1 R01 AR080726-01A1   NIH (NIAMS, NIGMS)            Jayasuriya (PI)           09/04/23-08/31/28

The goals of this project are to optimize cellular and bioactive components of a Fibrin scaffold to produce robust fibrocartilage matrix re-synthesis to bridge and reunify meniscus tears; evaluate its efficacy for improving meniscal fibrocartilage healing in a preclinical large animal model; and determine the efficacy of scaffold-augmented meniscus repair in attenuating post-traumatic osteoarthritis in the knee.

Role: Principal Investigator

W81XWH2010773   U.S. Department of Defense (CDMRP)              Jayasuriya (PI)           09/30/20-03/29/24

The goals of this study are to analyze healing response resulting from cartilage progenitor cell (CPC)-treatment of white-white zone meniscus tears, and to analyze the extent of osteoarthritis changes in knee articular cartilage following CPC-treatment of meniscus tears.

Role: Principal Investigator

1 R21 AR077326   NIH (NIAMS)              Jayasuriya (PI)           04/01/20-03/31/22

National Institute of Arthritis and Musculoskeletal and Skin and Disease

Our long-term goal is to determine whether stimulating CXCR4 pathway signaling will stimulate fibrocartilage healing in a rabbit model of meniscus injury. The goal of this study is to evaluate the efficacy of meniscus repair resulting from CXCR4 overexpression in CPCs and BM-MSCs.

Role: Principal Investigator

OREF/MTF Research Grant            Jayasuriya (PI)          05/01/19 - 04/31/21

Orthopaedic Research and Education Foundation, Rosemont, IL

There are two goals in this two-year project: The first is to quantify the number of viable cartilage progenitor cells that can be successfully extracted from donor cartilage graft tissue for the purpose of cell-mediated meniscus tissue repair. In this first part, we are identifying graft conditions that allow for optimal viable progenitor cell quantities to be extracted from donor tissues. The second goal is to use these donor cells to repair meniscal defects using an immunocompetent rodent model of knee injury. 

Role: Principle Investigator

IDeA-CTR Pilot Project (Parent Grant: U54GM115677)          Jayasuriya (PI)          02/14/17 - 02/13/18

Advance-Clinical and Translational Research (Advance-CTR), Providence, RI

The goal of this one-year pilot project is to evaluate the clinical availability and reparative capacity of a newly identified human cartilage-derived mesenchymal stem cell population for the development of cell-based meniscus repair strategies.

Role: Principle Investigator

Biomedical Research Grant (#20154146)          Jayasuriya (PI)          04/01/16 - 03/30/18

Rhode Island Foundation, Providence, RI

The goal of this one-year project is to elucidate the biological mechanism by which matrilin-3 prevents accelerated osteoarthritis.

Role: Principle Investigator

http://www.ncbi.nlm.nih.gov/sites/myncbi/1FMKpNVJMk1QK/bibliography/49510426/public/?sort=date&direction=ascending

Department of Orthopaedics, Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI.