Following medical school, I pursued clinical training in pediatrics. It was during my residency that I became interested in biomedical research. This led to a metabolism fellowship, clinical training in metabolism and pediatric endocrinology, and a research focus on mechanisms that regulate somatic growth. My laboratory had continuous NIH funding since from 1983 to 2023. I served as a graduate program trainer from 1995 to 2022 (MCB, Pathobiology, MPPB). In July of 2023, I entered (nearly complete) retirement and closed my laboratory.
| Marks, Peter W., Gruppuso, Philip A., Adashi, Eli Y. "Urgent Need for Next-Generation COVID-19 Vaccines." JAMA, vol. 329, no. 1, 2023, pp. 19. |
| Ohman, Anders, Raigani, Siavash, Santiago, John C., Heaney, Megan G., Boylan, Joan M., Parry, Nicola, Carroll, Cailah, Baptista, Sofia G., Uygun, Korkut, Gruppuso, Philip A., Sanders, Jennifer A., Yeh, Heidi. "Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function." American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 322, no. 1, 2022, pp. G21-G33. |
| Adashi, Eli Y., Gruppuso, Philip A. "Intranasal SARS-CoV-2 Vaccines: Indispensable and Inevitable." American Journal of Preventive Medicine, vol. 63, no. 6, 2022, pp. 1062-1063. |
| Raigani, Siavash, Santiago, John, Ohman, Anders, Heaney, Megan, Baptista, Sofia, Coe, Taylor M., de Vries, Reinier J., Rosales, Ivy, Shih, Angela, Markmann, James F., Gruppuso, Philip, Uygun, Korkut, Sanders, Jennifer, Yeh, Heidi. "Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ex situ innate immune responses." Frontiers in Immunology, vol. 13, 2022. |
| Adashi, Eli Y., Gruppuso, Philip A. "SARS-CoV-2 Vaccines: The Mucosal Immunity Imperative." Mayo Clinic Proceedings, vol. 97, no. 10, 2022, pp. 1771-1773. |
| Gruppuso, Philip A., Ahmed, Rashid, Adashi, Eli Y. "Valproate Teratogenicity." Obstetrics & Gynecology, vol. 140, no. 3, 2022, pp. 408-411. |
| Morris, Devin B., Gruppuso, Philip A., McGee, Heather A., Murillo, Anarina L., Grover, Atul, Adashi, Eli Y. "Diversity of the National Medical Student Body - Four Decades of Inequities." New England Journal of Medicine, vol. 384, no. 17, 2021, pp. 1661-1668. |
| Morris DB, Gruppuso PA, Adashi EY. "Diversity of the National Medical Student Body. Reply." New England Journal of Medicine, vol. 385, no. 5, 2021, pp. 479-480. |
| Santiago JC, Boylan JM, Lemieux FA, Gruppuso PA, Sanders JA, Rand DM. "Mitochondrial genotype alters the impact of rapamycin on the transcriptional response to nutrients in Drosophila." BMC genomics, vol. 22, no. 1, 2021, pp. 213. |
| Fredette, Meghan E., Zonfrillo, Mark R., Park, Sangshin, Quintos, Jose Bernardo, Gruppuso, Philip A., Topor, Lisa Swartz. "Self‐reported insulin pump prescribing practices in pediatric type 1 diabetes." Pediatric Diabetes, vol. 22, no. 5, 2021, pp. 758-765. |
| Adashi, Eli Y., Gruppuso, Philip A. "The Centers for Medicare and Medicaid Services (CMS) COVID-19 Brief: Unsettling Racial and Ethnic Health Disparities." The Journal of the American Board of Family Medicine, vol. 34, no. Suppl, 2021, pp. S13-S15. |
| Li NY, Gruppuso PA, Kalagara S, Eltorai AEM, DePasse JM, Daniels AH. "Critical Assessment of the Contemporary Orthopaedic Surgery Residency Application Process." The Journal of Bone and Joint Surgery-American Volume, vol. 101, no. 21, 2019, pp. e114. |
| Adashi EY, Ahmed AH, Gruppuso PA. "The Importance of Being Curious." The American Journal of Medicine, vol. 132, no. 6, 2019, pp. 673-674. |
| Zabala V, Boylan JM, Thevenot P, Frank A, Senthoor D, Iyengar V, Kim H, Cohen A, Gruppuso PA, Sanders JA. "Transcriptional changes during hepatic ischemia-reperfusion in the rat." PLoS ONE, vol. 14, no. 12, 2019, pp. e0227038. |
| Chorzalska A, Ahsan N, Rao RSP, Roder K, Yu X, Morgan J, Tepper A, Hines S, Zhang P, Treaba DO, Zhao TC, Olszewski AJ, Reagan JL, Liang O, Gruppuso PA, Dubielecka PM. "Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK-ERK and NF-κB pathways in a model of chronic myeloid leukemia." Molecular oncology, vol. 12, no. 5, 2018, pp. 630-647. |
| Gruppuso PA, Boylan JM, Zabala V, Neretti N, Abshiru NA, Sikora JW, Doud EH, Camarillo JM, Thomas PM, Kelleher NL, Sanders JA. "Stability of histone post-translational modifications in samples derived from liver tissue and primary hepatic cells." PLoS ONE, vol. 13, no. 9, 2018, pp. e0203351. |
| Boylan JM, Francois-Vaughan H, Gruppuso PA, Sanders JA. "Engraftment and Repopulation Potential of Late Gestation Fetal Rat Hepatocytes." Transplantation, vol. 101, no. 10, 2017, pp. 2349-2359. |
| Adashi, Eli Y., Krishna, Gopika R., Gruppuso, Philip A. "For-Profit Medical Education—Reply." JAMA, vol. 318, no. 3, 2017, pp. 302. |
| Adashi, Eli Y., Krishna, Gopika R., Gruppuso, Philip A. "For-Profit Medical Schools—A Flexnerian Legacy Upended." JAMA, 2017. |
| Adeola O. Adebayo Michael, Nagib Ahsan, Valerie Zabala, Heather Francois-Vaughan, Stephanie Post, Kate E. Brilliant, Arthur R. Salomon, Jennifer A. Sanders, Philip A. Gruppuso. "Proteomic analysis of laser capture microdissected focal lesions in a rat model of progenitor marker-positive hepatocellular carcinoma." Oncotarget, vol. 8, no. 16, 2017, pp. 26041-26056. |
| Gruppuso PA, Adashi EY. "Residency Placement Fever: Is It Time for a Reevaluation?." Academic Medicine, vol. 92, no. 7, 2017, pp. 923-926. |
| Francois-Vaughan, Heather, Adebayo, Adeola O., Brilliant, Kate E., Parry, Nicola M.A., Gruppuso, Philip A., Sanders, Jennifer A. "Persistent effect of mTOR inhibition on preneoplastic foci progression and gene expression in a rat model of hepatocellular carcinoma." Carcinogenesis, vol. 37, no. 4, 2016, pp. 408-419. |
| Boylan JM, Sanders JA, Gruppuso PA. "Regulation of fetal liver growth in a model of diet restriction in the pregnant rat." American journal of physiology. Regulatory, integrative and comparative physiology, vol. 311, no. 3, 2016, pp. R478-88. |
| Gruppuso, Philip A, Sanders, Jennifer A. "Regulation of liver development: implications for liver biology across the lifespan." J Mol Endocrinol, vol. 56, no. 3, 2016, pp. R115-R125. |
| Gruppuso, Philip A, Sanders, Jennifer A. "Regulation of liver development: implications for liver biology across the lifespan." J Mol Endocrinol, vol. 56, no. 3, 2016, pp. R115-25. |
| Ahsan, Nagib, Rao, R. Shyama Prasad, Gruppuso, Philip A., Ramratnam, Bharat, Salomon, Arthur R. "Targeted proteomics: Current status and future perspectives for quantification of food allergens." Journal of Proteomics, vol. 143, 2016, pp. 15-23. |
| George, Paul, Green, Emily P., Park, Yoon S., Gruppuso, Philip A. "A 5-year experience with an elective scholarly concentrations program." Medical Education Online, vol. 20, no. 1, 2015, pp. 29278. |
| Boylan JM, Salomon AR, Tantravahi U, Gruppuso PA. "Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit." Experimental Cell Research, 2015. |
| Adebayo AO, Zandbergen F, Kozul-Horvath CD, Gruppuso PA, Hamilton JW. "Chronic exposure to low-dose arsenic modulates lipogenic gene expression in mice." Journal of Biochemical and Molecular Toxicology, vol. 29, no. 1, 2015, pp. 1-9. |
| Boylan JM, Sanders JA, Neretti N, Gruppuso PA. "Profiling of the fetal and adult rat liver transcriptome and translatome reveals discordant regulation by the mechanistic target of rapamycin (mTOR)." American journal of physiology. Regulatory, integrative and comparative physiology, vol. 309, no. 1, 2015, pp. ajpregu.00114.2015. |
| George P, Park YS, Ip J, Gruppuso PA, Adashi EY. "The Association Between Premedical Curricular and Admission Requirements and Medical School Performance and Residency Placement: A Study of Two Admission Routes." Academic Medicine, vol. 91, no. 3, 2015, pp. 388-94. |
| Lamming DW, Demirkan G, Boylan JM, Mihaylova MM, Peng T, Ferreira J, Neretti N, Salomon A, Sabatini DM, Gruppuso PA. "Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)." The FASEB Journal, vol. 28, no. 1, 2014, pp. 300-15. |
| Spade, Daniel J., McDonnell, Elizabeth V., Heger, Nicholas E., Sanders, Jennifer A., Saffarini, Camelia M., Gruppuso, Philip A., De Paepe, Monique E., Boekelheide, Kim. "Xenotransplantation Models to Study the Effects of Toxicants on Human Fetal Tissues." Birth Defects Res B, vol. 101, no. 6, 2014, pp. 410-422. |
| Garcia B, Francois-Vaughan H, Onikoyi O, Kostadinov S, De Paepe ME, Gruppuso PA, Sanders JA. "Xenotransplantation of human fetal adipose tissue: a model of in vivo adipose tissue expansion and adipogenesis." Journal of lipid research, vol. 55, no. 12, 2014, pp. 2685-91. |
| Demirkan G, Salomon AR, Gruppuso PA. "Phosphoproteomic analysis of liver homogenates." Methods in Molecular Biology, vol. 909, 2012, pp. 151-63. |
| Sanders JA, Schorl C, Patel A, Sedivy JM, Gruppuso PA. "Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion." BMC physiology, vol. 12, 2012, pp. 1. |
| Bhutta, Abdul Q., Wen, Sicheng, Boylan, Joan M., Gruppuso, Philip, Moss, Steven F. "Su1666 Cag-Dependent Activation of mTOR Signaling by H. pylori." Gastroenterology, vol. 142, no. 5, 2012, pp. S-477. |
| Sanders JA, Brilliant KE, Clift D, Patel A, Cerretti B, Claro P, Mills DR, Hixson DC, Gruppuso PA. "The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat." Experimental and molecular pathology, vol. 93, no. 1, 2012, pp. 40-9. |
| Pingul MM, Hughes N, Wu A, Stanley CA, Gruppuso PA. "Hepatocyte nuclear factor 4α gene mutation associated with familial neonatal hyperinsulinism and maturity-onset diabetes of the young." The Journal of Pediatrics, vol. 158, no. 5, 2011, pp. 852-4. |
| Demirkan G, Yu K, Boylan JM, Salomon AR, Gruppuso PA. "Phosphoproteomic profiling of in vivo signaling in liver by the mammalian target of rapamycin complex 1 (mTORC1)." PLoS ONE, vol. 6, no. 6, 2011, pp. e21729. |
| Villa-Cuesta E, Boylan JM, Tatar M, Gruppuso PA. "Resveratrol inhibits protein translation in hepatic cells." PLoS ONE, vol. 6, no. 12, 2011, pp. e29513. |
| Gruppuso PA, Boylan JM, Sanders JA. "The physiology and pathophysiology of rapamycin resistance: implications for cancer." Cell Cycle, vol. 10, no. 7, 2011, pp. 1050-8. |
| Adashi EY, Gruppuso PA. "Commentary: the unsustainable cost of undergraduate medical education: an overlooked element of U.S. health care reform." Academic Medicine, vol. 85, no. 5, 2010, pp. 763-5. |
| Green EP, Borkan JM, Pross SH, Adler SR, Nothnagle M, Parsonnet J, Gruppuso PA. "Encouraging scholarship: medical school programs to promote student inquiry beyond the traditional medical curriculum." Academic Medicine, vol. 85, no. 3, 2010, pp. 409-18. |
| Boninger M, Troen P, Green E, Borkan J, Lance-Jones C, Humphrey A, Gruppuso P, Kant P, McGee J, Willochell M, Schor N, Kanter SL, Levine AS. "Implementation of a longitudinal mentored scholarly project: an approach at two medical schools." Academic Medicine, vol. 85, no. 3, 2010, pp. 429-37. |
| Jimenez RH, Lee JS, Francesconi M, Castellani G, Neretti N, Sanders JA, Sedivy J, Gruppuso PA. "Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR)." PLoS ONE, vol. 5, no. 2, 2010, pp. e9084. |
| Parsonnet J, Gruppuso PA, Kanter SL, Boninger M. "Required vs. elective research and in-depth scholarship programs in the medical student curriculum." Academic Medicine, vol. 85, no. 3, 2010, pp. 405-8. |
| Sullivan-Bolyai S, Bova C, Leung K, Trudeau A, Lee M, Gruppuso P. "Social Support to Empower Parents (STEP): an intervention for parents of young children newly diagnosed with type 1 diabetes." The Diabetes Educator, vol. 36, no. 1, 2010, pp. 88-97. |
| Temu TM, Wu KY, Gruppuso PA, Phornphutkul C. "The mechanism of ascorbic acid-induced differentiation of ATDC5 chondrogenic cells." AJP: Endocrinology and Metabolism, vol. 299, no. 2, 2010, pp. E325-34. |
| Gruppuso PA, Dollase R, Dumenco L, Taylor J, Green E. "The Warren Alpert Medical School of Brown University." Academic Medicine, vol. 85, no. 9 Suppl, 2010, pp. S520-4. |
| Phornphutkul C, Gruppuso PA. "Disorders of the growth plate." Current opinion in endocrinology, diabetes, and obesity, vol. 16, no. 6, 2009, pp. 430-4. |
| Kim MS, Wu KY, Auyeung V, Chen Q, Gruppuso PA, Phornphutkul C. "Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling." AJP: Endocrinology and Metabolism, vol. 296, no. 6, 2009, pp. E1374-E1382. |
| Jimenez RH, Boylan JM, Lee JS, Francesconi M, Castellani G, Sanders JA, Gruppuso PA. "Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines." PLoS ONE, vol. 4, no. 10, 2009, pp. e7373. |
| Borkan J, Feldmann E, Dollase R, Gruppuso PA. "Redesigning the clinical curriculum at the Warren Alpert Medical School of Brown University." Medicine and health, Rhode Island, vol. 92, no. 9, 2009, pp. 300-2. |
| Phornphutkul C, Lee M, Voigt C, Wu KY, Ehrlich MG, Gruppuso PA, Chen Q. "The effect of rapamycin on bone growth in rabbits." Journal of Orthopaedic Research, vol. 27, no. 9, 2009, pp. 1157-61. |
| Gruppuso PA, Palenchar E, Viticonte J. "The Warren Alpert Medical School of Brown University: Class of 2009." Medicine and health, Rhode Island, vol. 92, no. 9, 2009, pp. 292-6. |
| Gruppuso PA, Tsai SW, Boylan JM, Sanders JA. "Hepatic translation control in the late-gestation fetal rat." American journal of physiology. Regulatory, integrative and comparative physiology, vol. 295, no. 2, 2008, pp. R558-67. |
| Phornphutkul C, Wu KY, Auyeung V, Chen Q, Gruppuso PA. "mTOR signaling contributes to chondrocyte differentiation." Developmental dynamics : an official publication of the American Association of Anatomists, vol. 237, no. 3, 2008, pp. 702-12. |
| Yoo SJ, Jimenez RH, Sanders JA, Boylan JM, Brautigan DL, Gruppuso PA. "The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells." Journal of cellular biochemistry, vol. 105, no. 1, 2008, pp. 290-300. |
| Sanders JA, Lakhani A, Phornphutkul C, Wu KY, Gruppuso PA. "The effect of rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal rats." AJP: Cell Physiology, vol. 295, no. 2, 2008, pp. C406-13. |
| Gruppuso PA, Palenchar E, Viticonte J. "The Warren Alpert Medical School of Brown University: class of 2008." Medicine and health, Rhode Island, vol. 91, no. 8, 2008, pp. 242-6. |
| Garg S, Gruppuso PA, Dumenco L. "Redesigning the medical science curriculum at the Warren Alpert Medical School of Brown University." Medicine and health, Rhode Island, vol. 90, no. 9, 2007, pp. 272-4. |
| Yoo SJ, Boylan JM, Brautigan DL, Gruppuso PA. "Subunit composition and developmental regulation of hepatic protein phosphatase 2A (PP2A)." Archives of Biochemistry and Biophysics, vol. 461, no. 2, 2007, pp. 186-93. |
| Gruppuso PA, MacConnell J, Viticonte J. "The Warren Alpert Medical School of Brown University: Class of 2007." Medicine and health, Rhode Island, vol. 90, no. 9, 2007, pp. 266-71. |
| Sanders JA, Gruppuso PA. "Coordinated regulation of c-Myc and Max in rat liver development." American journal of physiology. Gastrointestinal and liver physiology, vol. 290, no. 1, 2006, pp. G145-55. |
| Gruppuso PA. "Medical education at Brown Medical School." Medicine and health, Rhode Island, vol. 89, no. 9, 2006, pp. 298. |
| Anand P, Gruppuso PA. "Rapamycin inhibits liver growth during refeeding in rats via control of ribosomal protein translation but not cap-dependent translation initiation." Journal of Nutrition, vol. 136, no. 1, 2006, pp. 27-33. |
| Dreger, A., Chase, C., Sousa, A., Gruppuso, P.A., Frader, J. "Re: Houk CP, et al. Intersex Classification Scheme: A Response to the Call for a Change." Journal of pediatric endocrinology & metabolism : JPEM, vol. 19, no. 2, 2006. |
| Dreger A, Chase C, Sousa A, Gruppuso PA, Frader J. "Re: Houk CP, et al. Intersex classification scheme: a response to the call for a change. J Pediatr Endocrinol Metab 2005; 18: 735-738." Journal of pediatric endocrinology & metabolism : JPEM, vol. 19, no. 2, 2006, pp. 193. |
| Phornphutkul C, Wu KY, Gruppuso PA. "The role of insulin in chondrogenesis." Molecular and cellular endocrinology, vol. 249, no. 1-2, 2006, pp. 107-15. |
| Dreger, A.D., Chase, C., Sousa, A., Gruppuso, P.A., Frader, J. "Changing the Nomenclature/Taxonomy for Intersex: A Scientific and Clinical Rationale." Journal of pediatric endocrinology & metabolism : JPEM, vol. 18, no. 8, 2005. |
| Dreger AD, Chase C, Sousa A, Gruppuso PA, Frader J. "Changing the nomenclature/taxonomy for intersex: a scientific and clinical rationale." Journal of pediatric endocrinology & metabolism : JPEM, vol. 18, no. 8, 2005, pp. 729-33. |
| Boylan JM, Gruppuso PA. "D-type cyclins and G1 progression during liver development in the rat." Biochemical and Biophysical Research Communications, vol. 330, no. 3, 2005, pp. 722-30. |
| Gruppuso PA, Boylan JM, Anand P, Bienieki TC. "Effects of maternal starvation on hepatocyte proliferation in the late gestation fetal rat." Pediatric Research, vol. 57, no. 2, 2005, pp. 185-91. |
| Sanders JA, Gruppuso PA. "Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation." Biochimica et biophysica acta, vol. 1743, no. 1-2, 2005, pp. 141-50. |
| Anand P, Gruppuso PA. "The regulation of hepatic protein synthesis during fasting in the rat." Journal of Biological Chemistry, vol. 280, no. 16, 2005, pp. 16427-36. |
| Embree-Ku M, Gruppuso PA. "The role of nuclear factor kappaB in late-gestation liver development in the rat." Hepatology, vol. 42, no. 2, 2005, pp. 326-34. |
| Kadmon, P.M., Gruppuso, P.A. "Glycemic Control with Metformin or Insulin Therapy in Adolescents with Type 2 Diabetes Mellitus." Journal of pediatric endocrinology & metabolism : JPEM, vol. 17, no. 9, 2004. |
| Kadmon PM, Gruppuso PA. "Glycemic control with metformin or insulin therapy in adolescents with type 2 diabetes mellitus." Journal of pediatric endocrinology & metabolism : JPEM, vol. 17, no. 9, 2004, pp. 1185-93. |
| Sullivan-Bolyai S, Grey M, Deatrick J, Gruppuso P, Giraitis P, Tamborlane W. "Helping other mothers effectively work at raising young children with type 1 diabetes." The Diabetes Educator, vol. 30, no. 3, 2004, pp. 476-84. |
| Phornphutkul, C. "Insulin-like growth factor-I signaling is modified during chondrocyte differentiation." The Journal of endocrinology, vol. 183, no. 3, 2004, pp. 477-486. |
| Sanchez-Esteban J, Wang Y, Gruppuso PA, Rubin LP. "Mechanical stretch induces fetal type II cell differentiation via an epidermal growth factor receptor-extracellular-regulated protein kinase signaling pathway." American Journal of Respiratory Cell and Molecular Biology, vol. 30, no. 1, 2004, pp. 76-83. |
| Cerezo CS, Kulpa-Oliver V, Gruppuso PA, Morin MJ. "Regulation of adolescent rat intestinal epithelial inducible nitric oxide synthase expression in endotoxin tolerance: modulation of signal transduction." Shock, vol. 21, no. 5, 2004, pp. 476-83. |
| Giannone PJ, Abu Dayyeh BK, Bienieki TC, Wands JR, Gruppuso PA. "Targeted hepatic overexpression of human IRS-1: postnatal effects in the developing mouse." Biochimica et biophysica acta, vol. 1672, no. 2, 2004, pp. 112-9. |
| Gruppuso PA. "Achieving glycemic control in young children with type 1 diabetes: approaches, pitfalls and new technologies." Medicine and health, Rhode Island, vol. 86, no. 4, 2003, pp. 107-11. |
| Sullivan-Bolyai S, Deatrick J, Gruppuso P, Tamborlane W, Grey M. "Constant vigilance: mothers' work parenting young children with type 1 diabetes." Journal of Pediatric Nursing, vol. 18, no. 1, 2003, pp. 21-9. |
| Khamzina L, Gruppuso PA, Wands JR. "Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development." Gastroenterology, vol. 125, no. 2, 2003, pp. 572-85. |
| Boylan JM, Gruppuso PA. "Insulin receptor substrate-1 is present in hepatocyte nuclei from intact rats." Endocrinology, vol. 143, no. 11, 2002, pp. 4178-83. |
| Anand P, Boylan JM, Ou Y, Gruppuso PA. "Insulin signaling during perinatal liver development in the rat." AJP: Endocrinology and Metabolism, vol. 283, no. 4, 2002, pp. E844-52. |
| Sullivan-Bolyai, Susan, Deatrick, Janet, Gruppuso, Philip, Tamborlane, William, Grey, Margaret. "Mothers'Experiences Raising Young Children With Type 1 Diabetes." Journal for Specialists in Pediatric Nursing, vol. 7, no. 3, 2002, pp. 93-103. |
| Gruppuso PA. "The clinical laboratory evaluation of GH responsiveness." The Journal of Clinical Endocrinology & Metabolism, vol. 87, no. 2, 2002, pp. 466-8. |
| Phornphutkul C, Okubo T, Wu K, Harel Z, Tracy TF Jr, Pinar H, Chen S, Gruppuso PA, Goodwin G. "Aromatase p450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty." The Journal of Clinical Endocrinology & Metabolism, vol. 86, no. 2, 2001, pp. 649-52. |
| Tseng YT, Kopel R, Stabila JP, McGonnigal BG, Nguyen TT, Gruppuso PA, Padbury JF. "Beta-adrenergic receptors (betaAR) regulate cardiomyocyte proliferation during early postnatal life." The FASEB Journal, vol. 15, no. 11, 2001, pp. 1921-6. |
| Morin MJ, Karr SM, Faris RA, Gruppuso PA. "Developmental variability in expression and regulation of inducible nitric oxide synthase in rat intestine." American journal of physiology. Gastrointestinal and liver physiology, vol. 281, no. 2, 2001, pp. G552-9. |
| Boylan JM, Anand P, Gruppuso PA. "Ribosomal protein S6 phosphorylation and function during late gestation liver development in the rat." Journal of Biological Chemistry, vol. 276, no. 48, 2001, pp. 44457-63. |
| Boney CM, Sekimoto H, Gruppuso PA, Frackelton AR Jr. "Src family tyrosine kinases participate in insulin-like growth factor I mitogenic signaling in 3T3-L1 cells." Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, vol. 12, no. 7, 2001, pp. 379-86. |
| Kadmon PM, Noto RB, Boney CM, Goodwin G, Gruppuso PA. "Thyroid storm in a child following radioactive iodine (RAI) therapy: a consequence of RAI versus withdrawal of antithyroid medication." The Journal of Clinical Endocrinology & Metabolism, vol. 86, no. 5, 2001, pp. 1865-7. |
| Awad MM, Sanders JA, Gruppuso PA. "A potential role for p15(Ink4b) and p57(Kip2) in liver development." FEBS Letters, vol. 483, no. 2-3, 2000, pp. 160-4. |
| Awad MM, Gruppuso PA. "Cell cycle control during liver development in the rat: evidence indicating a role for cyclin D1 posttranscriptional regulation." Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, vol. 11, no. 6, 2000, pp. 325-34. |
| Phornphutkul C, Fausto-Sterling A, Gruppuso PA. "Gender self-reassignment in an XY adolescent female born with ambiguous genitalia." Pediatrics, vol. 106, no. 1 Pt 1, 2000, pp. 135-7. |
| Awad MM, Enslen H, Boylan JM, Davis RJ, Gruppuso PA. "Growth regulation via p38 mitogen-activated protein kinase in developing liver." Journal of Biological Chemistry, vol. 275, no. 49, 2000, pp. 38716-21. |
| Gruppuso PA, Boylan JM. "Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK." FEBS Letters, vol. 466, no. 1, 2000, pp. 200-4. |
| Phornphutkul C, Frick GP, Goodman HM, Berry SA, Gruppuso PA. "Hepatic growth hormone signaling in the late gestation fetal rat." Endocrinology, vol. 141, no. 10, 2000, pp. 3527-33. |
| Gruppuso PA, Boylan JM, Vaslet CA. "Identification of candidate growth-regulating genes that are overexpressed in late gestation fetal liver in the rat." Biochimica et biophysica acta, vol. 1494, no. 3, 2000, pp. 242-7. |
| Boney CM, Gruppuso PA, Faris RA, Frackelton AR Jr. "The critical role of Shc in insulin-like growth factor-I-mediated mitogenesis and differentiation in 3T3-L1 preadipocytes." Molecular endocrinology (Baltimore, Md.), vol. 14, no. 6, 2000, pp. 805-13. |
| Gruppuso PA, Bienieki TC, Faris RA. "The relationship between differentiation and proliferation in late gestation fetal rat hepatocytes." Pediatric Research, vol. 46, no. 1, 1999, pp. 14-9. |
| Phornphutkul C, Boney CM, Gruppuso PA. "A novel presentation of Addison disease: hypoglycemia unawareness in an adolescent with insulin-dependent diabetes mellitus." The Journal of Pediatrics, vol. 132, no. 5, 1998, pp. 882-4. |
| Boney CM, Smith RM, Gruppuso PA. "Modulation of insulin-like growth factor I mitogenic signaling in 3T3-L1 preadipocyte differentiation." Endocrinology, vol. 139, no. 4, 1998, pp. 1638-44. |
| Boylan JM, Gruppuso PA. "Uncoupling of hepatic, epidermal growth factor-mediated mitogen-activated protein kinase activation in the fetal rat." Journal of Biological Chemistry, vol. 273, no. 6, 1998, pp. 3784-90. |
| Leeds P, Kren BT, Boylan JM, Betz NA, Steer CJ, Gruppuso PA, Ross J. "Developmental regulation of CRD-BP, an RNA-binding protein that stabilizes c-myc mRNA in vitro." Oncogene, vol. 14, no. 11, 1997, pp. 1279-86. |
| Gruppuso PA, Awad M, Bienieki TC, Boylan JM, Fernando S, Faris RA. "Modulation of mitogen-independent hepatocyte proliferation during the perinatal period in the rat." In vitro cellular & developmental biology. Animal, vol. 33, no. 7, 1997, pp. 562-8. |
| Boylan JM, Gruppuso PA. "A comparative study of the hepatic mitogen-activated protein kinase and Jun-NH2-terminal kinase pathways in the late-gestation fetal rat." Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, vol. 7, no. 9, 1996, pp. 1261-9. |
| Lipeski LE, Boylan JM, Gruppuso PA. "A comparison of epidermal growth factor receptor-mediated mitogenic signaling in response to transforming growth factor alpha and epidermal growth factor in cultured fetal rat hepatocytes." Biochemistry and molecular biology international, vol. 39, no. 5, 1996, pp. 975-83. |
| Lesser KB, Gruppuso PA, Terry RB, Carpenter MW. "Exercise fails to improve postprandial glycemic excursion in women with gestational diabetes." The Journal of maternal-fetal medicine, vol. 5, no. 4, 1996, pp. 211-7. |
| Boney CM, Fiedorek FT Jr, Paul SR, Gruppuso PA. "Regulation of preadipocyte factor-1 gene expression during 3T3-L1 cell differentiation." Endocrinology, vol. 137, no. 7, 1996, pp. 2923-8. |
| Gruppuso PA, Boylan JM. "Developmental changes in the activity and cellular localization of hepatic casein kinase II in the rat." Journal of cellular biochemistry, vol. 58, no. 1, 1995, pp. 65-72. |
| Partyka CM, Gelardi NL, Fadden K, Rifai A, Gruppuso PA, Oh W, Reddy GS. "Lack of production and growth-modulating effects of 1a,25-dihydroxyvitamin D3 in cultured fetal rat hepatocytes." Biology of the neonate, vol. 67, no. 3, 1995, pp. 194-202. |
| Gruppuso PA, Boylan JM, Bienieki TC, Curran TR Jr. "Evidence for a direct hepatotrophic role for insulin in the fetal rat: implications for the impaired hepatic growth seen in fetal growth retardation." Endocrinology, vol. 134, no. 2, 1994, pp. 769-75. |
| Schwartz R, Gruppuso PA, Petzold K, Brambilla D, Hiilesmaa V, Teramo KA. "Hyperinsulinemia and macrosomia in the fetus of the diabetic mother." Diabetes Care, vol. 17, no. 7, 1994, pp. 640-8. |
| Boylan JM, Gruppuso PA. "In vitro and in vivo regulation of hepatic mitogen-activated protein kinases in fetal rats." The American journal of physiology, vol. 267, no. 6 Pt 1, 1994, pp. G1078-86. |
| Hoegsberg B, Gruppuso PA, Coustan DR. "Hyperinsulinemia in macrosomic infants of nondiabetic mothers." Diabetes Care, vol. 16, no. 1, 1993, pp. 32-6. |
| Curran TR Jr, Bahner RI Jr, Oh W, Gruppuso PA. "Mitogen-independent DNA synthesis by fetal rat hepatocytes in primary culture." Experimental Cell Research, vol. 209, no. 1, 1993, pp. 53-7. |
| Aparicio L, Carpenter MW, Schwartz R, Gruppuso PA. "Prenatal diagnosis of familial neonatal hyperinsulinemia." Acta Paediatrica, vol. 82, no. 8, 1993, pp. 683-6. |
| Thompson NL, Panzica MA, Hull G, Lin SH, Curran TR, Gruppuso PA, Baum O, Reutter W, Hixson DC. "Spatiotemporal expression of two cell-cell adhesion molecule 105 isoforms during liver development." Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, vol. 4, no. 4, 1993, pp. 257-68. |
| Boylan JM, Brautigan DL, Madden J, Raven T, Ellis L, Gruppuso PA. "Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats." Journal of Clinical Investigation, vol. 90, no. 1, 1992, pp. 174-9. |
| Gruppuso PA, Boylan JM, Carter PA, Madden JA, Raven T. "Hepatic insulin and EGF receptor phosphorylation and dephosphorylation in fetal rats." The American journal of physiology, vol. 262, no. 1 Pt 1, 1992, pp. E6-13. |
| Gruppuso PA, Boylan JM. "Heterogeneity of hepatic protein tyrosine phosphatases." Second messengers and phosphoproteins, vol. 14, no. 3, 1992, pp. 99-108. |
| Gruppuso PA, Boylan JM, Levine BA, Ellis L. "Insulin receptor tyrosine kinase domain auto-dephosphorylation." Biochemical and Biophysical Research Communications, vol. 189, no. 3, 1992, pp. 1457-63. |
| Aparicio LF, Ocrant I, Boylan JM, Gruppuso PA. "Protein tyrosine phosphatase activation during nerve growth factor-induced neuronal differentiation of PC12 cells." Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, vol. 3, no. 6, 1992, pp. 363-7. |
| Fausto N, Mead JE, Gruppuso PA, Castilla A, Jakowlew SB. "Effects of TGF-beta s in the liver: cell proliferation and fibrogenesis." Ciba Foundation symposium, vol. 157, 1991, pp. 165-74; discussion 174-7. |
| Gruppuso PA, Curran TR, Mead JE, Fausto N, Oh W. "Fetal growth factors as determinants of intrauterine hepatic growth." Diabetes, vol. 40 Suppl 2, 1991, pp. 51-5. |
| Gruppuso PA, Mikumo R, Brautigan DL, Braun L. "Growth arrest induced by transforming growth factor beta 1 is accompanied by protein phosphatase activation in human keratinocytes." Journal of Biological Chemistry, vol. 266, no. 6, 1991, pp. 3444-8. |
| Gruppuso PA, Boylan JM, Smiley BL, Fallon RJ, Brautigan DL. "Hepatic protein tyrosine phosphatases in the rat." Biochem. J., vol. 274 ( Pt 2), 1991, pp. 361-7. |
| Gruppuso PA, Walker TD, Carter PA. "Ontogeny of hepatic type I insulin-like growth factor receptors in the rat." Pediatric Research, vol. 29, no. 3, 1991, pp. 226-30. |
| Braun L, Dürst M, Mikumo R, Gruppuso P. "Differential response of nontumorigenic and tumorigenic human papillomavirus type 16-positive epithelial cells to transforming growth factor beta 1." Cancer Research, vol. 50, no. 22, 1990, pp. 7324-32. |
| Gruppuso PA. "Hepatic protein kinase-C and protein phosphatase type-2A in the fetal rat." Pediatric Research, vol. 27, no. 6, 1990, pp. 599-603. |
| Gruppuso PA, Boylan JM, Posner BI, Faure R, Brautigan DL. "Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats." Journal of Clinical Investigation, vol. 85, no. 6, 1990, pp. 1754-60. |
| Patten JL, Johns DR, Valle D, Eil C, Gruppuso PA, Steele G, Smallwood PM, Levine MA. "Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright's hereditary osteodystrophy." New England Journal of Medicine, vol. 322, no. 20, 1990, pp. 1412-9. |
| Fausto N, Mead JE, Gruppuso PA, Braun L. "TGF-beta in liver development, regeneration, and carcinogenesis." Annals of the New York Academy of Sciences, vol. 593, 1990, pp. 231-42. |
| Braun L, Gruppuso P, Mikumo R, Fausto N. "Transforming growth factor beta 1 in liver carcinogenesis: messenger RNA expression and growth effects." Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, vol. 1, no. 3, 1990, pp. 103-11. |
| Gruppuso PA, Mead JE, Fausto N. "Transforming growth factor receptors in liver regeneration following partial hepatectomy in the rat." Cancer Research, vol. 50, no. 5, 1990, pp. 1464-9. |
| Gruppuso PA. "Effects of fetal hypoinsulinemia on fetal hepatic insulin binding in the rat." Biochimica et biophysica acta, vol. 1010, no. 2, 1989, pp. 270-3. |
| Gruppuso PA. "Expression of hepatic transforming growth factor receptors during late gestation in the fetal rat." Endocrinology, vol. 125, no. 6, 1989, pp. 3037-43. |
| Gruppuso PA, Schwartz R. "Hypoglycemia in children." Pediatrics in Review, vol. 11, no. 4, 1989, pp. 117-24. |
| Gruppuso PA, Brautigan DL. "Induction of hepatic glycogenesis in the fetal rat." The American journal of physiology, vol. 256, no. 1 Pt 1, 1989, pp. E49-54. |
| Gruppuso PA, Frank BH, Schwartz R. "Binding of proinsulin and proinsulin conversion intermediates to human placental insulin-like growth factor I receptors." The Journal of Clinical Endocrinology & Metabolism, vol. 67, no. 1, 1988, pp. 194-7. |
| Gruppuso PA, Brautigan DL. "Compartmentalized protein phosphorylation/dephosphorylation in glycogen particles from rabbit skeletal muscle." Biochemistry international, vol. 16, no. 6, 1988, pp. 1027-32. |
| Carpenter MW, Coustan DR, Widness JA, Gruppuso PA, Malone M, Rotondo LM. "Postpartum testing for antecedent gestational diabetes." American Journal of Obstetrics and Gynecology, vol. 159, no. 5, 1988, pp. 1128-31. |
| Chan SJ, Seino S, Gruppuso PA, Schwartz R, Steiner DF. "A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia." Proceedings of the National Academy of Sciences, vol. 84, no. 8, 1987, pp. 2194-7. |
| Gruppuso PA, Shriner CL, Brautigan DL. "Latent forms of type-1 protein phosphatase in rabbit skeletal muscle." Biochemical and Biophysical Research Communications, vol. 148, no. 3, 1987, pp. 1174-81. |
| Gruppuso PA, Susa JB, Sehgal P, Frank B, Schwartz R. "Metabolism and placental transfer of 125I-proinsulin and 125I-tyrosylated C-peptide in the pregnant rhesus monkey." Journal of Clinical Investigation, vol. 80, no. 4, 1987, pp. 1132-7. |
| Domenech M, Gruppuso PA, Nishino VT, Susa JB, Schwartz R. "Preserved fetal plasma amino acid concentrations in the presence of maternal hypoaminoacidemia." Pediatric Research, vol. 20, no. 11, 1986, pp. 1071-6. |
| Brautigan DL, Gruppuso PA, Mumby M. "Protein phosphatase type-1 and type-2 catalytic subunits both bind inhibitor-2 and monoclonal immunoglobulins." Journal of Biological Chemistry, vol. 261, no. 32, 1986, pp. 14924-8. |
| Elbein SC, Gruppuso P, Schwartz R, Skolnick M, Permutt MA. "Hyperproinsulinemia in a family with a proposed defect in conversion is linked to the insulin gene." Diabetes, vol. 34, no. 8, 1985, pp. 821-4. |
| Domenech M, Gruppuso PA, Susa JB, Schwartz R. "Induction in utero of hepatic glucose-6-phosphatase by fetal hypoinsulinemia." Biology of the neonate, vol. 47, no. 2, 1985, pp. 92-8. |
| Gruppuso PA, DeLuca F, O'Shea PA, Schwartz R. "Near-total pancreatectomy for hyperinsulinism. Spontaneous remission of resultant diabetes." Acta paediatrica Scandinavica, vol. 74, no. 2, 1985, pp. 311-5. |
| Brautigan DL, Shriner CL, Gruppuso PA. "Phosphorylase phosphatase catalytic subunit. Evidence that the Mr = 33,000 enzyme fragment is derived from a native protein of Mr = 70,000." Journal of Biological Chemistry, vol. 260, no. 7, 1985, pp. 4295-302. |
| Gruppuso PA, Johnson GL, Constantinides M, Brautigan DL. "Phosphorylase phosphatase regulatory subunit. "Western" blotting with immunoglobulins against inhibitor-2 reveals a protein of Mr = 60,000." Journal of Biological Chemistry, vol. 260, no. 7, 1985, pp. 4288-94. |
| Susa JB, Gruppuso PA, Widness JA, Domenech M, Clemons GK, Sehgal P, Schwartz R. "Chronic hyperinsulinemia in the fetal rhesus monkey: effects of physiologic hyperinsulinemia on fetal substrates, hormones, and hepatic enzymes." American Journal of Obstetrics and Gynecology, vol. 150, no. 4, 1984, pp. 415-20. |
| Gruppuso PA, Gorden P, Kahn CR, Cornblath M, Zeller WP, Schwartz R. "Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin." New England Journal of Medicine, vol. 311, no. 10, 1984, pp. 629-34. |
| Gruppuso PA, Susa JB, Domenech M, Cha CJ, Schwartz R. "Chronic hyperglucagonemia in rats: effects on insulin, substrates, and hepatic enzymes of intermediary metabolism." Metabolism: clinical and experimental, vol. 32, no. 9, 1983, pp. 911-8. |
| Gruppuso PA, O'Shea PA, Orson JM, Brem AS. "Juvenile nephronophthsis with blindness in a three-month-old infant." Clinical Pediatrics, vol. 22, no. 2, 1983, pp. 1114-1118. |
| Gruppuso PA, Migliori R, Susa JB, Schwartz R. "Chronic maternal hyperinsulinemia and hypoglycemia. A model for experimental intrauterine growth retardation." Biology of the neonate, vol. 40, no. 3-4, 1981, pp. 113-20. |
| Gruppuso PA, Kinter LB. "DDT inhibition of active chlorophenol red transport in goldfish (Carassius auratus) renal tubules." Bulletin of environmental contamination and toxicology, vol. 10, no. 3, 1973, pp. 181-6. |
Our laboratory focused on the mechanisms that regulate normal and abnormal cellular growth. We used the liver as a model system to study the control of hepatocyte proliferation during normal liver development, liver regeneration and liver injury. We did so based on the premise that understanding normal hepatocyte growth regulation would provide insight into abnormal growth (cancer) and the proliferative response of the liver's facultative stem cells to liver injury. We concentrated on the following areas: developmental stage-specific alterations in hepatocyte mitogenic signaling, changes in translation control during the perinatal period, and hepatocyte cell cycle control during development. Our model systems were the rat and mouse with a particular focus on the tripling of liver mass that takes place during the last several days of gestation. Our work employed both in vitro (primary culture and hepatic cell lines) and in vivo approaches.
We arrived at an unexpected picture of how hepatocyte proliferation is regulated through late fetal and postnatal development. Our data indicated that the stimulation for rapid fetal hepatocyte growth is largely independent of the signal transduction pathways that stimulate the proliferation of adult rat hepatocytes. A manifestation of this difference between fetal and adult hepatocyte growth control is the resistance of fetal hepatocytes to the growth (translation and cell cycle) inhibitory effects of the drug rapamycin. Rapamycin resistance is a characteristic previously attributed to transformed cell types. In pursuing this observation, we identified translation and cell cycle control mechanisms that appear to relate to the dysregulated growth seen in the liver's response to carcinogens and injury. Most recently, we focused on the regenerative capacity of fetal liver cells, their epigenetic phenotype, and their ability to repopulate an injured adult liver.
| Year | Degree | Institution |
|---|---|---|
| 1977 | MD | University of Rochester |
| 1973 | BA | Union College |
| Trainee | Brown University, diabetes | 1982-1983 | Providence, RI |
| Fellow | Rhode Island Hospital, pediatric endocrinology and metabolism | 1981-1983 | Providence, RI |
| Chief Resident | Rhode Island Hospital, Pediatrics | 1980-1981 | Providence, RI |
| Resident | Rhode Island Hospital, Pediatrics | 1978-1980 | Providence, RI |
| Intern | Rhode Island Hospital, Pediatrics | 1977-1978 | Providence, RI |
| Name | Title |
|---|---|
| Neretti, Nicola | Associate Professor of Molecular Biology, Cell Biology, and Biochemistry, Associate Director for the Center on the Biology of Aging |
| Salomon, Arthur | Professor of Molecular Biology, Cell Biology, and Biochemistry, Professor of Chemistry |
| Sanders, Jennifer | Pathobiology Graduate Program Co-Director, Associate Professor of Pathology and Laboratory Medicine (Research), Associate Professor of Pediatrics (Research) |
ACADEMIC APPOINTMENTS
Professor of Pediatrics, Brown University, 1994-present
Professor of Molecular Biology, Cell Biology & Biochemistry (Research), Brown University, 1994-2023
Professor of Medical Science, September 2015-present
Associate Dean for Medical Education, August 2005-2013
HOSPITAL APPOINTMENTS
Staff Physician, Rhode Island Hospital, July 1994-2012
| Certification | American Board of Pediatrics, Pediatric endocrinology | 1984- | |
| Certification | American Board of Pediatrics, General pediatrics | 1982- | |
| Medical License | Rhode Island | 1977-Present | #6035 |
| Staff Physician. Rhode Island Hospital, 1994-2014 |
| Vice Chair for Research. Rhode Island Hospital, 1990-2004 |
| Associate Physician. Rhode Island Hospital, 1989-1994 |
| Assistant Physician. Rhode Island Hospital, 1983-1989 |
| Consulting Physician. Women & Infants Hospital of Rhode Island, 1983-2014 |
Since my original faculty appointment in Brown in 1983, I had a role in both the pre-clerkship and clinical medical curricula. My involvement in medical education, including the directorship of Brown's MD/PhD program for several years, led to my appointment as Associate Dean for Medical Education in 2005, a position I held until June 2013. Thereafter, my role was as a lecturer in the medical school's preclerkship curriculum. The focus of my teaching was biochemistry, nutrition science and pharmacology. I gave my last lecture in December 2023.
| BIOL 3642 - IMS 1 - Scientific Foundations of Medicine |
