Judy Liu obtained an M.D./ Ph.D. from Albert Einstein College of Medicine. Her dissertation work was on inflammation in the brain. She went on to complete an internship in internal medicine and a residency in neurology at the Harvard teaching hospital, Beth Israel Deaconess Medical Center. In her final year, she was chief resident. After her residency she did a post-doctoral fellowship in neural development. At the same time she was an attending neurologist at Beth Israel Deaconess Medical Center in the department of Neurology. She joined the faculty at Children’s National Medical Center (CNMC) in 2009 to start her own research group, which studies how malformations of the cortex arise and their consequences. She came to Brown University in 2017.
Li, Peijun, Fu, Xiaoqin, Smith, Nathan A., Ziobro, Julie, Curiel, Julian, Tenga, Milagros J., Martin, Brandon, Freedman, Samuel, Cea-Del Rio, Christian A., Oboti, Livio, Tsuchida, Tammy N., Oluigbo, Chima, Yaun, Amanda, Magge, Suresh N., O’Neill, Brent, Kao, Amy, Zelleke, Tesfaye G., Depositario-Cabacar, Dewi T., Ghimbovschi, Svetlana, Knoblach, Susan, Ho, Chen-Ying, Corbin, Joshua G., Goodkin, Howard P., Vicini, Stefano, Huntsman, Molly M., Gaillard, William D., Valdez, Gregorio, Liu, Judy S.
Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy
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The Liu lab studies epilepsy that arises from common cortical malformations. These malformations, called focal cortical dysplasias, only affect a discreet part of the brain, however, they give rise to severe, medically refractory epilepsy. Patients with these dysplasias often have them removed surgically to treat the seizures. By studying the resected brain tissue, the Liu lab identified the circadian molecular clock as an important factor in epilepsy. By using animal models they determined that the abnormal function of the circadian molecular clock in the seizure focus leads to a decreased seizure threshold during sleep. This phenomenon may cause the sleep associated epilepsy commonly found in these patients.