My research program is aimed at the understanding of the pathogenesis of cardiac arrhythmias. Our approach involves three main lines of investigation: 1) Elucidation of transcriptional program(s) that regulate the expression of membrane polypeptides involved in determining the duration of cardiac action potential; 2) Investigation of the trafficking and localization of voltage-gated potassium channels in the heart; and 3) Creation of genetically modified animal models for studying sudden cardiac death.
KOREN, GIDEON (PI) 08/01/2013-05/31/2019 (NCE)
Title: A Multi-Scale Approach to Cardiac Arrhythmia: from the Molecule to the Organ
This project focuses on building a computer model of action potential and calcium handling at multi-scale level from single cell to organ to predict the risk of sudden cardiac death and generate a testable hypothesis that can be tested in the experiments.
KOREN, GIDEON (PI) 07/01/2017 – 06/30/2021
Title: Cardiac ubiquitin ligases: regulation and role in modulating cardiac excitation
The overall goal of this study is to investigate the role of LITAF in QT interval regulation.
The characterization of the function of LITAF is important as this protein controls cardiac excitation and
therefore arrhythmia formation. The identification of the relationship between expression of these proteins
and the expression of ion channels in the heart as well as that of proteins that determine calcium regulation should provide more complete knowledge into the genetic and electrophysiologic factors involved in repolarization disorders and cardiac arrhythmias.
KOREN, GIDEON (MPI) 01/20/2019-12/31/2022
Title: Scarring and Arrhythmia in Infarcted Aged Hearts: Role of Senescent Firoblasts
This project studies the role of senescent cardiac fibroblasts in infarct wound healing and arrhythmogenesis.