Office number : 401-444-1649
Dr. Brodsky's research program focuses on the tumor extracullular matrix in order to discover novel biomarkers and therapeutic opportunities.
Dr. Brodsky received postdoctoral training from Dr. Pamela A. Silver at the Dana-Farber Cancer Institute/Harvard Medical School where he discovered mechanisms of mRNA export. He was among the first to use chromatin immunoprecipitation combined with genomic tiling arrays to define the coupling of transcription and mRNA processing.
Dr. Brodsky received his BA from the University of Pennsylvania where he worked with Dr. Ponzy Lu exploring DNA dynamics during electrophoresis. Dr. Brodsky received his PhD from MIT working with Dr. James R. Williamson where he developed a structural model of the HIV tat-TAR protein-RNA interaction using NMR spectroscopy.
Dr. Brodsky joined the Pathology department in 2014.
| Guo KS, Brodsky AS. "Tumor collagens predict genetic features and patient outcomes." NPJ genomic medicine, vol. 8, no. 1, 2023, pp. 15. |
| Lakis NS, Brodsky AS, Karashchuk G, Audesse AJ, Yang D, Sturtevant A, Lombardo K, Wong IY, Webb AE, Anthony DC. "Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation." Acta Neuropathologica Communications, vol. 10, no. 1, 2022, pp. 159. |
| Audesse AJ, Karashchuk G, Gardell ZA, Lakis NS, Maybury-Lewis SY, Brown AK, Leeman DS, Teo YV, Neretti N, Anthony DC, Brodsky AS, Webb AE. "FOXO3 regulates a common genomic program in aging and glioblastoma stem cells." Aging and Cancer, vol. 2, no. 4, 2021, pp. 137-159. |
| Liu, Wenguang, Brodsky, Alexander S., Feng, Meng, Liu, Yajun, Ding, Jing, Jayasuriya, Chathuraka T., Chen, Qian. "Senescent Tissue-Resident Mesenchymal Stromal Cells Are an Internal Source of Inflammation in Human Osteoarthritic Cartilage." Frontiers in Cell and Developmental Biology, vol. 9, 2021, pp. 725071. |
| Klinger JR, Pereira M, Del Tatto M, Brodsky AS, Wu KQ, Dooner MS, Borgovan T, Wen S, Goldberg LR, Aliotta JM, Ventetuolo CE, Quesenberry PJ, Liang OD. "Mesenchymal Stem Cell Extracellular Vesicles Reverse Sugen/Hypoxia Pulmonary Hypertension in Rats." American Journal of Respiratory Cell and Molecular Biology, vol. 62, no. 5, 2020, pp. 577-587. |
| Brodsky, Alexander S., Khurana, Jay, Yang, Dongfang, Gamsiz, Ece, Wong, Ian, Resnick, Murray. "Abstract 1223: Somatic mutations in collagens impact patient outcomes in cancer." Experimental and Molecular Therapeutics, 2019. |
| Zhao, Chaohui Lisa, Singh, Kamaljeet, Brodsky, Alexander S., Lu, Shaolei, Graves, Theresa A., Fenton, Mary Anne, Yang, Dongfang, Sturtevant, Ashlee, Resnick, Murray B., Wang, Yihong. "Stromal ColXα1 expression correlates with tumor-infiltrating lymphocytes and predicts adjuvant therapy outcome in ER-positive/HER2-positive breast cancer." BMC Cancer, vol. 19, no. 1, 2019, pp. 1036. |
| Wang Y, Lu S, Xiong J, Singh K, Hui Y, Zhao C, Brodsky AS, Yang D, Jolly G, Ouseph M, Schorl C, DeLellis RA, Resnick MB. "ColXα1 is a stromal component that colocalizes with elastin in the breast tumor extracellular matrix." The journal of pathology. Clinical research, vol. 5, no. 1, 2018, pp. 40-52. |
| Wang Y, Brodsky AS, Xiong J, Lopresti ML, Yang D, Resnick MB. "Stromal Clusterin Expression Predicts Therapeutic Response to Neoadjuvant Chemotherapy in Triple Negative Breast Cancer." Clinical Breast Cancer, vol. 18, no. 3, 2018, pp. e373-e379. |
| Chowanadisai W, Messerli SM, Miller DH, Medina JE, Hamilton JW, Messerli MA, Brodsky AS. "Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors." PLoS ONE, vol. 11, no. 3, 2016, pp. e0151089. |
| Wang Y, Resnick MB, Lu S, Hui Y, Brodsky AS, Yang D, Yakirevich E, Wang L. "Collagen type III α1 as a useful diagnostic immunohistochemical marker for fibroepithelial lesions of the breast." Human Pathology, vol. 57, 2016, pp. 176-181. |
| Wood SM, Gill AJ, Brodsky AS, Lu S, Friedman K, Karashchuk G, Lombardo K, Yang D, Resnick MB. "Fatty acid-binding protein 1 is preferentially lost in microsatellite instable colorectal carcinomas and is immune modulated via the interferon γ pathway." Modern Pathology, vol. 30, no. 1, 2016, pp. 123-133. |
| Brodsky, Alexander S., Xiong, Jinjun, Yang, Dongfang, Schorl, Christoph, Fenton, Mary Anne, Graves, Theresa A., Sikov, William M., Resnick, Murray B., Wang, Yihong. "Identification of stromal ColXα1 and tumor-infiltrating lymphocytes as putative predictive markers of neoadjuvant therapy in estrogen receptor-positive/HER2-positive breast cancer." BMC Cancer, vol. 16, no. 1, 2016, pp. 274. |
| Friedman K, Brodsky AS, Lu S, Wood S, Gill AJ, Lombardo K, Yang D, Resnick MB. "Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, vol. 29, no. 5, 2016, pp. 528-41. |
| Grive KJ, Gustafson EA, Seymour KA, Baddoo M, Schorl C, Golnoski K, Rajkovic A, Brodsky AS, Freiman RN. "TAF4b Regulates Oocyte-Specific Genes Essential for Meiosis." PLOS Genetics, vol. 12, no. 6, 2016, pp. e1006128. |
| Yakirevich, Evgeny, Ali, Siraj M., Mega, Anthony, McMahon, Caitlin, Brodsky, Alexander S., Ross, Jeffrey S., Allen, Justin, Elvin, Julia A., Safran, Howard, Resnick, Murray B. "A Novel SDHA-deficient Renal Cell Carcinoma Revealed by Comprehensive Genomic Profiling." The American Journal of Surgical Pathology, vol. 39, no. 6, 2015, pp. 858-863. |
| Brown, Caitlin W., Brodsky, Alexander S., Freiman, Richard N. "Abstract POSTER-BIOL-1352: Notch3 promotes anoikis resistance in ovarian cancer." Clin Cancer Res , vol. 21, no. 16 Supplement, 2015, pp. POSTER-BIOL-1352-POSTER-BIOL-1352. |
| Brodsky AS, Fischer A, Miller DH, Vang S, MacLaughlan S, Wu HT, Yu J, Steinhoff M, Collins C, Smith PJ, Raphael BJ, Brard L. "Expression profiling of primary and metastatic ovarian tumors reveals differences indicative of aggressive disease." PLoS ONE, vol. 9, no. 4, 2014, pp. e94476. |
| Brown, C. W., Brodsky, A. S., Freiman, R. N. "Notch3 Overexpression Promotes Anoikis Resistance in Epithelial Ovarian Cancer via Upregulation of COL4A2." Molecular Cancer Research, vol. 13, no. 1, 2014, pp. 78-85. |
| Casella, Cinzia, Miller, Daniel H., Lynch, Kerry, Brodsky, Alexander S. "Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells." Gynecologic Oncology, vol. 135, no. 2, 2014, pp. 333-341. |
| Ellermeier C, Vang S, Cleveland K, Durand W, Resnick MB, Brodsky AS. "Prognostic microRNA expression signature from examination of colorectal primary and metastatic tumors." Anticancer research, vol. 34, no. 8, 2014, pp. 3957-67. |
| Vang S, Wu HT, Fischer A, Miller DH, MacLaughlan S, Douglass E, Comisar L, Steinhoff M, Collins C, Smith PJ, Brard L, Brodsky AS. "Identification of ovarian cancer metastatic miRNAs." PLoS ONE, vol. 8, no. 3, 2013, pp. e58226. |
| Moore RG, Lange TS, Robinson K, Kim KK, Uzun A, Horan TC, Kawar N, Yano N, Chu SR, Mao Q, Brard L, DePaepe ME, Padbury JF, Arnold LA, Brodsky A, Shen TL, Singh RK. "Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model." PLoS ONE, vol. 7, no. 4, 2012, pp. e34443. |
| Lu S, Mukkada VA, Mangray S, Cleveland K, Shillingford N, Schorl C, Brodsky AS, Resnick MB. "MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets." PLoS ONE, vol. 7, no. 7, 2012, pp. e40676. |
| Stuckey A, Fischer A, Miller DH, Hillenmeyer S, Kim KK, Ritz A, Singh RK, Raphael BJ, Brard L, Brodsky AS. "Integrated genomics of ovarian xenograft tumor progression and chemotherapy response." BMC Cancer, vol. 11, 2011, pp. 308. |
| Miller DH, Fischer AK, Chu KF, Burr R, Hillenmeyer S, Brard L, Brodsky AS. "T0901317 inhibits cisplatin-induced apoptosis in ovarian cancer cells [corrected]." International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, vol. 21, no. 8, 2011, pp. 1350-6. |
| Wood JG, Hillenmeyer S, Lawrence C, Chang C, Hosier S, Lightfoot W, Mukherjee E, Jiang N, Schorl C, Brodsky AS, Neretti N, Helfand SL. "Chromatin remodeling in the aging genome of Drosophila." Aging Cell, vol. 9, no. 6, 2010, pp. 971-8. |
| Bronson MW, Hillenmeyer S, Park RW, Brodsky AS. "Estrogen coordinates translation and transcription, revealing a role for NRSF in human breast cancer cells." Molecular endocrinology (Baltimore, Md.), vol. 24, no. 6, 2010, pp. 1120-35. |
| Neretti N, Wang PY, Brodsky AS, Nyguyen HH, White KP, Rogina B, Helfand SL. "Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage." Proceedings of the National Academy of Sciences, vol. 106, no. 7, 2009, pp. 2277-82. |
| McKee AE, Neretti N, Carvalho LE, Meyer CA, Fox EA, Brodsky AS, Silver PA. "Exon expression profiling reveals stimulus-mediated exon use in neural cells." Genome Biology, vol. 8, no. 8, 2007, pp. R159. |
| Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M. "Genome-wide analysis of estrogen receptor binding sites." Nature Genetics, vol. 38, no. 11, 2006, pp. 1289-97. |
| Gama-Carvalho M, Barbosa-Morais NL, Brodsky AS, Silver PA, Carmo-Fonseca M. "Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors." Genome Biology, vol. 7, no. 11, 2006, pp. R113. |
| Swinburne IA, Meyer CA, Liu XS, Silver PA, Brodsky AS. "Genomic localization of RNA binding proteins reveals links between pre-mRNA processing and transcription." Genome Research, vol. 16, no. 7, 2006, pp. 912-21. |
| Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M. "Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1." Cell, vol. 122, no. 1, 2005, pp. 33-43. |
| Brodsky AS, Meyer CA, Swinburne IA, Hall G, Keenan BJ, Liu XS, Fox EA, Silver PA. "Genomic mapping of RNA polymerase II reveals sites of co-transcriptional regulation in human cells." Genome Biology, vol. 6, no. 8, 2005, pp. R64. |
| Brodsky AS, Johnston AP, Trau M, Silver PA. "Analysis of RNA-protein interactions by flow cytometry." Current opinion in molecular therapeutics, vol. 5, no. 3, 2003, pp. 235-40. |
| Brodsky AS, Silver PA. "A microbead-based system for identifying and characterizing RNA-protein interactions by flow cytometry." Mol Cell Proteomics, vol. 1, no. 12, 2002, pp. 922-9. |
| Dayie KT, Brodsky AS, Williamson JR. "Base flexibility in HIV-2 TAR RNA mapped by solution (15)N, (13)C NMR relaxation." Journal of molecular biology, vol. 317, no. 2, 2002, pp. 263-78. |
| Brodsky AS, Silver PA. "Identifying proteins that affect mRNA localization in living cells." Methods, vol. 26, no. 2, 2002, pp. 151-5. |
| Hennig M, Williamson JR, Brodsky AS, Battiste JL. "Recent advances in RNA structure determination by NMR." Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.], vol. Chapter 7, 2001, pp. Unit 7.7. |
| Brodsky AS, Silver PA. "Pre-mRNA processing factors are required for nuclear export." RNA, vol. 6, no. 12, 2000, pp. 1737-49. |
| Brodsky AS, Silver PA. "Nuclear transport HEATs up." J. Geophys. Res., vol. 1, no. 3, 1999, pp. E66-7. |
| Brodsky AS, Erlacher HA, Williamson JR. "NMR evidence for a base triple in the HIV-2 TAR C-G.C+ mutant-argininamide complex." Nucleic acids research, vol. 26, no. 8, 1998, pp. 1991-5. |
| Brodsky AS, Williamson JR. "Solution structure of the HIV-2 TAR-argininamide complex." Journal of molecular biology, vol. 267, no. 3, 1997, pp. 624-39. |
Our goal is to understand which tumors respond to chemotherapy and which do not. We have compared primary and metastatic tumors to identify which tumors are the most aggressive and resistant to treatment. We have discovered new proteins and microRNA biomarkers strongly associated with chemotherapy response and survival. In the laboratory, we have discovered a new approach to enhance the anti-tumor activity of statins and are investigating how statins could be used to prevent tumor relapse.
In recent years, I have made significant advances in the biology of collagens and the extracellular matrix (ECM) in cancer. I demonstrated that large-scale analysis of ECM proteins, and collagens in particular, greatly improves interpreting the impact of molecular alterations in tumor samples, and the prediction of patient survival and therapy options. We hypothesize that genetic mutational burden adversely modulates ECM function, especially in collagen components. Evaluating tumor transcriptional profiles using the 43 annotated collagen genes alone performs as well as machine learning and other classification algorithms, effectively stratifying patient samples using straightforward criteria that are easier to validate with smaller gene sets. While stroma has long been associated with cancer progression, the specific composition of the ECM, secreted by a range of cell types, is a critical determinant to tumor states and patient outcomes. In earlier work, I published major contributions to the field using genomics to gain new insights into RNA binding protein and microRNA actions, mechanisms, and impacts in cancer. My laboratory was among the first to compare the expression of mRNAs and microRNAs in primary and metastatic ovarian tumors. We defined sets of primary tumors with more metastatic-like attributes, leading to worse outcomes for patients. Building on that body of work, I evaluated the impact of how such aggressive tumors respond to treatment. That research led to the discovery of the importance of collagens, typically expressed in specific tissues, yet dysregulated in some tumors that respond poorly to therapy.
NIH RO1 (co-I) (2022-2027)
NIH RO1 (co-I) (2023-2028)
DOD CDMRP IDEA Award (PI) (completed)
CardioPulmonary Vascular Biology COBRE Pilot award (PI) (completed)
AGA Research Foundation (PI) (completed)
Cancer COBRE pilot award (PI) (completed)
DEANs award (co-PI) (completed)
Mary Kay Foundation (PI) (completed)
Ellison Medical Foundation (PI) (completed)
Susan G. Komen Breast Cancer Foundation (co-PI) (completed)
ARRA Supplement: Biocurrents Research Center (PI subcontract) (completed)
DOD/CDMRP Breast Cancer Synergy Award(Completed)
NHGRI K22 Genome Scholar Career Development Award (Completed)
1. Brodsky A.S., Williamson, J. R. (1997) “The Solution Structure of the HIV-2 TAR-
Argininamide Complex” J. Mol. Biol. 267 634-649. (PMID: 9126842).
2. Brodsky A.S., Erlacher, H.A., and Williamson, J.R. (1998) “NMR Evidence for a Base Triple in the HIV-2 TAR-C-G.C+ Mutant Argininamide Complex”, Nuc. Acids Res., 26 1991-1995. (PMID: 9518494, PMCID: PMC147484).
3. Brodsky A.S., Silver, P. A. “Nuclear Transport HEATs Up”, Nat Cell Biol, 1 E66-E67. (1999). PMID: 10559913.
4. Hennig, M., Williamson, J. R., Brodsky A.S., Battiste, J. L. “Recent Advances in RNA Structure Determination by NMR” Curr Prog in Nuc Acid Chem, 7.7.1-7.7.29 (2000). PMID: 18428875.
5. Brodsky A.S., Silver, P. A. (2000) “Pre-mRNA Processing Factors are required for Nuclear Export” RNA, 6 1737 (Awarded paper of the year in RNA). (PMID: 11142374, PMCID: PMC1370044).
6. Dayie, K., Brodsky A.S., Williamson, J. R. (2002) “Base Flexibility in HIV-2 TAR RNA Mapped by Solution 15N, 13C NMR Relaxation” J. Mol. Biol., 317 263-278. (PMID: 11902842).
7. Brodsky AS*, Silver, P. A. (2002) “A microbead-based system for identifying and characterizing RNA-protein interactions by flow cytometry” Mol Cell Proteomics, 1 922-929. (PMID: 12543929).
8. Brodsky A.S., Silver, P. A. “Identifying Proteins that Affect mRNA Localization in Living Cells” Methods 26 151-5 (2002). PMID: 12054891.
9. Brodsky A.S.*, Johnston, A.P., Trau, M., and Silver P.A. (2003) “Analysis of RNA-protein interactions by flow cytometry” Curr Opin Mol Ther. 5 235-40. (PMID: 12870432).
10. Brodsky A.S., Silver PA. “Identifying Proteins that Affect mRNA Localization in Living Cells” (2002) Methods 26(2) 151-155. (PMID: 12054891).
11. Carroll, J. S., Liu, X. S., Brodsky A.S., Li, W., Szary, A. J., Shao, W., Meyer, C. A., Hestermann, E. V., Geistlinger, T. R., Fox, E. A., Silver, P. A., Brown, M. (2005) “Chromosome-wide Mapping of Estrogen Receptor Binding Reveals Long-range Combinatorial Regulation” Cell 122 33-43. (PMID: 16009131).
12. Brodsky A.S.*, Meyer, C. A., Hall, G., Swinburne, I., Keenan, B. K., Liu, X., Fox, E. A., and Silver, P. A. (2005) “Genomic Mapping of RNA Polymerase II Reveals Sites of Co-Transcriptional Regulation in Human Cells” Genome Biology 6(8):R64, Epub Jul 15. (PMID: 16086846, PMCID: PMC1273631) (designated highly accessed).
13. Swinburne, I, Meyer, C. A., Liu, X. S., Silver, P.A.* and Brodsky A.S.* (2006) “Genomic Localization of RNA-binding Proteins Reveals Links Between pre-mRNA Processing and Transcription” Genome Research, 16(7), Epub Jun 12, 2006. (PMID: 16769980, PMCID: PMC1484458).
14. Carroll, J. S., Meyer, C. A., Song, J., Li, Wei, Geistlinger, T. R., Eeckhoute,J.,Brodsky A.S., Keeton, E.K., Fertuck, K. C., Hall, G. F., Wang, Q., Bekiranov, S., Sementchenko, V., Fox, E. A., Silver, P. A., Gingeras, T. R., Liu, X. S., Brown, M. (2006) “Genome-wide Analysis of Estrogen Receptor Binding Sites” Nature Genetics 38 1289-97 Epub 2006 Oct. (PMID: 17013392).
15. Gama-Carvalho, M, Barbosa-Morais, N. L., Brodsky A.S., Silver, P. and Carmo-Fonseca, M. (2006) “Genome wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors” Genome Biology Nov 30; 7(11):R113 [Epub ahead of print] (designated highly accessed). (PMID: 17137510, PMCID: PMC1794580).
16. McKee, A. M., Neretti, N., Carvalho, L. E., Meyer, C.A., Fox, E. A., Brodsky A.S.*, and Silver, P. A. (2007) “Exon expression profiling reveals stimulus-mediated exon use in neural cells”, Genome Biology Aug 2;8(8):R159 [Epub ahead of print] (designated highly accessed). (PMID: 17683528, PMCID: PMC2374990).
17. Neretti, N., Wang, P. Y, Brodsky A.S., White, K. P., Rogina, B., and Helfand, S. L. (2009) “Long-live Indy induces reduced mitochondrial ROS production and oxidative damage”, Proc Natl Acad Sci USA 106 2277 (PMID: 19164521, PMCID: PMC2629441).
18. Bronson, M. W., Hillenmeyer, S., Park, P. W., and Brodsky A.S.* (2010) “Estrogen Coordinates Translation and Transcription Revealing a Role for NRSF in Human Breast Cancer Cells” Mol Endo, Jun; 24(6):1120-35. Epub 2010 Apr 14 (PMID: 20392875, PMCID: PMC2875799).
19. Wood, J., Hillenmeyer, S., Lawrence, C., Chang, C., Hosier, S., Lightfoot, W., Mukerjee, E., Jiang, N., Schorl, C., Brodsky A.S., Neretti, N., and Helfand, S. L. (2010) “Chromatin remodeling in the aging genome of Drosophila”, Aging Cell, 9(6) 971-8, Epub 2010 Oct 21 (PMID: 20961390, PMCID: PMC2980570).
20. Stuckey, A., Fischer, A., Miller, D.H., Hillenmeyer, S., Kim, K.K., Singh, R.K., Raphael, B. J., Brard, L., and Brodsky A.S.* (2011) “Integrated Genomics of Ovarian Xenograft Tumor Progression and Chemotherapy Response”. BMC Cancer, Jul 22; 11(1): 308 [Epub]. (PMID 21781307, PMCID: PMC3155912).
21. Miller D.H., Fischer A., Chu K.F., Burr R., Hillenmeyer S., Brard L., and Brodsky A.S.* (2011) “T0901317 Inhibits Cisplatin Induced Apoptosis in Ovarian Cancer Cells” Int. J. Gynecol. Cancer [Epub Sep 5, 2011] (PMID 21921802, PMCID: PMC3203312).
22. Moore, R.G., Lange, T.S., Robinson, K., Kim K.K., Uzun, A, Horan, T.C., Kawar, N., Yano, N., Chu, S.R., Mao, Q., Brard, L., DePaepe, M.E., Padbury, J.F., Arnold, L.A., Brodsky A.S., Shen, T.L., Singh, R.K. (2012) “Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model” PLoS One; 7(4):e34443. Epub 2012 Apr 3. (PMID: 22509304, PMCID: PMC3317945).
23. Lu, S., Vincent, M. A., Mangray, S., Cleveland, K., Shillingford, N., Schorl, C., Brodsky A.S., Resnick, M. B. (2012) “MicroRNA Profiling in Mucosal Biopsies of Eosinophilic Esophagitis Patients Pre and Post Treatment with Steroids and Relationship with mRNA Targets” PLoS One, 7(4) e40676 [Epub July 16, 2012] (PMID: 22815788, PMCID: PMC3398046).
24. Vang, S., Wu, H.-T., Fischer, A., Miller, D.H., MacLaughlan, S., Douglass, E., Steinhoff, M., Collins, C., Smith, P.J. Brard, L., Brodsky A.S.* (2013) “Identification of Ovarian Cancer Metastatic miRNAs” PLoS One, 8(3) e58226 [Epub March 12, 2013]
(PMID: 23554878, PMCID: PMC3595263).
25. Brodsky A.S.*, Fischer, A., Miller, D.H., Vang, S., MacLaughlan, S., Wu, H.-T., Yu, J., Steinhoff, M., Collins, C., Smither, J.S., and Brard, L. (2014) “Expression Profiling of Primary and Metastatic Ovarian Tumors Reveals Differences Indicative of Aggressive Disease” PLoS One, 9(4) e94476 [Epub April 14, 2014] (PMID: 24732363, PMC3986100).
26. Ellermeier, C., Vang, S., Cleveland, K., Durand, W., Resnick, M. B.* and Brodsky, A. S.* (2014) “Prognostic MicroRNA Expression Signature from Examination of Colorectal Primary and Metastatic Tumors”, Anticancer Research, 34(8) 3957-67. (PMID: 25075017).
27. Casella C, Miller DH, Lynch K, Brodsky A.S.*. Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells. Gynecol Oncol. 2014 Nov; 135(2):333-41.
doi: 10.1016/j.ygyno.2014.08.015. Epub 2014 Aug 16. (PMID: 25134999).
28. Brown CW, Brodsky A.S., Freiman RN. Notch3 Overexpression Promotes Anoikis Resistance in Epithelial Ovarian Cancer via Upregulation of COL4A2. Mol Cancer Res. 2015 Jan; 13(1):78-85. doi: 10.1158/1541-7786.MCR-14-0334. Epub 2014 Aug 28. (PMID: 25169943).
29. Yakirevich E, Ali SM, Mega A, McMahon C, Brodsky A.S., Ross JS, Allen J, Elvin JA, Safran H, Resnick MB. A Novel SDHA-deficient Renal Cell Carcinoma Revealed by Comprehensive Genomic Profiling. Am. J. Surg. Pathol. 2015 Jun;39(6):858-63
(PMID: 25724004).
30. Friedman K, Brodsky A.S., Lu S, Wood S, Gill AJ, Lombardo K, Yang D, Resnick MB. Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment. Mod Pathol. 2016 May;29(5):528-41.
(PMID: 26965581).
31. Brodsky A.S.*, Xiong J, Yang D, Schorl C, Fenton MA, Graves TA, Sikov WM, Resnick MB, Wang Y. Identification of stromal ColXalpha1 and tumor-infiltrating lymphocytes as putative predictive markers of neoadjuvant therapy in estrogen receptor-positive/HER2-positive breast cancer. BMC Cancer. 2016 Apr 18;16:274. (PMID: 27090210; PMCID: PMC4835834).
32. Chowanadisai W, Messerli SM, Miller DH, Medina JE, Hamilton JW, Messerli MA, Brodsky A.S.*. Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors. PloS one. 2016; 11(3):e0151089. (PMID: 26986722).
33. Grive KJ, Gustafson EA, Seymour KA, Baddoo M, Schorl C, Golnoski K, Rajkovic A, Brodsky A.S., Freiman RN. TAF4b Regulates Oocyte-Specific Genes Essential for Meiosis. PLoS Genet. 2016; 12(6):e1006128. PMID: 27341508.
34. Wang Y, Resnick MB, Lu S, Hui Y, Brodsky A.S., Yang D, Yakirevich E, Wang L. Collagen Type III alpha1 as a useful diagnostic immunohistochemical marker for fibroepithelial lesions of the breast. Human Pathol. 2016 Nov;57:176-181.
(PMID: 27498063).
35. Wood SM, Gill AJ, Brodsky A.S., Lu S, Friedman K, Karashchuk G, Lombardo K, Yang D, Resnick MB. Fatty acid-binding protein 1 is preferentially lost in microsatellite instable colorectal carcinomas and is immune modulated via the interferon gamma pathway. Mod Pathol. 2017 Jan;30(1):123-133. PMID: 27687006.
36. Wang Y, Brodsky A.S., Xiong J, Lopresti ML, Yang D, Resnick MB. Stromal Clusterin Expression Predicts Therapeutic Response to Neoadjuvant Chemotherapy in Triple Negative Breast Cancer. Clin Breast Cancer. 2018 Jun;18(3):e373-e379. PMID: 28890185.
37. Wang Y, Lu S, Xiong J, Singh K, Hui Y, Zhao C, Brodsky AS, Yang D, Jolly G, Ouseph M, Schorl C, DeLellis RA, Resnick MB. ColXα1 is a stromal component that colocalizes with elastin in the breast tumor extracellular matrix. J Pathol Clin Res. 2019 Jan;5(1):40-52. doi: 10.1002/cjp2.115. Epub 2018 Nov 1. PMID: 30207088; PMCID: PMC6317058.
38. Zhao CL, Singh K, Brodsky AS, Lu S, Graves TA, Fenton MA, Yang D, Sturtevant A, Resnick MB, Wang Y. Stromal ColXα1 expression correlates with tumor-infiltrating lymphocytes and predicts adjuvant therapy outcome in ER-positive/HER2-positive breast cancer. BMC Cancer. 2019 Nov 1;19(1):1036. doi: 10.1186/s12885-019-6134-y.
PMID: 31675929; PMCID: PMC6825361.
39. Klinger JR, Pereira M, Del Tatto M, Brodsky AS, Wu KQ, Dooner MS, Borgovan T, Wen S, Goldberg LR, Aliotta JM, Ventetuolo CE, Quesenberry PJ, Liang OD. Mesenchymal Stem Cell Extracellular Vesicles Reverse Sugen/Hypoxia Pulmonary Hypertension in Rats. Am J Respir Cell Mol Biol. 2019 Nov 13; doi: 10.1165/rcmb.2019-0154OC. [Epub ahead of print] PMID: 31721618.
40. Baird GL, Walsh T, Aliotta J, Allahua M, Andrew R, Bourjeily G, Brodsky AS, Denver N, Dooner M, Harrington EO, Klinger JR, MacLean MR, Mullin CJ, Pereira M, Poppas A, Whittenhall M, Ventetuolo CE. Insights from the Menstrual Cycle in Pulmonary Arterial Hypertension. Ann Am Thorac Soc. 2021;18(2):218-28. Epub 2020/09/05. doi: 10.1513/AnnalsATS.202006-671OC. PubMed PMID: 32885987; PMCID: PMC7869782.
41. Aboulgheit A, Potz BA, Scrimgeour LA, Karbasiafshar C, Shi G, Zhang Z, Machan JT, Schorl C, Brodsky AS, Braga K, Pfeiffer M, Gao M, Cummings O, Sodha NR, Abid MR, Sellke FW. Effects of High Fat Versus Normal Diet on Extracellular Vesicle-Induced Angiogenesis in a Swine Model of Chronic Myocardial Ischemia. J Am Heart Assoc. 2021;10(4):e017437. Epub 2021/02/10. doi: 10.1161/JAHA.120.017437. PubMed PMID: 33559477.
42. Liu W, Brodsky AS, Feng M, Liu Y, Ding J, Jayasuriya CT, Chen Q. Senescent Tissue-Resident Mesenchymal Stromal Cells Are an Internal Source of Inflammation in Human Osteoarthritic Cartilage. Front Cell Dev Biol. 2021;9:725071. Epub 2021/09/24. doi: 10.3389/fcell.2021.725071. PubMed PMID: 34552931; PMCID: PMC8450518.
43. Audesse AJ, Karashchuk G, Gardell ZA, Lakis NS, Maybury-Lewis SY, Brown AK, Leeman DS, Teo YV, Neretti N, Anthony DC, Brodsky AS, Webb AE. FOXO3 regulates a common genomic program in aging and glioblastoma stem cells. Aging and Cancer. 2021;2(4):137-59.
44. Brodsky, AS*, Khurana, J., Guo, K., Wu, E. Y., Yang, D., Wong, I. Y., Uzun, E.D., Resnick, M.B. Somatic Mutations in Collagens are Associated with a Distinct Tumor Environment and Overall Survival in Gastric Cancer. BMC Cancer. 2022; 4; 22(1):139 PMID: 35120467.
45. Lakis NS#, Brodsky AS#, Karashchuk G, Audesse AJ, Yang D, Sturtevant A, Lombardo K, Wong IY, Webb AE, Anthony DC. Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation. Acta Neuropathol Commun. 2022 Nov 4;10(1):159. doi: 10.1186/s40478-022-01459-9. PMID: 36333778. # co-first author
| Year | Degree | Institution |
|---|---|---|
| 1998 | PhD | Massachusetts Institute of Technology |
| 1993 | MS | University of Pennsylvania |
| 1992 | BA | University of Pennsylvania |
| Name | Title |
|---|---|
| Bertone, Paul | Associate Professor of Medicine (Research) |
| Chen, Qian | Michael G. Ehrlich, MD Professor of Orthopedic Research, Professor of Medical Science |
| Lawler, Sean | Associate Professor of Pathology and Laboratory Medicine |
| Resnick, Murray | Professor of Pathology and Laboratory Medicine |
| Wang, Yihong | Professor of Pathology and Laboratory Medicine |
| Webb, Ashley | Assistant Professor of Molecular Biology, Cell Biology, and Biochemistry |
