Ted Wilson, PhD, is the Provost’s Assistant Professor of Neuroimmunology and Brain Science in the Department of Neuroscience at Brown University. His research focuses on the cellular mechanisms that shape vulnerability and resilience in neurodegenerative disease. His laboratory integrates a range of experimental approaches to address three interconnected priorities: defining the cellular neurobiology underlying neurodegeneration, identifying new therapeutic targets, and developing biomarkers and diagnostic platforms to advance precision and personalized medicine.
Dr. Wilson earned his PhD in Neuroscience at McGill University, where he developed a foundation in molecular and cellular approaches to brain disease. He then pursued postdoctoral training at Stanford University, expanding his expertise in neuroinflammation, aging, and mechanisms of resilience to neurodegenerative pathology.
Dr. Wilson’s research program aims to bridge basic mechanistic insight with clinical translation, with the long-term goal of enabling earlier detection and intervention strategies for neurodegenerative diseases.
| Do AN, Song S, Ali M, Timsina J, Wang L, Western D, Liu M, Sanford J, Rosende-Roca M, Boada M, Puerta R, Wilson EN, Ruiz A, Pastor P, Alzheimer's Disease Neuroimaging Initiative (ADNI), Wyss-Coray T, Cruchaga C, Sung YJ. "CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex-specific alteration of multiple proteins involved in Alzheimer's disease." Alzheimer's & Dementia, vol. 22, no. 1, 2026, pp. e71063. |
| Oh HS, Urey DY, Karlsson L, Zhu Z, Shen Y, Farinas A, Timsina J, Duggan MR, Chen J, Guldner IH, Morshed N, Yang C, Western D, Ali M, Le Guen Y, Trelle A, Herukka SK, Rauramaa T, Hiltunen M, Lipponen A, Luikku AJ, Poston KL, Mormino E, Wagner AD, Wilson EN, Channappa D, Leinonen V, Stevens B, Ehrenberg AJ, Gottesman RF, Coresh J, Walker KA, Zetterberg H, Bennett DA, Franzmeier N, Hansson O, Cruchaga C, Wyss-Coray T. "A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease." Nature Medicine, vol. 31, no. 5, 2025, pp. 1592-1603. |
| Grandke F, Fehlmann T, Kern F, Gate DM, Wolff TW, Leventhal O, Channappa D, Hirsch P, Wilson EN, Meese E, Liu C, Shi Q, Flotho M, Li Y, Chen C, Yu Y, Xu J, Junkin M, Wang Z, Wu T, Liu L, Hou Y, Andreasson KI, Gansen JS, Mass E, Poston K, Wyss-Coray T, Keller A. "A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration." Nature Communications, vol. 16, no. 1, 2025, pp. 1965. |
| Ali M, Timsina J, Western D, Liu M, Beric A, Budde J, Do A, Heo G, Wang L, Gentsch J, Schindler SE, Morris JC, Holtzman DM, Ruiz A, Alvarez I, Aguilar M, Pastor P, Rutledge J, Oh H, Wilson EN, Guen YL, Khalid RR, Knight Alzheimer Disease Research Center (Knight ADRC), Alzheimer Disease Neuroimaging Initiative (ADNI), Fundació ACE Alzheimer Center Barcelona (FACE), Barcelona-1, Stanford Alzheimer Disease Research Center (Stanford ADRC), Robins C, Pulford DJ, Tarawneh R, Ibanez L, Wyss-Coray T, Sung YJ, Cruchaga C. "Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum." Neuron, vol. 113, no. 9, 2025, pp. 1363-1379.e9. |
| Wilson EN, Umans J, Swarovski MS, Minhas PS, Mendiola JH, Midttun Ø, Ulvik A, Shahid-Besanti M, Linortner P, Mhatre SD, Wang Q, Channappa D, Corso NK, Tian L, Fredericks CA, Kerchner GA, Plowey ED, Cholerton B, Ueland PM, Zabetian CP, Gray NE, Quinn JF, Montine TJ, Sha SJ, Longo FM, Wolk DA, Chen-Plotkin A, Henderson VW, Wyss-Coray T, Wagner AD, Mormino EC, Aghaeepour N, Poston KL, Andreasson KI. "Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction." NPJ Parkinson's disease, vol. 11, no. 1, 2025, pp. 96. |
| Trelle AN, Young CB, Vossler H, Ramos Benitez J, Cody KA, Mendiola JH, Swarovski MS, Guen YL, Feinstein I, Butler RR 3rd, Channappa D, Romero A, Park J, Shahid-Besanti M, Corso NK, Chau K, Smith AN, Skylar-Scott I, Yutsis MV, Fredericks CA, Tian L, Younes K, Kerchner GA, Deutsch GK, Davidzon GA, Sha SJ, Henderson VW, Longo FM, Greicius MD, Wyss-Coray T, Andreasson KI, Poston KL, Wagner AD, Mormino EC, Wilson EN. "Plasma Aβ(42)/Aβ(40) is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum." Alzheimer's & Dementia, vol. 21, no. 2, 2025, pp. e14442. |
| Trelle AN, Cody KA, Nguyen TT, Winer JR, Weiss S, Sai I, Channappa D, Mendiola J, Al-Rajhi A, Raghuraman K, Sha SJ, Wilson EN, Wyss-Coray T, Wagner AD, Maecker HT, Mormino EC. "Plasma proteomic signatures of preclinical Alzheimer's disease biomarkers and memory in clinically unimpaired older adults." medRxiv : the preprint server for health sciences, 2025. |
| Trelle AN, Sheng J, Wilson EN, Romero A, Park J, Deutsch GK, Sha SJ, Greicius MD, Andreasson KI, Kerchner GA, Mormino EC, Wagner AD. "Synergistic effects of APOE ε4 and Alzheimer's pathology on the neural correlates of episodic remembering in cognitively unimpaired older adults." bioRxiv : the preprint server for biology, 2025. |
| Sheng J, Trelle AN, Romero A, Park J, Tran TT, Sha SJ, Andreasson KI, Wilson EN, Mormino EC, Wagner AD. "Top-down attention and Alzheimer's pathology affect cortical selectivity during learning, influencing episodic memory in older adults." Science Advances, vol. 11, no. 24, 2025, pp. eads4206. |
| Winer JR, Vossler H, Young CB, Smith V, Romero A, Shahid-Besanti M, Abdelnour C, Wilson EN, Anders D, Pacheco Morales A, Andreasson KI, Yutsis MV, Henderson VW, Davidzon GA, Mormino EC, Poston KL. "(18)F-PI-2620 Tau PET is associated with cognitive and motor impairment in Lewy body disease." Brain communications, vol. 7, no. 1, 2024, pp. fcae458. |
| Young CB, Vossler H, Romero A, Smith V, Park J, Trelle AN, Winer JR, Wilson EN, Zeineh MM, Sha SJ, Khalighi M, Yutsis MV, Morales AP, Anders D, Zaharchuk G, Henderson VW, Andreasson KI, Wagner AD, Poston KL, Davidzon GA, Mormino EC. "[18F]PI-2620 Tau PET signal across the aging and Alzheimer's disease clinical spectrum." Imaging neuroscience (Cambridge, Mass.), vol. 2, 2024. |
| Cruchaga C, Ali M, Shen Y, Do A, Wang L, Western D, Liu M, Beric A, Budde J, Gentsch J, Schindler S, Morris J, Holtzman D, Fernández M, Ruiz A, Alvarez I, Aguilar M, Pastor P, Rutledge J, Oh H, Wilson E, Le Guen Y, Khalid R, Robins C, Pulford D, Ibanez L, Wyss-Coray T, Ju Sung Y. "Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer's disease." Research square, 2024. |
| Plastini MJ, Abdelnour C, Young CB, Wilson EN, Shahid-Besanti M, Lamoureux J, Andreasson KI, Kerchner GA, Montine TJ, Henderson VW, Poston KL. "Multiple biomarkers improve diagnostic accuracy across Lewy body and Alzheimer's disease spectra." Annals of Clinical and Translational Neurology, vol. 11, no. 5, 2024, pp. 1197-1210. |
| Guilliot S, Wilson EN, Touchon J, Soto ME. "Nanolithium, a New Treatment Approach to Alzheimer's Disease: A Review of Existing Evidence and Clinical Perspectives." The journal of prevention of Alzheimer's disease, vol. 11, no. 2, 2024, pp. 428-434. |
| Wilson E, Umans J, Swarovski M, Minhas P, Midttun Ø, Ulvik AA, Shahid-Besanti M, Linortner P, Mhatre S, Wang Q, Channappa D, Corso N, Tian L, Fredericks C, Kerchner G, Plowey E, Cholerton B, Ueland P, Zabetian C, Gray N, Quinn J, Montine T, Sha S, Longo F, Wolk D, Chen-Plotkin A, Henderson V, Wyss-Coray T, Wagner A, Mormino E, Aghaeepour N, Poston K, Andreasson K. "Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction." Research square, 2024. |
| Abdelnour C, Young CB, Shahid-Besanti M, Smith A, Wilson EN, Ramos Benitez J, Vossler H, Plastini MJ, Winer JR, Kerchner GA, Cholerton B, Andreasson KI, Henderson VW, Yutsis M, Montine TJ, Tian L, Mormino EC, Poston KL. "Plasma pTau181 Reveals a Pathological Signature that Predicts Cognitive Outcomes in Lewy Body Disease." Annals of Neurology, vol. 96, no. 3, 2024, pp. 526-538. |
| Abiose O, Rutledge J, Moran-Losada P, Belloy ME, Wilson EN, He Z, Trelle AN, Channappa D, Romero A, Park J, Yutsis MV, Sha SJ, Andreasson KI, Poston KL, Henderson VW, Wagner AD, Wyss-Coray T, Mormino EC. "Post-translational modifications linked to preclinical Alzheimer's disease-related pathological and cognitive changes." Alzheimer's & Dementia, vol. 20, no. 3, 2024, pp. 1851-1867. |
| Western D, Timsina J, Wang L, Wang C, Yang C, Phillips B, Wang Y, Liu M, Ali M, Beric A, Gorijala P, Kohlfeld P, Budde J, Levey AI, Morris JC, Perrin RJ, Ruiz A, Marquié M, Boada M, de Rojas I, Rutledge J, Oh H, Wilson EN, Le Guen Y, Reus LM, Tijms B, Visser PJ, van der Lee SJ, Pijnenburg YAL, Teunissen CE, Del Campo Milan M, Alvarez I, Aguilar M, Dominantly Inherited Alzheimer Network (DIAN), Alzheimer’s Disease Neuroimaging Initiative (ADNI), Greicius MD, Pastor P, Pulford DJ, Ibanez L, Wyss-Coray T, Sung YJ, Cruchaga C. "Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease." Nature Genetics, vol. 56, no. 12, 2024, pp. 2672-2684. |
| Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Uenaka T, Wang Q, Mhatre SD, Liu L, Conley T, Ennerfelt H, Jung YJ, Prasad P, Jenkins BC, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Ullian EM, Serrano GE, Beach TG, Rabinowitz JD, Wernig M, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI. "Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies." bioRxiv : the preprint server for biology, 2024. |
| Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Wang Q, Mhatre SD, Uenaka T, Crapser J, Conley T, Ennerfelt H, Jung YJ, Liu L, Prasad P, Jenkins BC, Ay YA, Matrongolo M, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Yang T, Ullian EM, Serrano GE, Beach TG, Wernig M, Rabinowitz JD, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI. "Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies." Science, vol. 385, no. 6711, 2024, pp. eabm6131. |
| Sheng J, Trelle AN, Romero A, Park J, Tran TT, Sha SJ, Andreasson KI, Wilson EN, Mormino EC, Wagner AD. "Top-down attention and Alzheimer's pathology impact cortical selectivity during learning, influencing episodic memory in older adults." bioRxiv : the preprint server for biology, 2024. |
| Wilson EN, Wang C, Swarovski MS, Zera KA, Ennerfelt HE, Wang Q, Chaney A, Gauba E, Ramos Benitez JA, Le Guen Y, Minhas PS, Panchal M, Tan YJ, Blacher E, A Iweka C, Cropper H, Jain P, Liu Q, Mehta SS, Zuckerman AJ, Xin M, Umans J, Huang J, Durairaj AS, Serrano GE, Beach TG, Greicius MD, James ML, Buckwalter MS, McReynolds MR, Rabinowitz JD, Andreasson KI. "TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models." Nature Neuroscience, vol. 27, no. 5, 2024, pp. 873-885. |
| Oh HS, Rutledge J, Nachun D, Pálovics R, Abiose O, Moran-Losada P, Channappa D, Urey DY, Kim K, Sung YJ, Wang L, Timsina J, Western D, Liu M, Kohlfeld P, Budde J, Wilson EN, Guen Y, Maurer TM, Haney M, Yang AC, He Z, Greicius MD, Andreasson KI, Sathyan S, Weiss EF, Milman S, Barzilai N, Cruchaga C, Wagner AD, Mormino E, Lehallier B, Henderson VW, Longo FM, Montgomery SB, Wyss-Coray T. "Organ aging signatures in the plasma proteome track health and disease." J. Geophys. Res., vol. 624, no. 7990, 2023, pp. 164-172. |
| Chaney AM, Cropper HC, Jain P, Wilson E, Simonetta F, Johnson EM, Alam IS, Patterson ITJ, Swarovski M, Stevens MY, Wang Q, Azevedo C, Nagy SC, Ramos Benitez J, Deal EM, Vogel H, Andreasson KI, James ML. "PET imaging of TREM1 identifies CNS-infiltrating myeloid cells in a mouse model of multiple sclerosis." Science Translational Medicine, vol. 15, no. 702, 2023, pp. eabm6267. |
| Cruchaga C, Western D, Timsina J, Wang L, Wang C, Yang C, Ali M, Beric A, Gorijala P, Kohlfeld P, Budde J, Levey A, Morris J, Perrin R, Ruiz A, Marquié M, Boada M, de Rojas I, Rutledge J, Oh H, Wilson E, Guen YL, Alvarez I, Aguilar M, Greicius M, Pastor P, Pulford D, Ibanez L, Wyss-Coray T, Sung YJ, Phillips B. "Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer's disease." Research square, 2023. |
| Shuken SR, Rutledge J, Iram T, Losada PM, Wilson EN, Andreasson KI, Leib RD, Wyss-Coray T. "Limited Proteolysis-Mass Spectrometry Reveals Aging-Associated Changes in Cerebrospinal Fluid Protein Abundances and Structures." Nature aging, vol. 2, no. 5, 2022, pp. 379-388. |
| Wilson EN, Young CB, Ramos Benitez J, Swarovski MS, Feinstein I, Vandijck M, Le Guen Y, Kasireddy NM, Shahid M, Corso NK, Wang Q, Kennedy G, Trelle AN, Lind B, Channappa D, Belnap M, Ramirez V, Skylar-Scott I, Younes K, Yutsis MV, Le Bastard N, Quinn JF, van Dyck CH, Nairn A, Fredericks CA, Tian L, Kerchner GA, Montine TJ, Sha SJ, Davidzon G, Henderson VW, Longo FM, Greicius MD, Wagner AD, Wyss-Coray T, Poston KL, Mormino EC, Andreasson KI. "Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease." Alzheimer's research & therapy, vol. 14, no. 1, 2022, pp. 172. |
| Arnold MR, Coughlin DG, Brumbach BH, Smirnov DS, Concha-Marambio L, Farris CM, Ma Y, Kim Y, Wilson EN, Kaye JA, Hiniker A, Woltjer RL, Galasko DR, Quinn JF. "α-Synuclein Seed Amplification in CSF and Brain from Patients with Different Brain Distributions of Pathological α-Synuclein in the Context of Co-Pathology and Non-LBD Diagnoses." Annals of Neurology, vol. 92, no. 4, 2022, pp. 650-662. |
| Trelle AN, Carr VA, Wilson EN, Swarovski MS, Hunt MP, Toueg TN, Tran TT, Channappa D, Corso NK, Thieu MK, Jayakumar M, Nadiadwala A, Guo W, Tanner NJ, Bernstein JD, Litovsky CP, Guerin SA, Khazenzon AM, Harrison MB, Rutt BK, Deutsch GK, Chin FT, Davidzon GA, Hall JN, Sha SJ, Fredericks CA, Andreasson KI, Kerchner GA, Wagner AD, Mormino EC. "Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease." Neurology, vol. 96, no. 10, 2021, pp. e1470-e1481. |
| Feinstein I, Wilson EN, Swarovski MS, Andreasson KI, Angst MS, Greicius MD. "Plasma Biomarkers of Tau and Neurodegeneration During Major Cardiac and Noncardiac Surgery." JAMA Neurology, vol. 78, no. 11, 2021, pp. 1407-1409. |
| Wilson EN, Andreasson KI. "TAM-ping down amyloid in Alzheimer's disease." Nature Immunology, vol. 22, no. 5, 2021, pp. 543-544. |
| Wilson EN, Do Carmo S, Welikovitch LA, Hall H, Aguilar LF, Foret MK, Iulita MF, Jia DT, Marks AR, Allard S, Emmerson JT, Ducatenzeiler A, Cuello AC. "NP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats." Journal of Alzheimer's disease : JAD, vol. 73, no. 2, 2020, pp. 723-739. |
| Wilson EN, Swarovski MS, Linortner P, Shahid M, Zuckerman AJ, Wang Q, Channappa D, Minhas PS, Mhatre SD, Plowey ED, Quinn JF, Zabetian CP, Tian L, Longo FM, Cholerton B, Montine TJ, Poston KL, Andreasson KI. "Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau." Brain, vol. 143, no. 3, 2020, pp. 932-943. |
| Liu Q, Johnson EM, Lam RK, Wang Q, Bo Ye H, Wilson EN, Minhas PS, Liu L, Swarovski MS, Tran S, Wang J, Mehta SS, Yang X, Rabinowitz JD, Yang SS, Shamloo M, Mueller C, James ML, Andreasson KI. "Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity." Nature Immunology, vol. 20, no. 8, 2019, pp. 1023-1034. |
| Liu Q, Liang X, Wang Q, Wilson EN, Lam R, Wang J, Kong W, Tsai C, Pan T, Larkin PB, Shamloo M, Andreasson KI. "PGE(2) signaling via the neuronal EP2 receptor increases injury in a model of cerebral ischemia." Proceedings of the National Academy of Sciences, vol. 116, no. 20, 2019, pp. 10019-10024. |
| Wilson EN, Do Carmo S, Iulita MF, Hall H, Austin GL, Jia DT, Malcolm JC, Foret MK, Marks AR, Butterfield DA, Cuello AC. "Microdose Lithium NP03 Diminishes Pre-Plaque Oxidative Damage and Neuroinflammation in a Rat Model of Alzheimer's-like Amyloidosis." Current Alzheimer research, vol. 15, no. 13, 2018, pp. 1220-1230. |
| Wilson EN, Do Carmo S, Iulita MF, Hall H, Ducatenzeiler A, Marks AR, Allard S, Jia DT, Windheim J, Cuello AC. "BACE1 inhibition by microdose lithium formulation NP03 rescues memory loss and early stage amyloid neuropathology." Translational psychiatry, vol. 7, no. 8, 2017, pp. e1190. |
| Iulita MF, Bistué Millón MB, Pentz R, Aguilar LF, Do Carmo S, Allard S, Michalski B, Wilson EN, Ducatenzeiler A, Bruno MA, Fahnestock M, Cuello AC. "Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease." Neurobiology of disease, vol. 108, 2017, pp. 307-323. |
| Wilson EN, Abela AR, Do Carmo S, Allard S, Marks AR, Welikovitch LA, Ducatenzeiler A, Chudasama Y, Cuello AC. "Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease." Cerebral Cortex, vol. 27, no. 2, 2017, pp. 1501-1511. |
| Qi Y, Klyubin I, Harney SC, Hu N, Cullen WK, Grant MK, Steffen J, Wilson EN, Do Carmo S, Remy S, Fuhrmann M, Ashe KH, Cuello AC, Rowan MJ. "Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents." Acta neuropathologica communications, vol. 2, 2014, pp. 175. |
| Year | Degree | Institution |
|---|---|---|
| 2016 | PhD | McGill University |
| 2011 | MS | McGill University |
| 2008 | BS | Dalhousie University |
