Brief Bio
Dr. Qian Chen is the Michael G. Ehrlich, MD Endowed Chair in Orthopaedic Research, Professor of Medical Science, and Vice Chair for Research in the Department of Orthopaedics at the Warren Alpert Medical School of Brown University. He is the director of Center of Biomedical Research Excellence in Skeletal Health and Repair in Rhode Island Hospital, a multi-disciplinary translational research center established by National Institute of Health.
Dr. Chen received his PhD degree in Cell, Molecular, and Developmental Biology from Tufts University School of Medicine in Boston, and performed Post-Doctoral Fellowship at Harvard Medical School and Massachusetts General Hospital. Dr. Chen’s research interest includes cartilage molecular biology, aging and development, extracellular matrix, epigenetics and RNAi, mechanotransduction, osteoarthritis, nanomedicine and gene therapy.
Throughout Dr. Chen’s research career, he received the Independent Scientist Award from NIH, the Satterfield Arthritis Investigator Award from Arthritis Foundation, and the Kappa Delta Award from American Academy of Orthopaedic Surgeons. Dr. Chen served on multiple NIH study sections and advisory panels, and on the review board of Veteran’s Administration. He served as the Basic Science Section Editor of the journal Current Opinions in Orthopaedics, and the topic Chair of Cartilage, Synovium, and Meniscus for the annual meetings of the Orthopaedic Research Society. He is the editor of the books “Osteoarthritis: Diagnosis, Treatment and Surgery” and "Osteoarthritis: Progress in Basic Research and Treatment" .
| Deren ME, Yang X, Guan Y, Chen Q Biological and Chemical Removal of Primary Cilia Affects Mechanical Activation of Chondrogenesis Markers in Chondroprogenitors and Hypertrophic Chondrocytes. IJMS/International journal of molecular sciences. 2016; 17 (2) : 188. |
| Li, Pengcui, Deng, Jin, Wei, Xiaochun, Jayasuriya, Chathuraka, Zhou, Jingming, Chen, Qian, Zhang, Jianzhong, Wei, Lei, Wei, Fangyuan Blockade of hypoxia-induced CXCR4 with AMD3100 inhibits production of OA-associated catabolic mediators IL-1β and MMP-13. Molecular Medicine Reports. 2016; |
| Yang W, Kang X, Liu J, Li H, Ma Z, Jin X, Qian Z, Xie T, Qin N, Feng D, Pan W, Chen Q, Sun H, Wu S Clock Gene Bmal1 Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1.. Endocrinology. 2016; 157 (8) : 3096-107. |
| Yang, Xu, Guan, Yingjie, Tian, Shaoqi, Wang, Yuanhe, Sun, Kang, Chen, Qian Mechanical and IL-1β Responsive miR-365 Contributes to Osteoarthritis Development by Targeting Histone Deacetylase 4. IJMS/IJMS. 2016; 17 (4) : 436. |
| Thomas, Nathan P., Li, Pengcui, Fleming, Braden C., Chen, Qian, Wei, Xiaochun, Xiao-Hua, Pan, Li, Gang, Wei, Lei Attenuation of Cartilage Pathogenesis in Post-traumatic Osteoarthritis (PTOA) in Mice by blocking the Stromal Derived Factor 1 Receptor (CXCR4) with the specific inhibitor, AMD3100.. Journal of Orthopaedic Research. 2015; 33 (7) : 1071-1078. |
| Sun, Xiaojuan, Wei, Lei, Chen, Qian, Terek, Richard M. MicroRNA regulates vascular endothelial growth factor expression in chondrosarcoma cells.. Clinical Orthopaedics and Related Research®. 2015; 473 (3) : 907-13. |
| Sun X, Charbonneau C, Wei L, Chen Q, Terek RM miR-181a Targets RGS16 to Promote Chondrosarcoma Growth, Angiogenesis, and Metastasis. Molecular Cancer Research. 2015; 13 (9) : 1347-57. |
| Zhou, Jingming, Li, Pengcui, Chen, Qian, Wei, Xiaochun, Zhao, Ting, Wang, Zhengke, Wei, Lei Mitogen-activated protein kinase p38 induces HDAC4 degradation in hypertrophic chondrocytes. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2015; 1853 (2) : 370-376. |
| Jayasuriya, Chathuraka T., Chen, Qian Potential benefits and limitations of utilizing chondroprogenitors in cell-based cartilage therapy. Connect Tissue Res. 2015; 56 (4) : 265-271. |
| Zhou J, Chen Q, Lanske B, Fleming BC, Terek R, Wei X, Zhang G, Wang S, Li K, Wei L Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice.. Arthritis Res Ther. 2014; 16 (1) : R11. |
| Zhang, Congming, Wei, Xiaochun, Chen, Chongwei, Cao, Kun, Li, Yongping, Jiao, Qiang, Ding, Juan, Zhou, Jingming, Fleming, Braden, Chen, Qian, Shang, Xianwen, Wei, Lei Indian Hedgehog in Synovial Fluid Is a Novel Marker for Early Cartilage Lesions in Human Knee Joint. IJMS. 2014; 15 (5) : 7250-7265. |
| Foradori MJ, Chen Q, Fernandez CA, Harper J, Li X, Tsang PC, Langer R, Moses MA Matrilin-1 is an inhibitor of neovascularization.. Journal of Biological Chemistry. 2014; 289 (20) : 14301-9. |
| Wang, Zhengke, Luo, Junming, Iwamoto, Satori, Chen, Qian Matrilin-2 Is Proteolytically Cleaved by ADAMTS-4 and ADAMTS-5. Molecules. 2014; 19 (6) : 8472-8487. |
| Jayasuriya, Chathuraka, Zhou, Fiona, Pei, Ming, Wang, Zhengke, Lemme, Nicholas, Haines, Paul, Chen, Qian Matrilin-3 Chondrodysplasia Mutations Cause Attenuated Chondrogenesis, Premature Hypertrophy and Aberrant Response to TGF-β in Chondroprogenitor Cells. IJMS. 2014; 15 (8) : 14555-14573. |
| Yang X, Trehan SK, Guan Y, Sun C, Moore DC, Jayasuriya CT, Chen Q Matrilin-3 Inhibits Chondrocyte Hypertrophy as a Bone Morphogenetic Protein-2 Antagonist. Journal of Biological Chemistry. 2014; 289 (50) : 34768-79. |
| Guan Y, Yang X, Yang W, Charbonneau C, Chen Q Mechanical activation of mammalian target of rapamycin pathway is required for cartilage development.. The FASEB Journal. 2014; 28 (10) : 4470-81. |
| Li P, Wei X, Guan Y, Chen Q, Zhao T, Sun C, Wei L MicroRNA-1 regulates chondrocyte phenotype by repressing histone deacetylase 4 during growth plate development.. The FASEB Journal. 2014; 28 (9) : 3930-3941. |
| Sun, X., Charbonneau, C., Wei, L., Yang, W., Chen, Q., Terek, R. M. CXCR4-targeted therapy inhibits VEGF expression and chondrosarcoma angiogenesis and metastasis.. Molecular Cancer Therapeutics. 2013; 12 (7) : 1163-1170. |
| Yang W, Wang J, Moore DC, Liang H, Dooner M, Wu Q, Terek R, Chen Q, Ehrlich MG, Quesenberry PJ, Neel BG Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.. J. Geophys. Res.. 2013; 499 (7459) : 491-5. |
| Zhao, Jing, Xia, Weibo, Nie, Min, Zheng, Xin, Wang, Qiuping, Wang, Xiran, Wang, Wenbo, Ning, Zhiwei, Huang, Wei, Jiang, Yan, Li, Mei, Wang, Ou, Xing, Xiaoping, Sun, Yue, Luo, Lianmei, He, Shuli, Yu, Wei, Lin, Qiang, Pei, Yu, Zhang, Fan, Han, Youxia, Tong, Yanmin, Che, Ying, Shen, Ruixin, Hu, Yingying, Zhou, Xueying, Chen, Qian, Xu, Ling A haplotype of MATN3 is associated with vertebral fracture in Chinese postmenopausal women: Peking Vertebral Fracture (PK-VF) study. Bone. 2012; 50 (4) : 917-924. |
| Wei, F., Zhou, J., Wei, X., Zhang, J., Fleming, B.C., Terek, R., Pei, M., Chen, Q., Liu, T., Wei, L. Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage.. Osteoarthritis and Cartilage. 2012; 20 (7) : 755-763. |
| Weng, Tujun, Yi, Lingxian, Huang, Junlan, Luo, Fengtao, Wen, Xuan, Du, Xiaolan, Chen, Qian, Deng, Chuxia, Chen, Di, Chen, Lin Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice. Arthritis and rheumatism. 2012; 64 (12) : 3982-3992. |
| Jayasuriya, Chathuraka T, Goldring, Mary B, Terek, Richard, Chen, Qian Matrilin-3 Induction of IL-1 receptor antagonist Is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression. Arthritis Res Ther. 2012; 14 (5) : R197. |
| Li, Jing, Huang, Jingang, Dai, Liming, Yu, Degang, Chen, Qian, Zhang, Xiaoling, Dai, Kerong miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4. Arthritis Res Ther. 2012; 14 (2) : R75. |
| Guan Y, Chen Q, Yang X, Haines P, Pei M, Terek R, Wei X, Zhao T, Wei L Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV.. AJP: Cell Physiology. 2012; 303 (1) : C33-C40. |
| Kanbe, Katsuaki, Chen, Qian, Nakamura, Atsushi, Hobo, Kaori Inhibition of MAP kinase in synovium by treatment with tocilizumab in rheumatoid arthritis. Clinical Rheumatology. 2011; 30 (11) : 1407-1413. |
| Li, Kai, Wei, Fangyuan, Zhou, Jingming, Wei, Xiaochun, Chen, Qian, Fleming, Braden, Terek, Richard, Wei, Lei Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage. Bone. 2010; 47 : S361-S362. |
| Sun, Xiaojuan, Wei, Lei, Chen, Qian, Terek, Richard M CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression. Molecular cancer. 2010; 9 (1) : 17. |
| Chen, Qian, Wei, Lei, Yang, Xu Pre-clinical animal models of osteoarthritis. Bone. 2010; 47 : S350-S351. |
| Chen, Qian Rheumatoid and osteoarthritis in cartilage and bone health. Bone. 2010; 47 : S354. |
| Chang, Jen-Huei, Shen, Hsain-Chung, Huang, Guo-Shu, Pan, Ru-Yu, Wu, Chi-Fang, Lee, Chian-Her, Chen, Qian A Biomechanical Comparison of All-Inside Meniscus Repair Techniques. Journal of Surgical Research. 2009; 155 (1) : 82-88. |
| Kanbe, Katsuaki, Inoue, Kazuhiko, Inoue, Yasuo, Chen, Qian Inducement of mitogen-activated protein kinases in frozen shoulders. Journal of Orthopaedic Science. 2009; 14 (1) : 56-61. |
| Kim MS, Wu KY, Auyeung V, Chen Q, Gruppuso PA, Phornphutkul C Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling.. AJP: Endocrinology and Metabolism. 2009; 296 (6) : E1374-E1382. |
| Wei, Lei, Sun, Xiaojuan, Kanbe, Katsuaki, Terek, Richard, Chen, Qian Critical roles for chemokine SDF-1 signaling in the development of growth plate chondrocyte hypertrophy. Bone. 2008; 43 : S32. |
| Pei, M., Luo, J., Chen, Q. Enhancing and maintaining chondrogenesis of synovial fibroblasts by cartilage extracellular matrix protein matrilins. Osteoarthritis and Cartilage. 2008; 16 (9) : 1110-1117. |
| Zhang, Yue, Wang, Zheng-ke, Luo, Jun-ming, Kanbe, Katsuaki, Chen, Qian Multiple functions of the von Willebrand Factor A domain in matrilins: secretion, assembly, and proteolysis. Journal of Orthopaedic Surgery and Research. 2008; 3 (1) : 21. |
| Chen, Qian Relationship between bone and cartilage damage. Bone. 2008; 43 : S17. |
| Lee, Mark C. Epiphysiodesis with Infusion of Stromal Cell-Derived Factor-1 in Rabbit Growth Plates. The Journal of Bone and Joint Surgery-American Volume. 2007; 89 (1) : 102. |
| van der Weyden, Louise, Wei, Lei, Luo, Junming, Yang, Xu, Birk, David E., Adams, David J., Bradley, Allan, Chen, Qian Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis.. The American Journal of Pathology. 2006; 169 (2) : 515-27. |
| Kanbe, Katsuaki, Inoue, Kazuhiko, Xiang, Charlie, Chen, Qian Identification of clock as a mechanosensitive gene by large-scale DNA microarray analysis: downregulation in osteoarthritic cartilage. Mod Rheumatol. 2006; 16 (3) : 131-136. |
| Kanbe, Katsuaki, Inoue, Kazuhiko, Xiang, Charlie, Chen, Qian Identification of clock as a mechanosensitive gene by large-scale DNA microarray analysis: downregulation in osteoarthritic cartilage. Mod Rheumatol. 2006; 16 (3) : 131-136. |
| Vezeridis, Peter S., Semeins, Cornelis M., Chen, Qian, Klein-Nulend, Jenneke Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation. Biochemical and Biophysical Research Communications. 2006; 348 (3) : 1082-1088. |
| Kanbe, Katsuaki, Yang, Xu, Wei, Lei, Sun, Changqi, Chen, Qian Pericellular Matrilins Regulate Activation of Chondrocytes by Cyclic Load-Induced Matrix Deformation. J Bone Miner Res. 2006; 22 (2) : 318-328. |
| Lee, Chian-Her, Huang, Guo-Shu, Chao, Kuo-Hua, Wu, Shing-Sheng, Chen, Qian Differential Pretensions of a Flexor Tendon Graft for Anterior Cruciate Ligament Reconstruction: A Biomechanical Comparison in a Porcine Knee Model. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2005; 21 (5) : 540-546. |
| Chen, Qian Skeletal mechanobiology: where does it go in the ???post-dinosaur??? age?. Current Opinion in Orthopaedics. 2005; 16 (5) : 309-310. |
| Phornphutkul, C. Insulin-like growth factor-I signaling is modified during chondrocyte differentiation. The Journal of endocrinology. 2004; 183 (3) : 477-486. |
| Chen, Qian Rebuilding the musculoskeletal system. Current Opinion in Orthopaedics. 2004; 15 (5) : 317. |
| Kanbe, K., Takemura, T., Takeuchi, K., Chen, Q., Takagishi, K., Inoue, K. Synovectomy reduces stromal-cell-derived factor-1 (SDF-1) which is involved in the destruction of cartilage in osteoarthritis and rheumatoid arthritis. Journal of Institutional and Theoretical Economics JITE. 2004; 86 (2) : 296-300. |
| Chen, Qian, Johnson, David M., Haudenschild, Dominik R., Goetinck, Paul F. Cartilage Matrix Protein: Expression Patterns in Chicken, Mouse, and Humana. Annals of the New York Academy of Sciences. 1996; 785 (1) : 238-240. |
Ongoing Research Support
P20GM104937 Chen (PI) 09/15/12-08/31/17
Center of Biomedical Research Excellence in Skeletal Health and Repair
The goal of this project is to establish a multi-disciplinary research center to treat cartilage joint diseases.
Role: PI
R01 AR 059142-01A1 Wei (PI) 04/01/11-01/31/16
Histone Deacetylation Regulates Growth Plate Development
The goal of this project is to understand how HDAC4 regulates growth plate development by CaMKIV, P38 MAPK, and miR-1.
Role: Co-Investigator
R01CA166089-01A1 Terek (PI) 09/25/13-07/31/18
Targeting CXCR4 and microRNA as Therapy
The goal of this project is to develop therapy to treat chondrosarcoma.
Role: Co-Investigator
R01AR066746-01A1 Yang (PI) 09/01/15-08/30/20
The goal of this project is to study how the property of cartilage stem cells is regulated by the protein tyrosine phosphatase SHP2 under physiological and pathological conditions
Role: Co-Investigator
Completed Research Support
Rhode Island Research Alliance Collaborative Grant Award Chen (PI) 07/01/14-06/30/15
Novel SiRNA Delivery Technology via Biomimetic Nanomaterial for Treatment of Joint Arthritis
The goal of this project is to develop therapy to treat joint arthritis.
Role: PI
R01 AG 017021 Chen (PI) 09/01/98-02/28/14
Biophysical Regulation of Chondrocyte Differentiation
The major goals of this project are to study the effect of mechanical stress on chondrocyte properties
Role: PI
| Year | Degree | Institution |
|---|---|---|
| 1992 | PhD | Tufts University |
| 1985 | BS | Fudan University |
1994-1996 Postdoctoral Fellowship, Arthritis Foundation, Atlanta, GA
1995 Outstanding Research Presentation Award, 15th Annual East Coast Connective Tissue
Society Meeting, Piscataway, NJ
1996-1999 Arthritis Investigator Award (J.V. Satterfield Award), Arthritis Foundation, Atlanta, GA
1997-2002 The FIRST Award, National Institute on Aging, NIH, Bethesda, MD
1997 New Investigator Recognition Award, Orthopaedic Research Society, Chicago, IL
1999 Novartis Foundation Bursary, London, UK
1998-2003 Independent Scientist Award, NIH (PHS-Research Career Development Award), Bethesda, MD
2000 Kappa Delta Young Investigator Award, American Academy of Orthopaedic Surgeons
2001 Hinkle Society Award, Penn State College of Medicine, Hershey, PA
2006-present Trustee, Rhode Island Hospital Orthopaedic Foundation
| Name | Title |
|---|---|
| Chen, Yupeng | Assistant Professor of Orthopaedics |
| Darling, Eric | Associate Professor of Medical Science, Associate Professor of Engineering, Associate Professor of Orthopaedics |
| Ehrlich, Michael | Vincent Zecchino, MD Professor of Orthopaedic Surgery, Professor of Orthopaedics |
| Fleming, Braden | Lucy Lippitt Professor of Orthopedics, Professor of Engineering |
| Guan, Yingjie | Assistant Professor of Medicine (Research) |
| Jay, Gregory | Professor of Emergency Medicine, Professor of Medicine, Professor of Engineering (Research) |
| Jayasuriya, Chathuraka | Assistant Professor of Orthopaedics (Research) |
| Moore, Douglas | Clinical Assistant Professor of Orthopaedics |
| Terek, Richard | Professor of Orthopaedics |
| Wei, Lei | Associate Professor of Orthopaedics (Research) |
| Yang, Wentian | Associate Professor of Medicine, Associate Professor of Orthopaedics |
