Brief Bio
Dr. Qian Chen is the Michael G. Ehrlich, MD Endowed Chair in Orthopaedic Research, Professor of Medical Science, and Vice Chair for Research in the Department of Orthopaedics at the Warren Alpert Medical School of Brown University. He is the director of Center of Biomedical Research Excellence in Skeletal Health and Repair in Rhode Island Hospital, a multi-disciplinary translational research center established by National Institute of Health.
Dr. Chen received his PhD degree in Cell, Molecular, and Developmental Biology from Tufts University School of Medicine in Boston, and performed Post-Doctoral Fellowship at Harvard Medical School and Massachusetts General Hospital. Dr. Chen’s research interest includes cartilage molecular biology, aging and development, extracellular matrix, epigenetics and RNAi, mechanotransduction, osteoarthritis, nanomedicine and gene therapy.
Throughout Dr. Chen’s research career, he received the Independent Scientist Award from NIH, the Satterfield Arthritis Investigator Award from Arthritis Foundation, and the Kappa Delta Award from American Academy of Orthopaedic Surgeons. Dr. Chen served on multiple NIH study sections and advisory panels, and on the review board of Veteran’s Administration. He served as the Basic Science Section Editor of the journal Current Opinions in Orthopaedics, and the topic Chair of Cartilage, Synovium, and Meniscus for the annual meetings of the Orthopaedic Research Society. He is the editor of the books “Osteoarthritis: Diagnosis, Treatment and Surgery” and "Osteoarthritis: Progress in Basic Research and Treatment" .
| Li, Neill Y., Vorrius, Brandon, Ge, Jonathan, Qiao, Zhen, Zhu, Shuang, Katarincic, Julia, Chen, Qian. "Matrilin-2 within a three-dimensional lysine-modified chitosan porous scaffold enhances Schwann cell migration and axonal outgrowth for peripheral nerve regeneration." Frontiers in Bioengineering and Biotechnology, vol. 11, 2023. |
| Vorrius, Brandon, Qiao, Zhen, Ge, Jonathan, Chen, Qian. "Smart Strategies to Overcome Drug Delivery Challenges in the Musculoskeletal System." Pharmaceuticals, vol. 16, no. 7, 2023, pp. 967. |
| Xu, Daohua, Wu, Longhuo, Chen, Qian. "Editorial: Bone and Cartilage Diseases—The Role and Potential of Natural Products." Frontiers in Pharmacology, vol. 13, 2022. |
| Liu Y, Schwam J, Chen Q. "Senescence-Associated Cell Transition and Interaction (SACTAI): A Proposed Mechanism for Tissue Aging, Repair, and Degeneration." Cells, vol. 11, no. 7, 2022, pp. 1089. |
| Li NY, Ge J, Vorrius B, Akelman E, Chen Q. "COBRE for Skeletal Health and Repair: The Impact of Aging on the Capacity for Peripheral Nerve Regeneration." Rhode Island medical journal (2013), vol. 104, no. 2, 2021, pp. 39-45. |
| Chen, Guo-Li, Chen, Qian, Lin, Li-Jun, Zhu, Shuang, Yang, Bing-Sheng, Li, Si-Jing, Tong, Ge, Tan, Jian-Ye, Wu, Guo-Feng, Li, Lin. "Protein post-translational modifications after spinal cord injury." Neural Regeneration Research, vol. 16, no. 10, 2021, pp. 1935. |
| Liu, Wenguang, Brodsky, Alexander S., Feng, Meng, Liu, Yajun, Ding, Jing, Jayasuriya, Chathuraka T., Chen, Qian. "Senescent Tissue-Resident Mesenchymal Stromal Cells Are an Internal Source of Inflammation in Human Osteoarthritic Cartilage." Frontiers in Cell and Developmental Biology, vol. 9, 2021, pp. 725071. |
| Feng, Meng, Liu, Wenguang, Ding, Jing, Qiu, Yusheng, Chen, Qian. "Sonic Hedgehog Induces Mesenchymal Stromal Cell Senescence-Associated Secretory Phenotype and Chondrocyte Apoptosis in Human Osteoarthritic Cartilage." Frontiers in Cell and Developmental Biology, vol. 9, 2021, pp. 716610. |
| Qiao Z, Zhang H, Ji HF, Chen Q. "Computational View toward the Inhibition of SARS-CoV-2 Spike Glycoprotein and the 3CL Protease." Computation (Basel, Switzerland), vol. 8, no. 2, 2020. |
| Twomey-Kozak, John, Desai, Salomi, Liu, Wenguang, Li, Neill Y., Lemme, Nicholas, Chen, Qian, Owens, Brett D., Jayasuriya, Chathuraka T. "Distal-Less Homeobox 5 Is a Therapeutic Target for Attenuating Hypertrophy and Apoptosis of Mesenchymal Progenitor Cells." International Journal of Molecular Sciences, vol. 21, no. 14, 2020, pp. 4823. |
| Go GY, Jo A, Seo DW, Kim WY, Kim YK, So EY, Chen Q, Kang JS, Bae GU, Lee SJ. "Ginsenoside Rb1 and Rb2 upregulate Akt/mTOR signaling–mediated muscular hypertrophy and myoblast differentiation." Journal of Ginseng Research, vol. 44, no. 3, 2020, pp. 435-441. |
| Liu, Wenguang, Feng, Meng, Jayasuriya, Chathuraka T., Peng, Hang, Zhang, Long, Guan, Yingjie, Froehlich, John A., Terek, Richard M., Chen, Qian. "Human osteoarthritis cartilage‐derived stromal cells activate joint degeneration through TGF‐beta lateral signaling." The FASEB Journal, 2020. |
| Liu, Yajun, Chen, Qian. "Senescent Mesenchymal Stem Cells: Disease Mechanism and Treatment Strategy." Current Molecular Biology Reports, vol. 6, no. 4, 2020, pp. 173-182. |
| Xie, Chenxi, Chen, Qian. "Adipokines: New Therapeutic Target for Osteoarthritis?." Current Rheumatology Reports, vol. 21, no. 12, 2019. |
| Hodax JK, Quintos JB, Gruppuso PA, Chen Q, Desai S, Jayasuriya CT. "Aggrecan is required for chondrocyte differentiation in ATDC5 chondroprogenitor cells." PLoS ONE, vol. 14, no. 6, 2019, pp. e0218399. |
| Sun, Xiaojuan, Chen, Yupeng, Yu, Hongchuan, Machan, Jason T, Alladin, Ashna, Ramirez, Jose, Taliano, Ross, Hart, Jesse, Chen, Qian, Terek, Richard M. "Anti-miRNA Oligonucleotide Therapy for Chondrosarcoma." Molecular Cancer Therapeutics, 2019, pp. molcanther.1020.2018. |
| Jin X, Kang X, Zhao L, Xu M, Xie T, Li H, Li F, Qian Z, Ma Z, Zhang Y, Yang W, Zhang Z, Gao X, Chen Q, Sun H, Wu S. "Cartilage Ablation of Sirt1 Causes Inhibition of Growth Plate Chondrogenesis by Hyperactivation of mTORC1 Signaling." Endocrinology, vol. 160, no. 12, 2019, pp. 3001-3017. |
| Hu, Nan, Gao, Yun, Jayasuriya, Chathuraka T., Liu, Wenguang, Du, Heng, Ding, Jing, Feng, Meng, Chen, Qian. "Chondrogenic induction of human osteoarthritic cartilage-derived mesenchymal stem cells activates mineralization and hypertrophic and osteogenic gene expression through a mechanomiR." Arthritis Research & Therapy, vol. 21, no. 1, 2019. |
| Yuan QL, Zhang YG, Chen Q. "Mesenchymal stem cell-derived extracellular vesicles: potential therapeutics as MSC trophic mediators in regenerative medicine." Anatomical record (Hoboken, N.J. : 2007), 2019. |
| Li H, Li D, Ma Z, Qian Z, Kang X, Jin X, Li F, Wang X, Chen Q, Sun H, Wu S. "Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss." Autophagy, vol. 14, no. 10, 2018, pp. 1726-1741. |
| Guan, Ying-Jie, Li, Jing, Yang, Xu, Du, Shaohua, Ding, Jing, Gao, Yun, Zhang, Ying, Yang, Kun, Chen, Qian. "Evidence that miR-146a attenuates aging- and trauma-induced osteoarthritis by inhibiting Notch1, IL-6, and IL-1 mediated catabolism." Aging Cell, vol. 17, no. 3, 2018, pp. e12752. |
| Jayasuriya CT, Hu N, Li J, Lemme N, Terek R, Ehrlich MG, Chen Q. "Molecular characterization of mesenchymal stem cells in human osteoarthritis cartilage reveals contribution to the OA phenotype." Scientific Reports, vol. 8, no. 1, 2018, pp. 7044. |
| Wang, Shilei, Bao, Yan, Guan, Yinjie, Zhang, Chunqiu, Liu, Haiying, Yang, Xu, Gao, Lilan, Guo, Tongtong, Chen, Qian. "Strain distribution of repaired articular cartilage defects by tissue engineering under compression loading." Journal of Orthopaedic Surgery and Research, vol. 13, no. 1, 2018. |
| Liu, Qihai, Wang, Jun, Chen, Yupeng, Zhang, Zhanpeng, Saunders, Laura, Schipani, Ernestina, Chen, Qian, Ma, Peter X. "Suppressing mesenchymal stem cell hypertrophy and endochondral ossification in 3D cartilage regeneration with nanofibrous poly( l -lactic acid) scaffold and matrilin-3." Acta Biomaterialia, vol. 76, 2018, pp. 29-38. |
| Wu, Longhuo, Liu, Haiqing, Li, Linfu, Xu, Daohua, Gao, Yun, Guan, Yingjie, Chen, Qian. "5,7,3′,4′-Tetramethoxyflavone protects chondrocytes from ER stress-induced apoptosis through regulation of the IRE1α pathway." Connective Tissue Research, vol. 59, no. 2, 2017, pp. 157-166. |
| Yang, Kun, Gao, Yun, Yang, Mingfu, Xu, Zuoshang, Chen, Qian. "Creating conditional dual fluorescence labeled transgenic animals for studying function of small noncoding RNAs." Connective Tissue Research, vol. 58, no. 1, 2017, pp. 103-115. |
| Xu, Daohua, Gao, Yun, Hu, Nan, Wu, Longhuo, Chen, Qian. "miR-365 Ameliorates Dexamethasone-Induced Suppression of Osteogenesis in MC3T3-E1 Cells by Targeting HDAC4." International Journal of Molecular Sciences, vol. 18, no. 5, 2017, pp. 977. |
| Miah, S. M. Shahjahan, Jayasuriya, Chathuraka T., Salter, Alexander I., Reilly, Emma C., Fugere, Céline, Yang, Wentian, Chen, Qian, Brossay, Laurent. "Ptpn11 Deletion in CD4+ Cells Does Not Affect T Cell Development and Functions but Causes Cartilage Tumors in a T Cell-Independent Manner." Frontiers in Immunology, vol. 8, 2017, pp. 1326. |
| Thomas NP, Wu WJ, Fleming BC, Wei F, Chen Q, Wei L. "Synovial inflammation plays a greater role in post-traumatic osteoarthritis compared to idiopathic osteoarthritis in the Hartley guinea pig knee." BMC Musculoskeletal Disorders, vol. 18, no. 1, 2017, pp. 556. |
| Zhang C, Qiu L, Gao L, Guan Y, Xu Q, Zhang X, Chen Q. "A novel dual-frequency loading system for studying mechanobiology of load-bearing tissue." Materials Science and Engineering: C, vol. 69, 2016, pp. 262-7. |
| Deren ME, Yang X, Guan Y, Chen Q. "Biological and Chemical Removal of Primary Cilia Affects Mechanical Activation of Chondrogenesis Markers in Chondroprogenitors and Hypertrophic Chondrocytes." IJMS, vol. 17, no. 2, 2016, pp. 188. |
| Li, Pengcui, Deng, Jin, Wei, Xiaochun, Jayasuriya, Chathuraka, Zhou, Jingming, Chen, Qian, Zhang, Jianzhong, Wei, Lei, Wei, Fangyuan. "Blockade of hypoxia-induced CXCR4 with AMD3100 inhibits production of OA-associated catabolic mediators IL-1β and MMP-13." Molecular Medicine Reports, vol. 14, no. 2, 2016, pp. 1475-82. |
| Yang W, Kang X, Liu J, Li H, Ma Z, Jin X, Qian Z, Xie T, Qin N, Feng D, Pan W, Chen Q, Sun H, Wu S. "Clock Gene Bmal1 Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1." Endocrinology, vol. 157, no. 8, 2016, pp. 3096-3107. |
| Chen Y, Cossman J, Jayasuriya CT, Li X, Guan Y, Fonseca V, Yang K, Charbonneau C, Yu H, Kanbe K, Ma P, Darling E, Chen Q. "Deficient Mechanical Activation of Anabolic Transcripts and Post-Traumatic Cartilage Degeneration in Matrilin-1 Knockout Mice." PLoS ONE, vol. 11, no. 6, 2016, pp. e0156676. |
| Yang, Xu, Guan, Yingjie, Tian, Shaoqi, Wang, Yuanhe, Sun, Kang, Chen, Qian. "Mechanical and IL-1β Responsive miR-365 Contributes to Osteoarthritis Development by Targeting Histone Deacetylase 4." IJMS, vol. 17, no. 4, 2016, pp. 436. |
| Jayasuriya CT, Chen Y, Liu W, Chen Q. "The influence of tissue microenvironment on stem cell-based cartilage repair." Annals of the New York Academy of Sciences, vol. 1383, no. 1, 2016, pp. 21-33. |
| Thomas, Nathan P., Li, Pengcui, Fleming, Braden C., Chen, Qian, Wei, Xiaochun, Xiao-Hua, Pan, Li, Gang, Wei, Lei. "Attenuation of Cartilage Pathogenesis in Post-traumatic Osteoarthritis (PTOA) in Mice by blocking the Stromal Derived Factor 1 Receptor (CXCR4) with the specific inhibitor, AMD3100." Journal of Orthopaedic Research, vol. 33, no. 7, 2015, pp. 1071-1078. |
| Tong, Wenxue, Geng, Yiyun, Huang, Yan, Shi, Yu, Xiang, Shengnan, Zhang, Ning, Qin, Ling, Shi, Qin, Chen, Qian, Dai, Kerong, Zhang, Xiaoling. "In Vivo Identification and Induction of Articular Cartilage Stem Cells by Inhibiting NF-κB Signaling in Osteoarthritis." STEM CELLS, vol. 33, no. 10, 2015, pp. 3125-3137. |
| Sun, Xiaojuan, Wei, Lei, Chen, Qian, Terek, Richard M. "MicroRNA regulates vascular endothelial growth factor expression in chondrosarcoma cells." Clinical Orthopaedics and Related Research®, vol. 473, no. 3, 2015, pp. 907-13. |
| Sun X, Charbonneau C, Wei L, Chen Q, Terek RM. "miR-181a Targets RGS16 to Promote Chondrosarcoma Growth, Angiogenesis, and Metastasis." Molecular Cancer Research, vol. 13, no. 9, 2015, pp. 1347-57. |
| Zhou, Jingming, Li, Pengcui, Chen, Qian, Wei, Xiaochun, Zhao, Ting, Wang, Zhengke, Wei, Lei. "Mitogen-activated protein kinase p38 induces HDAC4 degradation in hypertrophic chondrocytes." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol. 1853, no. 2, 2015, pp. 370-376. |
| Jayasuriya, Chathuraka T., Chen, Qian. "Potential benefits and limitations of utilizing chondroprogenitors in cell-based cartilage therapy." Connective Tissue Research, vol. 56, no. 4, 2015, pp. 265-271. |
| Zhou J, Chen Q, Lanske B, Fleming BC, Terek R, Wei X, Zhang G, Wang S, Li K, Wei L. "Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice." Arthritis Res Ther, vol. 16, no. 1, 2014, pp. R11. |
| Wang S, Wei X, Zhou J, Zhang J, Li K, Chen Q, Terek R, Fleming BC, Goldring MB, Ehrlich MG, Zhang G, Wei L. "Identification of α2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis." Arthritis & Rheumatology, vol. 66, no. 7, 2014, pp. 1843-53. |
| Zhang, Congming, Wei, Xiaochun, Chen, Chongwei, Cao, Kun, Li, Yongping, Jiao, Qiang, Ding, Juan, Zhou, Jingming, Fleming, Braden, Chen, Qian, Shang, Xianwen, Wei, Lei. "Indian Hedgehog in Synovial Fluid Is a Novel Marker for Early Cartilage Lesions in Human Knee Joint." IJMS, vol. 15, no. 5, 2014, pp. 7250-7265. |
| Desai HV, Voruganti IS, Jayasuriya C, Chen Q, Darling EM. "Live-cell, temporal gene expression analysis of osteogenic differentiation in adipose-derived stem cells." Tissue engineering. Part A, vol. 20, no. 5-6, 2014, pp. 899-907. |
| Foradori MJ, Chen Q, Fernandez CA, Harper J, Li X, Tsang PC, Langer R, Moses MA. "Matrilin-1 is an inhibitor of neovascularization." Journal of Biological Chemistry, vol. 289, no. 20, 2014, pp. 14301-9. |
| Wang, Zhengke, Luo, Junming, Iwamoto, Satori, Chen, Qian. "Matrilin-2 Is Proteolytically Cleaved by ADAMTS-4 and ADAMTS-5." Molecules, vol. 19, no. 6, 2014, pp. 8472-8487. |
| Jayasuriya, Chathuraka, Zhou, Fiona, Pei, Ming, Wang, Zhengke, Lemme, Nicholas, Haines, Paul, Chen, Qian. "Matrilin-3 Chondrodysplasia Mutations Cause Attenuated Chondrogenesis, Premature Hypertrophy and Aberrant Response to TGF-β in Chondroprogenitor Cells." IJMS, vol. 15, no. 8, 2014, pp. 14555-14573. |
| Yang X, Trehan SK, Guan Y, Sun C, Moore DC, Jayasuriya CT, Chen Q. "Matrilin-3 Inhibits Chondrocyte Hypertrophy as a Bone Morphogenetic Protein-2 Antagonist." Journal of Biological Chemistry, vol. 289, no. 50, 2014, pp. 34768-79. |
| Guan Y, Yang X, Yang W, Charbonneau C, Chen Q. "Mechanical activation of mammalian target of rapamycin pathway is required for cartilage development." The FASEB Journal, vol. 28, no. 10, 2014, pp. 4470-81. |
| Li P, Wei X, Guan Y, Chen Q, Zhao T, Sun C, Wei L. "MicroRNA-1 regulates chondrocyte phenotype by repressing histone deacetylase 4 during growth plate development." The FASEB Journal, vol. 28, no. 9, 2014, pp. 3930-3941. |
| Sun, X., Charbonneau, C., Wei, L., Yang, W., Chen, Q., Terek, R. M. "CXCR4-targeted therapy inhibits VEGF expression and chondrosarcoma angiogenesis and metastasis." Molecular Cancer Therapeutics, vol. 12, no. 7, 2013, pp. 1163-1170. |
| Desai HV, Voruganti IS, Jayasuriya C, Chen Q, Darling EM. "Live-cell, temporal gene expression analysis of osteogenic differentiation in adipose-derived stem cells." Tissue engineering. Part A, vol. 19, no. 1-2, 2013, pp. 40-8. |
| Yang W, Wang J, Moore DC, Liang H, Dooner M, Wu Q, Terek R, Chen Q, Ehrlich MG, Quesenberry PJ, Neel BG. "Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling." Nature, vol. 499, no. 7459, 2013, pp. 491-5. |
| Zhao, Jing, Xia, Weibo, Nie, Min, Zheng, Xin, Wang, Qiuping, Wang, Xiran, Wang, Wenbo, Ning, Zhiwei, Huang, Wei, Jiang, Yan, Li, Mei, Wang, Ou, Xing, Xiaoping, Sun, Yue, Luo, Lianmei, He, Shuli, Yu, Wei, Lin, Qiang, Pei, Yu, Zhang, Fan, Han, Youxia, Tong, Yanmin, Che, Ying, Shen, Ruixin, Hu, Yingying, Zhou, Xueying, Chen, Qian, Xu, Ling. "A haplotype of MATN3 is associated with vertebral fracture in Chinese postmenopausal women: Peking Vertebral Fracture (PK-VF) study." Bone, vol. 50, no. 4, 2012, pp. 917-924. |
| Wei, F., Zhou, J., Wei, X., Zhang, J., Fleming, B.C., Terek, R., Pei, M., Chen, Q., Liu, T., Wei, L. "Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage." Osteoarthritis and Cartilage, vol. 20, no. 7, 2012, pp. 755-763. |
| Weng, Tujun, Yi, Lingxian, Huang, Junlan, Luo, Fengtao, Wen, Xuan, Du, Xiaolan, Chen, Qian, Deng, Chuxia, Chen, Di, Chen, Lin. "Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice." Arthritis and rheumatism, vol. 64, no. 12, 2012, pp. 3982-3992. |
| Jayasuriya, Chathuraka T, Goldring, Mary B, Terek, Richard, Chen, Qian. "Matrilin-3 Induction of IL-1 receptor antagonist Is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression." Arthritis Res Ther, vol. 14, no. 5, 2012, pp. R197. |
| Li, Jing, Huang, Jingang, Dai, Liming, Yu, Degang, Chen, Qian, Zhang, Xiaoling, Dai, Kerong. "miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4." Arthritis Res Ther, vol. 14, no. 2, 2012, pp. R75. |
| Guan Y, Chen Q, Yang X, Haines P, Pei M, Terek R, Wei X, Zhao T, Wei L. "Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV." AJP: Cell Physiology, vol. 303, no. 1, 2012, pp. C33-C40. |
| Kanbe, Katsuaki, Chen, Qian, Nakamura, Atsushi, Hobo, Kaori. "Inhibition of MAP kinase in synovium by treatment with tocilizumab in rheumatoid arthritis." Clinical Rheumatology, vol. 30, no. 11, 2011, pp. 1407-1413. |
| Guan YJ, Yang X, Wei L, Chen Q. "MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4." The FASEB Journal, vol. 25, no. 12, 2011, pp. 4457-66. |
| Li, Kai, Wei, Fangyuan, Zhou, Jingming, Wei, Xiaochun, Chen, Qian, Fleming, Braden, Terek, Richard, Wei, Lei. "Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage." Bone, vol. 47, 2010, pp. S361-S362. |
| Wei L, Fleming BC, Sun X, Teeple E, Wu W, Jay GD, Elsaid KA, Luo J, Machan JT, Chen Q. "Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model." Journal of Orthopaedic Research, vol. 28, no. 7, 2010, pp. 900-6. |
| Sun, Xiaojuan, Wei, Lei, Chen, Qian, Terek, Richard M. "CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression." Molecular cancer, vol. 9, no. 1, 2010, pp. 17. |
| Chen, Qian, Wei, Lei, Yang, Xu. "Pre-clinical animal models of osteoarthritis." Bone, vol. 47, 2010, pp. S350-S351. |
| Chen, Qian. "Rheumatoid and osteoarthritis in cartilage and bone health." Bone, vol. 47, 2010, pp. S354. |
| Wei L, Kanbe K, Lee M, Wei X, Pei M, Sun X, Terek R, Chen Q. "Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation." Developmental Biology, vol. 341, no. 1, 2010, pp. 236-45. |
| Chang, Jen-Huei, Shen, Hsain-Chung, Huang, Guo-Shu, Pan, Ru-Yu, Wu, Chi-Fang, Lee, Chian-Her, Chen, Qian. "A Biomechanical Comparison of All-Inside Meniscus Repair Techniques." Journal of Surgical Research, vol. 155, no. 1, 2009, pp. 82-88. |
| Sun X, Wei L, Chen Q, Terek RM. "HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity." Journal of Biological Chemistry, vol. 284, no. 33, 2009, pp. 21881-90. |
| Kanbe, Katsuaki, Inoue, Kazuhiko, Inoue, Yasuo, Chen, Qian. "Inducement of mitogen-activated protein kinases in frozen shoulders." Journal of Orthopaedic Science, vol. 14, no. 1, 2009, pp. 56-61. |
| Kim MS, Wu KY, Auyeung V, Chen Q, Gruppuso PA, Phornphutkul C. "Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling." AJP: Endocrinology and Metabolism, vol. 296, no. 6, 2009, pp. E1374-E1382. |
| Phornphutkul C, Lee M, Voigt C, Wu KY, Ehrlich MG, Gruppuso PA, Chen Q. "The effect of rapamycin on bone growth in rabbits." Journal of Orthopaedic Research, vol. 27, no. 9, 2009, pp. 1157-61. |
| Wei, Lei, Sun, Xiaojuan, Kanbe, Katsuaki, Terek, Richard, Chen, Qian. "Critical roles for chemokine SDF-1 signaling in the development of growth plate chondrocyte hypertrophy." Bone, vol. 43, 2008, pp. S32. |
| Pei, M., Luo, J., Chen, Q. "Enhancing and maintaining chondrogenesis of synovial fibroblasts by cartilage extracellular matrix protein matrilins." Osteoarthritis and Cartilage, vol. 16, no. 9, 2008, pp. 1110-1117. |
| Phornphutkul C, Wu KY, Auyeung V, Chen Q, Gruppuso PA. "mTOR signaling contributes to chondrocyte differentiation." Developmental dynamics : an official publication of the American Association of Anatomists, vol. 237, no. 3, 2008, pp. 702-12. |
| Zhang, Yue, Wang, Zheng-ke, Luo, Jun-ming, Kanbe, Katsuaki, Chen, Qian. "Multiple functions of the von Willebrand Factor A domain in matrilins: secretion, assembly, and proteolysis." Journal of Orthopaedic Surgery and Research, vol. 3, no. 1, 2008, pp. 21. |
| Zhang Y, Wang ZK, Luo JM, Kanbe K, Chen Q. "Multiple functions of the von Willebrand Factor A domain in matrilins: secretion, assembly, and proteolysis." Journal of Orthopaedic Surgery and Research, vol. 3, 2008, pp. 21. |
| Namdari S, Wei L, Moore D, Chen Q. "Reduced limb length and worsened osteoarthritis in adult mice after genetic inhibition of p38 MAP kinase activity in cartilage." Arthritis and rheumatism, vol. 58, no. 11, 2008, pp. 3520-9. |
| Chen, Qian. "Relationship between bone and cartilage damage." Bone, vol. 43, 2008, pp. S17. |
| Lee, Mark C. "Epiphysiodesis with Infusion of Stromal Cell-Derived Factor-1 in Rabbit Growth Plates." The Journal of Bone and Joint Surgery-American Volume, vol. 89, no. 1, 2007, pp. 102. |
| Wei L, Sun XJ, Wang Z, Chen Q. "CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase." Arthritis Res Ther, vol. 8, no. 2, 2006, pp. R37. |
| Yang, Xu, Vezeridis, Peter S, Nicholas, Brian, Crisco, Joseph J, Moore, Douglas C, Chen, Qian. "Differential expression of type X collagen in a mechanically active 3-D chondrocyte culture system: a quantitative study." Journal of Orthopaedic Surgery and Research, vol. 1, no. 1, 2006, pp. 15. |
| van der Weyden, Louise, Wei, Lei, Luo, Junming, Yang, Xu, Birk, David E., Adams, David J., Bradley, Allan, Chen, Qian. "Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis." The American Journal of Pathology, vol. 169, no. 2, 2006, pp. 515-27. |
| Kanbe, Katsuaki, Inoue, Kazuhiko, Xiang, Charlie, Chen, Qian. "Identification of clock as a mechanosensitive gene by large-scale DNA microarray analysis: downregulation in osteoarthritic cartilage." Mod Rheumatol, vol. 16, no. 3, 2006, pp. 131-136. |
| Kanbe, Katsuaki, Inoue, Kazuhiko, Xiang, Charlie, Chen, Qian. "Identification of clock as a mechanosensitive gene by large-scale DNA microarray analysis: downregulation in osteoarthritic cartilage." Mod Rheumatol, vol. 16, no. 3, 2006, pp. 131-136. |
| Vezeridis, Peter S., Semeins, Cornelis M., Chen, Qian, Klein-Nulend, Jenneke. "Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation." Biochemical and Biophysical Research Communications, vol. 348, no. 3, 2006, pp. 1082-1088. |
| Kanbe, Katsuaki, Yang, Xu, Wei, Lei, Sun, Changqi, Chen, Qian. "Pericellular Matrilins Regulate Activation of Chondrocytes by Cyclic Load-Induced Matrix Deformation." Journal of Bone and Mineral Research, vol. 22, no. 2, 2006, pp. 318-328. |
| Lee, Chian-Her, Huang, Guo-Shu, Chao, Kuo-Hua, Wu, Shing-Sheng, Chen, Qian. "Differential Pretensions of a Flexor Tendon Graft for Anterior Cruciate Ligament Reconstruction: A Biomechanical Comparison in a Porcine Knee Model." Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 21, no. 5, 2005, pp. 540-546. |
| Chen, Qian. "Skeletal mechanobiology: where does it go in the ???post-dinosaur??? age?." Current Opinion in Orthopaedics, vol. 16, no. 5, 2005, pp. 309-310. |
| Phornphutkul, C. "Insulin-like growth factor-I signaling is modified during chondrocyte differentiation." The Journal of endocrinology, vol. 183, no. 3, 2004, pp. 477-486. |
| Chen, Qian. "Rebuilding the musculoskeletal system." Current Opinion in Orthopaedics, vol. 15, no. 5, 2004, pp. 317. |
| Kanbe, K., Takemura, T., Takeuchi, K., Chen, Q., Takagishi, K., Inoue, K. "Synovectomy reduces stromal-cell-derived factor-1 (SDF-1) which is involved in the destruction of cartilage in osteoarthritis and rheumatoid arthritis." Journal of Institutional and Theoretical Economics JITE, vol. 86, no. 2, 2004, pp. 296-300. |
| Mosher TJ, Chen Q, Smith MB. "1H magnetic resonance spectroscopy of nanomelic chicken cartilage: effect of aggrecan depletion on cartilage T2." Osteoarthritis and Cartilage, vol. 11, no. 10, 2003, pp. 709-15. |
| Kanbe K, Takagishi K, Chen Q. "Stimulation of matrix metalloprotease 3 release from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokine receptor 4." Arthritis and rheumatism, vol. 46, no. 1, 2002, pp. 130-7. |
| Wu Q, Zhang Y, Chen Q. "Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation." Journal of Biological Chemistry, vol. 276, no. 38, 2001, pp. 35290-6. |
| Zhen X, Wei L, Wu Q, Zhang Y, Chen Q. "Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone." Journal of Biological Chemistry, vol. 276, no. 7, 2001, pp. 4879-85. |
| You J, Reilly GC, Zhen X, Yellowley CE, Chen Q, Donahue HJ, Jacobs CR. "Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts." Journal of Biological Chemistry, vol. 276, no. 16, 2001, pp. 13365-71. |
| Zhang Y, Chen Q. "Changes of matrilin forms during endochondral ossification. Molecular basis of oligomeric assembly." Journal of Biological Chemistry, vol. 275, no. 42, 2000, pp. 32628-34. |
| Wu QQ, Chen Q. "Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals." Experimental Cell Research, vol. 256, no. 2, 2000, pp. 383-91. |
| You J, Yellowley CE, Donahue HJ, Zhang Y, Chen Q, Jacobs CR. "Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow." Journal of Biomechanical Engineering, vol. 122, no. 4, 2000, pp. 387-93. |
| Chen Q, Zhang Y, Johnson DM, Goetinck PF. "Assembly of a novel cartilage matrix protein filamentous network: molecular basis of differential requirement of von Willebrand factor A domains." Molecular biology of the cell, vol. 10, no. 7, 1999, pp. 2149-62. |
| Zhang Y, Chen Q. "The noncollagenous domain 1 of type X collagen. A novel motif for trimer and higher order multimer formation without a triple helix." Journal of Biological Chemistry, vol. 274, no. 32, 1999, pp. 22409-13. |
| Linsenmayer TF, Long F, Nurminskaya M, Chen Q, Schmid TM. "Type X collagen and other up-regulated components of the avian hypertrophic cartilage program." Progress in nucleic acid research and molecular biology, vol. 60, 1998, pp. 79-109. |
| Chen Q, Johnson DM, Haudenschild DR, Goetinck PF. "Cartilage matrix protein: expression patterns in chicken, mouse, and human." Annals of the New York Academy of Sciences, vol. 785, 1996, pp. 238-40. |
| Chen, Qian, Johnson, David M., Haudenschild, Dominik R., Goetinck, Paul F. "Cartilage Matrix Protein: Expression Patterns in Chicken, Mouse, and Humana." Annals of the New York Academy of Sciences, vol. 785, no. 1, 1996, pp. 238-240. |
| Chen Q, Johnson DM, Haudenschild DR, Tondravi MM, Goetinck PF. "Cartilage matrix protein forms a type II collagen-independent filamentous network: analysis in primary cell cultures with a retrovirus expression system." Molecular biology of the cell, vol. 6, no. 12, 1995, pp. 1743-53. |
| Chen Q, Johnson DM, Haudenschild DR, Goetinck PF. "Progression and recapitulation of the chondrocyte differentiation program: cartilage matrix protein is a marker for cartilage maturation." Developmental Biology, vol. 172, no. 1, 1995, pp. 293-306. |
| Haudenschild DR, Tondravi MM, Hofer U, Chen Q, Goetinck PF. "The role of coiled-coil alpha-helices and disulfide bonds in the assembly and stabilization of cartilage matrix protein subunits. A mutational analysis." Journal of Biological Chemistry, vol. 270, no. 39, 1995, pp. 23150-4. |
| Chen Q, Gibney EP, Leach RM, Linsenmayer TF. "Chicken tibial dyschondroplasia: a limb mutant with two growth plates and possible defects of collagen crosslinking." Developmental dynamics : an official publication of the American Association of Anatomists, vol. 196, no. 1, 1993, pp. 54-61. |
| Chen Q, Linsenmayer TF. "Distributions of fibronectin in the developing avian cartilaginous growth plate." Progress in clinical and biological research, vol. 383B, 1993, pp. 495-504. |
| Chen Q, Fitch JM, Gibney E, Linsenmayer TF. "Type II collagen during cartilage and corneal development: immunohistochemical analysis with an anti-telopeptide antibody." Developmental dynamics : an official publication of the American Association of Anatomists, vol. 196, no. 1, 1993, pp. 47-53. |
| Chen Q, Linsenmayer C, Gu H, Schmid TM, Linsenmayer TF. "Domains of type X collagen: alteration of cartilage matrix by fibril association and proteoglycan accumulation." The Journal of cell biology, vol. 117, no. 3, 1992, pp. 687-94. |
| Chen Q, Fitch JM, Linsenmayer C, Linsenmayer TF. "Type X collagen: covalent crosslinking to hypertrophic cartilage-collagen fibrils." Bone and mineral, vol. 17, no. 2, 1992, pp. 223-7. |
| Linsenmayer TF, Chen QA, Gibney E, Gordon MK, Marchant JK, Mayne R, Schmid TM. "Collagen types IX and X in the developing chick tibiotarsus: analyses of mRNAs and proteins." Development, vol. 111, no. 1, 1991, pp. 191-6. |
| Chen QA, Gibney E, Fitch JM, Linsenmayer C, Schmid TM, Linsenmayer TF. "Long-range movement and fibril association of type X collagen within embryonic cartilage matrix." Proceedings of the National Academy of Sciences, vol. 87, no. 20, 1990, pp. 8046-50. |
| Chen Q, Taljanidisz J, Sarkar S, Tao T, Gergely J. "Cloning, sequencing and expression of a full-length rabbit fast skeletal troponin-C cDNA." FEBS Letters, vol. 228, no. 1, 1988, pp. 22-6. |
Ongoing Research Support
P30GM122732 Chen (PI) 09/01/17-08/31/22
Center of Biomedical Research Excellence in Skeletal Health and Repair
The goal of this project is to transition a multi-disciplinary research center to treat cartilage joint diseases.
Role: PI
R01 AR-072027 Y. Chen (PI) 9/1/17-8/31/22
NIH/NIAMS
Developing Nanomaterial Platform for Intra-Cartilage Delivery of RNA Therapeutics against Joint Diseases
The goal of this research is to develop a nanomaterial platform to treat joint diseases and symptoms.
Role: Co-Investigator
1 R61/R33 AR076807 Chen (PI) 9/1/19-8/31/22
Repressing Retrotransposon LINE-1: New Concepts for Osteoarthritis Treatment
The scientific goal of this project is to determine whether retrotransposon Long Interspersed Nuclear Element-1 (LINE-1), which is repressed in normal somatic cells but de-repressed during aging, contribute to aging-associated OA.
Role: PI
3P30GM122732-05S1 Chen (PI) 9/1/21-8/31/22
Developing Brain Theranostics of ADRD infiltrating the Blood-Brain Barrier
The focus of this COBRE supplement project is to develop a novel siRNA theranostics crossing the BBB using the Nanopieces (NP) technology for the treatment of ADRD.
Role: PI
1 R41 TR002298-01A1 Chen (PI) 3/1/20-2/28/22 (no cost extension)
STTR: Developing Nanopieces, a Platform RNAi Delivery Technology for Treatment of Multiple Diseases
The goal of this project is to develop drug delivery in difficult-to-reach matrix-rich tissues with a new generation of platform RNA delivery vehicle nanopieces.
Role: PI
NIH/NIAMS, R61AR076807-02S1 Chen (PI) 09/01/20-08/31/22 (no cost extension)
Determining the Role of Retrotransposon Line-1 in Alzheimer’s Disease
The scientific goal of this project is to determine whether retrotransposon Long Interspersed Nuclear Element-1 (LINE-1), which is repressed in normal somatic cells but de-repressed during aging, contribute to aging-associated AD.
Role: PI
Completed Research Support
3P30GM122732-04S1 Chen (PI) 9/1/20-8/31/21
Developing Brain Theranostics of ADRD infiltrating the Blood-Brain Barrier
The focus of this COBRE supplement project is to develop a novel siRNA theranostics crossing the BBB using the Nanopieces (NP) technology for the treatment of ADRD.
Role: PI
3P30GM122732-03S1 Chen (PI) 9/1/19-8/31/20
Developing novel Alzheimer's disease RNA therapeutics crossing the blood-brain barrier
The focus of this COBRE ADRD pilot project is to develop a novel ADRD RNA therapeutics crossing the BBB using the Nanopieces (NP) technology, the nucleic acid therapeutics delivery platform established in the COBRE Nanomedicine Core.
Role: PI
R01-AR066746-01A1 Yang (PI) 09/21/15-08/31/20
ROLE OF PTPN11 IN CARTILAGE STEM CELLS AND TUMORIGENESIS
The goal of this project is to study how the property of cartilage stem cells is regulated by the protein tyrosine phosphatase SHP2 under physiological and pathological conditions
Role: Co-Investigator
R01CA166089-01A1 Terek (PI) 09/25/13-07/31/19
Targeting CXCR4 and microRNA as Therapy
The goal of this project is to develop therapy to treat chondrosarcoma.
Role: Co-Investigator
P20 GM104937 Chen (PI) 09/15/12-08/31/17
Center of Biomedical Research Excellence in Skeletal Health and Repair
The goal of this project is to sustain a multi-disciplinary research center to treat cartilage joint diseases.
Role: PI
R01 AR 059142-01A1 Wei (PI) 04/01/11-01/31/16
Histone Deacetylation Regulates Growth Plate Development
The goal of this project is to understand how HDAC4 regulates growth plate development by CaMKIV, P38 MAPK, and miR-1.
Role: Co-Investigator
Rhode Island Research Alliance Collaborative Grant Award Chen (PI) 07/01/14-06/30/15
Novel SiRNA Delivery Technology via Biomimetic Nanomaterial for Treatment of Joint Arthritis
The goal of this project is to develop therapy to treat joint arthritis.
Role: PI
R01 AG 017021 Chen (PI) 09/01/98-02/28/14
Biophysical Regulation of Chondrocyte Differentiation
The major goals of this project are to study the effect of mechanical stress on chondrocyte properties
Role: PI
1 P20 RR024484 Chen (PI) 09/01/07-07/31/12
Center of Biomedical Research Excellence in Skeletal Health and Repair
The goal of this project is to establish a multi-disciplinary research center to treat cartilage joint diseases.
Role: PI
3P20RR024484-03S1 Chen (PI) 08/20/09-08/19/2012
ARRA Supplemental Fund to COBRE in Skeletal Health and Repair
The goal of this study is to develop translational strategies to treat chemokine induced joint diseases.
R01 AG 014399 Chen (PI) 02/01/97-12/31/11
Stabilization of Matrix Structure in Mature Cartilage
The goal of this project is to analyze the mechanisms that stabilize cartilage matrix structure
Role: PI
| Year | Degree | Institution |
|---|---|---|
| 1992 | PhD | Tufts University |
| 1985 | BS | Fudan University |
1994-1996 Postdoctoral Fellowship, Arthritis Foundation, Atlanta, GA
1995 Outstanding Research Presentation Award, 15th Annual East Coast Connective Tissue
Society Meeting, Piscataway, NJ
1996-1999 Arthritis Investigator Award (J.V. Satterfield Award), Arthritis Foundation, Atlanta, GA
1997-2002 The FIRST Award, National Institute on Aging, NIH, Bethesda, MD
1997 New Investigator Recognition Award, Orthopaedic Research Society, Chicago, IL
1999 Novartis Foundation Bursary, London, UK
1998-2003 Independent Scientist Award, NIH (PHS-Research Career Development Award), Bethesda, MD
2000 Kappa Delta Young Investigator Award, American Academy of Orthopaedic Surgeons
2001 Hinkle Society Award, Penn State College of Medicine, Hershey, PA
2006-present Trustee, Rhode Island Hospital Orthopaedic Foundation
| Name | Title |
|---|---|
| Brodsky, Alexander | Associate Professor of Pathology and Laboratory Medicine (Research) |
| Brossay, Laurent | Charles A. and Helen B. Stuart Professor of Medical Science, Professor of Molecular Microbiology and Immunology |
| Colvin, Vicki | Adjunct Professor of Engineering |
| Darling, Eric | Associate Professor of Medical Science, Associate Professor of Engineering, Associate Professor of Orthopaedics |
| Fleming, Braden | Lucy Lippitt Professor of Orthopaedics, Professor of Engineering |
| Guan, Yingjie | Assistant Professor of Pathology and Laboratory Medicine (Research), Assistant Professor of Medicine (Research) |
| Helfand, Stephen | George D. Eggleston Professor of Biochemistry, Vice Chair of Neurology |
| Jay, Gregory | John and Mary Panton and Emergency Medicine Professor of Translational Science, Professor of Orthopaedics, Professor of Medicine, Professor of Engineering (Research) |
| Jayasuriya, Chathuraka | Associate Professor of Orthopaedics |
| Neretti, Nicola | Associate Professor of Molecular Biology, Cell Biology, and Biochemistry, Associate Director for the Center on the Biology of Aging |
| Sedivy, John | Hermon C. Bumpus Professor of Biology, Associate Dean and Director, Center for the Biology of Aging |
| Tatar, Marc | Professor of Biology |
| Terek, Richard | Professor of Orthopaedics |
| Wei, Lei | Associate Professor of Orthopaedics (Research) |
| Wilson, Ira | Associate Provost for Academic Space, Professor of Health Services, Policy and Practice, Professor of Medicine |
| Yang, Wentian | Professor of Medicine, Professor of Orthopaedics |
