James R. Klinger Professor of Medicine

 Dr. Klinger completed his fellowship in pulmonary and critical care medicine at Brown University after completing his residency in internal medicine at the Medical College of Pennsylvania. He is currently the Medical Director of the Pulmonary Hypertension Center at Rhode Island Hospital. His basic science interests include the natriuretic peptides-cGMP signalling pathway and its role in modulating pulmonary hypertensive and right ventricular hypertrophic responses and pulmonary endothelial barrier function and the role of mesenchymal stem cells, extracellular vesicles and micro RNAs in pathogenesis of pulmonary hypertension. His clinical research is focused on the use of investigational agents to treat adult patients with pulmonary hypertension. His interests also include treatment and prevention of venous thromboembolism. Dr. Klinger is a former chair of the program committee of the pulmonary circulation assembly of the American Thoracic Society and former chair of the Pulmonary Vascular Disease network of the American College of Chest Physicians. He is the editor of 2 textbooks on Pulmonary Arterial Hypertension and currently serves on the steering committees of several clinical trials and educational programs.  He is a member of the Scientific Liason Committe of the Pulmonary Hypertensoin Assocation and an Associate Editor of the journal "Lung".  Dr. Klinger's lab currently has a full time opening for a post-doctoral candidate to work in the area of pulmonary vascular permeability and acute lung injury.

Brown Affiliations

Research Areas

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