Dr. Helfand received his BS at Stanford University where he worked with Dr. Norman K. Wessells and discovered the neuronal growth factor Ciliary NeuroTrophic Factor. Dr. Helfand obtained his MD degree from Albert Einstein College of Medicine. During this time he spent a year at UC London with Drs. Martin Raff and Av Mitchison. He completed his Medical Internship at Montefiore Medical Center and his Neurology Residency at the Massachusetts General Hospital. He is Board Certified in Neurology.
After Postdoctoral training with Drs. Corey Goodman and David Hogness at Stanford and at Yale with John Carlson and Doug Kankel he took a position at the University of Connecticut Health Center where he worked from 1990 to 2005.
In 2005 he moved to Brown University where he is Professor in the Department of Molecular Biology, Cell Biology and Biochemistry in the Division of Biology and Medicine. His laboratory focuses on understanding the molecular genetic mechanisms underlying aging and longevity using the model system, Drosophila melanogaster. Dr. Helfand is an Ellison Medical Foundation Senior Scholar, recipient of a MERIT award from the National Institute on Aging, has twice been awarded the Glenn Award for Research in Biological Mechanisms of Aging and was awarded the Glenn Foundation/American Federation of Aging Research Breakthroughs in Gerontology Award.
R01 AG024353 (Helfand, PI) 8/1/04 – 4/30/19
Control of Gene Expression and Life Span
The goals of this project are to study the effects of age-related changes in chromatin on gene expression.
The overall goals of this project are to determine how changes in chromatin affect aging, with the intention of developing interventions capable of acting upon chromatin structure to restore a “younger” heterochromatin profile and extend healthy life span.
P01 AG051449 (Sedivy, PI) 9/1/16 - 5/30/21
Somatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?
Project 2 Helfand (PI): Regulation of retrotransposable element activity in Drosophila
The major goals are to exploit the Drosophila model system to study the role of retrotransposable elements (RTEs) in the progression of cellular dysfunction that occurs during aging, and to develop interventions that suppress RTE activity and extend healthy lifespan.
CFAR Developmental Award Helfand(PI) 7/1/16 – 6/30/17
Identification of pathways that Repress HIV proviruses using an in vivo Drosophila-based screen. The overall goal for this project is to develop new drugs for treating and potentially curing HIV-AIDS.
Glenn AFAR BIG Award (Helfand, PI) 07/01/14-6/30/17
American Federation for Aging Research
Chromatin-regulated activation of retrotransposable elements – a novel molecular mechanism of aging
The major goals are to examine the chromatin mechanisms responsible for transposable element repression and to explore the potential for augmenting these mechanisms as interventions for extending healthy lifespan.
Refereed journal articles
1) Helfand, S.L., Smith, G.A., and Wessells, N.K. (1976) Survival and development in culture of dissociated parasympathetic neurons from ciliary ganglia. Dev. Biol. 50: 541-547.
2) Helfand, S.L., Riopelle, R.J., and Wessells, N.K. (1978) Non-equivalence of conditioned medium and nerve growth factor for sympathetic, parasympathetic and sensory neurons. Exp. Cell Res. 113: 39-45.
3) Helfand, S.L., Werkmeister, J., and Roder, J.C. (1982) The relationship between target cell binding, chemiluminescence and cytolysis. J. Exp. Med. 156: 492-505.
4) Roder, J.C., Helfand, S.L., Werkmeister, J., McGarry, R., Beaumont, T.J., and Duwe, A. (1982) Oxygen intermediates are triggered early in the cytoytic pathway of human NK cells. Nature 298: 569-572.
5) Werkmeister, J.A., Helfand, S.L., Rubin, P., Haliotis, T., Pross, H., and Roder, J.C. (1982) Tumor cell differentiation modulates susceptibility to natural killer cells. Cell. Immun. 69: 122-127.
6) Roder, J.C., Todd, R.F., Rubin, P., Haliotis, T., Helfand, S.L., Werkmeister, J., Pross, H.F., Boxer, L.A., Schlossman, S.F., and Fauci, A.S. (1983) The Chediak-Higashi gene in humans III. Studies on the mechanism of NK impairment. Clinical Exp. Immuno. 51: 359-368.
7) Helfand, S.L., Werkmeister, J., Pross, H., and Roder, J.C. (1983) Oxygen intermediates are required for interferon activation of NK cells. J. Interferon Res. 2: 143-151.
8) Werkmeister, J., Helfand, S.L., Roder, J., and Pross, H. (1983) The chemiluminescence response of human natural killer cels. II. Association of a decreased response with low natural killer activity. Eur. J. Immunol. 13: 514-520.
9) McGarry, R.C., Helfand, S.L., Quarles, R.H., and Roder, J.C. (1983) Recognition of myelin-associated gylcoprotein by the monoclonal antibody HNK-1. Nature 306: 376-378.
10) Beachy, P.A., Helfand, S.L. Hogness, D.S. (1985) Segmental distribution of bithorax complex proteins during Drosophila development. Nature 313: 545-551.
11) Helfand, S.L. and Carlson, J. (1989) Isolation and characterization of an olfactory mutant in Drosophila with a chemically specific defect. Proc. Natl. Acad. Sci. USA 86: 2908-2912.
12) Woodward, C., Huang,T., Sun, H., Helfand, S.L., and Carlson, J. (1989) Genetic analysis of olfactory behavior in Drosophila: A new screen yields the ota mutants. Genetics. 123: 315-326.
13) McKenna, M., Monte, P., Helfand, S.L., Woodard, C., and Carlson, J. A novel chemosensory response in Drosophila and the isolation of the acj mutations which affect it. (1989) Proc. Natl. Acad. Sci. USA 86: 8118-8122.
14) Irvine, K.D., Helfand, S.L. and Hogness, D.S. The large upstream control region of the Drosophila homeotic gene Ultrabithorax. (1991) Development 111: 407-424.
15) Helfand, S.L., Blake,K.J., Rogina, B., Stracks, M.D., Centurion, A. and Naprta, B. Temporal patterns of gene expression in the antenna of the adult Drosophila melanogaster. (1995) Genetics 140: 549-555.
16) Blake, K.J., Rogina, B., Centurion, A. and Helfand, S. L. Changes in gene expression during post-eclosional development in the olfactory system of Drosophila melanogaster. (1995) Mechanisms of Development 52: 179-185.
17) Rogina, B. and Helfand, S. L. Regulation of gene expression is linked to life span in the adult Drosophila. (1995) Genetics 141: 1043-1048.
18) Blake, K. J., Hoopengardner, B., Centurion, A. and Helfand, S. L. A molecular marker shows that adult maturation is independent of the rate of pre-adult development in Drosophila melanogaster. (1996) Developmental Genetics 18: 125-130.
19) Helfand, S. L. and Naprta, B. The expression of a reporter protein, ß-galactosidase, is preserved during maturation and aging in some cells of the adult Drosophila melanogaster. (1996) Mechanisms of Development 55:45-51.
20) Rogina, B. and Helfand, S. L. Timing of expression of a gene in the adult Drosophila is regulated by mechanisms independent of temperature and metabolic rate. (1996) Genetics 143: 1643-1651
21) Rogina, B. and Helfand, S. L. Spatial and temporal pattern of expression of the wingless and engrailed genes in the adult antenna is regulated by age-dependent mechanisms. (1997) Mechanisms of Development 63: 89 - 97.
22) Rogina, B., Benzer, S., and Helfand, S. L. Drosophila drop-dead mutations accelerate the time course of age-related markers. (1997) Proc. Natl. Acad. Sci. (USA), 94: 6303-6306.
23) Rogina, B., Vaupel, J. W., Partridge, L., Helfand, S. L. Regulation of gene expression is preserved in aging Drosophila melanogaster. (1998) Current Biology, 8: 475-478.
24) Rogina, B. and Helfand, S.L. Cu, Zn superoxide dismutase deficiency accelerates the time course of an age-related marker in Drosophila melanogaster. (2000) Biogerontology 1: 161-167.
25) Rogina, B. Reenan, R. A., Nilsen S. P. and Helfand, S. L. Extended life-span conferred by cotransporter gene mutations in Drosophila. (2000) Science, 290: 2137-40.
26) Hoopengardner, B and Helfand, S. L. Temperature Compensation and Temporal Expression Mediated by an Enhancer Element in Drosophila. (2002) Mechanisms of Development, 110: 27-37.
27) Knauf, F., Rogina, B., Jiang, Z., Aronson, P. A., and Helfand, S. L. (2002) Functional Characterization and Immunolocalization of the Novel Transporter Encoded by the Life-Extending Gene Indy. Proc. Natl. Acad. Sci. (USA), 99:14315-14319.
28) Rogina, B., Helfand, S. L. and Frankel, S. (2002) Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction, Science, 298: 1745.
29) Marden, J.H., Rogina, B., Montooth,K.L. and Helfand, S. L. (2003) Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies. . Proc. Natl. Acad. Sci. (USA), 100: 3369-3373.
30) Fridell, Y-W., Sánchez-Blanco, Silvia, B. A. and Helfand, S. L., (2004) Functional Characterization of a Drosophila Mitochondrial Uncoupling Protein. Journal of Bioenergetics and Biomembranes, 36 (3): 219-228.
31) Woods, J, Rogina, B, Lavu, S., Howitz, K., *Helfand, S. L, *Tatar, M., and *Sinclair, D. (2004) Sirtuin activators mimic calorie restriction and delay aging in metazoans. Nature, 430 (7000): 686-9. (* co-contributing authors)
32) Bauer, J., Goupil, S., Garber, G., and Helfand, S. L. (2004) An accelerated assay for the identification of life span extending interventions in Drosophila melanogaster. Proc. Natl. Acad. Sci. (USA), 101:12980-12985.
33) Rogina, B. and Helfand, S. L. (2004) Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. (USA), 101: 15998-16003.
34) Fridell, Y-W, Sanchez-Blanco, A., Silvia, B. and Helfand, S. L. (2005) Targeted Expression of the Human Uncoupling Protein 2 (hUCP2) to Adult Neurons Extends Life Span in the Fly. Cell Metabolism, 1: 145-152.
35) Zheng, J-Y, Mutcherson, R, and Helfand, S. L. Calorie restriction delays lipid oxidative damage in Drosophila melanogaster. Aging Cell 2005; 4: 209-16.
36) Bross, TG, Rogina, B, and Helfand S.L. (2005) Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction. Aging Cell. 4: 309-17. (Cover picture)
37) Bauer JH, Poon PC, Glatt-Deeley H, Abrams JM, and Helfand S.L. (2005) Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span. Curr Biol. 15:2063-8.
38) Sanchez-Blanco A, Fridell YW, and Helfand S.L. (2006) Involvement of Drosophila Uncoupling Protein 5 in Metabolism and Aging. Genetics 172:1-12.
39) Knauf F, Mohebbi N, Teichert C, Herold D, Rogina B, Helfand S.L., Gollasch M, Luft FC, and Aronson, PA. (2006) The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates. Biochemical Journal 397: 25-29.
40) Bauer JH, Chang C, Morris SNS, Hozier S, Andersen S, Waitzman JS, Helfand S.L. (2007) Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling. Proc. Natl. Acad. Sci. (USA), 14; 104(33):13355-60Aug 8; [Epub ahead of print]
41) Bauer J.H., Morris SNS, Chang C, Flatt T, Wood JG and Helfand S.L. (2009) dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster. Aging 1: 38-48.
42) Neretti N, Wang PY, Brodsky AS, Nyguyen HH, White KP, Rogina B, Helfand S.L. (2009) Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage. Proc Natl Acad Sci U S A. 2009 Jan 21. [Epub ahead of print]
43) Wang PY, Neretti N, Whitaker R, Hosier S, Chang C, Lu D, Rogina B, Helfand SL. (2009) Long-lived Indy and calorie restriction interact to extend life span. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9262-7. Epub 2009 May 22.
44) Fridell, Y-W, Hoh, M, Kreneisz, Orsolya, Hosier, S, Chengyi, C, Scantling D, Mulkey, D and Helfand SL. (2009) Increased Uncoupling Protein (UCP) activity in Drosophila Insulin-Producing neurons attenuates Insulin signaling and extends lifespan. Aging Jul 21;1(8):699-713.
45) Bauer JH, Chang C, Bae G, Morris SN, Helfand SL.(2010) Dominant-negative Dmp53 extends life span through the dTOR pathway in D. melanogasgter. Mech Ageing Dev. 2010 Mar;131(3):193-201. Epub 2010 Feb 1.
46) Bauer, JH, Antosh, M., Chang, C., Schorl, C., Kolli, S., *Neretti, Helfand SL. Comparative transcriptional profiling identifies takeout as a gene that regulates life span. (2010) Aging May;2(5):298-310.PMID: 20519778
47) Wood JG, Hillenmeyer S, Lawrence C, Chang C, Hosier S, Lightfoot W, Mukherjee E, Jiang N, Schorl C, Brodsky AS, Neretti N, Helfand SL. (2010) Chromatin remodeling in the aging genome of Drosophlia. Aging Cell. 2010 Dec;9(6):971-8. doi: 10.1111/j.1474-9726.2010.00624.x. Epub 2010 Oct 21.PMID: 20961390
48) Antosh M, Whitaker R, Kroll A, Hosier S, Chang C, Bauer J, Cooper L, Neretti N, Helfand SL. (2011) Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila. Cell Cycle. 2011 Mar 15;10(6).
49) Antosh M, Fox D, Helfand SL, Cooper LN and Neretti N. (2011) New comparative genomics approach reveals a conserved health span signature across species. Aging (Albany NY). 2011 Jun;3(6):576-83. PMID: 21775776
50) Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, König J, Lieske S, Carmean CM, Frederick DW, Weismann D, Knauf F, Irusta PM, De Cabo R, Helfand SL, Samuel VT and Shulman GI. (2011) Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metabolism 2011 Aug 3;14(2):184-95. PMID: 21803289
51) Chamseddin KH, Khan SQ, Nguyen ML, Antosh M, Morris SN, Kolli S, Neretti N, Helfand SL, Bauer JH. “takeout-dependent longevity in associated with altered Juvenile Hormone signaling”. Mech Ageing Dev. 2012 Nov;133(11-12):637-46. Epub 2012 Aug 30. PMID: 22940452
52) Rogina B, and Helfand SL (2013). Indy mutations and Drosophila longevity. Front Genet., 4: 47.doi: 10:3389/fgene.2013.00047. eCollection 2013. PMCID:PMC3619052.
53) Whitaker R, Faulkner S, Miyokawa R, Burhenn L, Henriksen M, Wood JG, and Helfand SL (2013). Increased expression of Drosophila Sir 2 extends life span in a dose-dependent manner. Aging, 5(9):682-691. PMID: 24036492.
54) Savva YA, Jepson JEC, Chang Y-J, Whitaker R, Jones BC, St. Laurent G, Tackett MR, Kapranov P, Jiang N, Du G, Helfand SL and Reenan RA (2013). RNA editing regulates transposon-mediated heterochromatic gene silencing. Nature Comm., 4:2745. Doi: 10.1048/ncomms3745.
55) Jiang N, Du GY, Tobias E, Wood JG, Whitaker R, Neretti N and Helfand SL (2013). Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging. Aging, 5(11):813-824 (Cover picture). PMC Journal-in process.
56) Zhu CT, Chang C, Reenan JA and Helfand SL (2014). Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion. Aging, 6(1): 58-69..
57) Ding F, Gil MP, Franklin M, Ferreira J, Tatar M, Helfand SL, Neretti N (2014). Transcriptional response to dietary restriction in Drosophila melanogaster. J Insect Physiol. May 10. pii: S0022-1910(14)00076-6. Doi: 10.1016/j.insphys.2014.05.002 [Epub ahead of print].
58) Whitaker R, Gil MP, Ding F, Tatar M, Helfand SL, Neretti N (2014). Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster. Aging May 6(5):355-368. 2014.
59) Pu, M., Ni Z., Wang M., Wang X., Wood J. G., Helfand S. L., Yu H. and Lee S. S. (2015). "Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span." Genes Dev 29(7): 718-731.
60) Wood JG, Jones BC, Jiang N, Chang C, Hosier S, Wickremesinghe P, Garcia M, Hartnett DA, Burhenn L, Neretti N, *Helfand S.L. (2016). Chromatin-modifying genetic interventions suppress age- associated transposable element activation and extend life span in Drosophila. Proc. Natl. Acad. Sci. USA. Oct 4;113(40):11277-11282. PMID:27621458
This report was the subject of a Commentary in PNAS (Orr, W.C. (2016) Tightening the connection between transposable element mobilization and aging Proc Natl Acad Sci USA., a focus of Research Highlights in Nature Reviews Genetics, reported in world-wide newspaper articles and the focus of a Providence NBC television news segment.
61) Jones BC, Wood, JG, Chang C, Tam AD, Franklin MJ., Siegel ER, *Helfand SL (2016). A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan. Nature Communications, Dec 21: DOI: 10.1038/ncoms13856.
1) Goodman, C.S., Bastiani, M.M., Doe, C.Q., du Lac, S., Helfand, S.L., Kuwada, K.Y., Thomas, J.B. (1984) Neuronal recognition during development: cellular and molecular approaches. Science 225: 1271-1279.
2) Bastiani, M.J., Doe, C.Q., Helfand, S.L., and Goodman, C.S. (1985) Neuronal specificity and growth cone guidance in grasshopper and Drosophila embryos. Trends in Neuroscience 84: 257-266.
3) Hogness, D.S., Lipshitz, H.D., Beachy, P.A., Peattie, D.A., Saint, R.A., Goldschmidt-Clermont, M., Harte, P.J., Gavis, E.R., and Helfand, S.L. (1985) Regulation and products of the Ubx domain of the bithorax complex. Cold Spring Harbor Symp. Quant. Biol. 50: 181-194.
4) Helfand, S. L. and Rogina, B. Regulation of gene expression during aging. (2000) In “Molecular Genetics of Aging” Pages 67-80 Results and Problems in Cell Differentiation, Vol. 29, ed. Siegfried Hekimi, Springer-Verlag, Germany.
5) Helfand, S.L. and Inouye, S.K. Rejuvenating views of the aging process. (2002) Nature Reviews Genetics, 3: 149-153.
6) Helfand, S. L. Chaperones Take Flight. (2002) Science, 295: 809-810.
7) Helfand, S. L. and Rogina, B. Genetics of aging in the fruit fly, Drosophila melanogaster. (2003) Annual Review of Genetics, 37: 329-48.
8) Helfand, S. L. and Inouye, S. L. Aging, life span, genetics and the fruit fly. (2003) Clinical Neuroscience Research, 2: 270-278.
9) Helfand, S. L. and Rogina, B. “From genes to aging in the Drosophila”(2003) Advances in Genetics, Vol. 49, pp 67-109. Edited by J. C. Hall, J. C. Dunlap and T. Friedman, Academic Press, San Diego.
10) Helfand, S. L. and Rogina, B. Molecular genetics of aging: Is this the end of the beginning? (2003) BioEssays 25: 134-141.
11) Bauer JH and Helfand SL (2006). New tricks of an old molecule: lifespan regulation by p53. Aging Cell, 5: 437-40.
12) Bauer JH and Helfand SL (2006). The humble fly: what a model system can reveal about the human biology of aging. Rhode Island Medical Journal, 89(9): 314-5.
13) Bauer JH and Helfand SL (2009). Sir2 and longevity: the p53 connection. Cell Cycle, 8(12):1821. PMCID:PMC2827152.
14) Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM Jr, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, and Vijg J (2010) Impact Papers on Aging in 2009. Aging, Mar;2(3):111-21. PMCID:PMC2871240.
15) Shulman GI and Helfand SL (2011). Indy knockdown in mice mimics elements of dietary restriction. Aging, 3(8):701. PMCID:PMC3184973.
16) Wood JG and Helfand SL (2013). Chromatin structure and transposable elements in organismal aging. Frontiers in Genetics of Aging, 4;4:274 PMCID:3849598.
17) Gorbunova, V., Boeke, J.D., Helfand, S.L., and Sedivy, J.M. (2014). Human Genomics. Sleeping dogs of the genome. Science 346: 1187-1188 (PMID: 25477445).
18) Wood JG and Helfand SL (2013). Chromatin structure and transposable elements in organismal aging. Frontiers in Genetics of Aging, 4;4:274 PMCID:3849598.
19) Gorbunova, V., Boeke, J.D., Helfand, S.L., and Sedivy, J.M. (2014). Human Genomics. Sleeping dogs of the genome. Science 346: 1187-1188 (PMID: 25477445).
20) Willmes, DM. Helfand, SL, and Birkenfeld, AL. (2016). The longevity transporter mIndy (Slc13A5) as a target for treating hepatic steatosis and insulin resistance. Aging 8 (2): 208-209.
Chapters in books
1) Helfand, S.L., Werkmeister, J., and Roder, J.C. (1982) The role of free oxygen radicals in the activation of the NK cytolytic pathway. In: Herberman, R., Editor, NK Cells and Other Natural Effector Cells. Academic Press. Page: 1011-1020.
2) Werkmeister, J., Helfand, S.L., Haliotis, T., Pross, H., and Roder, J.C. (1982) Specificity of natural killer (NK) cells: nature of target cell structure. In: Herberman, R., Editor, NK Cells and Other Effector Cells. Academic Press. Page: 743-750.
3) Helfand, S. L. and Rogina, B. Regulation of gene expression during aging. In: Hekimi, Siegfried, editor. Molecular Genetics of Aging: Results and Problems in Cell Differentiation, vol. 29. Germany: Springer-Verlag; 2000. p. 67-80.
4) Helfand, S. L. and Rogina, B. From genes to aging in the Drosophila. In: Hall, J.C., Dunlap, J. C., Friedman, T., editors. Advances in Genetics. San Diego: Academic Press; 2003 vol. 49, p 67-109.
5) Helfand, S. L. and Rogina, B. Genetics of aging in the fruit fly, Drosophila melanogaster. Annual Review of Genetics 2003; 37: 329-48.
6) Helfand, S. L., Bauer, J. H. and Wood, J. G. (2009) Calorie Restriction in lower organisms. In Molecular Biology of Aging edited by L. Guarente, L. Partridge, and D. Wallace. Vol 51; 73-93. Cold Spring Harbor Laboratory Press, New York.
7) Bauer J. H. and Helfand S.L. (2011) The Genetics of Dietary Modulation of Lifespan Book is Mechanisms of Life History Evoluation edited by Thomas Flatt and Andrease Heyland, Oxford University Press, Oxford
8) Wood, J.G., Whitaker, R. and Helfand S.L. (2013) Genetic and biochemical tools for investigating sirtuin function in Drosophila melanogaster. Sirtuins: Methods and Protocols, Methods in Molecular Biology edited by Matthew Hirschey, Series Editor John M. Walker. vol. 1077: p57-67. Springer, Humana Press, New York, Heidelberg, Dordrecht, London.
9) Krieling, JA, Jones, BC, Wood, JG, De Cecco, M, Criscone, SW, Neretti, N, Helfand, SL*, and Sedivy, JM*. (2016) Contribution of Retrotransposable Elements to Aging, In “Human Retrotransposons in Health and Disease” Ed. G. Cristofari, Springer, New York, Heidelberg, Dordrecht, London. * Co-Contributing authors.
1974 Fairclough Book Prize for Classics, Stanford University
1975 Distinction, Departmental Honors (Biology) Stanford University
1975 NSF Undergraduate Fellowship (Advisor: N.K. Wessells), Stanford University
1976 Predoctoral Trainee Fellowship (Advisor: D.P. Purpura and N.K. Wessells), Stanford University and Albert Einstein College of Medicine
1977 Roche Award in Neuroscience, American Medical Student Association-National Research Meeting Award
1978 Albert Cass Scholarship for Research in Neuroimmunology
1979 Medical Research Council Fellowship in Neuroimmunology (Advisor: M.C. Raff), Department of Zoology, University College, London
1981 Queen's University Development Fund Award-Neuroimmunology (Advisor: J.C. Roder), Department of Biology, Queen's University, Kingston, Ontario
1983 Boston Society of Psychiatry and Neurology Sandoz Award for Medical Research, Department of Neurology, Massachusetts General Hospital
1983-1984 NIH Postdoctoral Fellowship (Advisor: C.S.Goodman), Stanford University
1984-1989 NIH Physician Scientist Award (Advisors: C.S.Goodman, D.S. Hogness, J. Carlson, D. K. Kankel), Stanford University and Yale University
1986 Diplomate, American Board of Psychiatry and Neurology
1990 University of Connecticut Research Initiation Program Grant
1991 American Cancer Society Institutional Research Grant Award
1991 University of Connecticut Faculty Research Grant
1992-1996 National Science Foundation Grant
1992 American Federation of Aging Research Award
1993 Sandoz Award for Gerontological Research
1993 University of Connecticut Faculty Research Grant
1994-1996 The Patrick & Catherine Weldon Donaghue Medical Research Foundation Award, mentor for Dr. Blanka Rogina.
1995 American Federation of Aging Research Award
1995 Gordon Conference Travel Award
1995 1995 Summer Training Course in Experimental Aging Research, National Institutes on Aging
1995 American Federation of Aging Research Fellowship, mentor for Mr. Timothy Kuwada.
1995 Nathan W. and Margaret T. Shock Aging Research Foundation Award
1997-1999 National Institutes on Aging-R03
1998 University of Connecticut Faculty Research Grant
1999-2004 R01 National Institutes on Aging
2000-2005 The Donaghue Foundation Investigator Program for Health-Related Research Award
2000 Burroughs Wellcome Travel Grant to study in UK
2001-2005 Ellison Medical Foundation Senior Investigator Award
2003 American Federation of Aging Research Fellowship, mentor for Mr. Brian Silvia.
2004 American Federation of Aging Research Fellowship, mentor for Mr. Sanchez-Blanco.
2004-2016 R37 NIH MERIT Award, National Institutes on Aging
2004-2009 R01 National Institutes on Aging
2005-2010 R01 National Institute on Aging
2005-2009 K01 mentor for Dr. Yih-Woei Fridell
2005-2007 American Federation of Aging Research Fellowship, mentor for Postdoctoral Fellowship for Dr. Johannes Bauer
2007-2009 NIA K99—mentor for Dr. Johannes Bauer
2007 Frontiers in Aging Distinguished Speaker, Baylor Medical School
2007 Keynote speaker at Biology of Aging Gordon Conference, Switzerland
2007-2009 Glenn Award for Research in Biological Mechanisms of Aging
2009-2011 Glenn Award for Research in Biological Mechanisms of Aging
2010-2011 Glenn, American Federation of Aging Research Fellowship, mentor for Postdoctoral Fellowship for Dr. Jason Wood
2011-2012 Glenn, American Federation of Aging Research Fellowship, mentor for Postdoctoral Fellowship for Dr. Nan Jiang
2011 Keynote Speaker, Fifth Annual Division of Aging Biology New Investigators Forum, NIA
2012-2014 Johnson & Johnson / Brown OVPR TIPAP Award
2013 Keynote Speaker for AGE meeting in Baltimore, MD, June 2, 2013.
2014-2015 Brown University DEANS Emerging Areas of New Science Award
2014-2016 Glenn/AFAR Breakthroughs in Gerontology Award
2014-2019 R01 National Institutes on Aging
|Chen, Qian||Michael G. Ehrlich, MD Professor of Orthopedic Research, Professor of Medical Science|
|Neretti, Nicola||Assistant Professor of Biology|
|Reenan, Robert||Professor of Biology|
|Sedivy, John||Hermon C. Bumpus Professor of Biology, Professor of Medical Science|
|Tatar, Marc||Professor of Biology|
Pride and Prejudice and the Development of Scientific Theories: The course is designed to examine how the pace and shape of scientific progress is affected by the social/cultural context and the "personality" of the individual. We will look into how the interplay between society and the individual affects how scientific theories arise, are presented, are debated and are accepted. The course will initially focus on Charles Darwin and his theory of Natural Selection. We will then read and discuss a book that more directly addresses the question of science, society and individuals--Stephen J. Gould's "The Mismeasure of Man". Finally selected chapters of the Origin of Species will be read and discussed.
|BIOL 0190P - Development of Scientific Theories: Context and the Individual|
|BIOL 0190P - Pride and Prejudice in the Development of Scientific Theories|
|BIOL 2350 - The Biology of Aging|