Dr. Fleming joined the Department of Orthopaedics at Brown University in June 2003. He received his doctorate in Mechanical Engineering from the University of Vermont in 1996 and then served on the faculty of the Department of Orthopaedics & Rehabilitation at the University of Vermont for seven years. His primary research interests focus on the lower extremity with a particular interest in knee ligament injuries, soft tissue biomechanics and biomedical instrumentation. Recent translational projects include the development of experimental models to investigate graft healing and the progression of osteoarthritis following ACL injury, repair and reconstruction, the development of tissue engineering methods to stimulate ligament healing, the design of methods to non-invasively monitor the biomechanical properties of healing soft tissues, and the application of biotribologic principles to provide cartilage protection following joint injury. He is the Co-Director of the Bioengineering Core of the COBRE for Skeletal Health and Repair. Most of his research has been funded by the NIH or DOD. He has received several awards for his work including the William A. Grana Award for Best Original Research (2020); OREF Clinical Research Award (2020; 2022; O'Donoghue Sports Injury Research Award (2020; 2005); Kappa Delta Award (2013; 1994); Cabaud Research Award (2013; 2009), ACL Study Group Traveling Fellowship (2010-2012); Bruce Selya Research Award (2005), GOTS-Beiersdorf Research Award (2000), the American Society of Biomechanics Post-doctoral Young Scientist Award (1999), and the Albert Trillat Young Investigator Award (1997).
| Kaushal SG, Kim JY, Singh M, Han M, Flannery SW, Barnes DA, Ecklund K, Murray MM, Badger GJ, Fleming BC, Kiapour AM. "Comprehensive evaluation of magnetic resonance imaging sequences for signal intensity based assessment of anterior cruciate ligament healing following surgical treatment." Journal of Orthopaedic Research, 2024. |
| Sun C, Chang K, Fleming BC, Owens BD, Beveridge JE, Gage A, Talley-Bruns RC, McAllister S, Costa MQ, Pinette MP, Hague M, Molino J, Xiao Y, Lu S, Wei L. "A novel large animal model of posttraumatic osteoarthritis induced by inflammation with mechanical stability." American journal of translational research, vol. 15, no. 7, 2023, pp. 4573-4586. |
| Zandiyeh, Payam, Parola, Lauren R., Costa, Meggin Q., Hague, Madalyn J., Molino, Janine, Fleming, Braden C., Beveridge, Jillian E. "Long-Term Bilateral Neuromuscular Function and Knee Osteoarthritis after Anterior Cruciate Ligament Reconstruction." Bioengineering, vol. 10, no. 7, 2023, pp. 812. |
| Donnenfield JI, Fleming BC, Proffen BL, Podury A, Murray MM. "Microscopic and transcriptomic changes in porcine synovium one year following disruption of the anterior cruciate ligament." Osteoarthritis and Cartilage, vol. 31, no. 12, 2023, pp. 1554-1566. |
| Flannery SW, Beveridge JE, Proffen BL, Walsh EG, BEAR Trial Team, Kramer DE, Murray MM, Kiapour AM, Fleming BC. "Predicting anterior cruciate ligament failure load with T(2)* relaxometry and machine learning as a prospective imaging biomarker for revision surgery." Scientific reports, vol. 13, no. 1, 2023, pp. 3524. |
| Barnes DA, Badger GJ, Yen YM, Micheli LJ, Kramer DE, Fadale PD, Hulstyn MJ, Owens BD, BEAR Trial Team, Flannery SW, Ecklund K, Sanborn RM, Costa MQ, Chrostek C, Proffen BL, Sant N, Murray MM, Fleming BC, Kiapour AM. "Quantitative MRI Biomarkers to Predict Risk of Reinjury Within 2 Years After Bridge-Enhanced ACL Restoration." The American Journal of Sports Medicine, vol. 51, no. 2, 2023, pp. 3635465221142323. |
| Donnenfield JI, Proffen BL, Fleming BC, Murray MM. "Responding to ACL Injury and its Treatments: Comparative Gene Expression between Articular Cartilage and Synovium." Bioengineering, vol. 10, no. 5, 2023. |
| Fleming BC. "Reviewer Fatigue." The American Journal of Sports Medicine, vol. 51, no. 14, 2023, pp. 3632-3633. |
| Donnenfield JI, Karamchedu NP, Proffen BL, Molino J, Fleming BC, Murray MM. "Transcriptomic changes in porcine articular cartilage one year following disruption of the anterior cruciate ligament." PLoS ONE, vol. 18, no. 5, 2023, pp. e0284777. |
| Flannery SW, Kiapour AM, Edgar DJ, Murray MM, Beveridge JE, Fleming BC. "A transfer learning approach for automatic segmentation of the surgically treated anterior cruciate ligament." Journal of Orthopaedic Research, vol. 40, no. 1, 2022, pp. 277-284. |
| Sun C, Cao C, Zhao T, Guo H, Fleming BC, Owens B, Beveridge J, McAllister S, Wei L. "A2M inhibits inflammatory mediators of chondrocytes by blocking IL-1β/NF-κB pathway." Journal of Orthopaedic Research, vol. 41, no. 1, 2022, pp. 241-248. |
| Donnenfield JI, Karamchedu NP, Fleming BC, Molino J, Proffen BL, Murray MM. "Articular cartilage and synovium may be important sources of post-surgical synovial fluid inflammatory mediators." American journal of translational research, vol. 14, no. 3, 2022, pp. 1640-1651. |
| Flannery, Sean W., Barnes, Dominique A., Costa, Meggin Q., Menghini, Danilo, Kiapour, Ata M., Walsh, Edward G., Team, BEAR Trial, Kramer, Dennis E., Murray, Martha M., Fleming, Braden C. "Automated Segmentation of the Healed Anterior Cruciate Ligament from T2* Relaxometry MRI Scans." Journal of Orthopaedic Research, 2022. |
| Menghini D, Kaushal SG, Flannery SW, Ecklund K, BEAR Trial Team, Murray MM, Fleming BC, Kiapour AM, Proffen B, Sant N, Portilla G, Sanborn R, Freiberger C, Henderson R, Barnett S, Yen YM, Kramer DE, Micheli LJ. "Changes in the Cross-Sectional Profile of Treated Anterior Cruciate Ligament Within 2 Years After Surgery." Orthopaedic Journal of Sports Medicine, vol. 10, no. 10, 2022, pp. 23259671221127326. |
| BEAR-MOON Design Group., Spindler KP, Imrey PB, Yalcin S, Beck GJ, Calbrese G, Cox CL, Fadale PD, Farrow L, Fitch R, Flanigan D, Fleming BC, Hulstyn MJ, Jones MH, Kaeding C, Katz JN, Kriz P, Magnussen R, McErlean E, Melgaard C, Owens BD, Saluan P, Strnad G, Winalski CS, Wright R. "Design Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial." Orthopaedic Journal of Sports Medicine, vol. 10, no. 1, 2022, pp. 232596712110654. |
| Flannery, Sean W., Murray, Martha M., Badger, Gary J., Ecklund, Kirsten, Proffen, Benedikt, Sant, Nicholas, Portilla, Gabriela, Sanborn, Ryan, Freiberger, Christina, Rachael, Rachael, Barnett, Samuel, Yen, Yi-Meng, Micheli, Lyle, Kramer, Dennis E., Fleming, Braden C., Kiapour, Ata M., None, None. "Early MRI-based quantitative outcomes are associated with a positive functional performance trajectory from 6 to 24 months post-ACL surgery." Knee Surgery, Sports Traumatology, Arthroscopy, 2022. |
| Costa MQ, Badger GJ, Chrostek CA, Carvalho OD, Faiola SL, Fadale PD, Hulstyn MJ, Gil HC, Shalvoy RM, Fleming BC. "Effects of Initial Graft Tension and Patient Sex on Knee Osteoarthritis Outcomes After ACL Reconstruction: A Randomized Controlled Clinical Trial With 10- to 12-Year Follow-up." The American Journal of Sports Medicine, 2022, pp. 3635465221124917. |
| Pinette, Megan P., Molino, Janine, Proffen, Benedikt L., Murray, Martha M., Fleming, Braden C. "Effects of Male and Female Sex on the Development of Posttraumatic Osteoarthritis in the Porcine Knee After Anterior Cruciate Ligament Surgery." The American Journal of Sports Medicine, 2022, pp. 036354652211021. |
| Fleming BC. "Fifty Years of ACL Biomechanics: What's Next?." The American Journal of Sports Medicine, vol. 50, no. 14, 2022, pp. 3745-3748. |
| Parola LR, Pinette MP, Proffen BL, Sant NJ, Karamchedu NP, Costa MQ, Molino J, Fleming BC, Murray MM. "Hydrogel treatment for idiopathic osteoarthritis in a Dunkin Hartley Guinea pig model." PLoS ONE, vol. 17, no. 11, 2022, pp. e0278338. |
| Altahawi FF, Reinke EK, MOON Knee Group., Briskin I, Cantrell WA, Flanigan DC, Fleming BC, Huston LJ, Li X, Oak SR, Obuchowski NA, Scaramuzza EA, Winalski CS, Zajichek A, Spindler KP, Jones MH. "Meniscal Treatment as a Predictor of Worse Articular Cartilage Damage on MRI at 2 Years After ACL Reconstruction: The MOON Nested Cohort." The American Journal of Sports Medicine, vol. 50, no. 4, 2022, pp. 951-961. |
| Donnenfield JI, Karamchedu NP, Proffen BL, Molino J, Murray MM, Fleming BC. "Predicting severity of cartilage damage in a post-traumatic porcine model: Synovial fluid and gait in a support vector machine." PLoS ONE, vol. 17, no. 6, 2022, pp. e0268198. |
| Sanborn RM, Badger GJ, Fleming BC, Kiapour AM, BEAR Trial Team, Fadale PD, Hulstyn MJ, Owens BD, Proffen B, Sant N, Portilla G, Freiberger C, Henderson R, Barnett S, Costa M, Chrostek C, Ecklund K, Micheli LJ, Murray MM, Yen YM, Kramer DE. "Preoperative Risk Factors for Subsequent Ipsilateral ACL Revision Surgery After an ACL Restoration Procedure." The American Journal of Sports Medicine, 2022, pp. 3635465221137873. |
| Sanborn RM, Badger GJ, BEAR Trial Team., Yen YM, Murray MM, Christino MA, Proffen B, Sant N, Barnett S, Fleming BC, Kramer DE, Micheli LJ. "Psychological Readiness to Return to Sport at 6 Months Is Higher After Bridge-Enhanced ACL Restoration Than Autograft ACL Reconstruction: Results of a Prospective Randomized Clinical Trial." Orthopaedic Journal of Sports Medicine, vol. 10, no. 2, 2022, pp. 23259671211070542. |
| Flannery SW, Walsh EG, Sanborn RM, Chrostek CA, Costa MQ, Kaushal SG, Murray MM, Fleming BC, Kiapour AM. "Reproducibility and postacquisition correction methods for quantitative magnetic resonance imaging of the anterior cruciate ligament (ACL)." Journal of Orthopaedic Research, 2022. |
| Menghini D, Kaushal SG, Flannery SW, Ecklund K, Murray MM, Fleming BC, Kiapour AM. "Three-dimensional magnetic resonance imaging analysis shows sex-specific patterns in changes in anterior cruciate ligament cross-sectional area along its length." Journal of Orthopaedic Research, 2022. |
| Zandiyeh P, Parola LR, Fleming BC, Beveridge JE. "Wavelet analysis reveals differential lower limb muscle activity patterns long after anterior cruciate ligament reconstruction." Journal of Biomechanics, vol. 133, 2022, pp. 110957. |
| Barnett SC, Murray MM, Flannery SW, BEAR Trial Team., Menghini D, Fleming BC, Kiapour AM, Proffen B, Sant N, Portilla G, Sanborn R, Freiberger C, Henderson R, Ecklund K, Yen YM, Kramer D, Micheli L. "ACL Size, but Not Signal Intensity, Is Influenced by Sex, Body Size, and Knee Anatomy." Orthopaedic Journal of Sports Medicine, vol. 9, no. 12, 2021, pp. 23259671211063836. |
| Karamchedu NP, Murray MM, Sieker JT, Proffen BL, Portilla G, Costa MQ, Molino J, Fleming BC. "Bridge-Enhanced Anterior Cruciate Ligament Repair Leads to Greater Limb Asymmetry and Less Cartilage Damage Than Untreated ACL Transection or ACL Reconstruction in the Porcine Model." The American Journal of Sports Medicine, 2021, pp. 363546521989265. |
| Barnett SC, Murray MM, Badger GJ, BEAR Trial Team., Yen YM, Kramer DE, Sanborn R, Kiapour A, Proffen B, Sant N, Fleming BC, Micheli LJ. "Earlier Resolution of Symptoms and Return of Function After Bridge-Enhanced Anterior Cruciate Ligament Repair As Compared With Anterior Cruciate Ligament Reconstruction." Orthopaedic Journal of Sports Medicine, vol. 9, no. 11, 2021, pp. 23259671211052530. |
| Thome AP Jr, O'Donnell R, DeFroda SF, Cohen BH, Cruz AI Jr, Fleming BC, Owens BD. "Effect of Skeletal Maturity on Fixation Techniques for Tibial Eminence Fractures." Orthopaedic Journal of Sports Medicine, vol. 9, no. 11, 2021, pp. 23259671211049476. |
| Karamchedu NP, Fleming BC, Donnenfield JI, Proffen BL, Costa MQ, Molino J, Murray MM. "Enrichment of inflammatory mediators in the synovial fluid is associated with slower progression of mild to moderate osteoarthritis in the porcine knee." American journal of translational research, vol. 13, no. 7, 2021, pp. 7667-7676. |
| Behnke AL, Parola LR, Karamchedu NP, Badger GJ, Fleming BC, Beveridge JE. "Neuromuscular function in anterior cruciate ligament reconstructed patients at long-term follow-up." Clinical biomechanics (Bristol, Avon), vol. 81, 2021, pp. 105231. |
| Costa, Meggin Q., Murray, Martha M., Sieker, Jakob T., Karamchedu, Naga Padmini, Proffen, Benedikt L., Fleming, Braden C. "Peripheral shift in the viable chondrocyte population of the medial femoral condyle after anterior cruciate ligament injury in the porcine knee." PLOS ONE, vol. 16, no. 8, 2021, pp. e0256765. |
| Kiapour AM, Flannery SW, Murray MM, Miller PE, BEAR Trial Team., Proffen BL, Sant N, Portilla G, Sanborn R, Freiberger C, Henderson R, Barnett S, Ecklund K, Yen YM, Kramer DE, Micheli LJ, Fleming BC. "Regional Differences in Anterior Cruciate Ligament Signal Intensity After Surgical Treatment." The American Journal of Sports Medicine, 2021, pp. 3635465211047554. |
| Karamchedu NP, Fleming BC, Proffen BL, Sant NJ, Portilla G, Parola LR, Molino J, Murray MM. "Terminal Sterilization Influences the Efficacy of an Extracellular Matrix-Blood Composite for Treating Post-Traumatic Osteoarthritis in the Rat Model." Journal of Orthopaedic Research, 2021. |
| Fleming BC. "Valley of Death." The American Journal of Sports Medicine, vol. 49, no. 13, 2021, pp. 3476-3478. |
| Flannery SW, Kiapour AM, Edgar DJ, Murray MM, Fleming BC. "Automated magnetic resonance image segmentation of the anterior cruciate ligament." Journal of Orthopaedic Research, 2020. |
| Murray MM, Fleming BC, Badger GJ, BEAR Trial Team., Freiberger C, Henderson R, Barnett S, Kiapour A, Ecklund K, Proffen B, Sant N, Kramer DE, Micheli LJ, Yen YM. "Bridge-Enhanced Anterior Cruciate Ligament Repair Is Not Inferior to Autograft Anterior Cruciate Ligament Reconstruction at 2 Years: Results of a Prospective Randomized Clinical Trial." The American Journal of Sports Medicine, 2020, pp. 363546520913532. |
| DeFroda SF, Karamchedu NP, Budacki R, Wiley T, Fadale PD, Hulstyn MJ, Shalvoy RM, Badger GJ, Fleming BC, Owens BD. "Evaluation of Graft Tensioning Effects in Anterior Cruciate Ligament Reconstruction between Hamstring and Bone-Patellar Tendon Bone Autografts." The journal of knee surgery, 2020. |
| Barnett S, Badger GJ, Kiapour A, Yen YM, Henderson R, Freiberger C, Proffen B, Sant N, Trainor B, Fleming BC, Micheli LJ, Murray MM, Kramer DE. "Females Have Earlier Muscle Strength and Functional Recovery After Bridge-Enhanced Anterior Cruciate Ligament Repair." Tissue engineering. Part A, vol. 26, no. 13-14, 2020, pp. 702-711. |
| Freiberger C, Kiapour AM, Liu S, BEAR Trial Team., Henderson RN, Barnett S, Sant NJ, Proffen BL, Fleming BC, Ecklund K, Kramer DE, Micheli LJ, Murray MM, Yen YM. "Higher Physiologic Platelet Counts in Whole Blood Are Not Associated With Improved ACL Cross-sectional Area or Signal Intensity 6 Months After Bridge-Enhanced ACL Repair." Orthopaedic Journal of Sports Medicine, vol. 8, no. 7, 2020, pp. 2325967120927655. |
| Fleming BC, Fadale PD, Hulstyn MJ, Shalvoy RM, Tung GA, Badger GJ. "Long Term Outcomes of Anterior Cruciate Ligament Reconstruction Surgery: 2020 OREF Clinical Research Award Paper." Journal of Orthopaedic Research, 2020. |
| Ayturk UM, Sieker JT, Haslauer CM, Proffen BL, Weissenberger MH, Warman ML, Fleming BC, Murray MM. "Proteolysis and cartilage development are activated in the synovium after surgical induction of post traumatic osteoarthritis." PLoS ONE, vol. 15, no. 2, 2020, pp. e0229449. |
| Fleming BC. "The Other Side of COVID-19." The American Journal of Sports Medicine, vol. 48, no. 14, 2020, pp. 3415-3416. |
| DeFroda SF, ODonnell RM, Fadale PD, Owens BD, Fleming BC. "The role of magnetic resonance imaging in evaluating postoperative ACL reconstruction healing and graft mechanical properties: a new criterion for return to play?." The Physician and Sportsmedicine, 2020, pp. 1-7. |
| Kiapour, Ata M., Yang, Daniel S., Badger, Gary J., Karamchedu, Naga Padmini, Murray, Martha M., Fadale, Paul D., Hulstyn, Michael J., Shalvoy, Robert M., Fleming, Braden C. "Anatomic Features of the Tibial Plateau Predict Outcomes of ACL Reconstruction Within 7 Years After Surgery." The American Journal of Sports Medicine, vol. 47, no. 2, 2019, pp. 303-311. |
| Murray MM, Kalish LA, Fleming BC, BEAR Trial Team., Flutie B, Freiberger C, Henderson RN, Perrone GS, Thurber LG, Proffen BL, Ecklund K, Kramer DE, Yen YM, Micheli LJ. "Bridge-Enhanced Anterior Cruciate Ligament Repair: Two-Year Results of a First-in-Human Study." Orthopaedic Journal of Sports Medicine, vol. 7, no. 3, 2019, pp. 2325967118824356. |
| Beveridge JE, Proffen BL, Karamchedu NP, Chin KE, Sieker JT, Badger GJ, Kiapour AM, Murray MM, Fleming BC. "Cartilage Damage Is Related to ACL Stiffness in a Porcine Model of ACL Repair." Journal of Orthopaedic Research, vol. 37, no. 10, 2019, pp. 2249-2257. |
| Kiapour AM, Ecklund K, Murray MM, BEAR Trial Team., Flutie B, Freiberger C, Henderson R, Kramer D, Micheli L, Thurber L, Yen YM, Fleming BC. "Changes in Cross-sectional Area and Signal Intensity of Healing Anterior Cruciate Ligaments and Grafts in the First 2 Years After Surgery." The American Journal of Sports Medicine, 2019, pp. 363546519850572. |
| Fleming BC. "Out of Control." The American Journal of Sports Medicine, vol. 47, no. 14, 2019, pp. 3311-3313. |
| Murray MM, Kiapour AM, Kalish LA, Ecklund K, BEAR Trial Team., Fleming BC, Freiberger C, Henderson R, Kramer D, Micheli L, Yen YM. "Predictors of Healing Ligament Size and Magnetic Resonance Signal Intensity at 6 Months After Bridge-Enhanced Anterior Cruciate Ligament Repair." The American Journal of Sports Medicine, 2019, pp. 363546519836087. |
| MOON Knee Group., Jones MH, Oak SR, Andrish JT, Brophy RH, Cox CL, Dunn WR, Flanigan DC, Fleming BC, Huston LJ, Kaeding CC, Kolosky M, Kuyumcu G, Lynch TS, Magnussen RA, Matava MJ, Parker RD, Reinke EK, Scaramuzza EA, Smith MV, Winalski C, Wright RW, Zajichek A, Spindler KP. "Predictors of Radiographic Osteoarthritis 2 to 3 Years After Anterior Cruciate Ligament Reconstruction: Data From the MOON On-site Nested Cohort." Orthopaedic Journal of Sports Medicine, vol. 7, no. 8, 2019, pp. 2325967119867085. |
| Newberry J, Desai S, Adler C, Li N, Karamchedu NP, Fleming BC, Jayasuriya CT. "SDF-1 preconditioned HPC scaffolds mobilize cartilage-derived progenitors and stimulate meniscal fibrocartilage repair in human explant tissue culture." Connective Tissue Research, 2019, pp. 1-11. |
| Kiapour AM, Sieker JT, Proffen BL, Lam TT, Fleming BC, Murray MM. "Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: Proteomics analysis of porcine knee synovial fluid." PLoS ONE, vol. 14, no. 3, 2019, pp. e0212662. |
| Jones MH, MOON Knee Group., Spindler KP, Andrish JT, Cox CL, Dunn WR, Duryea J, Duong CL, Flanigan DC, Fleming BC, Huston LJ, Kaeding CC, Matava MJ, Obuchowski NA, Oksendahl HL, Parker RD, Scaramuzza EA, Smith MV, Winalski CS, Wright RW, Reinke EK. "Differences in the Lateral Compartment Joint Space Width After Anterior Cruciate Ligament Reconstruction: Data From the MOON Onsite Cohort." The American Journal of Sports Medicine, vol. 46, no. 4, 2018, pp. 876-882. |
| Fleming, Braden C. "Imaging and Biomechanics." The American Journal of Sports Medicine, vol. 47, no. 1, 2018, pp. 19-21. |
| Ware JK, Owens BD, Akelman MR, Karamchedu NP, Fadale PD, Hulstyn MJ, Shalvoy RM, Badger GJ, Fleming BC. "Preoperative KOOS and SF-36 Scores Are Associated With the Development of Symptomatic Knee Osteoarthritis at 7 Years After Anterior Cruciate Ligament Reconstruction." The American Journal of Sports Medicine, vol. 46, no. 4, 2018, pp. 869-875. |
| Getgood A, Brown C, Lording T, Amis A, Claes S, Geeslin A, Musahl V, ALC Consensus Group. "The anterolateral complex of the knee: results from the International ALC Consensus Group Meeting." Knee Surgery, Sports Traumatology, Arthroscopy, 2018. |
| DeFroda SF, Karamchedu NP, Owens BD, Bokshan SL, Sullivan K, Fadale PD, Hulstyn MJ, Shalvoy RM, Badger GJ, Fleming BC. "Tibial tunnel widening following anterior cruciate ligament reconstruction: A retrospective seven-year study evaluating the effects of initial graft tensioning and graft selection." The Knee, vol. 25, no. 6, 2018, pp. 1107-1114. |
| Sieker JT, Proffen BL, Waller KA, Chin KE, Karamchedu NP, Akelman MR, Perrone GS, Kiapour AM, Konrad J, Fleming BC, Murray MM. "Transcriptional profiling of synovium in a porcine model of early post-traumatic osteoarthritis." Journal of Orthopaedic Research, vol. 36, 2018, pp. 2128-2139. |
| Mae, Tatsuo, Fleming, Braden C. "ACL Graft Tensioning." Controversies in the Technical Aspects of ACL Reconstruction, 2017, pp. 289-299. |
| Perrone GS, Proffen BL, Kiapour AM, Sieker JT, Fleming BC, Murray MM. "Bench-to-Bedside: Bridge-Enhanced Anterior Cruciate Ligament Repair." Journal of Orthopaedic Research, 2017. |
| Mehta N, Duryea J, Badger GJ, Akelman MR, Jones MH, Spindler KP, Fleming BC. "Comparison of 2 Radiographic Techniques for Measurement of Tibiofemoral Joint Space Width." Orthopaedic Journal of Sports Medicine, vol. 5, no. 9, 2017, pp. 2325967117728675. |
| Fleming BC. "Conflicted." The American Journal of Sports Medicine, vol. 45, no. 8, 2017, pp. 1727-1729. |
| Fleming BC, Biercevicz A, Murray MM, Li W, Wang V. "Emerging Techniques for Imaging Tendons and Ligaments." Magnetic Resonance in Tissue Engineering and Regenerative Medicine, edited by Kotecha M,Magin R, Mao J, Hoboken, John Wiley & Sons, 2017, pp. 209-236. |
| Waller KA, Chin KE, Jay GD, Zhang LX, Teeple E, McAllister S, Badger GJ, Schmidt TA, Fleming BC. "Intra-articular Recombinant Human Proteoglycan 4 Mitigates Cartilage Damage After Destabilization of the Medial Meniscus in the Yucatan Minipig." The American Journal of Sports Medicine, vol. 45, no. 7, 2017, pp. 363546516686965. |
| Samuelson K, Balk EM, Sevetson EL, Fleming BC. "Limited Evidence Suggests a Protective Association Between Oral Contraceptive Pill Use and Anterior Cruciate Ligament Injuries in Females: A Systematic Review." Sports Health: A Multidisciplinary Approach, vol. 9, no. 6, 2017, pp. 498-510. |
| Beveridge JE, Machan JT, Walsh EG, Kiapour AM, Karamchedu NP, Chin KE, Proffen BL, Sieker JT, Murray MM, Fleming BC. "Magnetic resonance measurements of tissue quantity and quality using T2 * relaxometry predict temporal changes in the biomechanical properties of the healing ACL." Journal of Orthopaedic Research, vol. 36, no. 6, 2017, pp. 1701-1709. |
| Larson KM, Zhang L, Elsaid KA, Schmidt TA, Fleming BC, Badger GJ, Jay GD. "Reduction of friction by recombinant human proteoglycan 4 in IL-1α stimulated bovine cartilage explants." Journal of Orthopaedic Research, vol. 35, no. 3, 2017, pp. 580-589. |
| Beveridge, Jillian E., Walsh, Edward G., Murray, Martha M., Fleming, Braden C. "Sensitivity of ACL volume and T 2 ∗ relaxation time to magnetic resonance imaging scan conditions." Journal of Biomechanics, vol. 56, 2017, pp. 117-121. |
| Kiapour AM, Fleming BC, Murray MM. "Structural and Anatomic Restoration of the Anterior Cruciate Ligament Is Associated With Less Cartilage Damage 1 Year After Surgery: Healing Ligament Properties Affect Cartilage Damage." Orthopaedic Journal of Sports Medicine, vol. 5, no. 8, 2017, pp. 2325967117723886. |
| Thomas NP, Wu WJ, Fleming BC, Wei F, Chen Q, Wei L. "Synovial inflammation plays a greater role in post-traumatic osteoarthritis compared to idiopathic osteoarthritis in the Hartley guinea pig knee." BMC Musculoskeletal Disorders, vol. 18, no. 1, 2017, pp. 556. |
| Sieker JT, Proffen BL, Waller KA, Chin KE, Karamchedu NP, Akelman MR, Perrone GS, Kiapour AM, Konrad J, Murray MM, Fleming BC. "Transcriptional Profiling of Articular Cartilage in a Porcine Model of Early Post-traumatic Osteoarthritis." Journal of Orthopaedic Research, 2017. |
| Du G, Zhan H, Ding D, Wang S, Wei X, Wei F, Zhang J, Bilgen B, Reginato AM, Fleming BC, Deng J, Wei L. "Abnormal Mechanical Loading Induces Cartilage Degeneration by Accelerating Meniscus Hypertrophy and Mineralization After ACL Injuries In Vivo." The American Journal of Sports Medicine, vol. 44, no. 3, 2016, pp. 652-63. |
| Teeple E, Karamchedu NP, Larson KM, Zhang L, Badger GJ, Fleming BC, Jay GD. "Arthroscopic irrigation of the bovine stifle joint increases cartilage surface friction and decreases superficial zone lubricin." Journal of Biomechanics, vol. 49, no. 13, 2016, pp. 3106-3110. |
| Chin KE, Karamchedu NP, Patel TK, Badger GJ, Akelman MR, Moore DC, Proffen BL, Murray MM, Fleming BC. "Comparison of micro-CT post-processing methods for evaluating the trabecular bone volume fraction in a rat ACL-transection model." Journal of Biomechanics, 2016. |
| Akelman MR, Fadale PD, Hulstyn MJ, Shalvoy RM, Garcia A, Chin KE, Duryea J, Badger GJ, Tung GA, Fleming BC. "Effect of matching or overconstraining knee laxity during anterior cruciate ligament reconstruction on knee osteoarthritis and clinical outcomes: A randomized controlled trial with 84-month follow-up." The American Journal of Sports Medicine, vol. 44, no. 7, 2016, pp. 1660-70. |
| Christino MA, Fleming BC, Machan JT, Shalvoy RM. "Psychological Factors Associated With Anterior Cruciate Ligament Reconstruction Recovery." Orthopaedic Journal of Sports Medicine, vol. 4, no. 3, 2016, pp. 2325967116638341. |
| Waller, K., Zhang, L., Teeple, E., McAllister, S., Schmidt, T., Fleming, B., Jay, G. "Recombinant lubricin reduces joint damage and inflammation following traumatic injury." Osteoarthritis and Cartilage, vol. 24, 2016, pp. S521-S522. |
| Morris RC, Hulstyn MJ, Fleming BC, Owens BD, Fadale PD. "Return to Play Following Anterior Cruciate Ligament Reconstruction." Clinics in Sports Medicine, vol. 35, no. 4, 2016, pp. 655-668. |
| Murray MM, Flutie BM, Kalish LA, Ecklund K, Fleming BC, Proffen BL, Micheli LJ. "The Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR) Procedure: An Early Feasibility Cohort Study." Orthopaedic Journal of Sports Medicine, vol. 4, no. 11, 2016, pp. 2325967116672176. |
| Thomas, Nathan P., Li, Pengcui, Fleming, Braden C., Chen, Qian, Wei, Xiaochun, Xiao-Hua, Pan, Li, Gang, Wei, Lei. "Attenuation of Cartilage Pathogenesis in Post-traumatic Osteoarthritis (PTOA) in Mice by blocking the Stromal Derived Factor 1 Receptor (CXCR4) with the specific inhibitor, AMD3100." Journal of Orthopaedic Research, vol. 33, no. 7, 2015, pp. 1071-1078. |
| Kiapour AM, Fleming BC, Murray MM. "Biomechanical Outcomes of Bridge-enhanced Anterior Cruciate Ligament Repair Are Influenced by Sex in a Preclinical Model." Clinical Orthopaedics and Related Research®, 2015. |
| Sieker, J.T., Ayturk, U.M., Proffen, B.L., Fleming, B.C., Murray, M.M. "Early intraarticular triamcinolone acetonide administration alters anterior cruciate ligament injury-induced changes in synovial membrane gene expression." Osteoarthritis and Cartilage, vol. 23, 2015, pp. A401-A402. |
| Proffen BL, Perrone GS, Fleming BC, Sieker JT, Kramer J, Hawes ML, Badger GJ, Murray MM. "Electron beam sterilization does not have a detrimental effect on the ability of extracellular matrix scaffolds to support in vivo ligament healing." Journal of Orthopaedic Research, 2015. |
| Proffen BL, Sieker JT, Murray MM, Akelman MR, Chin KE, Perrone GS, Patel TK, Fleming BC. "Extracellular matrix-blood composite injection reduces post-traumatic osteoarthritis after anterior cruciate ligament injury in the rat." Journal of Orthopaedic Research, vol. 34, no. 6, 2015, pp. 995-1003. |
| Proffen, B.L., Sieker, J.T., Murray, M.M., Chin, K.E., Patel, T.K., Robbins, E., Akelman, M.R., Machan, J.T., Fleming, B.C. "Injection of extracellular matrix gel following anterior cruciate ligament injury mitigates osteoarthritic changes in a rat model." Osteoarthritis and Cartilage, vol. 23, 2015, pp. A401. |
| Teeple E, Aslani K, Shalvoy MR, Medrano JE, Zhang L, Machan JT, Fleming BC, Jay GD. "Lubricin deficiency in the murine lumbar intervertebral disc results in elevated torsional apparent modulus." Journal of Biomechanics, vol. 48, no. 10, 2015, pp. 2210-3. |
| Jones MH, Spindler KP, Fleming BC, Duryea J, Obuchowski NA, Scaramuzza EA, Oksendahl HL, Winalski CS, Duong CL, Huston LJ, Parker RD, Kaeding CC, Andrish JT, Flanigan DC, Dunn WR, Reinke EK. "Meniscus treatment and age associated with narrower radiographic joint space width 2 - 3 years after ACL reconstruction: Data from the MOON onsite cohort." Osteoarthritis and Cartilage, 2015. |
| Biercevicz, A. M., Akelman, M. R., Fadale, P. D., Hulstyn, M. J., Shalvoy, R. M., Badger, G. J., Tung, G. A., Oksendahl, H. L., Fleming, B. C. "MRI volume and signal intensity of ACL graft predict clinical, functional, and patient-oriented outcome measures after ACL reconstruction." The American Journal of Sports Medicine, vol. 43, no. 3, 2015, pp. 693-699. |
| Jones, M.H., Spindler, K.P., Fleming, B.C., Duryea, J., Obuchowski, N.A., Scaramuzza, E.A., Oksendahl, H.L., Winalski, C.S., Duong, C.L., Huston, L.J., Parker, R.D., Kaeding, C.C., Andrish, J., Flanigan, D.C., Dunn, W.R., Reinke, E.K. "Predictors of lateral compartment joint space difference two or more years after ACL reconstruction: Data from the moon onsite cohort." Osteoarthritis and Cartilage, vol. 23, 2015, pp. A280. |
| Kiapour AM, Fleming BC, Proffen BL, Murray MM. "Sex Influences the Biomechanical Outcomes of Anterior Cruciate Ligament Reconstruction in a Preclinical Large Animal Model." The American Journal of Sports Medicine, vol. 43, no. 7, 2015, pp. 1623-31. |
| Biercevicz AM, Proffen BL, Murray MM, Walsh EG, Fleming BC. "T 2 * relaxometry and volume predict semi-quantitative histological scoring of an ACL bridge-enhanced primary repair in a porcine model." Journal of Orthopaedic Research, vol. 33, no. 8, 2015, pp. 1180-1187. |
| Biercevicz AM, Akelman MR, Rubin LE, Walsh EG, Merck D, Fleming BC. "The uncertainty of predicting intact anterior cruciate ligament degeneration in terms of structural properties using T2* relaxometry in a human cadaveric model." Journal of Biomechanics, vol. 48, no. 6, 2015, pp. 1188-1192. |
| Proffen BL, Vavken P, Haslauer CM, Fleming BC, Harris CE, Machan JT, Murray MM. "Addition of autologous mesenchymal stem cells to whole blood for bioenhanced ACL repair has no benefit in the porcine model." The American Journal of Sports Medicine, vol. 43, no. 2, 2014, pp. 320-30. |
| Zhou J, Chen Q, Lanske B, Fleming BC, Terek R, Wei X, Zhang G, Wang S, Li K, Wei L. "Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice." Arthritis Res Ther, vol. 16, no. 1, 2014, pp. R11. |
| Wang S, Wei X, Zhou J, Zhang J, Li K, Chen Q, Terek R, Fleming BC, Goldring MB, Ehrlich MG, Zhang G, Wei L. "Identification of α2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis." Arthritis & Rheumatology, vol. 66, no. 7, 2014, pp. 1843-53. |
| Biercevicz AM, Walsh EG, Murray MM, Akelman MR, Fleming BC. "Improving the clinical efficiency of T2(⁎) mapping of ligament integrity." Journal of Biomechanics, vol. 47, no. 10, 2014, pp. 2522-5. |
| Klinge, Stephen, McClure, Philip, Vopat, Bryan, Paller, David, Koruprolu, Sarath, Fleming, Braden, Hulstyn, Michael, Fadale, Paul. "In-Vitro Anatomic Double-Bundle and Single-Bundle Anterior Cruciate Ligament Reconstructions Demonstrate Equivalent Laxity after Time Zero Cyclic Loading." Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 30, no. 6, 2014, pp. e7. |
| Fleming BC, Proffen BL, Vavken P, Shalvoy MR, Machan JT, Murray MM. "Increased platelet concentration does not improve functional graft healing in bio-enhanced ACL reconstruction." Knee Surgery, Sports Traumatology, Arthroscopy, vol. 23, no. 4, 2014, pp. 1161-1170. |
| Zhang C, Wei X, Chen C, Cao K, Li Y, Jiao Q, Ding J, Zhou J, Fleming BC, Chen Q, Shang X, Wei L. "Indian hedgehog in synovial fluid is a novel marker for early cartilage lesions in human knee joint." International Journal of Molecular Sciences, vol. 15, no. 5, 2014, pp. 7250-65. |
| Jones, M.H., Reinke, E.K., Duryea, J., Fleming, B.C., Scaramuzza, E., Obuchowski, N., Spindler, K.P. "Meniscus treatment and age predict medial compartment joint space difference at a minimum of two years after ACL reconstruction: data from the moon onsite cohort." Osteoarthritis and Cartilage, vol. 22, 2014, pp. S241-S242. |
| Biercevicz AM, Murray MM, Walsh EG, Miranda DL, Machan JT, Fleming BC. "T2 * MR relaxometry and ligament volume are associated with the structural properties of the healing ACL." Journal of Orthopaedic Research, vol. 32, no. 4, 2014, pp. 492-9. |
| "Time Zero." The American Journal of Sports Medicine, vol. 42, no. 7, 2014, pp. 1531-1533. |
| Kiapour AM, Shalvoy MR, Murray MM, Fleming BC. "Validation of Porcine Knee as a Sex-specific Model to Study Human Anterior Cruciate Ligament Disorders." Clinical Orthopaedics and Related Research®, 2014. |
| Teeple E, Jay GD, Elsaid KA, Fleming BC. "Animal models of osteoarthritis: challenges of model selection and analysis." The AAPS journal, vol. 15, no. 2, 2013, pp. 438-46. |
| Rainbow MJ, Miranda DL, Cheung RT, Schwartz JB, Crisco JJ, Davis IS, Fleming BC. "Automatic determination of an anatomical coordinate system for a three-dimensional model of the human patella." Journal of Biomechanics, vol. 46, no. 12, 2013, pp. 2093-2096. |
| Fleming, Braden C. "Bio-enhancement of ACL Graft Healing." The ACL Handbook, 2013, pp. 285-299. |
| Murray MM, Fleming BC. "Biology of anterior cruciate ligament injury and repair: Kappa delta ann doner vaughn award paper 2013." Journal of Orthopaedic Research, vol. 31, no. 10, 2013, pp. 1501-6. |
| Coats-Thomas MS, Miranda DL, Badger GJ, Fleming BC. "Effects of ACL reconstruction surgery on muscle activity of the lower limb during a jump-cut maneuver in males and females." Journal of Orthopaedic Research, vol. 31, no. 12, 2013, pp. 1890-6. |
| Vavken P, Proffen B, Peterson C, Fleming BC, Machan JT, Murray MM. "Effects of suture choice on biomechanics and physeal status after bioenhanced anterior cruciate ligament repair in skeletally immature patients: a large-animal study." Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 29, no. 1, 2013, pp. 122-32. |
| Proffen BL, Fleming BC, Murray MM. "Histologic Predictors of Maximum Failure Loads Differ between the Healing ACL and ACL Grafts after 6 and 12 Months In Vivo." Orthopaedic Journal of Sports Medicine, vol. 1, no. 6, 2013. |
| Biercevicz AM, Miranda DL, Machan JT, Murray MM, Fleming BC. "In Situ, noninvasive, T2*-weighted MRI-derived parameters predict ex vivo structural properties of an anterior cruciate ligament reconstruction or bioenhanced primary repair in a porcine model." The American Journal of Sports Medicine, vol. 41, no. 3, 2013, pp. 560-6. |
| Vavken, Patrick, Fleming, Braden C. "In Vitro Models of ACL Injury." The ACL Handbook, 2013, pp. 123-137. |
| Miranda, Daniel L., Rainbow, Michael J., Crisco, Joseph J., Fleming, Braden C. "Kinematic differences between optical motion capture and biplanar videoradiography during a jump–cut maneuver." Journal of Biomechanics, vol. 46, no. 3, 2013, pp. 567-573. |
| Miranda DL, Fadale PD, Hulstyn MJ, Shalvoy RM, Machan JT, Fleming BC. "Knee biomechanics during a jump-cut maneuver: effects of sex and ACL surgery." Medicine & Science in Sports & Exercise, vol. 45, no. 5, 2013, pp. 942-51. |
| Haslauer CM, Elsaid KA, Fleming BC, Proffen BL, Johnson VM, Murray MM. "Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury." Osteoarthritis and Cartilage, vol. 21, no. 12, 2013, pp. 1950-7. |
| Vavken, Patrick, Murray, Martha M., Fleming, Braden C. "Outcome Assessment for ACL Tissue Engineering." The ACL Handbook, 2013, pp. 179-200. |
| Akelman, Matthew R., Teeple, Erin, Machan, Jason T., Crisco, Joseph J., Jay, Gregory D., Fleming, Braden C. "Pendulum mass affects the measurement of articular friction coefficient." Journal of Biomechanics, vol. 46, no. 3, 2013, pp. 615-618. |
| Waller KA, Zhang LX, Elsaid KA, Fleming BC, Warman ML, Jay GD. "Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis." Proceedings of the National Academy of Sciences, vol. 110, no. 15, 2013, pp. 5852-7. |
| Murray, Martha M., Fleming, Braden C. "The Biology of the Normal ACL." The ACL Handbook, 2013, pp. 63-72. |
| Fleming BC, Fadale PD, Hulstyn MJ, Shalvoy RM, Oksendahl HL, Badger GJ, Tung GA. "The effect of initial graft tension after anterior cruciate ligament reconstruction: a randomized clinical trial with 36-month follow-up." The American Journal of Sports Medicine, vol. 41, no. 1, 2013, pp. 25-34. |
| Murray MM, Fleming BC. "Use of a bioactive scaffold to stimulate anterior cruciate ligament healing also minimizes posttraumatic osteoarthritis after surgery." The American Journal of Sports Medicine, vol. 41, no. 8, 2013, pp. 1762-70. |
| Fleming, B.C., Machan, J.T., Shalvoy, M.R., Murray, M.M. "A collagen-platelet composite to stimulate healing after acl surgery also minimizes cartilage damage in the acl injured knee." Osteoarthritis and Cartilage, vol. 20, 2012, pp. S68-S69. |
| Proffen BL, McElfresh M, Fleming BC, Murray MM. "A comparative anatomical study of the human knee and six animal species." The Knee, vol. 19, no. 4, 2012, pp. 493-9. |
| Wei, F., Zhou, J., Wei, X., Zhang, J., Fleming, B.C., Terek, R., Pei, M., Chen, Q., Liu, T., Wei, L. "Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage." Osteoarthritis and Cartilage, vol. 20, no. 7, 2012, pp. 755-763. |
| Vavken P, Fleming BC, Mastrangelo AN, Machan JT, Murray MM. "Biomechanical outcomes after bioenhanced anterior cruciate ligament repair and anterior cruciate ligament reconstruction are equal in a porcine model." Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 28, no. 5, 2012, pp. 672-80. |
| Drewniak, Elizabeth I., Jay, Gregory D., Fleming, Braden C., Zhang, Ling, Warman, Matthew L., Crisco, Joseph J. "Cyclic loading increases friction and changes cartilage surface integrity in lubricin-mutant mouse knees." Arthritis and rheumatism, vol. 64, no. 2, 2012, pp. 465-73. |
| Mulcahey MK, Monchik KO, Yongpravat C, Badger GJ, Fadale PD, Hulstyn MJ, Fleming BC. "Effects of single-bundle and double-bundle ACL reconstruction on tibiofemoral compressive stresses and joint kinematics during simulated squatting." The Knee, vol. 19, no. 4, 2012, pp. 469-76. |
| Waller KA, Zhang LX, Fleming BC, Jay GD. "Preventing Friction-induced Chondrocyte Apoptosis: Comparison of Human Synovial Fluid and Hylan G-F 20." The Journal of Rheumatology, vol. 39, no. 7, 2012, pp. 1473-80. |
| Jay GD, Elsaid KA, Kelly KA, Anderson SC, Zhang L, Teeple E, Waller K, Fleming BC. "Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transection." Arthritis and rheumatism, vol. 64, no. 4, 2012, pp. 1162-1171. |
| Elsaid KA, Zhang L, Waller K, Tofte J, Teeple E, Fleming BC, Jay GD. "The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin's effect in exercised joints following ACL transection." Osteoarthritis and Cartilage, vol. 20, no. 8, 2012, pp. 940-948. |
| Beynnon BD, Johnson RJ, Naud S, Fleming BC, Abate JA, Brattbakk B, Nichols CE. "Accelerated versus nonaccelerated rehabilitation after anterior cruciate ligament reconstruction: a prospective, randomized, double-blind investigation evaluating knee joint laxity using roentgen stereophotogrammetric analysis." The American Journal of Sports Medicine, vol. 39, no. 12, 2011, pp. 2536-48. |
| Tompkins M, Monchik KO, Plante MJ, Fleming BC, Fadale PD. "Contact area and pressure in suture bridge rotator cuff repair using knotless lateral anchors." Knee Surgery, Sports Traumatology, Arthroscopy, vol. 19, no. 10, 2011, pp. 1788-93. |
| Fujiya H, Kousa P, Fleming BC, Churchill DL, Beynnon BD. "Effect of muscle loads and torque applied to the tibia on the strain behavior of the anterior cruciate ligament: an in vitro investigation." Clinical biomechanics (Bristol, Avon), vol. 26, no. 10, 2011, pp. 1005-11. |
| Teeple E, Elsaid KA, Jay GD, Zhang L, Badger GJ, Akelman M, Bliss TF, Fleming BC. "Effects of supplemental intra-articular lubricin and hyaluronic acid on the progression of posttraumatic arthritis in the anterior cruciate ligament-deficient rat knee." The American Journal of Sports Medicine, vol. 39, no. 1, 2011, pp. 164-72. |
| Murray, Martha, Magarian, Elise, Harrison, Sophia, Mastrangelo, Ashley, Zurakowski, David, Fleming, Braden C. "Paper # 255: Skeletal Maturity Significantly Affects Functional ACL Healing Using PRP." Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 27, no. 10, 2011, pp. e241-e242. |
| Mastrangelo AN, Vavken P, Fleming BC, Harrison SL, Murray MM. "Reduced platelet concentration does not harm PRP effectiveness for ACL repair in a porcine in vivo model." Journal of Orthopaedic Research, vol. 29, no. 7, 2011, pp. 1002-7. |
| Miranda, Daniel L., Schwartz, Joel B., Loomis, Andrew C., Brainerd, Elizabeth L., Fleming, Braden C., Crisco, Joseph J. "Static and Dynamic Error of a Biplanar Videoradiography System Using Marker-Based and Markerless Tracking Techniques." Journal of Biomechanical Engineering, vol. 133, no. 12, 2011, pp. 121002. |
| Tompkins M, Plante M, Monchik K, Fleming B, Fadale P. "The use of a non-benzodiazepine hypnotic sleep-aid (Zolpidem) in patients undergoing ACL reconstruction: a randomized controlled clinical trial." Knee Surgery, Sports Traumatology, Arthroscopy, vol. 19, no. 5, 2011, pp. 787-91. |
| Fleming BC, Vajapeyam S, Connolly SA, Magarian EM, Murray MM. "The use of magnetic resonance imaging to predict ACL graft structural properties." Journal of Biomechanics, vol. 44, no. 16, 2011, pp. 2843-6. |
| Vavken P, Saad FA, Fleming BC, Murray MM. "VEGF receptor mRNA expression by ACL fibroblasts is associated with functional healing of the ACL." Knee Surgery, Sports Traumatology, Arthroscopy, vol. 19, no. 10, 2011, pp. 1675-82. |
| Li, Kai, Wei, Fangyuan, Zhou, Jingming, Wei, Xiaochun, Chen, Qian, Fleming, Braden, Terek, Richard, Wei, Lei. "Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage." Bone, vol. 47, 2010, pp. S361-S362. |
| Miranda DL, Rainbow MJ, Leventhal EL, Crisco JJ, Fleming BC. "Automatic determination of anatomical coordinate systems for three-dimensional bone models of the isolated human knee." Journal of Biomechanics, vol. 43, no. 8, 2010, pp. 1623-6. |
| Murray MM, Magarian E, Zurakowski D, Fleming BC. "Bone-to-bone fixation enhances functional healing of the porcine anterior cruciate ligament using a collagen-platelet composite." Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 26, no. 9 Suppl, 2010, pp. S49-57. |
| Fleming BC, Magarian EM, Harrison SL, Paller DJ, Murray MM. "Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament." Journal of Orthopaedic Research, vol. 28, no. 6, 2010, pp. 703-9. |
| Wei L, Fleming BC, Sun X, Teeple E, Wu W, Jay GD, Elsaid KA, Luo J, Machan JT, Chen Q. "Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model." Journal of Orthopaedic Research, vol. 28, no. 7, 2010, pp. 900-6. |
| Magarian EM, Fleming BC, Harrison SL, Mastrangelo AN, Badger GJ, Murray MM. "Delay of 2 or 6 weeks adversely affects the functional outcome of augmented primary repair of the porcine anterior cruciate ligament." The American Journal of Sports Medicine, vol. 38, no. 12, 2010, pp. 2528-34. |
| Fleming BC, Oksendahl HL, Mehan WA, Portnoy R, Fadale PD, Hulstyn MJ, Bowers ME, Machan JT, Tung GA. "Delayed Gadolinium-Enhanced MR Imaging of Cartilage (dGEMRIC) following ACL injury." Osteoarthritis and Cartilage, vol. 18, no. 5, 2010, pp. 662-7. |
| Roemhildt ML, Coughlin KM, Peura GD, Badger GJ, Churchill D, Fleming BC, Beynnon BD. "Effects of increased chronic loading on articular cartilage material properties in the lapine tibio-femoral joint." Journal of Biomechanics, vol. 43, no. 12, 2010, pp. 2301-8. |
| Jay GD, Fleming BC, Watkins BA, McHugh KA, Anderson SC, Zhang LX, Teeple E, Waller KA, Elsaid KA. "Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection." Arthritis and rheumatism, vol. 62, no. 8, 2010, pp. 2382-2391. |
| Bowers ME, Tung GA, Oksendahl HL, Hulstyn MJ, Fadale PD, Machan JT, Fleming BC. "Quantitative magnetic resonance imaging detects changes in meniscal volume in vivo after partial meniscectomy." The American Journal of Sports Medicine, vol. 38, no. 8, 2010, pp. 1631-7. |
| Chang, Ming-Ching, Trinh, Nhon H., Fleming, Braden C., Kimia, Benjamin B. "Reliable fusion of knee bone laser scans to establish ground truth for cartilage thickness measurement." Medical Imaging 2010: Image Processing, 2010. |
| Murray MM, Magarian EM, Harrison SL, Mastrangelo AN, Zurakowski D, Fleming BC. "The effect of skeletal maturity on functional healing of the anterior cruciate ligament." The Journal of Bone and Joint Surgery-American Volume, vol. 92, no. 11, 2010, pp. 2039-49. |
| Roemhildt, M.L., Fleming, B.C., Beynnon, B.D., Churchill, D. "101 IN VITRO VALIDATION OF A VARUS LOADING DEVICE IN THE RABBIT KNEE." Osteoarthritis and Cartilage, vol. 17, 2009, pp. S62. |
| Joshi SM, Mastrangelo AN, Magarian EM, Fleming BC, Murray MM. "Collagen-platelet composite enhances biomechanical and histologic healing of the porcine anterior cruciate ligament." The American Journal of Sports Medicine, vol. 37, no. 12, 2009, pp. 2401-10. |
| Fleming BC, Spindler KP, Palmer MP, Magarian EM, Murray MM. "Collagen-platelet composites improve the biomechanical properties of healing anterior cruciate ligament grafts in a porcine model." The American Journal of Sports Medicine, vol. 37, no. 8, 2009, pp. 1554-63. |
| Drewniak, Elizabeth I., Jay, Gregory D., Fleming, Braden C., Crisco, Joseph J. "Comparison of two methods for calculating the frictional properties of articular cartilage using a simple pendulum and intact mouse knee joints." Journal of Biomechanics, vol. 42, no. 12, 2009, pp. 1996-9. |
| Oksendahl HL, Gomez N, Thomas CS, Badger GD, Hulstyn MJ, Fadale PD, Fleming BC. "Digital radiographic assessment of tibiofemoral joint space width: a variance component analysis." The journal of knee surgery, vol. 22, no. 3, 2009, pp. 205-12. |
| Monchik, Keith, Plante, Matthew, Yongpravat, Charlie, Fleming, Braden, Fadale, Paul D. "Effects of Single-Bundle and Double-Bundle ACL Reconstruction on Tibiofemoral Forces and Joint Kinematics Under Dynamic Loading (SS-42)." Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 25, no. 6, 2009, pp. e22-e23. |
| Murray MM, Palmer M, Abreu E, Spindler KP, Zurakowski D, Fleming BC. "Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: an in vivo study." Journal of Orthopaedic Research, vol. 27, no. 5, 2009, pp. 639-45. |
| Elsaid KA, Machan JT, Waller K, Fleming BC, Jay GD. "The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting tumor necrosis factor α on chondroprotection in an animal model." Arthritis and rheumatism, vol. 60, no. 10, 2009, pp. 2997-3006. |
| Spindler KP, Murray MM, Carey JL, Zurakowski D, Fleming BC. "The use of platelets to affect functional healing of an anterior cruciate ligament (ACL) autograft in a caprine ACL reconstruction model." Journal of Orthopaedic Research, vol. 27, no. 5, 2009, pp. 631-8. |
| Wright RW, Preston E, Fleming BC, Amendola A, Andrish JT, Bergfeld JA, Dunn WR, Kaeding C, Kuhn JE, Marx RG, McCarty EC, Parker RC, Spindler KP, Wolcott M, Wolf BR, Williams GN. "A systematic review of anterior cruciate ligament reconstruction rehabilitation: part I: continuous passive motion, early weight bearing, postoperative bracing, and home-based rehabilitation." The journal of knee surgery, vol. 21, no. 3, 2008, pp. 217-24. |
| Wright RW, Preston E, Fleming BC, Amendola A, Andrish JT, Bergfeld JA, Dunn WR, Kaeding C, Kuhn JE, Marx RG, McCarty EC, Parker RC, Spindler KP, Wolcott M, Wolf BR, Williams GN. "A systematic review of anterior cruciate ligament reconstruction rehabilitation: part II: open versus closed kinetic chain exercises, neuromuscular electrical stimulation, accelerated rehabilitation, and miscellaneous topics." The journal of knee surgery, vol. 21, no. 3, 2008, pp. 225-34. |
| Tocci SL, Tashjian RZ, Leventhal E, Spenciner DB, Green A, Fleming BC. "Biomechanical comparison of single-row arthroscopic rotator cuff repair technique versus transosseous repair technique." Journal of Shoulder and Elbow Surgery, vol. 17, no. 5, 2008, pp. 808-14. |
| Fleming BC, Carey JL, Spindler KP, Murray MM. "Can suture repair of ACL transection restore normal anteroposterior laxity of the knee? An ex vivo study." Journal of Orthopaedic Research, vol. 26, no. 11, 2008, pp. 1500-5. |
| Teeple, Erin, Elsaid, Khaled A., Fleming, Braden C., Jay, Gregory D., Aslani, Koosha, Crisco, Joseph J., Mechrefe, Anthony P. "Coefficients of friction, lubricin, and cartilage damage in the anterior cruciate ligament-deficient guinea pig knee." Journal of Orthopaedic Research, vol. 26, no. 2, 2008, pp. 231-7. |
| Elsaid KA, Fleming BC, Oksendahl HL, Machan JT, Fadale PD, Hulstyn MJ, Shalvoy R, Jay GD. "Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury." Arthritis and rheumatism, vol. 58, no. 6, 2008, pp. 1707-1715. |
| Bowers ME, Tung GA, Trinh N, Leventhal E, Crisco JJ, Kimia B, Fleming BC. "Effects of ACL interference screws on articular cartilage volume and thickness measurements with 1.5 T and 3 T MRI." Osteoarthritis and Cartilage, vol. 16, no. 5, 2008, pp. 572-8. |
| Le NA, Fleming BC. "Measuring fixed charge density of goat articular cartilage using indentation methods and biochemical analysis." Journal of Biomechanics, vol. 41, no. 3, 2008, pp. 715-20. |
| Bowers ME, Trinh N, Tung GA, Crisco JJ, Kimia BB, Fleming BC. "Quantitative MR imaging using "LiveWire" to measure tibiofemoral articular cartilage thickness." Osteoarthritis and Cartilage, vol. 16, no. 10, 2008, pp. 1167-73. |
| Fleming BC, Brady MF, Bradley MP, Banerjee R, Hulstyn MJ, Fadale PD. "Tibiofemoral compression force differences using laxity- and force-based initial graft tensioning techniques in the anterior cruciate ligament-reconstructed cadaveric knee." Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 24, no. 9, 2008, pp. 1052-60. |
| Drewniak EI, Crisco JJ, Spenciner DB, Fleming BC. "Accuracy of circular contact area measurements with thin-film pressure sensors." Journal of Biomechanics, vol. 40, no. 11, 2007, pp. 2569-72. |
| Jay, G., Elsaid, K., Fleming, B., Oksendahl, H., Fadale, P., Hulstyn, M., Shalvoy, R., Warman, M. "Anterior Cruciate Ligament Injury is Associated with Lack of Boundary Lubrication by Lubricin." Academic Emergency Medicine, vol. 14, no. 5 Supplement 1, 2007, pp. S139-S140. |
| Crisco, J J, Blume, J, Teeple, E, Fleming, B C, Jay, G D. "Assuming exponential decay by incorporating viscous damping improves the prediction of the coefficient of friction in pendulum tests of whole articular joints." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, vol. 221, no. 3, 2007, pp. 325-333. |
| Brady MF, Bradley MP, Fleming BC, Fadale PD, Hulstyn MJ, Banerjee R. "Effects of initial graft tension on the tibiofemoral compressive forces and joint position after anterior cruciate ligament reconstruction." The American Journal of Sports Medicine, vol. 35, no. 3, 2007, pp. 395-403. |
| Teeple E, Fleming BC, Mechrefe AP, Crisco JJ, Brady MF, Jay GD. "Frictional properties of Hartley guinea pig knees with and without proteolytic disruption of the articular surfaces." Osteoarthritis and Cartilage, vol. 15, no. 3, 2007, pp. 309-315. |
| Langer P, Nickisch F, Spenciner D, Fleming B, DiGiovanni CW. "In vitro evaluation of the effect lateral process talar excision on ankle and subtalar joint stability." Foot & Ankle International, vol. 28, no. 1, 2007, pp. 78-83. |
| Tashjian RZ, Levanthal E, Spenciner DB, Green A, Fleming BC. "Initial fixation strength of massive rotator cuff tears: in vitro comparison of single-row suture anchor and transosseous tunnel constructs." Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 23, no. 7, 2007, pp. 710-6. |
| Oksendahl HL, Fleming BC, Blanpied PR, Ritter M, Hulstyn MJ, Fadale PD. "Intra-articular anesthesia and knee muscle response." Clinical biomechanics (Bristol, Avon), vol. 22, no. 5, 2007, pp. 529-36. |
| Bowers ME, Tung GA, Fleming BC, Crisco JJ, Rey J. "Quantification of meniscal volume by segmentation of 3T magnetic resonance images." Journal of Biomechanics, vol. 40, no. 12, 2007, pp. 2811-5. |
| Brody JM, Hulstyn MJ, Fleming BC, Tung GA. "The meniscal roots: gross anatomic correlation with 3-T MRI findings." American Journal of Roentgenology, vol. 188, no. 5, 2007, pp. W446-50. |
| Trinh, Nhon H., Lester, Jonathan, Fleming, Braden C., Tung, Glenn, Kimia, Benjamin B. "Accurate Measurement of Cartilage Morphology Using a 3D Laser Scanner." Computer Vision Approaches to Medical Image Analysis, 2006, pp. 37-48. |
| Bradley, Michael P., Fleming, Braden C., Brady, Mark, Banerjee, Rahul, Fadale, Paul, Hulstyn, Michael. "Compression Force and Laxity Differences Using Different Initial Graft Tensioning Techniques in the Human Cadaver ACL Reconstructed Knee (SS-52)." Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 22, no. 6, 2006, pp. e26-e27. |
| Langer, Phillip R., Fleming, Braden, Spenciner, David, Hulstyn, Michael J., Fadale, Paul D. "In-Vitro Study of Hamstring Graft Morphometry and an Intraoperative Technique to Avoid Premature Amputation when Harvesting the Graft for ACL Reconstruction (SS-54)." Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 22, no. 6, 2006, pp. e27-e28. |
| Roemhildt ML, Coughlin KM, Peura GD, Fleming BC, Beynnon BD. "Material properties of articular cartilage in the rabbit tibial plateau." Journal of Biomechanics, vol. 39, no. 12, 2006, pp. 2331-7. |
| Langer P, Fadale P, Hulstyn M, Fleming B, Brady M. "Survey of orthopaedic and sports medicine physicians regarding use of medrol dosepak for sports injuries." Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 22, no. 12, 2006, pp. 1263-1269.e2. |
| Coughlin KM, Peura GD, Fleming BC, Hallock S, Beynnon BD. "In vivo loads in the medial compartment of the rabbit knee." Clinical biomechanics (Bristol, Avon), vol. 20, no. 9, 2005, pp. 1007-9. |
| Fleming, Braden C, Hulstyn, Michael J, Oksendahl, Heidi L, Fadale, Paul D. "Ligament injury, reconstruction and osteoarthritis." Current Opinion in Orthopaedics, vol. 16, no. 5, 2005, pp. 354-362. |
| Fleming BC, Hulstyn MJ, Oksendahl HL, Fadale PD. "Ligament Injury, Reconstruction and Osteoarthritis." Current Opinion in Orthopaedics, vol. 16, no. 5, 2005, pp. 354-362. |
| Fleming BC, Oksendahl H, Beynnon BD. "Open- or closed-kinetic chain exercises after anterior cruciate ligament reconstruction?." Exercise and Sport Sciences Reviews, vol. 33, no. 3, 2005, pp. 134-40. |
| Beynnon BD, Uh BS, Johnson RJ, Abate JA, Nichols CE, Fleming BC, Poole AR, Roos H. "Rehabilitation after anterior cruciate ligament reconstruction: a prospective, randomized, double-blind comparison of programs administered over 2 different time intervals." The American Journal of Sports Medicine, vol. 33, no. 3, 2005, pp. 347-59. |
| Walsh EF, Akelman E, Fleming BC, DaSilva MF. "Thumb carpometacarpal arthroscopy: a topographic, anatomic study of the thenar portal." The Journal of Hand Surgery, vol. 30, no. 2, 2005, pp. 373-9. |
| Beynnon BD, Johnson RJ, Abate JA, Fleming BC, Nichols CE. "Treatment of anterior cruciate ligament injuries, part 2." The American Journal of Sports Medicine, vol. 33, no. 11, 2005, pp. 1751-67. |
| Beynnon BD, Johnson RJ, Abate JA, Fleming BC, Nichols CE. "Treatment of anterior cruciate ligament injuries, part I." The American Journal of Sports Medicine, vol. 33, no. 10, 2005, pp. 1579-602. |
| Fleming, Braden C., Beynnon, Bruce D. "In Vivo Measurement of Ligament/Tendon Strains and Forces: A Review." Annals of Biomedical Engineering, vol. 32, no. 3, 2004, pp. 318-328. |
| Fleming BC, Beynnon BD. "In vivo measurement of ligament/tendon strains and forces: a review." Annals of Biomedical Engineering, vol. 32, no. 3, 2004, pp. 318-28. |
| Heijne A, Fleming BC, Renstrom PA, Peura GD, Beynnon BD, Werner S. "Strain on the anterior cruciate ligament during closed kinetic chain exercises." Medicine & Science in Sports & Exercise, vol. 36, no. 6, 2004, pp. 935-41. |
| Fleming BC. "Biomechanics of the anterior cruciate ligament." J Orthop Sports Phys Ther, vol. 33, no. 8, 2003, pp. A13-5. |
| Beynnon BD, Fleming BC, Churchill DL, Brown D. "The effect of anterior cruciate ligament deficiency and functional bracing on translation of the tibia relative to the femur during nonweightbearing and weightbearing." The American Journal of Sports Medicine, vol. 31, no. 1, 2003, pp. 99-105. |
| Fleming BC, Ohlén G, Renström PA, Peura GD, Beynnon BD, Badger GJ. "The effects of compressive load and knee joint torque on peak anterior cruciate ligament strains." The American Journal of Sports Medicine, vol. 31, no. 5, 2003, pp. 701-7. |
| Beynnon BD, Johnson RJ, Fleming BC, Kannus P, Kaplan M, Samani J, Renström P. "Anterior cruciate ligament replacement: comparison of bone-patellar tendon-bone grafts with two-strand hamstring grafts. A prospective, randomized study." The Journal of Bone and Joint Surgery-American Volume, vol. 84-A, no. 9, 2002, pp. 1503-13. |
| Beynnon BD, Fleming BC, Labovitch R, Parsons B. "Chronic anterior cruciate ligament deficiency is associated with increased anterior translation of the tibia during the transition from non-weightbearing to weightbearing." Journal of Orthopaedic Research, vol. 20, no. 2, 2002, pp. 332-7. |
| Fleming BC, Brattbakk B, Peura GD, Badger GJ, Beynnon BD. "Measurement of anterior-posterior knee laxity: a comparison of three techniques." Journal of Orthopaedic Research, vol. 20, no. 3, 2002, pp. 421-6. |
| Beynnon BD, Johnson RJ, Fleming BC. "The science of anterior cruciate ligament rehabilitation." Clinical Orthopaedics and Related Research®, no. 402, 2002, pp. 9-20. |
| Uh BS, Beynnon BD, Churchill DL, Haugh LD, Risberg MA, Fleming BC. "A new device to measure knee laxity during weightbearing and non-weightbearing conditions." Journal of Orthopaedic Research, vol. 19, no. 6, 2001, pp. 1185-91. |
| Fleming BC, Peura GD, Abate JA, Beynnon BD. "Accuracy and repeatability of Roentgen stereophotogrammetric analysis (RSA) for measuring knee laxity in longitudinal studies." Journal of Biomechanics, vol. 34, no. 10, 2001, pp. 1355-9. |
| Fleming BC, Renstrom PA, Beynnon BD, Engstrom B, Peura GD, Badger GJ, Johnson RJ. "The effect of weightbearing and external loading on anterior cruciate ligament strain." Journal of Biomechanics, vol. 34, no. 2, 2001, pp. 163-70. |
| Beynnon BD, Uh BS, Johnson RJ, Fleming BC, Renström PA, Nichols CE. "The elongation behavior of the anterior cruciate ligament graft in vivo. A long-term follow-up study." The American Journal of Sports Medicine, vol. 29, no. 2, 2001, pp. 161-6. |
| Fleming BC, Renstrom PA, Ohlen G, Johnson RJ, Peura GD, Beynnon BD, Badger GJ. "The gastrocnemius muscle is an antagonist of the anterior cruciate ligament." Journal of Orthopaedic Research, vol. 19, no. 6, 2001, pp. 1178-84. |
| Fleming BC, Abate JA, Peura GD, Beynnon BD. "The relationship between graft tensioning and the anterior-posterior laxity in the anterior cruciate ligament reconstructed goat knee." Journal of Orthopaedic Research, vol. 19, no. 5, 2001, pp. 841-4. |
| Reed BV, Ashikaga T, Fleming BC, Zimny NJ. "Effects of ultrasound and stretch on knee ligament extensibility." J Orthop Sports Phys Ther, vol. 30, no. 6, 2000, pp. 341-7. |
| Fleming BC, Peura GD, Beynnon BD. "Factors influencing the output of an implantable force transducer." Journal of Biomechanics, vol. 33, no. 7, 2000, pp. 889-93. |
| Fleming BC, Krag MH, Huston DR, Sugihara S. "Pin loosening in a halo-vest orthosis: a biomechanical study." Spine, vol. 25, no. 11, 2000, pp. 1325-31. |
| Fleming BC, Renstrom PA, Beynnon BD, Engstrom B, Peura G. "The influence of functional knee bracing on the anterior cruciate ligament strain biomechanics in weightbearing and nonweightbearing knees." The American Journal of Sports Medicine, vol. 28, no. 6, 2000, pp. 815-24. |
| Fleming BC, Good L, Peura GD, Beynnon BD. "Calibration and application of an intra-articular force transducer for the measurement of patellar tendon graft forces: an in situ evaluation." Journal of Biomechanical Engineering, vol. 121, no. 4, 1999, pp. 393-8. |
| Fleming BC, Beynnon BD, Renstrom PA, Johnson RJ, Nichols CE, Peura GD, Uh BS. "The strain behavior of the anterior cruciate ligament during stair climbing: an in vivo study." Arthroscopy: The Journal of Arthroscopic & Related Surgery, vol. 15, no. 2, 1999, pp. 185-91. |
| Beynnon BD, Fleming BC. "Anterior cruciate ligament strain in-vivo: a review of previous work." Journal of Biomechanics, vol. 31, no. 6, 1998, pp. 519-25. |
| Fleming BC, Huston DR, Krag MH, Sugihara S. "Pin force measurement in a halo-vest orthosis, in vivo." Journal of Biomechanics, vol. 31, no. 7, 1998, pp. 647-51. |
| Beynnon BD, Meriam CM, Ryder SH, Fleming BC, Johnson RJ. "The effect of screw insertion torque on tendons fixed with spiked washers." The American Journal of Sports Medicine, vol. 26, no. 4, 1998, pp. 536-9. |
| Fleming BC, Beynnon BD, Renstrom PA, Peura GD, Nichols CE, Johnson RJ. "The strain behavior of the anterior cruciate ligament during bicycling. An in vivo study." The American Journal of Sports Medicine, vol. 26, no. 1, 1998, pp. 109-18. |
| Beynnon BD, Risberg MA, Tjomsland O, Ekeland A, Fleming BC, Peura GD, Johnson RJ. "Evaluation of knee joint laxity and the structural properties of the anterior cruciate ligament graft in the human. A case report." The American Journal of Sports Medicine, vol. 25, no. 2, 1997, pp. 203-6. |
| Beynnon BD, Johnson RJ, Fleming BC, Peura GD, Renstrom PA, Nichols CE, Pope MH. "The effect of functional knee bracing on the anterior cruciate ligament in the weightbearing and nonweightbearing knee." The American Journal of Sports Medicine, vol. 25, no. 3, 1997, pp. 353-9. |
| Beynnon BD, Johnson RJ, Fleming BC, Stankewich CJ, Renström PA, Nichols CE. "The strain behavior of the anterior cruciate ligament during squatting and active flexion-extension. A comparison of an open and a closed kinetic chain exercise." The American Journal of Sports Medicine, vol. 25, no. 6, 1997, pp. 823-9. |
| Beynnon B, Yu J, Huston D, Fleming B, Johnson R, Haugh L, Pope MH. "A sagittal plane model of the knee and cruciate ligaments with application of a sensitivity analysis." Journal of Biomechanical Engineering, vol. 118, no. 2, 1996, pp. 227-39. |
| Beynnon BD, Fleming BC, Johnson RJ, Nichols CE, Renström PA, Pope MH. "Anterior cruciate ligament strain behavior during rehabilitation exercises in vivo." The American Journal of Sports Medicine, vol. 23, no. 1, 1995, pp. 24-34. |
| Tohyama H, Beynnon BD, Renström PA, Theis MJ, Fleming BC, Pope MH. "Biomechanical analysis of the ankle anterior drawer test for anterior talofibular ligament injuries." Journal of Orthopaedic Research, vol. 13, no. 4, 1995, pp. 609-14. |
| Fleming BC, Beynnon BD, Nichols CE, Renström PA, Johnson RJ, Pope MH. "An in vivo comparison between intraoperative isometric measurement and local elongation of the graft after reconstruction of the anterior cruciate ligament." The Journal of Bone and Joint Surgery-American Volume, vol. 76, no. 4, 1994, pp. 511-9. |
| Fleming BC, Beynnon BD, Tohyama H, Johnson RJ, Nichols CE, Renström P, Pope MH. "Determination of a zero strain reference for the anteromedial band of the anterior cruciate ligament." Journal of Orthopaedic Research, vol. 12, no. 6, 1994, pp. 789-95. |
| Beynnon BD, Johnson RJ, Fleming BC, Renström PA, Nichols CE, Pope MH, Haugh LD. "The measurement of elongation of anterior cruciate-ligament grafts in vivo." The Journal of Bone and Joint Surgery-American Volume, vol. 76, no. 4, 1994, pp. 520-31. |
| Fleming BC, Beynnon BD, Nichols CE, Johnson RJ, Pope MH. "An in vivo comparison of anterior tibial translation and strain in the anteromedial band of the anterior cruciate ligament." Journal of Biomechanics, vol. 26, no. 1, 1993, pp. 51-8. |
| Fleming B, Beynnon BD, Johnson RJ, McLeod WD, Pope MH. "Isometric versus tension measurements. A comparison for the reconstruction of the anterior cruciate ligament." The American Journal of Sports Medicine, vol. 21, no. 1, 1993, pp. 82-8. |
| Hazard R, Reeves V, Fenwick J, Fleming B, Pope M. "Test-retest variation in lifting capacity and indices of subject effort." Clinical biomechanics (Bristol, Avon), vol. 8, no. 1, 1993, pp. 20-4. |
| Kaigle AM, Pope MH, Fleming BC, Hansson T. "A method for the intravital measurement of interspinous kinematics." Journal of Biomechanics, vol. 25, no. 4, 1992, pp. 451-6. |
| Fleming BC, Johnson RJ, Shapiro E, Fenwick J, Howe JG, Pope MH. "Clinical versus instrumented knee testing on autopsy specimens." Clinical Orthopaedics and Related Research®, no. 282, 1992, pp. 196-207. |
| Fleming B, Beynnon B, Howe J, McLeod W, Pope M. "Effect of tension and placement of a prosthetic anterior cruciate ligament on the anteroposterior laxity of the knee." Journal of Orthopaedic Research, vol. 10, no. 2, 1992, pp. 177-86. |
| Halsey D, Fleming B, Pope MH, Krag M, Kristiansen T. "External fixator pin design." Clinical Orthopaedics and Related Research®, no. 278, 1992, pp. 305-12. |
| Beynnon BD, Pope MH, Wertheimer CM, Johnson RJ, Fleming BC, Nichols CE, Howe JG. "The effect of functional knee-braces on strain on the anterior cruciate ligament in vivo." The Journal of Bone and Joint Surgery-American Volume, vol. 74, no. 9, 1992, pp. 1298-312. |
| Beynnon B, Howe JG, Pope MH, Johnson RJ, Fleming BC. "The measurement of anterior cruciate ligament strain in vivo." International orthopaedics, vol. 16, no. 1, 1992, pp. 1-12. |
| Howe JG, Johnson RJ, Kaplan MJ, Fleming B, Jarvinen M. "Anterior cruciate ligament reconstruction using quadriceps patellar tendon graft. Part I. Long-term followup." The American Journal of Sports Medicine, vol. 19, no. 5, 1991, pp. 447-57. |
| Kaplan MJ, Howe JG, Fleming B, Johnson RJ, Jarvinen M. "Anterior cruciate ligament reconstruction using quadriceps patellar tendon graft. Part II. A specific sport review." The American Journal of Sports Medicine, vol. 19, no. 5, 1991, pp. 458-62. |
| Hazard RG, Reeves V, Weisman G, Fleming BC, Pope MH. "Dynamic lifting capacity: the relationship between peak force and weight as an indicator of effort." Journal of spinal disorders, vol. 4, no. 1, 1991, pp. 63-7. |
| Pope MH, Stankewich CJ, Beynnon BD, Fleming BC. "Effect of knee musculature on anterior cruciate ligament strain in vivo." Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology, vol. 1, no. 3, 1991, pp. 191-8. |
| Paley D, Fleming B, Catagni M, Kristiansen T, Pope M. "Mechanical evaluation of external fixators used in limb lengthening." Clinical Orthopaedics and Related Research®, no. 250, 1990, pp. 50-7. |
| Fleming B, Paley D, Kristiansen T, Pope M. "A biomechanical analysis of the Ilizarov external fixator." Clinical Orthopaedics and Related Research®, no. 241, 1989, pp. 95-105. |
| Emery M, Rodgers MM, Boerman J, Fleming BC, Howe J, Pope M. "Reliability of force/displacement measures in a clinical device designed to measure ligamentous laxity at the knee." J Orthop Sports Phys Ther, vol. 10, no. 11, 1989, pp. 441-7. |
| Stein A, Fleming B, Pope MH, Howe JG. "Total knee arthroplasty kinematics. An in vivo evaluation of four different designs." The Journal of Arthroplasty, vol. 3 Suppl, 1988, pp. S31-6. |
| Kristiansen T, Fleming B, Neale G, Reinecke S, Pope MH. "Comparative study of fracture gap motion in external fixation." Clinical biomechanics (Bristol, Avon), vol. 2, no. 4, 1987, pp. 191-5. |
The focus of the Fleming lab is to translate novel treatments of orthopaedics injuries from the bench to the clinic. Primary research interests focus on knee and soft tissue biomechanics, imaging and biomedical instrumentation. He has maintained a NIH funded research program for over 25 years.
Dr. Fleming's primary research interests focus on the biomechanics of the lower extremity and biomedical instrumentation. Recent projects include: 1) A randomized controlled trial comparing two initial graft tensioning procedures on ACL reconstruction outcomes and post-traumatic osteoarthritis is currently underway (12 to 15 year follow-up). At 7 years post-surgery, there were minimal differences between the two graft tension groups and both groups were presenting with post-traumatic osteoarthritis when compared to the matched uninjured control group. 2) In a collaboration with Dr. Martha Murray at Boston Children’s Hospital multiple pre-clinical studies have been performed to translate a novel ACL repair procedure from the bench to clinical trials. FDA regulated clinical trials are underway to demonstrate that the procedure is safe and effective. The BEAR implant was granted FDA approval in December 2020. 3) The lab is currently developing and optimizing MR imaging protocols to non-invasively evaluate ligament and graft healing after ACL surgery. We have shown that specific MR parameters are predictive of the biomechanical properties of the healing structure and reflective of the tissue histology. 4) In a collaboration with Dr. Gregory Jay, we have determined that the intra-articular administration of recombinant PRG4 reduces cartilage damage following ACL and meniscal injury. Work is currently underway to translate this into clinical use in the near future. 5) Additional studies and collaborations are underway to identify transcriptional and proteomic changes following joint injury to identify novel treatments to reduce the risk of post-traumatic osteoarthritis.
| Year | Degree | Institution |
|---|---|---|
| 1996 | PhD | University of Vermont |
| 1991 | MS | University of Vermont |
| 1983 | BS | University of Vermont |
| Name | Title |
|---|---|
| Brainerd, Elizabeth | Robert P. Brown Professor of Biology, Professor of Medical Science |
| Crisco, Joseph | Henry F. Lippitt Professor of Orthopedics, Professor of Engineering (Research) |
| Fadale, Paul | Professor of Orthopaedics |
| Gil, Holly | Associate Professor of Diagnostic Imaging, Clinician Educator |
| Hulstyn, Michael | Professor of Orthopaedics |
| Jay, Gregory | John and Mary Panton and Emergency Medicine Professor of Translational Science, Professor of Orthopaedics, Professor of Medicine, Professor of Engineering (Research) |
| Jayasuriya, Chathuraka | Associate Professor of Orthopaedics |
| Kimia, Benjamin | Professor of Engineering |
| Owens, Brett | Professor of Orthopaedics, Professor of Epidemiology |
| Shalvoy, Robert | Associate Professor of Orthopaedics, Clinician Educator |
| Toussaint, Kimani | Thomas J. Watson, Sr. Professor of Science |
| Tung, Glenn | Professor of Diagnostic Imaging |
| Walsh, Edward | Associate Professor of Brain Science (Research) |
| Wei, Lei | Associate Professor of Orthopaedics (Research) |
ACADEMIC APPOINTMENTS
ACADEMIC COMMITTEES
HOSPITAL APPOINTMENTS
OTHER APPOINTMENTS & COMMITTEES
| Director of the Bioengineering Core of the COBRE for Skeletal Health and Repair. Rhode Island Hospital, 2007-Present |
| Senior Investigator. Rhode Island Hospital, 2003-Present |
