Marc Tatar is Professor in The Division of Biology and Medicine at Brown University. Dr. Tatar has studied the demography, evolution and genetics of aging working with a variety of insect systems to explore the regulation and basic mechanisms of life history traits and senescence. Current work in the Tatar laboratory focuses on genetic analysis of Drosophila to understand how insulin/IGF signals and lipid hormones regulate aging, and how these endocrine signals interact with nutrition. Dr. Tatar received his Ph.D. from UC Davis in the laboratory of James Carey and completed post-doctoral training at the University of Minnesota with James Curtsinger. Dr. Tatar is an Ellison Senior Scholar, founding Joint Editor-in-Chief of Aging Cell, and a past member of the Board of Review Editors for Science.
| Zheng W, Rus F, Hernandez A, Kang P, Goldman W, Silverman N, Tatar M. "Dehydration triggers ecdysone-mediated recognition-protein priming and elevated anti-bacterial immune responses in Drosophila Malpighian tubule renal cells." BMC biology, vol. 16, no. 1, 2018, pp. 60. |
| Post S, Liao S, Yamamoto R, Veenstra JA, Nässel DR, Tatar M. "Drosophila insulin-like peptide dilp1 increases lifespan and glucagon-like Akh expression epistatic to dilp2." Aging Cell, 2018, pp. e12863. |
| Post, Stephanie, Karashchuk, Galina, Wade, John D., Sajid, Waseem, De Meyts, Pierre, Tatar, Marc. "Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity." Frontiers in Endocrinology, vol. 9, 2018. |
| Lu, Minglei, Wang, Pei, Zhou, Sijie, Flickinger, Bryce, Malhotra, Deepak, Ge, Yan, Tatar, Marc, Dworkin, Lance, Liu, Zhangsuo, Gong, Rujun. "Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities." Cellular Physiology and Biochemistry, vol. 49, no. 4, 2018, pp. 1633-1645. |
| Min KJ, Tatar M. "Unraveling the Molecular Mechanism of Immunosenescence in <i>Drosophila</i>." International Journal of Molecular Sciences, vol. 19, no. 9, 2018. |
| Lin, Feng, Hossain, Mohammed Akhter, Post, Stephanie, Karashchuk, Galina, Tatar, Marc, De Meyts, Pierre, Wade, John D. "Total Solid-Phase Synthesis of Biologically Active Drosophila Insulin-Like Peptide 2 (DILP2)." Australian Journal of Chemistry, vol. 70, no. 2, 2017, pp. 208. |
| Tatar M, Sedivy JM. "Mitochondria: Masters of Epigenetics." Cell, vol. 165, no. 5, 2016, pp. 1052-1054. |
| Post, Stephanie, Tatar, Marc. "Nutritional Geometric Profiles of Insulin/IGF Expression in Drosophila melanogaster." PLoS ONE, vol. 11, no. 5, 2016, pp. e0155628. |
| Bowman E, Tatar M. "Reproduction regulates Drosophila nutrient intake through independent effects of egg production and sex peptide: Implications for aging." Nutrition and healthy aging, vol. 4, no. 1, 2016, pp. 55-61. |
| Bai, Hua, Post, Stephanie, Kang, Ping, Tatar, Marc. "Drosophila Longevity Assurance Conferred by Reduced Insulin Receptor Substrate Chico Partially Requires d4eBP." PLoS ONE, vol. 10, no. 8, 2015, pp. e0134415. |
| Huang, Cheng-Wen, Wang, Horng-Dar, Bai, Hua, Wu, Ming-Shiang, Yen, Jui-Hung, Tatar, Marc, Fu, Tsai-Feng, Wang, Pei-Yu. "Tequila Regulates Insulin-Like Signaling and Extends Life Span in Drosophila melanogaster." The Journals of Gerontology: Series A, 2015, pp. glv094. |
| Tatar, Marc, Post, Stephanie, Yu, Kweon. "Nutrient control of Drosophila longevity." Trends in Endocrinology & Metabolism, vol. 25, no. 10, 2014, pp. 509-517. |
| Ding, Feifei, Gil, M. Pilar, Franklin, Michael, Ferreira, Jonathan, Tatar, Marc, Helfand, Stephen L., Neretti, Nicola. "Transcriptional response to dietary restriction in Drosophila melanogaster." Journal of Insect Physiology, vol. 69, 2014, pp. 101-106. |
| Bai, Hua, Kang, Ping, Hernandez, Ana Maria, Tatar, Marc. "Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila." PLOS Genetics, vol. 9, no. 11, 2013, pp. e1003941. |
| Rus F, Flatt T, Aggarwal K, Caffrey D, Tatar M, and Silverman N. "Crosstalk between the ecdysone signaling pathway and the Drosophila innate immune response." EMBO J, vol. 32, 2013, pp. 1626-38. |
| Rus, Florentina, Flatt, Thomas, Tong, Mei, Aggarwal, Kamna, Okuda, Kendi, Kleino, Anni, Yates, Elisabeth, Tatar, Marc, Silverman, Neal. "Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity." EMBO J, vol. 32, no. 11, 2013, pp. 1626-1638. |
| Yamamoto R, Bai H, Dolezal A, Amdam G, Tatar M. "Juvenile hormone regulation of Drosophila aging." BMC biology, vol. 11, 2013, pp. 85. |
| Bai H, Kang P, Tatar M. "The regulation of Drosophila aging by insulin/IGF signaling via FOXO mediated by TGF-/Activin control of autophagy." PLOS Genetics, vol. 9, no. 11, 2013, pp. e1003941. |
| Hong, Seung-Hyun, Lee, Kyu-Sun, Kwak, Su-Jin, Kim, Ae-Kyeong, Bai, Hua, Jung, Min-Su, Kwon, O-Yu, Song, Woo-Joo, Tatar, Marc, Yu, Kweon. "Correction: Minibrain/Dyrk1a Regulates Food Intake through the Sir2-FOXO-sNPF/NPY Pathway in Drosophila and Mammals." PLOS Genetics, vol. 8, no. 9, 2012. |
| Bai, Hua, Kang, Ping, Tatar, Marc. "Drosophila insulin-like peptide-6 ( dilp6 ) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain." Aging Cell, vol. 11, no. 6, 2012, pp. 978-985. |
| Bergland, Alan O., Chae, Hyo-seok, Kim, Young-Joon, Tatar, Marc. "Fine-Scale Mapping of Natural Variation in Fly Fecundity Identifies Neuronal Domain of Expression and Function of an Aquaporin." PLOS Genetics, vol. 8, no. 4, 2012, pp. e1002631. |
| Hong SH, Lee KS, Kwak SJ, Kim AK, Bai H, Jung MS, Kwon OY, Song WJ, Tatar M, Yu K. "Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals." PLOS Genetics, vol. 8, no. 8, 2012, pp. e1002857. |
| Yamamoto R, Tatar M. "Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan." Aging Cell, vol. 10, no. 4, 2011, pp. 729-32. |
| Villa-Cuesta E, Boylan JM, Tatar M, Gruppuso PA. "Resveratrol inhibits protein translation in hepatic cells." PLoS ONE, vol. 6, no. 12, 2011, pp. e29513. |
| O'Connor, Kathleen A., Brindle, Eleanor, Shofer, Jane, Trumble, Benjamin C., Aranda, Jennifer D., Rice, Karen, Tatar, Marc. "The effects of a long-term psychosocial stress on reproductive indicators in the baboon." Am. J. Phys. Anthropol., vol. 145, no. 4, 2011, pp. 629-638. |
| Villa-Cuesta E, Sage BT, Tatar M. "A role for Drosophila dFoxO and dFoxO 5'UTR internal ribosomal entry sites during fasting." PLoS ONE, vol. 5, no. 7, 2010, pp. e11521. |
| Baur, J. A., Chen, D., Chini, E. N., Chua, K., Cohen, H. Y., Cabo, R. d., Deng, C., Dimmeler, S., Gius, D., Guarente, L. P., Helfand, S. L., Imai, S.-I., Itoh, H., Kadowaki, T., Koya, D., Leeuwenburgh, C., McBurney, M., Nabeshima, Y.-I., Neri, C., Oberdoerffer, P., Pestell, R. G., Rogina, B., Sadoshima, J., Sartorelli, V., Serrano, M., Sinclair, D. A., Steegborn, C., Tatar, M., Tissenbaum, H. A., Tong, Q., Tsubota, K., Vaquero, A., Verdin, E. "Dietary restriction: standing up for sirtuins." Science, vol. 329, no. 5995, 2010, pp. 1012-3; author reply 1013-4. |
| Garbuzov, Alina, Tatar, Marc. "Hormonal regulation of Drosophila microRNA let-7 and miR-125 that target innate immunity." Fly, vol. 4, no. 4, 2010, pp. 306-311. |
| Tatar, Marc. "Reproductive aging in invertebrate genetic models." Annals of the New York Academy of Sciences, vol. 1204, no. 1, 2010, pp. 149-155. |
| Tatar M. "Can We Develop Genetically Tractable Models to Assess Healthspan (Rather Than Life Span) in Animal Models?." The Journals of Gerontology: Series A, vol. 64, no. 2, 2009, pp. 161-3. |
| Tatar, Marc. "Aging Cell - the Cowen era: looking back downstream from calmer waters." Aging Cell, vol. 7, no. 1, 2008, pp. 1-1. |
| Flatt T, Min KJ, D'Alterio C, Villa-Cuesta E, Cumbers J, Lehmann R, Jones DL, Tatar M. "Drosophila germ-line modulation of insulin signaling and lifespan." Proceedings of the National Academy of Sciences, vol. 105, no. 17, 2008, pp. 6368-73. |
| Min, Kyung-Jin, Yamamoto, Rochele, Buch, Susanne, Pankratz, Michael, Tatar, Marc. "Drosophila lifespan control by dietary restriction independent of insulin-like signaling." Aging Cell, vol. 7, no. 2, 2008, pp. 199-206. |
| Lee, Kyu-Sun, Kwon, O-Yu, Lee, Joon H., Kwon, Kisang, Min, Kyung-Jin, Jung, Sun-Ah, Kim, Ae-Kyeong, You, Kwan-Hee, Tatar, Marc, Yu, Kweon. "Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling." J. Geophys. Res., vol. 10, no. 4, 2008, pp. 468-475. |
| Flatt, T., Heyland, A., Rus, F., Porpiglia, E., Sherlock, C., Yamamoto, R., Garbuzov, A., Palli, S. R., Tatar, M., Silverman, N. "Hormonal regulation of the humoral innate immune response in Drosophila melanogaster." Journal of Experimental Biology, vol. 211, no. 16, 2008, pp. 2712-2724. |
| Bergland, A. O., Genissel, A., Nuzhdin, S. V., Tatar, M. "Quantitative Trait Loci Affecting Phenotypic Plasticity and the Allometric Relationship of Ovariole Number and Thorax Length in Drosophila melanogaster." Genetics, vol. 180, no. 1, 2008, pp. 567-582. |
| Neretti N, Remondini D, Tatar M, Sedivy JM, Pierini M, Mazzatti D, Powell J, Franceschi C, Castellani GC. "Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation." BMC Bioinformatics, vol. 8 Suppl 1, 2007, pp. S16. |
| Min KJ, Flatt T, Kulaots I, Tatar M. "Counting calories in Drosophila diet restriction." Experimental Gerontology, vol. 42, no. 3, 2007, pp. 247-51. |
| Tatar M. "Diet restriction in Drosophila melanogaster. Design and analysis." Interdisciplinary topics in gerontology, vol. 35, 2007, pp. 115-36. |
| Gershman, B., Puig, O., Hang, L., Peitzsch, R. M., Tatar, M., Garofalo, R. S. "High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO." Physiological Genomics, vol. 29, no. 1, 2007, pp. 24-34. |
| Zerofsky, Melissa, Harel, Ephat, Silverman, Neal, Tatar, Marc. "Aging of the innate immune response in Drosophila melanogaster." Aging Cell, vol. 4, no. 2, 2005, pp. 103-108. |
| Tatar, M. "Comment on "Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body." Science, vol. 307, no. 5710, 2005, pp. 675a-675a. |
| Cowen, Tim, Tatar, Marc, Shetty, Ashok. "Welcome to the new section of the Editorial Board of Aging Cell: Stem Cells in Aging." Aging Cell, vol. 4, no. 4, 2005, pp. 165-165. |
| Leroi, Armand M., Bartke, Andrzej, Benedictis, Giovanna De, Franceschi, Claudio, Gartner, Anton, Gonos, Eleftherios, Feder, Martin E., Kivisild, Toomas, Lee, Sylvia, Kartal-Özer, Nesrin, Schumacher, Michael, Sikora, Ewa, Slagboom, Eline, Tatar, Mark, Yashin, Anatoli I., Vijg, Jan, Zwaan, Bas. "What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?." Mechanisms of Ageing and Development, vol. 126, no. 3, 2005, pp. 421-429. |
| Wessells RJ, Fitzgerald E, Cypser JR, Tatar M, Bodmer R. "Insulin regulation of heart function in aging fruit flies." Nature Genetics, vol. 36, no. 12, 2004, pp. 1275-81. |
| Tatar M. "Unearthing Loci that influence life span." Science of aging knowledge environment : SAGE KE, vol. 2003, no. 9, 2003, pp. PE5. |
| Tatar M, Rand DM. "Aging. Dietary advice on Q." Science, vol. 295, no. 5552, 2002, pp. 54-5. |
| Bronikowski AM, Alberts SC, Altmann J, Packer C, Carey KD, Tatar M. "The aging baboon: comparative demography in a non-human primate." Proceedings of the National Academy of Sciences, vol. 99, no. 14, 2002, pp. 9591-5. |
| Good TP, Tatar M. "Age-specific mortality and reproduction respond to adult dietary restriction in Drosophila melanogaster." Journal of Insect Physiology, vol. 47, no. 12, 2001, pp. 1467-1473. |
| Tatar M, Chien SA, Priest NK. "Negligible Senescence during Reproductive Dormancy in Drosophila melanogaster." The American naturalist, vol. 158, no. 3, 2001, pp. 248-58. |
| Silbermann, Rebecca, Tatar, Marc. "REPRODUCTIVE COSTS OF HEAT SHOCK PROTEIN IN TRANSGENIC DROSOPHILA MELANOGASTER." Evolution, vol. 54, no. 6, 2000, pp. 2038. |
| Silbermann R, Tatar M. "Reproductive costs of heat shock protein in transgenic Drosophila melanogaster." Evolution, vol. 54, no. 6, 2000, pp. 2038-45. |
| Tatar M, Promislow DEL. "FITNESS COSTS OF FEMALE REPRODUCTION." Evolution, vol. 51, no. 4, 1997, pp. 1323-1326. |
| Tatar M, Carey JR. "GENETICS OF MORTALITY IN THE BEAN BEETLE CALLOSOBRUCHUS MACULATUS." Evolution, vol. 48, no. 4, 1994, pp. 1371-1376. |
| Tatar M, Carey JR, Vaupel JW. "LONG-TERM COST OF REPRODUCTION WITH AND WITHOUT ACCELERATED SENESCENCE IN CALLOSOBRUCHUS MACULATUS: ANALYSIS OF AGE-SPECIFIC MORTALITY." Evolution, vol. 47, no. 5, 1993, pp. 1302-1312. |
Ongoing Research Support
R37 AG024360 NIA Tatar (PI) (MERIT AWARD) 8/04 - 7/21
Genetic and Molecular Basis of Longevity
This project studies how the structure of the Drosophila insulin receptor specifically modulates aging through its action via the FOXO transcription factor.
Role: PI
P01 AG033561 NIA Tatar/Bodmer(PI) (Brown University/Sanford Burnham Inst.) 4/11 - 3/16
Genetic Analysis of Drosophila Functional Aging
This program project, based at the Sanford Burnham Research Institute in San Diego, studies the genetic basis of functional aging with Drosophila as a model system. The Tatar subproject analyses innate immunity senescence using the fly kidney (Malpighian tubule) as a model aging tissue.
Role: Project Leader and Core Leader
Recently Completed Research Support
R01 AG031152 NIA Tatar (PI) 9/08 – 8/13
Mechanisms of Aging Regulation by Drosophila Germline
Determined how reproduction modulates aging through the action of signals from germline stemcells, via regulation of systemic regulation of insulin/IGF signaling
Role: PI
Whitaker R, Gil MP, Ding F, Tatar M, Helfand SL, Neretti N. 2014 Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster. Aging (Albany NY) 6(5):355-68. PMID: 24864304
Ding F, Gil MP, Franklin M, Ferreira J, Tatar M, Helfand SL, Neretti N. 2014. Transcriptional response to dietary restriction in Drosophila melanogaster. J Insect Physiol. pii: S0022-1910(14)00076-6. doi: 10.1016/j.jinsphys.2014.05.002. [Epub ahead of print] PMID: 24819200
Tatar M, Post S, Yu K. 2014 Nutrient control of Drosophila longevity. Trends Endocrinol Metab. pii: S1043-2760(14)00042-3. doi: 10.1016/j.tem.2014.02.006.
Bai H, Kang P, Tatar M. 2013 The regulation of Drosophila aging by insulin/IGF signaling via FOXO mediated by TGF-/Activin control of autophagy. PLoS Genetics 9(11):e1003941. doi: 10.1371/journal.pgen.1003941
Yamamoto R, Bai H, Dolezal A, Amdam G, Tatar M. 2013 Juvenile hormone regulation of Drosophila aging. BMC Biology 11:85. doi:10.1186/1741-7007-11-85
Rus F, Flatt T, Aggarwal K, Caffrey D, Tatar M, and Silverman N. 2013 Crosstalk between the ecdysone signaling pathway and the Drosophila innate immune response. EMBO Journal. 32L1626-38. doi: 10.1038/emboj.2013.100
Paik D, Jang YG, Lee YE, Lee YN, Yamamoto R, Gee HY, Yoo S, Bae E, Min K, Tatar M, Park J-J. 2012. Misexpression screen delineates novel genes controlling Drosophila lifespan. Mech Aging Devel. 133: 234-245
Hong SY, Lee K-S, Kwak S-J, Kim A-K, Bai H, Jung M-S, Kwon O-Y, Song W-J, Tatar M, and Yu K. 2012. Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway. PLoS Genetics. 8(8)e1002857.
Bai H, Kang P, Tatar M. 2012. Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain. Aging Cell 11(6):978-85.
Bergland AO, Chae H-S, Kim Y-J, Tatar, M. 2012. Fine scale mapping of natural variation in fly fecundity identifies neuronal domain of expression and function of an aquaporin. PLoS Genetics 8(4): e1002631. doi: :10.1371/journal.pgen.1002631.
Villa-Cuesta E, Boylan JM, Tatar M, Gruppuso PA. 2011. Resveratrol inhibits protein translation in H4-II-E hepatic cells. PLoS One 6(12):e29513.
O’Connor KA, Brindle E, Shofer J, Trumble BC, Aranda JD, Rice K, Tatar M. 2011. The effects of a long-term psychosocial stress on reproductive indicators in the baboon. American Journal of Physical Anthropology 145:629-638.
Yamamoto R, Tatar M. 2011. Insulin receptor substrate chico acts with and without the transcription factor FOXO to extend Drosophila lifespan. Aging Cell 10: 729-32.
Tatar, M. 2011. The plate half-full: Status of research on the mechanisms of dietary restriction in Drosophila melanogaster. Exp. Gerontol. 286: 363-8.
Sajid, W., Kulahin, N., Schluckebier, G., Ribel, U., Henderson, H., Tatar, M., Hansen, B.F., Svendsen, A.M, Kiselyov, V.V., Nørgaard, P., Wahlund, P.-O., Brandt, J., Kohanski, R.A., Andersen A.S., De Meyts, P. 2011. High-resolution structure and biological properties of Drosophila insulin-like peptide 5 (DILP5) show evolutionary conservation of receptor binding properties but not of dimerization mechanism. J Biol Chem. 286(1):661-73. Epub 2010 Oct 25.
Hodkova, M., Tatar, M. 2011. Parallels in understanding the endocrine control of life span with Pyrrhocoris apterus and Drosophila melanogaster. In “Mechanisms of Life History Evolution” T. Flatt and A. Heyland (eds). Oxford University Press. 171-179.
Villa-Cuesta, E., Sage, B., Tatar, M. 2010. A role for Drosophila dFoxO and dFoxO 5’UTR internal ribosomal entry sites during fasting. PLoSONE. 9;5(7):e11521
Garbuzov, A., Tatar, M. 2010. Hormonal regulation of Drosophila microRNA let-7 and miR-125 that target innate immunity. FLY. 4:306-11.
Tatar, M. 2010. Reproductive aging in invertebrate genetic models. Ann. New York Acad. Sci. 1204:149-55.
Tatar, M. 2009. Metabolism by remote control. Cell Metabolism 10(3):164-6.
Flatt, T., Heyland, A., Rus, F., Porpiglia, E., Sherlock, C., Yamamoto, R., Garbuzov, A., Palli, S.R., Tatar, M., Silverman, N. 2008 Hormonal regulation of the humoral innate immune response in Drosophila melanogaster. J Exp Biol. 211:2712-24.
Bergland, A.O., Genissel, A., Nuzhdin, S.V., Tatar, M. 2008 Quantitative trait loci affecting phenotypic plasticity and the allometric relationship of ovariole number and thorax length in Drosophila melanogaster. Genetics. 180:567-82.
Flatt, T. Min, K.J., D'Alterio, C., Villa-Cuesta, E., Cumbers, J., Lehmann, R., Jones, D.L., and Tatar, M. 2008. Drosophila germ-line modulation of insulin signaling and lifespan. Proc. Natl. Acad. Sci. USA. 105: 6368-6373.
Min, K.J, Yamamoto, R., Buch, S. Pankratz, M., Tatar, M. 2008. Drosophila lifespan control by dietary restriction independent of insulin-like signaling. Aging Cell. 7: 199-206.
O'Brien, D., Min, K.J., Tatar, M. 2008. Use of stable isotopes to examine how dietary restriction extends Drosophila lifespan. Current Biology. 18: R155-156.
Lee, K-S., Kwon, O-Y., H. Lee, J.H. Kwon, K., Min, K-J. Jung, S-A., Kim, A-K., You, K-H., Tatar, M. and Yu, K. 2008. Drosophila short neuropeptide F signaling regulates growth by ERK mediated insulin signaling. Nature Cell Biology. 10: 468-475.
Tatar, M. 2007. Diet restriction in Drosophila melanogaster. Design and analysis. Interdiscip Top Gerontol. 2007;35:115-36.
Gershman, B., Puig, O., Hang, L., Peitzsh, R., Tatar, M. Garofalo, R. 2007. High resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO. Physiological Genomics. 29(1): 24-34.
Min, K.J., Tatar, M. 2007. Counting calories in Drosophila diet restriction. Experimental Gerontology. 42(3): 247-251
Min, K.J., Tatar, M. 2006. Drosophila diet restriction in practice: Do flies consume fewer nutrieints? Mechanisms of Aging and Development 127: 93-96.
Min, K.J., Hogan, M.F., Tatar, M., O'Brien, D.M 2006. Resource allocation to reproduction and soma in Drosophila: stable isotope analysis of carbon from dietary sugar. Journal of Insect Physiology. 52(7):763-70
Min, K.J., Tatar, M. 2006. Restriction of amino acids extends lifespan in Drosophila melanogaster. Mechanisms of Aging and Development. 127, 643-646
Leroi, A.M., et al., What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mech Ageing Dev, 2005. 126: 421-9.
Zerofsky, M., Heral, H., Silverman, N., Tatar, M. 2005. Aging of the innate immune response in Drosophila melanogaster. Aging Cell. 4:103-108.
Tatar, M., SIR2 calls upon the ER. Cell Metab, 2005. 2: 281-2.
Flatt, T., M.P. Tu, and M. Tatar, Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history. Bioessays, 2005. 27: 999-1010.
Tu, M.-P., Yin, C.-M., Tatar, M. 2005. Insulin signal regulation of juvenile hormone synthesis in Drosophila melanogaster. General and Comparative Endocrinology. 142: 347-356.
Tatar, M. 2004. The Neuroendocrine Regulation of Drosophila Aging. Experimental Medicine (Japanese). 22: 823-830. Reprinted in Experimental Gerontology (2004). 39: 1745-1750.
Wood, J.G., Rogina, B., Lavu, S., Howitz, K., Helfand, S.L., Tatar, M., Sinclair, D. 2004. Sirtuin activators mimic calorie restriction and delay aging in metazoans. Nature. 429:562-566.
Wessels, R.J., Fitzgerald, E., Cypser, J.R. Tatar, M., Bodmer, R. 2004. Insulin regulation of heart function in aging Drosophila. Nature Genetics, 36:1275-1281.
Hwangbo, D.S, Gershman, B., Tu, M-P., Palmer, M. Tatar, M. 2004. Drosophila dFOXO controls lifespan and regulates insulin signaling in brain and fat body. Nature 420:562-566.
Kingan, S.B., Tatar, M. Rand, D.M. 2003. Reduced polymorphism in the Chimpanzee semen coagulating protein, Semenogelin I. Journal Molecular Evolution 57:159-169.
Tu, M.-P., Tatar, M. 2003. Juvenile diet restriction and the aging and reproduction of adult Drosophila melanogaster. Aging Cell, 2:327-333.
Tatar, M., Bartke, A., Antebi, A. 2003. The endocrine regulation of aging by insulin-like signals. Science, 299: 1346-1351.
Tatar, M. 2002. Germline stem cells call the shots. Trends in Ecology and Evolutionary Biology, 17: 297-298.
Tu, M.-P., Epstein, D., Tatar, M. 2002. The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homolog chico. Aging Cell, 1: 75-80.
Tatar, M. 2002. The aging baboon: Comparative demography in a nonhuman primate. PNAS, 99: 9591-9595.
Bronikowski, A.M., Alberts, S.C., Altman, J., Packer, C., Carey, K.D., Tatar, M. 2002. The aging baboon: Comparative demography in a nonhuman primate. PNAS, 99: 9591-9595
Tu, M.-P., Yin, C.-M., Tatar, M. 2002. Impaired ovarian ecdysone synthesis of Drosophila melanogaster insulin receptor mutants. Aging Cell, 2: 158-160.
Tatar, M., Rand, D. 2002. Dietary advice on Q. Science. 295: 54-55.
Tatar, M. 2001. Senescence in C. W. Fox, D. A. Roff and D. J. Fairbain, eds. Evolutionary Ecology: Concepts and Case Studies. Oxford University Press, Oxford. Pp 128-141.
Tatar, M., Yin, C.-M. 2001. Slow aging during insect reproductive diapause: Why butterflies, grasshoppers and flies are like worms. Experimental Gerontology. 36: 723-738.
Tatar, M., Chien, S., Preist, N. 2001. Negligible senescence during reproductive diapause in Drosophila melanogaster. American Naturalist. 158: 248-258.
Linnen, C., Tatar, M., Promislow, D. 2001. Cultural artifacts: a comparison of senescence in natural, laboratory-adapted and artificially selected lines of Drosophila melanogaster. Evolutionary Ecology Research. 3: 877-888.
Herman, W.S., Tatar, M. 2001. Juvenile hormone regulates longevity during reproductive diapause in the migratory monarch butterfly. Proceeding Royal Society, B. London. 268: 2509-2514.
Good, T.P., Tatar, M. 2001. Age-specific mortality and reproduction respond to adult dietary restriction in Drosophila melanogaster. Journal of Insect Physiology 47: 1467-1473.
Tatar, M., Kopelman, A., Epstein, D., Tu, M.-P., Yin, C.-M., Garofalo, R.S. 2001. A mutant Drosophila insulin receptor homolog that extends lifespan and impairs neuroendocrine function. Science. 292: 107-110.
Tatar, M. 2000. Transgenic organisms in evolutionary ecology. Trends in Evolution and Ecology. 15: 207-211.
Silbermann, R., Tatar, M. 2000. Reproductive costs of transgenic hsp70 overexpression in Drosophila. Evolution. 54: 2038-2045.
Promislow, D.E.L., Tatar, M., Pletcher, S.D., Carey, J.R. 1999. Below-threshold mortality and its impact on studies in evolutionary ecology. Journal of Evolutionary Biology. 12: 312-328.
Tatar, M. 1999. Transgenes in the analysis of lifespan and fitness. American Naturalist. 154: S67-81.
Tatar, M. 1999. Evolution of senescence: Longevity and the expression of heat shock proteins. American Zoologist. 38: 72-81.
Shaw, F., Promislow, D.E.L, Tatar, M. Hughes, K., Geyer, C. 1999. Towards reconciling inferences concerning genetic variation in senescence. Genetics 152: 553-566.
Resler A.S, Kelly K., Kantor G., Khazaeli A.A., Tatar M., Curtsinger J.W. 1998. Genetic analysis of extended life span in Drosophila melanogaster - II. Replication of the backcross test and molecular characterization of the N14 Locus. Genetica. 104: 33-39.
Promislow, D.E.L., Tatar, M. 1998. Mutation and senescence: Where genetics and demography meet. Genetica. 102/103: 299-314.
Packer, C., Tatar, M., Collins, A. 1998. Reproductive cessation in female mammals. Nature. 392: 807-811
Tatar, M., Promislow, D.E.L. 1997. Fitness costs of reproduction. Evolution. 51:1323-1326.
Tatar, M., Gray, D.W., Carey, J.R. 1997. Altitudinal variation for senescence in Melanoplus grasshoppers. Oecologia. 111:357-364.
Tatar, M., Khazaeli, A.A., Curtsinger, J.W. 1997. Chaperoning extended life. Nature. 390:30.
Khazaeli, A.A., Tatar, M., Pletcher, S.D., Curtsinger, J.W. 1997. Heat-induced longevity extension in Drosophila. I. Heat treatment, mortality and thermotolerance. Journal of Gerontology. 52A: B48-B52.
Promislow, D.E.L., Tatar, M., Khazaeli, A., Curtsinger, J.W. 1996. Age-specific patterns of genetic variance in Drosophila melanogaster. I. Mortality. Genetics. 143: 839-848.
Tatar, M., Promislow, D.E.L., Khazaeli, A., Curtsinger, J.W. 1996. Age-specific patterns of genetic variance in Drosophila melanogaster. II. Fecundity and its relation to mortality. Genetics. 143: 849-858.
Curtsinger, J.W., Fukui, H.H., Khazaeli, A., Kirscher, J., Pletcher, S., Promislow, D., Tatar, M. 1995. Genetic variation and aging. Annual Review of Genetics. 29: 553-575.
Tatar, M., Carey, J.R. 1995. Nutrition mediates reproductive costs in the beetle Callosobruchus maculatus. Ecology. 76: 2066-2073.
Fox, C.W., Tatar, M. 1994. Oviposition substrate affects adult mortality, independent of reproduction, in the seed beetle Callosobruchus maculatus. Ecological Entomology. 19:108-110.
Carey, J.R., Liedo, P., Orozco, D., Tatar, M., Vaupel, J.W. 1994. A male-female longevity paradox in medfly cohorts. Journal of Animal Ecology. 64: 107-116.
Tatar, M., Carey, J.R. 1994. The genetics of mortality in the bean beetle Callosobruchus maculatus. Evolution. 48:1371-1376.
Tatar, M., Carey, J.R. 1994. Sex mortality differentials in the bean beetle: reframing the question. The American Naturalist. 144:165-175.
Promislow, D., Tatar, M. 1994. Comparative Approaches to the Study of Senescence: Bridging Genetics and Phylogenetics. In The Genetics and Evolution of Aging (eds. C.E. Finch and M.R. Rose). pp. 45-54.
Tatar, M., Carey, J.R., Vaupel, J.W. 1993. Long term cost of reproduction with and without accelerated senescence in Callosobruchus maculatus: analysis of age-specific mortality. Evolution. 47:1302-1312.
Minkenberg, O.P.J.M., Tatar, M., Rosenheim, J.A. 1992. Egg load as a major source of variability in insect foraging and oviposition behavior. Oikos. 65:134-142.
Tatar, M. 1991. Clutch size in the swallowtail butterfly, Battus philenor: the role of host quality and egg load within and among seasonal flights in California. Behavioral Ecology and Sociobiology. 28: 337-344.
Tatar, M. 1989. Swallowtail clutch size reconsidered. Oikos. 55: 135.
Tatar, M. 1984. Protandry in physiological time. Oikos. 43: 413.
| Year | Degree | Institution |
|---|---|---|
| 1994 | PhD | University of California, Davis |
| 1986 | MA | University of California, Davis |
| 1980 | BA | Earlham College |
Appointments and Honors
1994 Merton Love Award for Outstanding Dissertation in Ecology, UC Davis
1994 Graduate Award for Excellence in Gerontology, UC Davis
2001-2003 Manning Assistant Professor, Brown University
2002, 2004 National Academy of Sciences/Beckman Frontiers of Science
2011-2021 MERIT Award, National Institute of Aging
Referee to Nature, Science, Nature Genetics, Evolution, Ecology, Proceedings Royal Society, Experimental Gerontology, Journal Insect Ecology, Oecologia, Genetics, Molecular and Cellular Biology, Journal of Gerontology, Genetica, Genetical Research. Journal Insect Physiology, J. Experimental Biology, Molecular Ecology, Trends in Genetics
Permanent member NIA-B Study Section (2011-2018)
Board of Reviewing Editors, Science (2006-2007)
Founding Editor-in-Chief: Aging Cell (Blackwell, launched October 2002)
Section Editor, Aging Cell (2005 - present)
American Federation of Aging Research, National Scientific Advisory Council (2002)
| BIOL 0190F - Darwinian Medicine |
| BIOL 2350 - The Biology of Aging |
