Walker, S., Singh, T., Klei, L., Kosmicki, J., Shih-Chen, F., Aleksic, B., Biscaldi, M., Bolton, P.F., Brownfeld, J.M., Cai, J., Campbell, N.G., Carracedo, A., Chahrour, M.H., Chiocchetti, A.G., Coon, H., Crawford, E.L., Curran, S.R., Dawson, G., Duketis, E., Fernandez, B.A., Gallagher, L., Geller, E., Guter, S.J., Hill, R.S., Ionita-Laza, J., Jimenz Gonzalez, P., Kilpinen, H., Klauck, S.M., Kolevzon, A., Lee, I., Lei, I., Lei, J., Lehtimäki, T., Lin, C.F., Ma’ayan, A., Marshall, C.R., McInnes, A.L., Neale, B., Owen, M.J., Ozaki, N., Parellada, M., Parr, J.R., Purcell, S., Puura, K., Rajagopalan, D., Rehnström, K., Reichenberg, A., Sabo, A., Sachse, M., Sanders, S.J., Schafer, C., Schulte-Rüther, M., Skuse, D., Stevens, C., Szatmari, P., Tammimies, K., Valladares, O., Voran, A., Li-San, W., Weiss, L.A., Willsey, A.J., Yu, T.W., Yuen, R.K.; DDD Study; Homozygosity Mapping Collaborative for Autism; UK10K Consortium, Cook, E.H., Freitag, C.M., Gill, M., Hultman, C.M., Lehner, T., Palotie, A., Schellenberg, G.D., Sklar, P., State, M.W., Sutcliffe, J.S., Walsh, C.A., Scherer, S.W., Zwick, M.E., Barett, J.C., Cutler, D.J., Roeder, K., Devlin, B., Daly, M.J., and Buxbaum, J.D. (2014). Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 515: 209-215 (PMID: 25363760; PMCID: PMC4402723).
Pescosolido, M.F., Stein, D.M., Schmidt, M., El Achkar, C.M., Sabbagh, M., Rogg, J.M., Tantravahi, U., McLean, R.L., Liu, J.S., Poduri, A., and Morrow, E.M. (2014). Genetic and phenotypic diversity of NHE6 mutations in Christianson syndrome. Ann Neurol 76: 581-593 (PMID: 25044251; PMCID: PMC4304796).
Pescosolido, M.F., Schwede, M., Johnson Harrison, A., Schmidt, M., Gamsiz, E.D., Chen, W.S., Donahue, J.P., Shur, N., Jerskey, B.A., Phornphutkul, C., and Morrow, E.M. (2014). Expansion of the clinical phenotype associated with mutations in activity-dependent neuroprotective protein. J Med Genet 51: 587-589 (PMID: 25057125; PMCID: PMC4135390).
Gerber, A., Morrow, E.M., Sheinkopf, S.J., and Anders, T. (2014). The Rhode Island Consortium for Autism Research and Treatment (RI-CART): A new statewide autism collaborative. RI Med J 97: 31-34 (PMID: 24791265; PMCID: PMC4134665).
Stein, D.M., Gerber, A.H., and Morrow, E.M. (2014). Inaugural Christianson Syndrome Association conference: Families meeting for the first time. J Neurodev Disord 6: 13 (PMID: 25273398; PMCID: PMC4038054).
Chaste, P., Sanders, S.J., Mohan, K.N., Klei, L., Song, Y., Murtha, M.T., Hus, V., Lowe, J.K., Willsey, A.J., Moreno-De-Luca, D., Yu, T.W., Fombonne, E., Geschwind, D., Grice, D.E., Ledbetter, D.H., Lord, C., Mane, S.M., Martin, D.M., Morrow, E.M., Walsh, C.A., Sutcliffe, J.S., State, M.W., Martin, C.L., Devlin, B., Beaudet, A.L., Cook, E.H. Jr., and Kim, S.-J. (2014). Modest impact of risk for autism spectrum disorder of rare copy number variants at 15q11.2, specifically breakpoints 1 to 2. Autism Res 7: 355-362 (PMID: 24821083).
Yeo, R.A., Gangestad, S.W., Walton, E., Ehrlich, S., Pommy, J., Turner, J.A., Liu, J., Mayer, A.R., Schulz, S.C., Ho, B.C., Bustillo, J.R., Wassink, T.H., Sponheim, S.R., Morrow, E.M., and Calhoun, V.D. (2014). Genetic influences on cognitive endophenotypes in schizophrenia. Schizophr Res 156: 71-75 (PMID: 24768440).
Abrahams, B.S.*, Arking, D.E.*, Campbell, D.B.*, Mefford, H.C.*, Morrow, E.M.*, Weiss, L.A.*, Menashe, I., Wadkins, T., Banerjee-Basu, S., and Packer, A. (2013). SFARI Gene 2.0: A community-driven knowledgebase for the autism spectrum disorders (ASDs). Mol Autism 4: 36 (PMID: 24090431; PMCID: PMC3851189). *Authors contributed equally and are listed alphabetically
Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee, S.H., Ripke, S., Neale, B.M., Faraone, S.V., Purcell, S.M., Perlis, R.H., Mowry, B.J., Thapar, A., …[210 authors alphabetically listed], Morrow, E.M., Moskvina, V., …[125 authors alphabetically listed], Yu, T.W., Zammit, S., Zandi, P.P., Zhang, P., Zitman, F.G., Zöllner, S.; International Inflammatory Bowel Disease Genetics Consortium (IIBDGC), Devlin, B., Kelsoe, J.R., Sklar, P., Daly, M.J., O’Donovan, M.C., Craddock, N., Sullivan, P.F., Smoller, J.W., Kendler, K.S., and Wray, N.R. (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 45: 984-994 (PMID: 23933821; PMCID: PMC3800159).
Gamsiz, E.D., Viscidi, E.W., Frederick, A.M., Nagpal, S., Sanders, S.J., Murtha, M.T.; Simons Simplex Collection Genetics Consortium, Triche, E.W., Geschwind, D.H., State, M.W., Istrail, S., Cook, E.H. Jr., Devlin, B., and Morrow, E.M. (2013). Intellectual disability is associated with increased runs-of-homozygosity in simplex autism. Am J Hum Genet 93: 103-109 (PMID: 2380515; PMCID: PMC3710760).
Pescosolido, M.F., Gamsiz, E.D., Nagpal, S., and Morrow, E.M. (2013). Distribution of disease-associated copy number variants across distinct disorders of cognitive development. J Am Acad Child Adolesc Psychiatry 52: 414-430 (PMID: 23582872; PMCID: PMC3774163).
Minhas, H.M., Pescosolido, M.F., Schwede, M., Piasecka, J., Gaitanis, J., Tantravahi, U., and Morrow, E.M. (2013). An unbalanced translocation involving loss of 10q26.2 and gain of 11q25 in a pedigree with autism and cerebellar juvenile pilocytic astrocytoma. Am J Med Genet A 161A: 787-791 (PMID: 23495067; PMCID: PMC3606653).
Yeo, R.A., Gangestad, S.W., Liu, J., Ehrlich, S., Thoma, R.J., Pommy, J., Mayer, A.R., Schulz, S.C., Wassink, T.H., Morrow, E.M., Bustillo, J.R., Sponheim, S.R., Ho, B.C., and Calhoun, V.D. (2013). The impact of copy number deletions on general cognitive ability and ventricle size in patients with schizophrenia and healthy controls. Biol Psychiatry 73: 540-545 (PMID: 23237311; PMCID: PMC3582736).
Yu, T.W., Chahrour, M.H., Coulter, M.E., Jiralerspong, S., Okamura-Ikeda, K., Ataman, B., Schmitz-Abe, K., Harmin, D.A., Adli, M., Malik, A.N., D’Gama, A.M., Lim, E.T., Sanders, S.J., Mochida, G.H., Partlow, J.N., Sunu, C.M., Felie, J.M., Rodriguez, J., Nasir, R.H., Ware, J., Joseph, R.M., Hill, R.S., Kwan, B.Y., Al-Saffar, M., Mukaddes, N.M., Hashmi, A., Balkhy, S., Gascon, G.G., Hisama, F.M., LeClair, E., Poduri, A., Oner, O., Al-Saad, S., Al-Awadi, S.A., Bastaki, L., Ben-Omran, T., Teebi, A.S., Al-Gazali, L., Eapen, V., Stevens, C.R., Rappaport, L., Gabriel, S.B., Markianos, K., State, M.W., Greenberg, M.E., Taniguchi, H., Braverman, N.E., Morrow. E.M., and Walsh, C.A. (2013). Using whole-exome sequencing to identify inherited causes of autism. Neuron 77: 259-273 (PMID: 23352163; PMCID: PMC3694430). [cover photo]
Klei, L., Sanders, S.J., Murtha, M.T., Hus, V., Lowe, J.K., Willsey, A.J., Moreno-De-Luca, D., Yu, T.W., Fombonne, E., Geschwind, D., Grice, D.E., Ledbetter, D.H., Lord, C., Mane, S.M., Martin, C.L., Martin, D.M., Morrow, E.M., Walsh, C.A., Melhem, N.M., Chaste, P., Sutcliffe, J.S., State, M.W., Cook, E.H. Jr., Roeder, K., and Devlin, B. (2012). Common genetic variants, acting additively, are a major source of risk for autism. Mol Autism 3: 9 (PMID: 23067556; PMCID: PMC3579743).
Pescosolido, M.F., Yang, U., Sabbagh, M., and Morrow, E.M. (2012). Lighting a path: Genetic studies pinpoint neurodevelopmental mechanisms in autism and related disorders. Dialogues Clin Neurosci 14: 239-252 (PMID: 23226950; PMCID: PMC3513679).
Aguiar, D., Halldorsson, B.V., Morrow, E.M., and Istrail, S. (2012). DELISHUS: An Efficient and exact algorithm for genome-wide detection of hemizygous deletion polymorphism in autism. Bioinformatics 28: i154-i162 (PMID: 22689755; PMCID: PMC3371866).
Mefford, H.C., Rosenfeld, J.A., Shur, N., Slavotinek, A.M., Cox, V.A., Hennekam, R., Firth, H.V., Willatt, L., Wheeler, P., Morrow, E.M., Cook, J., Sullivan, R., Oh, A., Zonana, J., Keller, K., Hannibal, M.C., Ball, S., Kussmann, J., Gorski, J., Zelewski, S., Banks, V., Smith, W., Smith, R., Paull, L., Rosenbaum, K.N., Amor, D.J., Silva, J., Lamb, A., and Eichler, E.E. (2012). Further clinical and molecular delineation of the 15q24 microdeletion syndrome: Fifteen newly reported patients and two atypical deletions. J Med Genet 49: 110-118 (PMID: 22180641; PMCID: PMC3261729).
Sofos, E., Pescosolido, M.F., Quintos, J.B., Abuelo, D., Gunn, S., Hovanes, K., Morrow, E.M., and Shur, N. (2012). A novel familial 11p15.4 microduplication associated with intellectual disability, dysmorphic features, and obesity with involvement of the ZNF214 gene. Am J Med Genet A 158A: 50-58 (PMID: 22052655).
Sanders, S.J., Ercan-Sencicek, A.G., Hus, V., Luo, R., Murtha, M.T., Moreno-De-Luca, D., Chu, S.H., Moreau, M.P., Gupta, A.R., …[46 authors], Morrow, E.M., Ledbetter, D.H., Fombonne, E., Lord, C., Martin, C.L., Brooks, A.I., Sutcliffe, J.S., Cook, E.H. Jr., Geschwind, D., Roeder, K., Devlin, B., and State, M.W. (2011). Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron 70: 863-885 (PMID: 21658581; PMCID: PMC3939065).
Johnson, H.M., Gaitanis, J., and Morrow, E.M. (2011). Genetics in Autism Diagnosis: Adding Molecular Subtypes to Neurobehavioral Diagnosis. Med Health RI 94: 124-126.
Morrow, E.M. (2011). Commentary: Genetic Testing Makes Important Contributions to Autism Diagnosis. The Brown University Child and Adolescent Behavior Letter 27: 8.
Morrow, E.M. (2010). Genomic copy number variation in disorders of cognitive development. J Am Acad Child Adolesc Psychiatry 49: 1091-1104 (PMID: 20970697; PMCID: PMC3137887).
Ching, M.S., Shen, Y., Tan, W.H., Jeste, S.S., Morrow, E.M., Mukaddes, N.M., Yoo, S.Y., Hanson, E., Hundley, R., Austin, C., Becker, R.E., Berry, G.T., Driscoll, K., Engle, E.C., Friedman, S., Gusella, J.F., Hisama, F.M., Irons, M.B., Lafiosca, T., LeClair, E., Miller, D.T., Neessen, M., Picker, J.D., Rappaport, L., Rooney, C.M., Sarco, D.P., Stoler, J.M., Walsh, C.A., Wolff, R.R., Zhang, T., Nasir, R., and Wu, B.L. (2010). Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders. Am J Med Genet B Neuropsychiatr Genet 153B: 937-947 (PMID: 20468056; PMCID: PMC3001124).
Ehrlich, S., Morrow, E.M., Roffman, J.L., Wallace, S.R., Naylor, M., Bockholt, H.J., Lundquist, A., Yendiki, A., Ho, B., White, T., Manoach, D.S., Clark, V.P., Calhoun, V.D., Gollub, R.L., and Holt, D.J. (2010). The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults. Neuroimage 53: 992-1000 (PMID: 20026221; PMCID: PMC2888809).
Weiss, L.A., Arking, D.E.; Gene Discovery Project of Johns Hopkins and the Autism Consortium, …[16 authors], Korn, J., Kuruvilla, F., McCarroll, S., Morrow, E.M., Neale, B., Purcell, S., …[170 authors], Daly, M.J., and Chakravarti, A. (2009). A genome-wide linkage and association scan reveals novel loci for autism. Nature 461: 802-808 (PMID: 19812673; PMCID: PMC2772655).
Morrow, E.M., Yoo, S.Y., Flavell, S.W., Kim, T.K., Lin, Y., Hill, R.S., Mukaddes, N.M., Balkhy, S., Gascon, G., Hashmi, A., Al-Saad, S., Ware, J., Joseph, R.M., Greenblatt, R., Gleason, D., Ertelt, J.A., Apse, K.A., Bodell, A., Partlow, J.N., Barry, B., Yao, H., Markianos, K., Ferland, R.J., Greenberg, M.E., and Walsh, C.A. (2008). Identifying autism loci and genes by tracing recent shared ancestry. Science 321: 218-223 (PMID: 18621663; PMCID: PMC2586171). [cover photo]
Morrow, E.M. and Smoller, J.W. (2006). The Interface of Genetics and Clinical Psychiatry: Introduction. Harv Rev Psychiatry 14: 45-46. (Invited Editorial)
Clinical Phenotype and Neuropsychiatry
Books and Book Chapters
Eric M. Morrow, Joshua L. Roffman, Daniel H. Wolf, and Joseph T. Coyle. "Psychiatric Neuroscience: Incorporating Pathophysiology into Clinical Case Formulation" In: Theodore A. Stern, Jerrold F. Rosenbaum, Maurizio Fava, Joseph Biederman, and Scott Rauch, eds. Massachusetts General Hospital: Comprehensive Clinical Psychiatry. Philadelphia: Mosby/Elsevier. 2008, 543-564. [cover photo]
Eric M. Morrow. "The boy that is happiest when left alone" In: Sandra I. Kim, Todd A. Swanson, and Jonathan D. Wasserman, eds. Underground Clinical Vignettes: Pediatrics 4th ed. Lippincott Williams & Wilkins, 2007.
Journal Articles and Reviews
McCormick, C.E.B., Kavanaugh, B.C., Sipsock, D., Righi, G., Oberman, L.M., Moreno De Luca, D., Gamsiz Uzun, E.D., Best, C.R., Jerskey, B.A., Quinn, J.G., Jewel, S.B., Wu, P.-C., McLean, R.L., Levine, T.P., Tokadjian, H., Perkins, K.A., Clarke, E.B., Dunn, B., Gerber, A.H., Tenenbaum, E.J., Anders, T.F., Rhode Island Consortium for Autism Research and Treatment (RI-CART); Sheinkopf, S.J., and Morrow, E.M. (2020). Autism heterogeneity in a densely sampled U.S. population: Results from the first 1,000 participants in the RI-CART study. Autism Res 13: 474-488 (PMID: 31957984; PMCID: PMC7060113).
Kavanaugh, B.C., Warren, E.B., Baytas, O., Schmidt, M., Merck, D., Buch, K., Liu, J.S., Phornphutkul, C., Caruso, P., and Morrow, E.M. (2019). Longitudinal MRI findings in patient with SLC25A12 pathogenic variants inform disease progression and classification. Am J Med Genet A 179: 2284-2291 (PMID: 31403263; PMCID: PMC6788951).
Ouyang, Q., Kavanaugh, B.C., Joesch-Cohen, L., Dubois, B., Wu, Q., Schmidt, M., Baytas, O., Pastore, S.F., Harripaul, R., Mishra, S., Hussain, A., Kim, K.H., Holler-Managan, Y.F., Ayub, M., Mir, A., Vincent, J.B., Liu, J.S., and Morrow, E.M. (2019). GPT2 mutations in autosomal recessive developmental disability: Extending the clinical phenotype and population prevalence estimates. Hum Genet 138: 1183-1200 (PMID: 31471722; PMCID: PMC6748651).
Pescosolido, M.F., Kavanaugh, B.C., Pochet, N., Schmidt, M., Jerskey, B.A., Rogg, J.M., De Jager, P.L., Young-Pearse, T.L., Liu, J.S., and Morrow, E.M. (2019). Complex neurological phenotype in female carriers of NHE6 mutations. Mol Neuropsychiatry 5: 98-108 (PMID: 31192222; PMCID: PMC6528080).
Morrow, E.M. and Pescosolido, M.F. (2018). “Christianson Syndrome” In: Margaret P. Adam, Holly H. Ardinger, Roberta A. Pagon, Stephanie E. Wallace, Lora J.H. Bean, Karen Stephens, and Anne Amemiya, eds. GeneReviews [Internet]. Seattle, WA: University of Washington, Seattle (PMID: 29334451; Bookshelf ID: NBK475801).
Baytas, O., and Morrow, E.M. (2018). The role of mitochondrial glutamate metabolism in cognitive development and disease. Neuropsychopharmacology 43: 229-230 (PMID: 29192671; PMCID: PMC5719109). [invited Neuropsychopharmacology Reviews Hot Topic]
Righi, G., Benevides, J., Mazefsky, C., Siegel, M., Sheinkopf, S.J., Morrow, E.M.; and Autism and Developmental Disorders Inpatient Research Collaborative (ADDIRC) (2018). Predictors of inpatient psychiatric hospitalization for children and adolescents with Autism Spectrum Disorder. J Autism Dev Disord 48: 3647-3657 (PMID: 28536960; PMCID: PMC5924458).
Wink, L.K., Pedapati, E.V., Adams, R., Erickson, C.A., Pedersen, K.A., Morrow, E.M., Kaplan, D., Siegel, M.; and Autism and Developmental Disorders Inpatient Research Collaborative (ADDIRC) (2018). Characterization of medication use in a multicenter sample of pediatric inpatients with Autism Spectrum Disorder. J Autism Dev Disord 48: 3711-3719 (PMID: 28516426; PMCID: Not Applicable).
Gerber, A.H., McCormick, C.E.B., Levine, T.P., Morrow, E.M., Anders, T.F., and Sheinkopf, S.J. (2017). Brief report: Factors influencing healthcare satisfaction in adults with Autism Spectrum Disorder. J Autism Dev Disord 47: 1896-1903 (PMID: 28271179; PMCID: Not Applicable).
Yeo, R.A., Ryman, S.G., van den Heuvel, M.P., de Reus, M.A., Jung, R.E., Pommy, J., Mayer, A.R., Ehrlich, S., Schulz, S.C., Morrow, E.M., Manoach, D., Ho, B.C., Sponheim, S.R., and Calhoun, V.D. (2016). Graph metrics of structural brain networks in individuals with schizophrenia and healthy controls: Group differences, relationships with intelligence, and genetics. J Int Neuropsychol Soc 22: 240-249 (PMID: 26888620).
Siegel, M., Smith, K.A., Mazefsky, C., Gabriels, R.L., Erickson, C., Kaplan, D., Morrow, E.M., Wink, L., Santangelo, S.L.; and Autism and Developmental Disorders Inpatient Research Collaborative (ADDIRC) (2015). The autism inpatient collection: Methods and preliminary sample description. Mol Autism 6: 61 (PMID: 26557975; PMCID: PMC4640153).
Howe, Y.J., O’Rourke, J.A., Yatchmink, Y., Viscidi, E.W., Jones, R.N., and Morrow, E.M. (2015). Female autism phenotypes investigated at different levels of language and developmental abilities. J Autism Dev Disord 45: 3537-3549 (PMID: 26100851; PMCID: PMC4609595).
Harrison, A.J., Zimak, E.H., Sheinkopf, S.J., Manji, K.P., and Morrow, E.M. (2014). Observation-centered approach to ASD assessment in Tanzania. Intellect Dev Disabil 52: 330-347 (PMID: 25247726).
McLean, R.L., Johnson Harrison, A., Zimak, E., Joseph, R.M., and Morrow, E.M. (2014). Executive function in probands with autism with average IQ and their unaffected first-degree relatives. J Am Acad Child Adolesc Psychiatry 53: 1001-1009 (PMID: 25151423; PMCID: PMC4144046).
Howe, Y.J., Yatchmink, Y., Viscidi, E.W., and Morrow, E.M. (2014). Ascertainment and gender in autism spectrum disorders. J Am Acad Child Adolesc Psychiatry 53: 698-700 (PMID: 24839890; PMCID: PMC4288969).
Viscidi, E.W., Johnson, A.L., Spence, S.J., Buka, S.L., Morrow, E.M.*, and Triche, E.W. (2014). The association between epilepsy and autism symptoms and maladaptive behaviors in children with autism spectrum disorder. Autism 18: 996-1006 (PMID: 24165273; PMCID: PMC4002664).
*Corresponding author
Viscidi, E.W., Triche, E.W., Pescosolido, M.F., McLean, R.L., Joseph, R.M., Spence, S.J., and Morrow, E.M. (2013). Clinical characteristics of children with autism spectrum disorder and co-occurring epilepsy. PLoS One 8: e67797 (PMID: 23861807; PMCID: PMC3701630).
Chaste, P., Klei, L., Sanders, S.J., Murtha, M.T., Hus, V., Lowe, J.K., Willsey, A.J., Moreno-De-Luca, D., Yu, T.W., Fombonne, E., Geschwind, D., Grice, D.E., Ledbetter, D.H., Lord, C., Mane, S.M., Lese Martin, C., Martin, D.M., Morrow, E.M., Walsh, C.A., Sutcliffe, J.S., State, M.W., Devlin, B., Cook, E.H. Jr., and Kim, S.-J. (2013). Adjusting head circumference for covariates in autism: Clinical correlates of a highly heritable continuous trait. Biol Psychiatry 74: 576-584 (PMID: 23746936; PMCID: PMC3772969).
Cellular Mechanisms
Books and Book Chapters
Eric M. Morrow. "Neuronal Physiology and the Autonomic Nervous System" In: Drs. Seifter, Ratner, and Sloane, eds. Concepts in Medical Physiology. Lippincott Williams & Wilkins. October 2005.
Journal Articles and Reviews
Lizarraga, S.B., Ma, L., Maguire, A.M., van Dyck, L.I., Wu, Q., Ouyang, Q., Kavanaugh, B.C., Nagda, D., Livi, L.L., Pescosolido, M.F., Schmidt, M., Alabi, S., Cowen, M.H., Brito-Vargas, P., Hoffman-Kim, D., Gamsiz Uzun, E.D., Schlessinger, A., Jones, R.N., and Morrow, E.M. (2021). Human neurons from Christianson syndrome iPSCs reveal mutation-specific responses to rescue strategies. Sci Transl Med 13: eaaw0682 (PMID: 33568516; PMCID: PMC7888381).
Ouyang, Q., Joesch-Cohen, L., Mishra, S., Riaz, H.A., Schmidt, M., and Morrow, E.M. (2019). Functional assessment in vivo of the mouse homolog of the human ala-9-ser NHE6 variant. eNeuro 6: ENEURO.0046-19.2019 (PMID: 31676550; PMCID: PMC6893231).
Schwede, M., Nagpal, S., Gandal, M.J., Parikshak, N.N., Mirnics, K., Geschwind, D.H., and Morrow, E.M. (2018). Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex. J Neurodev Disord 10: 18 (PMID: 29859039; PMCID: PMC5984825).
Xu, M., Ouyang, Q., Gong, J., Pescosolido, M.F., Pruett, B.S., Mishra, S., Schmidt, M., Jones, R.N., Gamsiz Uzun, E.D., Lizarraga, S.B., and Morrow, E.M. (2017). Mixed neurodevelopmental and neurodegenerative pathology in Nhe6-null mouse model of Christianson syndrome. eNeuro 4: ENEURO.0388-17.2017 (PMID: 29349289; PMCID: PMC5771691).
Ma, L., Ouyang, Q., Werthmann, G.C., Thompson, H.M., and Morrow, E.M. (2017). Live-cell microscopy and fluorescence-based measurement of luminal pH in intracellular organelles. Front Cell Dev Biol 5: 71 (PMID: 28871281; PMCID: PMC5566985).
Ouyang, Q., Nakayama, T., Baytas, O., Davidson, S.M., Yang, C., Schmidt, M., Lizarraga, S.B., Mishra, S., El-Quessny, M., Niaz, S., Gul Butt, M., Imran Murtaza, S., Javed, A., Chaudhry, H.R., Vaughan, D.J., Hill, R.S., Partlow, J.N., Yoo, S.-Y., Lam, A.-T.N., Nasir, R., Al-Saffar, M., Barkovich, A.J., Schwede, M., Nagpal, S., Rajab, A., DeBerardinis, R.J., Housman, D.E., Mochida, G.H., and Morrow, E.M. (2016). Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features. Proc Natl Acad Sci USA 113: E5598-E5607 (PMID: 27601654; PMCID: PMC5035873).
Young-Pearse, T.L. and Morrow, E.M. (2016). Modeling developmental neuropsychiatric disorders with iPSC technology: Challenges and opportunities. Curr Opin Neurobiol 36: 66-73 (PMID: 26517284; PMCID: PMC4738093). (Invited review for issue on Neurobiology of Disease)
Brennand, K.J., Marchetto, M.C., Benvenisty, N., Brüstle, O., Ebert, A., Izpisua Belmonte, J.C., Kaykas, A., Lancaster, M.A., Livesey, F.J., McConnell, M.J., McKay, R.D., Morrow, E.M., Muotri, A.R., Panchision, D.M., Rubin, L.L., Sawa, A., Soldner, F., Song, H., Studer, L., Temple, S., Vaccarino, F.M., Wu, J., Vanderhaeghen, P., Gage, F.H., and Jaenisch, R. (2015). Creating patient-specific neural cells for the in vitro study of brain disorders. Stem Cell Reports 5: 933-945 (PMID: 26610635; PMCID: PMC4881284).
Lizarraga, S.B. and Morrow, E.M. (2015). Uncovering a role for SK2 in Angelman Syndrome. Cell Rep 12: 359-360 (PMID: 26200312). (Invited Commentary)
Gamsiz, E.D., Sciarra, L.N., Maguire, A.M., Pescosolido, M.F., van Dyck, L.I., and Morrow, E.M. (2015). Discovery of rare mutations in autism: Elucidating neurodevelopmental mechanisms. Neurotherapeutics 12: 553-571 (PMID: 26105128; PMCID: PMC4489950).
Ouyang, Q., Lizarraga, S.B., Schmidt, M., Yang, U., Gong, J., Ellisor, D., Kauer, J.A., and Morrow, E.M. (2013). Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development. Neuron 80: 97-112 (PMID: 24035762; PMCID: PMC3830955). [cover photo]
Schwede, M., Garbett, K., Mirnics, K., Geschwind, D.H., and Morrow, E.M. (2014). Genes for endosomal NHE6 and NHE9 are misregulated in autism brains. Mol Psychiatry 19: 277-279 (PMID: 23508127; PMCID: PMC3932404).
Lizarraga, S.B., Coser, K.R., Sabbagh, M., and Morrow, E.M. (2012). Methods for study of neuronal morphogenesis: Ex vivo RNAi electroporation in embryonic murine cerebral cortex. J Vis Exp 63: 3621 (PMID: 22643694; PMCID: PMC3369626).
Gamsiz, E.D., Ouyang, Q., Schmidt, M., Nagpal, S. and Morrow, E.M. (2012). Genome-wide transcriptome analysis in murine neural retina using high-throughput RNA sequencing. Genomics 99: 44-51 (PMID: 22032952; PMCID: PMC3392719).
Walsh, C.A., Morrow, E.M., and Rubenstein, J.L. (2008). Autism and brain development. Cell 135: 396-400 (PMID: 18984148; PMCID: PMC2701104).
| Year | Degree | Institution |
|---|---|---|
| 2007 | MSc | Harvard University |
| 2001 | MD | Harvard University |
| 1998 | PhD | Harvard University |
| 1992 | ScB | Massachusetts Institute of Technology |
2019-present Member, American College of Neuropsychopharmacology
2017 NARSAD Independent Investigator Grant
2017 Presidential Early Career Award for Scientists and Engineers (PECASE), White House Office of Science and Technology Policy, Executive Office of the President of the United States of America, Barack Obama administration
2016 Master of Arts ad eundem, Brown University
2014 Society of Biological Psychiatry A.E. Bennett Research Award in Clinical/Translational Research
2014-2018 Associate Member, American College of Neuropsychopharmacology
2012-present Investigator, Simons Foundation Autism Research Initiative
2011-2012 Psychiatry Research Mentor Award, Department of Psychiatry & Human Behavior, Warren Alpert Medical School of Brown University
2009 Roche/Nature Medicine Junior Investigator Award in Translational Neuroscience
2008 American Society of Human Genetics Trainee Award, Postdoctoral Finalist
2007 Burroughs Wellcome Career Award for Medical Scientists
2007 NARSAD Young Investigator Grant (Sidney R. Baer, Jr. Foundation Investigator)
2007 Massachusetts General Hospital Rappaport Neuroscience Scholarship
2007 Charles H. Hood Foundation Child Health Research Award
2005 Thomas P. Hackett Award, Massachusetts General Hospital
2003 National Institute of Mental Health Outstanding Resident Award
2001 Harold Lamport Biomedical Research Prize, Harvard Medical School
| Name | Title |
|---|---|
| Barnea, Gilad | Sidney A. Fox and Dorothea Doctors Fox Professor of Ophthalmology and Visual Science, Professor of Neuroscience, Director of the Center for the Neurobiology of Cells and Circuits, NIH Graduate Partnership Program (NIH GPP) Director |
| Buka, Stephen | Professor of Epidemiology |
| Gaitanis, John | Associate Professor of Pediatrics, Clinician Educator |
| Hoffman-Kim, Diane | Associate Professor of Neuroscience, Chair, Brown University Institutional Animal Care and Use Committee, Associate Professor of Engineering |
| Istrail, Sorin | James A. and Julie N. Brown Professor of Computational and Mathematical Sciences |
| Kauer, Julie | Adjunct Professor of Molecular Pharmacology, Physiology and Biotechnology |
| Phornphutkul, Chanika | Professor of Pediatrics, Clinician Educator, Professor of Pathology and Laboratory Medicine, Clinician Educator |
| Rogg, Jeffrey | Professor of Diagnostic Imaging, Clinician Educator |
| Sheinkopf, Stephen | Associate Professor of Psychiatry and Human Behavior, Associate Professor of Pediatrics |
| Tantravahi, Umadevi | Professor Emerita of Pathology and Laboratory Medicine, Clinician Educator |
| Triche, Elizabeth | Adjunct Assistant Professor of Epidemiology |
American Association for the Advancement of Science
American Society of Human Genetics
Autism Science Foundation
Autism and Developmental Disorders Inpatient Research Collaborative (ADDIRC)
Autism Sequencing Consortium
Developmental Disorders Genetics Research Program (DDGRP)
International Society for Autism Research
National Association for the Dually Diagnosed
Rhode Island Consortium for Autism Research and Treatment (RI-CART)
Society of Biological Psychiatry
Society for Developmental Biology
Society for Neuroscience
Dr. Morrow's teaching and mentorship bridges from the classroom to the clinic. He enjoys taking an active role in, and is dedicated to, mentoring students and junior faculty. He has formally mentored numerous undergraduate students, graduate students, medical students, post-doctoral research assistants, and junior faculty. These mentoring activities range from supervision of short-term independent research projects or research rotations to serving as a graduate program thesis advisor to sponsoring clinical and basic research post-doctoral research assistants. Dr. Morrow received the 2011-2012 Psychiatry Research Mentor Award from the Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University.
| BIOL 1545 - Human Genetics and Genomics |
| BIOL 2340 - Neurogenetics and Disease |
| BIOL 2545 - Human Genetics and Genomics |
